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1. 发明申请

US20140193651A1 MULTILAYER HYDROGELS WITH pH-RESPONSIVE SWELLING AND SURFACE WETTABILITY 有权
标题翻译：多层水凝胶，具有pH响应性和表面湿度
公开(公告)号：US20140193651A1
公开(公告)日：2014-07-10
申请号：US13798870
申请日：2013-03-13
申请人： The United States as Represented by the Secretary of the Army , THE UAB RESEARCH FOUNDATION
发明人： Eugenia P. Kharlampieva , Veronika Koziovskaya , Yun Wang , Donald Cropek , Imee Arcibal
IPC分类号： B05D1/00
CPC分类号： C08F226/06 , B05D1/005 , B05D1/185 , B05D3/107 , B05D5/00 , B05D5/04 , B05D5/08 , B05D7/50 , B05D7/52 , B05D7/56 , C09D5/00 , Y10T428/31859 , Y10T428/31909 , Y10T428/31928
摘要： A novel type of ultrathin cationic hydrogel coatings are provided that have high, quick and reversible swelling/shrinkage transitions and surface wettability in response to pH changes. The poly(4-vinyl pyridine) (PVP) hydrogel films are produced by selective cross-linking of PVP copolymers in layer-by-layer (LbL) films assembled by spin-assisted method. These multilayer hydrogels exhibit drastic and reversible 10-fold swelling when the pH is changed from neutral to acidic. The swelling amplitude of these coatings is controlled by varying cross-link densities within the films. The pH-responsive hydrogels open new prospects for developing “intelligent” materials with sharp stimuli-triggered responses for applications in sensing, transport regulation, and self-cleaning coatings.
摘要翻译：提供了一种新型的超薄阳离子水凝胶涂层，其具有响应于pH变化的高，快速和可逆的溶胀/收缩过渡和表面润湿性。聚（4-乙烯基吡啶）（PVP）水凝胶膜是通过用自旋辅助方法组装的层（LbL）膜中的PVP共聚物的选择性交联制备的。当pH从中性变为酸性时，这些多层水凝胶表现出剧烈且可逆的10倍溶胀。这些涂层的溶胀幅度由薄膜内的交联密度变化控制。 pH响应水凝胶为开发“智能”材料开辟了新的前景，对感应，运输调节和自清洁涂层的应用具有刺激性触发反应。

2. 发明申请

US20150250827A1 BIO-MIMETIC ULTRATHIN HYDROGEL COATINGS FOR PANCREATIC ISLET TRANSPLANTATION 审中-公开
标题翻译：用于胰岛素移植的生物超声波水凝胶涂层
公开(公告)号：US20150250827A1
公开(公告)日：2015-09-10
申请号：US14126943
申请日：2012-07-05
申请人： THE UAB RESEARCH FOUNDATION
发明人： Eugenia P. Kharlampieva , Veronika Kozlovskaya , J. Anthony Thompson , Wanxing Cui
IPC分类号： A61K35/39 , A61K35/15 , A61K9/50
CPC分类号： A61K35/39 , A61K9/06 , A61K9/5026 , A61K35/15 , A61K2035/126
摘要： The present disclosure provides multifunctional cytoprotective materials applied to coat living cells or aggregates of cells such as, but not limited to, pancreatic islets. The coating utilizes hydrogen-bonded interactions of a natural polyphenol (tannic acid) with poly(N-vinylpyrrolidone) deposited on the cell aggregate surface via non-ionic layer-by-layer assembly. The coating is conformal over the surface of such as mammalian islets. The coated islets maintain their viability and cell functionality for at least 96 hours in vitro. The coating demonstrates immunomodulatory cytoprotective properties suppressing pro-inflammatory cytokine synthesis in stimulated bone marrow-derived macrophages and diabetogenic BDC-2.5 T cells. The coating material combines high chemical stability under physiologically relevant conditions with capability of suppressing cytokine synthesis, crucial parameters for prolonged islet integrity, viability, and function in vivo.
摘要翻译：本公开提供了应用于包衣活细胞或细胞聚集体（例如但不限于胰岛）的多功能细胞保护材料。该涂层利用通过非离子逐层组装沉积在细胞聚集体表面上的天然多酚（鞣酸）与聚（N-乙烯基吡咯烷酮）的氢键相互作用。该涂层在诸如哺乳动物胰岛的表面上是共形的。包被的胰岛在体外维持其活力和细胞功能至少96小时。该涂层显示免疫调节细胞保护性质，抑制受刺激的骨髓来源的巨噬细胞和致糖尿病性BDC-2.5T细胞中的促炎细胞因子合成。涂层材料在生理相关条件下结合了高度的化学稳定性，抑制细胞因子合成的能力，延长胰岛完整性，生存力和体内功能的关键参数。

3. 发明授权

US09074034B2 Multilayer hydrogels with pH-responsive swelling and surface wettability 有权
标题翻译：多层水凝胶具有pH响应膨胀和表面润湿性
公开(公告)号：US09074034B2
公开(公告)日：2015-07-07
申请号：US13798870
申请日：2013-03-13
申请人： The UAB Research Foundation , The US Army Corp of Engineers
发明人： Eugenia P. Kharlampieva , Veronika Koziovskaya , Yun Wang , Donald Cropek , Imee Arcibal
IPC分类号： B32B27/08 , B05D3/12 , C08F226/06 , C09D5/00 , B05D5/00 , B05D7/00 , B05D3/10 , B05D5/04 , B05D5/08 , B05D1/00 , B05D1/18
CPC分类号： C08F226/06 , B05D1/005 , B05D1/185 , B05D3/107 , B05D5/00 , B05D5/04 , B05D5/08 , B05D7/50 , B05D7/52 , B05D7/56 , C09D5/00 , Y10T428/31859 , Y10T428/31909 , Y10T428/31928
摘要： A novel type of ultrathin cationic hydrogel coatings are provided that have high, quick and reversible swelling/shrinkage transitions and surface wettability in response to pH changes. The poly(4-vinyl pyridine) (PVP) hydrogel films are produced by selective cross-linking of PVP copolymers in layer-by-layer (LbL) films assembled by spin-assisted method. These multilayer hydrogels exhibit drastic and reversible 10-fold swelling when the pH is changed from neutral to acidic. The swelling amplitude of these coatings is controlled by varying cross-link densities within the films. The pH-responsive hydrogels open new prospects for developing “intelligent” materials with sharp stimuli-triggered responses for applications in sensing, transport regulation, and self-cleaning coatings.
摘要翻译：提供了一种新型的超薄阳离子水凝胶涂层，其具有响应于pH变化的高，快速和可逆的溶胀/收缩过渡和表面润湿性。聚（4-乙烯基吡啶）（PVP）水凝胶膜是通过用自旋辅助方法组装的层（LbL）膜中的PVP共聚物的选择性交联制备的。当pH从中性变为酸性时，这些多层水凝胶表现出剧烈且可逆的10倍溶胀。这些涂层的溶胀幅度由薄膜内的交联密度变化控制。 pH响应水凝胶为开发“智能”材料开辟了新的前景，对感应，运输调节和自清洁涂层的应用具有刺激性触发反应。

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