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41. 发明授权

US10680676B2 Underwater signal conversion 有权
公开(公告)号：US10680676B2
公开(公告)日：2020-06-09
申请号：US15729830
申请日：2017-10-11
申请人： The Government of the United States, as represented by the Secretary of the Army
发明人： Mark Govoni , John Suarez
IPC分类号： G01R1/20 , H04B5/00
摘要： Various embodiments associated with signal conversion while underwater are described. A source can transmit an alternating current signal with a relatively high frequency over a relatively long distance. The alternating current signal with the relatively high frequency can be converted to an alternating current signal with a relatively low frequency. An example of this conversion can be done by converting the alternating current signal with the relatively high frequency into a direct current signal. The direct current signal can then be converted into the alternating current signal with the relatively low frequency. The alternating current signal with the relatively low frequency can be transmitted from a transmission coil to a pick-up coil. After reception by the pick-up coil the alternating current signal with the relatively low frequency can be processed, such as processed to determine a direction of the source of the alternating current signal with the relatively high frequency.

42. 发明授权

US10493142B2 Gene optimized Hantaan virus M segment DNA vaccine for hemorrhagic fever with renal syndrome 有权
公开(公告)号：US10493142B2
公开(公告)日：2019-12-03
申请号：US15945768
申请日：2018-04-05
申请人： Government of the United States, as represented by the Secretary of the Army
发明人： Connie Schmaljohn
IPC分类号： A61K39/12 , C12N7/00 , C07K14/005 , A61K9/12 , A61K9/51 , A61K9/00 , A61K39/385 , A61K39/00
CPC分类号： A61K39/12 , A61K9/0009 , A61K9/0019 , A61K9/0021 , A61K9/0073 , A61K9/12 , A61K9/51 , A61K9/5115 , A61K39/385 , C07K14/005 , C12N7/00 , A61K2039/53 , A61K2039/575 , A61K2039/70 , C12N2760/12122 , C12N2760/12134 , C12N2760/12171 , C12N2800/22 , H05K999/99
摘要： A synthetic, codon-optimized Hantaan virus (HTNV) full-length M gene open reading frame that consists of a unique nucleotide sequence encoding HTNV proteins. This synthetic gene was cloned into a plasmid to form the first optimized HTNV full-length M gene that elicits neutralizing antibodies in animals when delivered in combination with a similarly optimized Puumala virus (PUUV) DNA vaccine. The invention obviates the need for an extraneous gene sequence that was previously required for expression of the non-optimized HTNV gene. The synthetic gene is engineered into a molecular vaccine system to prevent hemorrhagic fever with renal syndrome (HFRS) caused by infection with HTNV, SEOV, or DOBV. Alternatively, it can be combined with the optimized PUUV DNA vaccine to protect against HFRS caused by any hantavirus.

43. 发明授权

US10443032B2 Device and method for isolation of corneal endothelial cells 有权
公开(公告)号：US10443032B2
公开(公告)日：2019-10-15
申请号：US16060078
申请日：2017-04-19
申请人： THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY
发明人： Robert Haggins, Jr. , Erik Eaton, Jr. , Zachary Murray , Timothy Varney
IPC分类号： C12M3/00 , C12M1/00 , C12M1/12 , C12M1/36 , C12N5/071
摘要： An apparatus (8) for isolating corneal endothelial cells (34) (CECs) includes a base portion (10) having an interior recessed opening (14) with a bottom surface (16). A convex projection (18) is centrally located on the bottom surface (16) and is configured to receive an inverted cornea (32). A top portion (12) is configured to mate with the base portion (10). The top portion (12) includes a fluid chamber (24) with a lower surface (20). The lower surface (20) has an opening (22) therein in which the convex projection (18) projects when the top portion (12) is mated with the base portion (10).

44. 发明申请

US20190185547A1 FILOVIRUS ANTIBODY 审中-公开
公开(公告)号：US20190185547A1
公开(公告)日：2019-06-20
申请号：US16134041
申请日：2018-09-18
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. , THE GOVERNING COUNCEL OF THE UNIVERSITY OF TORONTO , THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY
发明人： Jonathan R. Lai , Jayne F. Koellhoffer , Julia Frei , Kartik Chandran , Sachdev Sidhu , Gang Chen , John M. Dye , Samantha Zak
IPC分类号： C07K16/10
CPC分类号： C07K16/10 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present invention addresses a need for antibodies useful for filovirus infections.

