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41. 发明申请

US20150196740A1 BALLOON CATHETER WITH FLUID INJECTION ELEMENTS 审中-公开
标题翻译：带流体注射元件的气泡导管
公开(公告)号：US20150196740A1
公开(公告)日：2015-07-16
申请号：US14154747
申请日：2014-01-14
申请人： MEDTRONIC CRYOCATH LP
发明人： George D. MALLIN , Claudia LUECKGE
IPC分类号： A61M25/10 , A61B18/02
CPC分类号： A61B18/02 , A61B2018/0022 , A61B2018/00255 , A61B2018/00267 , A61B2018/00351 , A61B2018/00357 , A61B2018/00375 , A61B2018/0212 , A61B2018/0262
摘要： A system and method for creating radial-linear lesions in tissue. The system includes a cryoablation device having a first balloon, a second balloon disposed about the first balloon, and one or more splines disposed between the first balloon and second balloon, each spline defining a plurality of ports. The splines may be in communication with a coolant supply, and the first balloon may be in communication with a coolant supply or non-coolant inflation fluid supply. When the first balloon is in the uninflated configuration, the splines may have a substantially linear configuration. Each of the splines may be radially oriented about an elongate shaft and transitionable between the substantially linear configuration and an arcuate configuration when the first balloon is in the inflated configuration. Coolant expelled from the splines between the first and second balloons creates an ablation pattern on the outer surface of the second balloon.
摘要翻译：用于在组织中产生径向线性损伤的系统和方法。该系统包括具有第一气球的冷冻消融装置，围绕第一气球设置的第二气球，以及设置在第一球囊和第二球囊之间的一个或多个花键，每个花键限定多个端口。花键可以与冷却剂供应源连通，并且第一气球可以与冷却剂供应或非冷却剂充气流体供应连通。当第一气球处于未膨胀构型时，花键可以具有基本线性的构型。每个花键可以围绕细长轴径向取向，并且当第一气球处于膨胀构型时可在基本线性构型和弧形构型之间转变。从第一和第二气球之间的花键排出的冷却剂在第二气球的外表面上产生消融图案。

42. 发明授权

US08926602B2 Triple balloon catheter 有权
标题翻译：三重气囊导管
公开(公告)号：US08926602B2
公开(公告)日：2015-01-06
申请号：US12695423
申请日：2010-01-28
申请人： Jean-Luc Pageard
发明人： Jean-Luc Pageard
IPC分类号： A61B18/02 , A61B18/00
CPC分类号： A61B18/02 , A61B2018/0022 , A61B2018/00255 , A61B2018/00261 , A61B2018/00375 , A61B2018/00577 , A61B2018/0212
摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body, a proximal end and a distal end; a first lumen; a second lumen; and an ablation element expandable from a first diameter to a second diameter, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more deformable balloon and/or flexible elements. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method, a tissue ablation device is provided and tissue in the left atrium is ablated with the device, whereby the ablation is created by freezing tissue.
摘要翻译：本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。在示例性实施例中，冷冻治疗装置包括导管主体，近端和远端; 第一个管腔第二个管腔以及可从第一直径扩展到第二直径的消融元件，所述消融元件具有与心脏组织的不平坦表面形貌一致的表面部分。消融元件可以包括一个或多个可变形的球囊和/或柔性元件。球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。在一种示例性方法中，提供组织消融装置，并且使用该装置消除左心房中的组织，由此通过冷冻组织产生消融。

