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41. 发明授权

US07758190B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US07758190B2
公开(公告)日：2010-07-20
申请号：US11820664
申请日：2007-06-20
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/10
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和破坏性干扰。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

42. 发明授权

US07661820B2 Ophthalmologic instrument 有权
标题翻译：眼科仪器
公开(公告)号：US07661820B2
公开(公告)日：2010-02-16
申请号：US11883288
申请日：2006-01-18
申请人： Naoko Hara , Hisashi Kataoka , Chihiro Kato
发明人： Naoko Hara , Hisashi Kataoka , Chihiro Kato
IPC分类号： A61B3/14 , A61B3/10 , A61B3/00
CPC分类号： A61B3/101
摘要： The present invention provides an ophthalmologic apparatus that can noninvasively measure the state of the lacrimal layer formed on the cornea surface and that can quantitatively measure the state of the lacrimal layer without utilizing a reflection image from the retina.The ophthalmologic apparatus according to the present invention comprises an optical projection system for projecting light of a specified pattern onto a cornea surface, and an imaging device for photographing a reflection image of the projected light from the cornea surface. An operating unit calculates the degree of distortion of the reflection image on the basis of the density value distribution of the image photographed by the imaging device. The operating unit can determine the state of the lacrimal layer using the calculated degree of distortion.
摘要翻译：本发明提供一种眼科装置，其可以非侵入性地测量形成在角膜表面上的泪液层的状态，并且可以定量地测量泪液层的状态，而不利用来自视网膜的反射图像。根据本发明的眼科装置包括用于将指定图案的光投射到角膜表面上的光学投影系统和用于拍摄来自角膜表面的投射光的反射图像的成像装置。操作单元基于由成像装置拍摄的图像的浓度值分布来计算反射图像的失真度。操作单元可以使用计算的失真程度确定泪液层的状态。

43. 发明申请

US20090225276A1 Ophthalmic Photography Apparatus 有权
标题翻译：眼科摄影器材
公开(公告)号：US20090225276A1
公开(公告)日：2009-09-10
申请号：US11922708
申请日：2006-06-07
申请人： Takayoshi Suzuki
发明人： Takayoshi Suzuki
IPC分类号： A61B3/14
CPC分类号： A61B3/101
摘要： To observe interference stripes produced by tear fluid, a low magnification light source 10 is turned on to illuminate the outermost layer of a tear film on the cornea Ec of a subject's eye. Light reflected from the cornea Ec forms an image on a CCD 16, and an interference stripes pattern 18a created by the lipid film on the cornea is displayed on a monitor 18. To measure the amount of tear fluid, light-emitting elements 20a, 20b of a high-magnification light source are turned on to irradiate a tear fluid meniscus Em that has accumulated on the lower eyelid portion of the anterior ocular segment. Light reflected on the surface of the meniscus Em forms an image on the CCD 16, and images 18b, 18c of the light-emitting elements 20a, 20b are displayed on the monitor 18 as clear images separated by an interval D. The amount of tear fluid can be quantitatively measured by measuring the interval D. A single such structure allows interference stripes created by the tear film of the anterior ocular segment to be observed and the amount of tear fluid to be measured.
摘要翻译：为了观察由泪液产生的干涉条纹，打开低倍率光源10以照射受试者眼睛的角膜Ec上的泪膜的最外层。从角膜Ec反射的光在CCD16上形成图像，并且将由角膜上的脂质膜产生的干涉条纹图案18a显示在监视器18上。为了测量泪液量，发光元件20a，20b 打开高倍率光源，以照射积聚在前眼部的下眼睑部分上的泪液半月板Em。在半月板Em的表面上反射的光在CCD 16上形成图像，并且发光元件20a，20b的图像18b，18c作为以间隔D隔开的清晰图像显示在监视器18上。撕裂量可以通过测量间隔D来定量测量流体。单个这样的结构允许观察由前眼部段的泪膜产生的干涉条纹和待测量的泪液量。

44. 发明申请

US20090005660A1 Device for measuring concentrations of constituents of tear sample 有权
标题翻译：用于测量泪液样品成分浓度的装置
公开(公告)号：US20090005660A1
公开(公告)日：2009-01-01
申请号：US11899596
申请日：2007-09-06
申请人： Anthony P. Cappo , Gregory Bennett , Jeffrey P. Gilbard , Paul T. Gavaris , Diptabhas Sarkar
发明人： Anthony P. Cappo , Gregory Bennett , Jeffrey P. Gilbard , Paul T. Gavaris , Diptabhas Sarkar
IPC分类号： A61B3/10
CPC分类号： G01N21/553 , A61B3/101 , G01N33/84
摘要： A medical diagnostic method utilizes a surface plasmon resonance apparatus provided with a sensing surface. A tear sample from an eye of a patient is placed into contact with the sensing surface. The surface plasmon resonance apparatus is then operated to determine concentrations of solutes such as salt and antigenic analytes in the tear sample.
摘要翻译：医疗诊断方法利用设置有感测表面的表面等离子体共振装置。来自患者眼睛的泪液样本被放置成与感测表面接触。然后操作表面等离子体共振装置以测定溶液在溶液样品中的浓度，例如盐和抗原性分析物。