45. 发明申请

US20150361247A1 TOUGHENING CROSS-LINKED THERMOSETS 审中-公开
标题翻译：加强交联热敏电阻
公开(公告)号：US20150361247A1
公开(公告)日：2015-12-17
申请号：US14791057
申请日：2015-07-02
申请人： Drexel University , Government of the United States as represented by the Secretary of the Army
发明人： Giuseppe R. Palmese , John J. LaScala , James M. Sands , Xing Geng
IPC分类号： C08K5/1515 , C08K3/00
CPC分类号： C08K5/1515 , C08F8/44 , C08F120/40 , C08F222/40 , C08F269/00 , C08K3/013 , C08K5/101 , C08L31/02 , C08L67/06 , C11C3/04 , C11C3/08
摘要： Grafted triglycerides comprising an acrylated triglyceride grafted with a fatty acid residue containing 4 to 28 carbon atoms. Also described are methods for making a grafted triglyceride and for curing a material selected from vinyl esters and unsaturated polyesters and mixtures thereof and optionally a reactive diluent. The method includes the steps of mixing a grafted triglyceride of the present invention with a material selected from vinyl esters, unsaturated polyesters and mixtures thereof to form a mixture, and curing the mixture to form a cured resin system. A cured resin system comprising a cured product obtained by the foregoing method and composites containing the cured product and a filler or reinforcing material are also disclosed. This method also includes use of the grafted triglycerides to make toughened resin and composite systems with reduced hazardous air pollutants without significantly reducing the glass transition temperature and significantly increasing the viscosity.
摘要翻译：接枝甘油三酸酯，其包含用含有4至28个碳原子的脂肪酸残基接枝的丙烯酸酯化的甘油三酯。还描述了制备接枝甘油三酯和固化选自乙烯基酯和不饱和聚酯及其混合物和任选的反应性稀释剂的材料的方法。该方法包括将本发明的接枝甘油三酯与选自乙烯基酯，不饱和聚酯及其混合物的材料混合以形成混合物，并固化该混合物以形成固化的树脂体系的步骤。还公开了包含通过上述方法获得的固化产物和含有固化产物和填料或增强材料的复合材料的固化树脂体系。该方法还包括使用接枝的甘油三酯来制造具有减少的有害空气污染物的增韧树脂和复合体系，而不显着降低玻璃化转变温度并显着提高粘度。

46. 发明申请

US20150127302A1 METHOD AND APPARATUS FOR OPTIMIZED ROUTING 审中-公开
标题翻译：优化路由的方法和装置
公开(公告)号：US20150127302A1
公开(公告)日：2015-05-07
申请号：US14073908
申请日：2013-11-07
申请人： Jeffrey Odell Johnson
发明人： Jeffrey Odell Johnson
IPC分类号： G06F17/50
CPC分类号： G06F17/5077
摘要： A method and apparatus for path optimization comprising receiving model data, obstacle data and impact data describing an environment, parsing the model and obstacle data and constructing a three-dimensional data grid and calculating the cost of a path traversal from a start node to an end node based on cost of movement and the impact data.
摘要翻译：一种用于路径优化的方法和装置，包括接收描述环境的模型数据，障碍物数据和影响数据，解析模型和障碍物数据并构建三维数据网格并计算从起始节点到结束的路径遍历的成本基于运动成本和影响数据的节点。

47. 发明申请

US20140193651A1 MULTILAYER HYDROGELS WITH pH-RESPONSIVE SWELLING AND SURFACE WETTABILITY 有权
标题翻译：多层水凝胶，具有pH响应性和表面湿度
公开(公告)号：US20140193651A1
公开(公告)日：2014-07-10
申请号：US13798870
申请日：2013-03-13
申请人： The United States as Represented by the Secretary of the Army , THE UAB RESEARCH FOUNDATION
发明人： Eugenia P. Kharlampieva , Veronika Koziovskaya , Yun Wang , Donald Cropek , Imee Arcibal
IPC分类号： B05D1/00
CPC分类号： C08F226/06 , B05D1/005 , B05D1/185 , B05D3/107 , B05D5/00 , B05D5/04 , B05D5/08 , B05D7/50 , B05D7/52 , B05D7/56 , C09D5/00 , Y10T428/31859 , Y10T428/31909 , Y10T428/31928
摘要： A novel type of ultrathin cationic hydrogel coatings are provided that have high, quick and reversible swelling/shrinkage transitions and surface wettability in response to pH changes. The poly(4-vinyl pyridine) (PVP) hydrogel films are produced by selective cross-linking of PVP copolymers in layer-by-layer (LbL) films assembled by spin-assisted method. These multilayer hydrogels exhibit drastic and reversible 10-fold swelling when the pH is changed from neutral to acidic. The swelling amplitude of these coatings is controlled by varying cross-link densities within the films. The pH-responsive hydrogels open new prospects for developing “intelligent” materials with sharp stimuli-triggered responses for applications in sensing, transport regulation, and self-cleaning coatings.
摘要翻译：提供了一种新型的超薄阳离子水凝胶涂层，其具有响应于pH变化的高，快速和可逆的溶胀/收缩过渡和表面润湿性。聚（4-乙烯基吡啶）（PVP）水凝胶膜是通过用自旋辅助方法组装的层（LbL）膜中的PVP共聚物的选择性交联制备的。当pH从中性变为酸性时，这些多层水凝胶表现出剧烈且可逆的10倍溶胀。这些涂层的溶胀幅度由薄膜内的交联密度变化控制。 pH响应水凝胶为开发“智能”材料开辟了新的前景，对感应，运输调节和自清洁涂层的应用具有刺激性触发反应。