43. 发明申请

US20140358137A1 COMPLIANT BALLOON WITH LIQUID INJECTION 有权
标题翻译：具有液体注射的合适的气球
公开(公告)号：US20140358137A1
公开(公告)日：2014-12-04
申请号：US13906929
申请日：2013-05-31
申请人： MEDTRONIC CRYOCATH LP
发明人： Yixin HU
IPC分类号： A61B18/14 , A61B18/04 , A61B18/02
CPC分类号： A61B18/1492 , A61B18/02 , A61B18/04 , A61B2018/0022 , A61B2018/00255 , A61B2018/00577 , A61B2018/0212 , A61B2018/046 , A61B2090/064
摘要： A system and method for occluding a pulmonary vein. The device includes a treatment device comprising an inner balloon, an outer balloon, and a space therebetween. Delivery of fluid to the inner balloon inflates the treatment element to a first diameter. If a greater treatment element diameter is required to completely occlude a pulmonary vein, fluid is delivered to the space between the first and second balloons, which expands the second balloon and causes the treatment element to have a second diameter that is greater than the first diameter. The fluid delivered to the inner balloon and fluid delivered to the space between the balloons may be from different sources and may be delivered and exhausted independently. Once the treatment element is caused to have a diameter sufficient to completely occlude the pulmonary vein, the treatment element is activated to cool or heat ostial tissue.
摘要翻译：一种闭塞肺静脉的系统和方法。该装置包括处理装置，该处理装置包括内部球囊，外部球囊和它们之间的空间。将流体输送到内部球囊将处理元件膨胀至第一直径。如果需要更大的治疗元件直径以完全闭塞肺静脉，则流体被输送到第一和第二气囊之间的空间，其膨胀第二气囊并使处理元件具有大于第一直径的第二直径。输送到内球囊的流体和输送到气球之间的流体可以来自不同的来源，并且可以独立地输送和排出。一旦使治疗元件具有足以完全闭塞肺静脉的直径，则治疗元件被激活以冷却或加热口腔组织。

44. 发明申请

US20140358136A1 APPARATUS AND METHODS RELATED TO SELECTIVE THERMAL INSULATION OF CRYOGENIC BALLOONS FOR LIMITED CRYOGENIC ABLATION OF VESSEL WALLS 审中-公开
标题翻译：与低温低温冷冻选择性热绝缘相关的装置和方法
公开(公告)号：US20140358136A1
公开(公告)日：2014-12-04
申请号：US14114367
申请日：2012-04-25
申请人： Brian KELLY , Gary Kelly , Barry Mullins , Fiachra Sweeney
发明人： Brian KELLY , Gary Kelly , Barry Mullins , Fiachra Sweeney
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00101 , A61B2018/0022 , A61B2018/00255 , A61B2018/00345 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262
摘要： Embodiments related to cryogenically ablating a vessel wall in a partial circumferential, non-continuous, or helical ablation pattern are disclosed. A catheter is disclosed that includes a cryoballoon for ablation of the vessel wall. A radially expandable insulative element is disposed over the cryoballoon to shield non-targeted tissue of the vessel wall from the cryoballoon and prevent ablation of the non-targeted tissue. Partial circumferential, non-continuous, and helical ablation can be effective for treating a variety of renal, cardio-renal, and other diseases including but not limited to hypertension, heart failure, renal disease, renal failure, contrast nephropathy, arrhythmia, and myocardial infarction. The insulative element may be, for example, a sheath component having opening(s) formed therethrough or may be an outer balloon within which the cryoballoon is disposed.
摘要翻译：公开了关于在部分圆周，非连续或螺旋消融模式中低温消融血管壁的实施例。公开了一种导管，其包括用于消融血管壁的低温球。将可径向膨胀的绝缘元件设置在该冷冻小球上方以将该血管壁的非目标组织与该低温球隔绝，并防止非目标组织的消融。部分圆周，非连续和螺旋消融可有效治疗各种肾，心肾和其他疾病，包括但不限于高血压，心力衰竭，肾脏疾病，肾衰竭，对比肾病，心律失常和心肌梗死。绝缘元件可以是例如具有通过其形成的开口的鞘部件，或者可以是设置有低血压的外球囊。