45. 发明授权

US07281801B2 Tear dynamics measured with optical coherence tomography 失效
标题翻译：用光学相干断层扫描测量撕裂动力学
公开(公告)号：US07281801B2
公开(公告)日：2007-10-16
申请号：US10941249
申请日：2004-09-15
申请人： Jianhua Wang
发明人： Jianhua Wang
IPC分类号： A61B3/00 , A61B3/10 , A61B6/00
CPC分类号： A61B3/101
摘要： A system and method are provided for measuring the thickness of a tear film layer and the heights of tear menisci around upper and lower eyelids of an eye. A plurality of images are acquired between consecutive blinks the eye using optical coherence tomography (OCT). The images depict the tear film layer and tear menisci as distinct from the cornea of the eye. In an embodiment, a plurality of reflectivity profiles from an OCT image are aligned and averaged. The difference between a first peak and a second peak of the average reflectivity profile is measured to determine the thickness of the tear film layer. The heights of the upper meniscus and the lower meniscus can also be measured from the same OCT image. In an embodiment, thickness measurements from the plurality of OCT images are combined. The measurements can be used to diagnose tear disorders, analyze treatments of dry eye and evaluate artificial tears.
摘要翻译：提供了一种系统和方法，用于测量泪膜层的厚度和眼睛上下眼睑附近的泪液半月板的高度。在使用光学相干断层摄影（OCT）的连续闪烁眼睛之间获取多个图像。图像描绘了与眼睛角膜不同的泪膜层和泪液半月板。在一个实施例中，来自OCT图像的多个反射率分布被对准并平均。测量平均反射率曲线的第一峰和第二峰之间的差异以确定泪膜层的厚度。上半月板和下弯月面的高度也可以从相同的OCT图像测量。在一个实施例中，组合来自多个OCT图像的厚度测量。测量可用于诊断眼泪疾病，分析干眼症治疗和评估人工泪液。

46. 发明申请

US20060109423A1 Tear dynamics measured with optical coherence tomography 失效
标题翻译：用光学相干断层扫描测量撕裂动力学
公开(公告)号：US20060109423A1
公开(公告)日：2006-05-25
申请号：US10941249
申请日：2004-09-15
申请人： Jianhua Wang
发明人： Jianhua Wang
IPC分类号： A61B3/10 , A61B3/14
CPC分类号： A61B3/101
摘要： A system and method are provided for measuring the thickness of a tear film layer and the heights of tear menisci around upper and lower eyelids of an eye. A plurality of images are acquired between consecutive blinks the eye using optical coherence tomography (OCT). The images depict the tear film layer and tear menisci as distinct from the cornea of the eye. In an embodiment, a plurality of reflectivity profiles from an OCT image are aligned and averaged. The difference between a first peak and a second peak of the average reflectivity profile is measured to determine the thickness of the tear film layer. The heights of the upper meniscus and the lower meniscus can also be measured from the same OCT image. In an embodiment, thickness measurements from the plurality of OCT images are combined. The measurements can be used to diagnose tear disorders, analyze treatments of dry eye and evaluate artificial tears.
摘要翻译：提供了一种系统和方法，用于测量泪膜层的厚度和眼睛上下眼睑附近的泪液半月板的高度。在使用光学相干断层摄影（OCT）的连续闪烁眼睛之间获取多个图像。图像描绘了与眼睛角膜不同的泪膜层和泪液半月板。在一个实施例中，来自OCT图像的多个反射率分布被对准并平均。测量平均反射率曲线的第一峰和第二峰之间的差异以确定泪膜层的厚度。上半月板和下弯月面的高度也可以从相同的OCT图像测量。在一个实施例中，组合来自多个OCT图像的厚度测量。测量可用于诊断眼泪疾病，分析干眼症治疗和评估人工泪液。

47. 发明授权

US06939298B2 Device and method for monitoring aqueous flow within the eye 失效
标题翻译：用于监测眼睛内的水流的装置和方法
公开(公告)号：US06939298B2
公开(公告)日：2005-09-06
申请号：US10376793
申请日：2003-02-28
申请人： Reay Brown , Mary G. Lynch
发明人： Reay Brown , Mary G. Lynch
IPC分类号： A61B3/117 , A61B5/00
CPC分类号： A61B3/101
摘要： The present invention provides a device and method for monitoring the flow of aqueous humor within the eye. The invention provides that the aqueous flow rate and/or pattern within the anatomical structures of the eye can be determined by monitoring a traceable component. Such determination provides diagnostic indications of the degree and location of ocular disease associated with aqueous outflow, such as glaucoma, and can further provide post-treatment indications of effectiveness.
摘要翻译：本发明提供了一种用于监测眼睛中房水流动的装置和方法。本发明提供了眼睛解剖结构内的水流量和/或图案可以通过监测可跟踪组分来确定。这样的确定提供了与水流出如青光眼相关的眼部疾病的程度和位置的诊断指示，并且可以进一步提供治疗后的有效性指示。