48. 发明申请

US20130253127A1 TOUGHENING CROSS-LINKED THERMOSETS 有权
公开(公告)号：US20130253127A1
公开(公告)日：2013-09-26
申请号：US13990360
申请日：2011-11-07
申请人： Giuseppe R. Palmese , John J. LaScala , James M. Sands , Xing Geng
发明人： Giuseppe R. Palmese , John J. LaScala , James M. Sands , Xing Geng
IPC分类号： C08F120/40 , C08L31/02
CPC分类号： C08K5/1515 , C08F8/44 , C08F120/40 , C08F222/40 , C08F269/00 , C08K3/013 , C08K5/101 , C08L31/02 , C08L67/06 , C11C3/04 , C11C3/08
摘要： Grafted triglycerides comprising an acrylated triglyceride grafted with a fatty acid residue containing 4 to 28 carbon atoms. Also described are methods for making a grafted triglyceride and for curing a material selected from vinyl esters and unsaturated polyesters and mixtures thereof and optionally a reactive diluent. The method includes the steps of mixing a grafted triglyceride of the present invention with a material selected from vinyl esters, unsaturated polyesters and mixtures thereof to form a mixture, and curing the mixture to form a cured resin system. A cured resin system comprising a cured product obtained by the foregoing method and composites containing the cured product and a filler or reinforcing material are also disclosed. This method also includes use of the grafted triglycerides to make toughened resin and composite systems with reduced hazardous air pollutants without significantly reducing the glass transition temperature and significantly increasing the viscosity.

49. 发明申请

US20130013342A1 Medical Information Handling Method 有权
标题翻译：医疗信息处理方法
公开(公告)号：US20130013342A1
公开(公告)日：2013-01-10
申请号：US13620045
申请日：2012-09-14
申请人： Tommy J. Morris
发明人： Tommy J. Morris
IPC分类号： G06Q50/24
CPC分类号： G06F19/3418 , G06F19/00 , G06F19/325 , G06F19/3456 , G06F19/3481 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/20 , G16H10/60 , G16H10/65 , G16H15/00 , G16H50/80 , Y02A90/22 , Y02A90/24 , Y02A90/26
摘要： A system and method used to create a longitudinal medical record for an injured person that in at least one embodiment begins a location remote from a medical facility. The system includes in at least one embodiment a plurality of mobile computing devices. In at least one embodiment, the mobile computing devices provide an interface for receiving information from a first responder or a medic.
摘要翻译：一种用于为受伤者创建纵向医疗记录的系统和方法，其在至少一个实施例中开始远离医疗设施的位置。该系统在至少一个实施例中包括多个移动计算设备。在至少一个实施例中，移动计算设备提供用于从第一响应者或医疗人员接收信息的接口。

50. 发明申请

US20120210901A1 SELF-SPRUNG STABILIZATION FIN SYSTEM FOR GUN-LAUNCHED ARTILLERY PROJECTILES 审中-公开
标题翻译：自动弹射器材自动弹簧稳定系统
公开(公告)号：US20120210901A1
公开(公告)日：2012-08-23
申请号：US12193330
申请日：2008-08-18
申请人： JAMES MAGUIRE BENDER
发明人： JAMES MAGUIRE BENDER
IPC分类号： F42B10/38 , F42B15/00 , F42B10/18
CPC分类号： F42B10/16
摘要： A system and process for the aerodynamic stabilization of rocket-assisted artillery projectiles launched from smooth-bore cannons comprises multiple stabilization fins stowed circumferentially and held by a cap until muzzle exit. At muzzle exit, the cap separates and allows the fins to self-deploy using the energy stored within the fin material, which is either shape memory alloy or spring steel. The fins are then locked into place and serve to stabilize the projectile without interfering with the discharge of hot propelling gasses from the rocket nozzle.
摘要翻译：从光膛炮发射的火箭辅助炮弹的空气动力学稳定系统和过程包括多个稳定翅片，其周向收纳并由盖子保持直到枪口出口。在枪口出口处，盖子分离并且允许翅片使用存储在翅片材料内的能量自身展开，翅片材料是形状记忆合金或弹簧钢。然后将翅片锁定就位并用于稳定射弹而不干扰来自火箭喷嘴的热推进气体的排放。

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