45. 发明申请

US20130110098A1 CRYOGENIC BALLOON DEVICE WITH RADIOFREQUENCY TIP 有权
标题翻译：具有放射性提示的低温球形装置
公开(公告)号：US20130110098A1
公开(公告)日：2013-05-02
申请号：US13282811
申请日：2011-10-27
申请人： Jean-Pierre Lalonde
发明人： Jean-Pierre Lalonde
IPC分类号： A61B18/02 , A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B2018/0022 , A61B2018/00255 , A61B2018/00351 , A61B2018/00357 , A61B2018/00613 , A61B2018/00642 , A61B2018/00702 , A61B2018/00714 , A61B2018/00791 , A61B2018/00863 , A61B2018/00898 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262
摘要： An intravascular ablation device, including a flexible elongate body; an expandable element positioned on the elongate body; a radiofrequency or electroporation treatment segment located distally of the expandable element; a cryogenic coolant source in fluid communication with an interior of the expandable element; and a radiofrequency or electroporation energy source in communication with the radiofrequency or electroporation treatment segment.
摘要翻译：一种血管内消融装置，包括柔性细长体; 定位在细长体上的可扩张元件; 位于可扩张元件的远侧的射频或电穿孔处理段; 与所述可膨胀元件的内部流体连通的低温冷却剂源; 以及与射频或电穿孔治疗部门通信的射频或电穿孔能量。

46. 发明授权

US08398624B2 System and method for performing ablation using an expandable member 有权
标题翻译：使用可扩展构件进行消融的系统和方法
公开(公告)号：US08398624B2
公开(公告)日：2013-03-19
申请号：US12119010
申请日：2008-05-12
申请人： Robert F Rioux , Paul DiCarlo
发明人： Robert F Rioux , Paul DiCarlo
IPC分类号： A61B18/18 , A61B18/04
CPC分类号： A61B18/1492 , A61B18/14 , A61B18/1482 , A61B2018/00166 , A61B2018/00214 , A61B2018/0022 , A61B2018/00238 , A61B2018/00255 , A61B2018/00547 , A61B2018/00559 , A61B2018/00577 , A61B2018/00702 , A61B2018/00875
摘要： An apparatus comprises a catheter, a conductive element and a balloon. The catheter has a lumen. The conductive element is disposed along the catheter. The balloon has an interior in fluid communication with the lumen of the catheter. The balloon is formed of a conductive material conductively coupled to the conductive element. The balloon has a collapsed configuration and an expanded configuration.
摘要翻译：一种装置包括导管，导电元件和气球。导管有一个内腔。导电元件沿导管设置。气囊具有与导管的内腔流体连通的内部。气球由导电性地耦合到导电元件的导电材料形成。气球具有收缩配置和扩展配置。

47. 发明申请

US20110184399A1 PARTIALLY COMPLIANT BALLOON DEVICE 有权
标题翻译：部分合适的气球装置
公开(公告)号：US20110184399A1
公开(公告)日：2011-07-28
申请号：US12694938
申请日：2010-01-27
申请人： Dan WITTENBERGER
发明人： Dan WITTENBERGER
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0022 , A61B2018/00255 , A61B2018/00375 , A61B2018/0212
摘要： A medical device is provided, having an elongate body defining a distal portion and a proximal portion; a first expandable member disposed on the distal portion of the elongate body and defining a cooling chamber therein, the first expandable member having a first rigidity; a second expandable member disposed around the first expandable member to define an interstitial region therebetween, where the second expandable member has a second rigidity less than the first rigidity; a gel disposed within the interstitial region; a coolant flow path in fluid communication with the cooling chamber; and a cryogenic coolant source in fluid communication with the coolant flow path.
摘要翻译：提供了一种医疗装置，其具有限定远侧部分和近端部分的细长主体; 第一可膨胀构件，其设置在细长主体的远端部分上并且在其中限定冷却室，第一可膨胀构件具有第一刚性; 第二可膨胀构件，其围绕所述第一可膨胀构件设置以在其间限定间隙区域，其中所述第二可膨胀构件具有小于所述第一刚性的第二刚性; 布置在间隙区内的凝胶; 与冷却室流体连通的冷却剂流动路径; 以及与冷却剂流动路径流体连通的低温冷却剂源。