48. 发明申请

US20050162611A1 Ophthalmic apparatus 有权
标题翻译：眼科仪器
公开(公告)号：US20050162611A1
公开(公告)日：2005-07-28
申请号：US11038527
申请日：2005-01-21
申请人： Tetsuyuki Miwa
发明人： Tetsuyuki Miwa
IPC分类号： A61B3/10 , A61B3/14
CPC分类号： A61B3/101 , A61B3/145
摘要： An ophthalmic apparatus comprising: an illuminating optical system which projects light to an examinee' eye; an image pickup unit which color-photographs an interference image caused by interference of light reflected by a tear layer of the eye; and an analyzing part which dissolves the photographed interference image to a plurality of color components, determines an appearance of interference stripes of each color component based on a signal of each color component, and obtains a value indicating a dry eye symptom based on at least one of the number of interference stripes of each color component and changes in signal level of each color component.
摘要翻译：一种眼科装置，包括：将光投射到被检眼的照明光学系统; 摄像单元，其对由眼睛的泪液层反射的光的干涉引起的干涉图像进行彩色照片; 以及将拍摄的干涉图像溶解成多个颜色成分的分析部，基于各颜色成分的信号，确定各颜色成分的干涉条纹的外观，并根据至少一个颜色成分获得表示干眼症状的值每个颜色分量的干涉条纹数量和每个颜色分量的信号电平的变化。

49. 发明申请

US20050104606A1 Systems and methods for measuring tear film osmolarity 失效
标题翻译：用于测量泪膜渗透压的系统和方法
公开(公告)号：US20050104606A1
公开(公告)日：2005-05-19
申请号：US10718498
申请日：2003-11-19
申请人： Eric Donsky
发明人： Eric Donsky
IPC分类号： A61B3/10 , A61K20060101 , G01R27/08
CPC分类号： A61B3/101
摘要： An osmolarity measuring system is configured to receive a contact lens in a measurement chamber. The measurement chamber includes a volume of fluid, and a series of electrodes are configured to measure the electrical properties of the fluid. A processing device correlates the measured electrical properties with an osmolarity measurement. Further, the processing device is configured to track trends in stored osmolarity measurements and alert the user to take an action, including the cessation or alteration of product use.
摘要翻译：渗透压测量系统被配置为在测量室中接收隐形眼镜。测量室包括一定体积的流体，并且一系列电极构造成测量流体的电性能。处理装置将测量的电性质与渗透压测量值相关联。此外，处理装置被配置为跟踪存储的渗透压浓度测量的趋势并警告用户采取行动，包括停止或改变产品使用。

50. 发明授权

US5143080A In vivo osmometer 失效
标题翻译：体内渗透压计
公开(公告)号：US5143080A
公开(公告)日：1992-09-01
申请号：US716980
申请日：1991-06-18
申请人： Kenneth K. York
发明人： Kenneth K. York
IPC分类号： A61B5/00 , G01N27/06 , G01N33/487
CPC分类号： A61B3/101 , A61B5/4261 , A61B5/4266
摘要： A first exemplary embodiment of an osmometer for the in vivo measurement of the osmolarity of a bodily fluid such as tears or sweat comprises a detachable, preferably disposable, probe in combination with means for measuring the conductivity between two electrodes of the probe. The osmometer further comprises means for converting the measured value of conductivity of the in vivo sample into a corresponding value of osmolarity and display means for displaying a visible representation of that value.In a second exemplary embodiment a sensor of some physical quantity (such as dew point temperature) related to the vapor pressure from a bodily fluid is mounted inside a confining, generally concave shell which is placed adjacent to a portion of the human body for a measurement to be made. For the case of measuring tear osmolarity in the open eye, the confining shell could take the form of a conventional eyecup. The sensor can be a thermocouple or thermistor controlled by a microprocessor to measure vapor pressure by the dew point depression method.
摘要翻译：用于体内测量体液如泪液或汗液的渗透压的渗透计的第一示例性实施方案包括可拆卸的，优选为一次性的探针，以及用于测量探针的两个电极之间的电导率的装置。渗透压计还包括用于将体内样品的测量值转换成相应的摩尔渗透压浓度值的装置和用于显示该值的可视表示的显示装置。在第二示例性实施例中，与来自体液的蒸气压相关的某些物理量（例如露点温度）的传感器安装在与人体的一部分相邻放置以测量的约束的，大体上凹的外壳中被制造。对于在眼睛中测量泪液渗透压的情况，限制的外壳可以采取常规眼罩的形式。传感器可以是由微处理器控制的热电偶或热敏电阻，通过露点抑制法测量蒸气压。

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