48. 发明申请

US20110184398A1 CRYOBALLOON REFRIGERANT DISPERSION CONTROL 有权
标题翻译： CRYOBALLOON制冷剂分散控制
公开(公告)号：US20110184398A1
公开(公告)日：2011-07-28
申请号：US12694561
申请日：2010-01-27
申请人： Gilles Desrochers
发明人： Gilles Desrochers
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2017/003 , A61B2018/0022 , A61B2018/00255 , A61B2018/0212 , A61B2018/0262 , A61B2090/065 , A61M25/0069 , A61M25/1011 , A61M2025/0079 , A61M2025/1088 , A61M2025/1093
摘要： A catheter based medical device including controlled refrigerant dispersion is disclosed. The device includes a fluid injection tube that carries refrigerant from a coolant supply to the distal portion of the device. An open distal end or one or more orifices may be provided on the injection tube for the refrigerant to be expelled into an expandable chamber such as a balloon disposed on the distal portion of the catheter. The dispersion of the refrigerant from the injection tube may be controlled or manipulable to direct the refrigerant to one or more target locations.
摘要翻译：公开了一种包括受控制冷剂分散体的基于导管的医疗装置。该装置包括将制冷剂从冷却剂供应运送到装置的远端部分的流体注入管。可以在注射管上设置一个开口的远端或一个或多个孔，用于制冷剂被排出到可扩张的腔室中，例如设置在导管的远端部分上的球囊。可以控制或操纵来自注射管的制冷剂的分散，以将制冷剂引导到一个或多个目标位置。

49. 发明授权

US07371231B2 System and method for performing ablation using a balloon 有权
标题翻译：使用气球进行消融的系统和方法
公开(公告)号：US07371231B2
公开(公告)日：2008-05-13
申请号：US10768037
申请日：2004-02-02
申请人： Robert F Rioux , Paul DiCarlo
发明人： Robert F Rioux , Paul DiCarlo
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/1492 , A61B18/14 , A61B18/1482 , A61B2018/00166 , A61B2018/00214 , A61B2018/0022 , A61B2018/00238 , A61B2018/00255 , A61B2018/00547 , A61B2018/00559 , A61B2018/00577 , A61B2018/00702 , A61B2018/00875
摘要： An apparatus comprises a catheter, a conductive element and a balloon. The catheter has a lumen. The conductive element is disposed along the catheter. The balloon has an interior in fluid communication with the lumen of the catheter. The balloon is formed of a conductive material conductively coupled to the conductive element. The balloon has a collapsed configuration and an expanded configuration.
摘要翻译：一种装置包括导管，导电元件和气球。导管有一个内腔。导电元件沿导管设置。气囊具有与导管的内腔流体连通的内部。气球由导电性地耦合到导电元件的导电材料形成。气球具有收缩配置和扩展配置。

50. 发明授权

US06251109B1 Process and device for the treatment of atrial arrhythmia 有权
标题翻译：治疗房性心律失常的过程和装置
公开(公告)号：US06251109B1
公开(公告)日：2001-06-26
申请号：US09233337
申请日：1999-01-20
申请人： James A. Hassett , John F. Swartz , Michael C. Bednarek
发明人： James A. Hassett , John F. Swartz , Michael C. Bednarek
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2017/22067 , A61B2018/00065 , A61B2018/00214 , A61B2018/00238 , A61B2018/00255 , A61B2018/00261 , A61B2018/00333 , A61B2018/00351 , A61B2018/00375 , A61B2018/00577 , A61B2018/1435 , A61B2018/1437 , A61B2018/1472 , A61M25/1011 , A61M2025/1052 , A61M2025/1072 , A61M2025/1086
摘要： A process for the treatment of atrial arrhythmia by use of ablation procedures including circumferential ablation of vessels, particularly pulmonary veins, associated with the left atrium of the heart. Also medical devices for such process including a pair of balloons secured to a catheter with one balloon located within the other balloon and an ablation catheter located within one of the balloons, which devices are used for the formation of a circumferential ablation lesion in the pulmonary vein.
摘要翻译：一种通过使用包括与心脏左心房相关的血管，特别是肺静脉的周边消融的消融手术来治疗心房心律失常的方法。还有用于这种过程的医疗装置，包括固定到导管的一对球囊，其中一个球囊位于另一个球囊内，以及消融导管，位于一个气囊内，该装置用于在肺静脉中形成周缘性消融病变。

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