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41. 发明授权

US08569051B2 Expression vector for gene therapy 有权
标题翻译：基因治疗的表达载体
公开(公告)号：US08569051B2
公开(公告)日：2013-10-29
申请号：US13423652
申请日：2012-03-19
申请人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
发明人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
IPC分类号： C12N15/63 , C12N15/113 , C07H21/04
CPC分类号： C12N15/63
摘要： Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.
摘要翻译：提供了具有转录调节元件的新组合的基因治疗的表达载体，其包括启动子，增强子，内含子，非翻译区（UTR）和基因座控制区（LCR）。表达载体能够持续表达肝组织特异性基因，因此可有效用于治疗血栓形成，血友病，肝癌等。

42. 发明授权

US08318199B2 Liposome for liver-specific delivery and release of therapeutic nucleic acids or drugs 有权
标题翻译：用于肝特异性递送和释放治疗性核酸或药物的脂质体
公开(公告)号：US08318199B2
公开(公告)日：2012-11-27
申请号：US12791600
申请日：2010-06-01
申请人： Meehyein Kim , Soo In Kim , Duckhyang Shin , Mahnhoon Park
发明人： Meehyein Kim , Soo In Kim , Duckhyang Shin , Mahnhoon Park
IPC分类号： A61K9/127 , C12N15/88 , A61K48/00
CPC分类号： A61K31/7088 , A61K9/1272
摘要： Disclosed herein is a composite of a nanoscale particle size. The composite is able to specifically deliver therapeutic agents such as therapeutic nucleic acids or drugs to the liver and selectively release them into hepatic cells to manifest potent therapeutic effects of the therapeutic agents. The composite may be comprised of an apolipoprotein A-1 and a liposome-forming material. A composition containing the composite and a pharmaceutically acceptable carrier is disclosed.
摘要翻译：本文公开了纳米级粒度的复合材料。复合材料能够将治疗剂例如治疗性核酸或药物特异性递送至肝脏并选择性地将其释放到肝细胞中以显示治疗剂的有效治疗作用。复合材料可以由载脂蛋白A-1和脂质体形成材料组成。公开了含有该复合物和药学上可接受的载体的组合物。

43. 发明申请

US20110045584A1 EXPRESSION VECTOR SUITABLE FOR EXPRESSION OF A CODING SEQUENCE FOR GENE THERAPY 有权
标题翻译：用于表达基因治疗编码序列的表达载体
公开(公告)号：US20110045584A1
公开(公告)日：2011-02-24
申请号：US12867716
申请日：2008-02-14
申请人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
发明人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
IPC分类号： C12N15/63 , C07H21/04
CPC分类号： C12N15/63
摘要： Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.
摘要翻译：提供了具有转录调节元件的新组合的基因治疗的表达载体，其包括启动子，增强子，内含子，非翻译区（UTR）和基因座控制区（LCR）。表达载体能够持续表达肝组织特异性基因，因此可有效用于治疗血栓形成，血友病，肝癌等。

44. 发明申请

US20110008885A1 LINEAR DOUBLE-STRANDED RNA MOLECULE INTERFERING WITH DIFFERENT TARGET GENES 审中-公开
标题翻译：线性双链RNA分子与不同目标基因的干扰
公开(公告)号：US20110008885A1
公开(公告)日：2011-01-13
申请号：US12667738
申请日：2008-07-07
申请人： Meehyein Kim , Duckhyang Shin , Hyeon Lee , Soo In Kim , Yeup Yoon
发明人： Meehyein Kim , Duckhyang Shin , Hyeon Lee , Soo In Kim , Yeup Yoon
IPC分类号： C12N5/071 , C07H21/02 , C12N15/63
CPC分类号： C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/51
摘要： A linear double-stranded RNA molecule, which comprises two or more consecutively or convergently linked short interfering RNAs (siRNAs) each reducing the expression of one of different target genes, and a recombinant expression vector comprising double-stranded DNA sequence expressing the linear double-stranded RNA molecule are provided. The linear double-stranded RNA molecule or the recombinant expression vector is useful for a method of reducing expression of target genes in a cell, the method comprising introducing the linear double-stranded RNA molecule or the recombinant expression vector into the cell, whereby the encoded siRNAs target different genes and reduce expression of the target genes. It was also proved that effective gene silencing activity can be induced when each siRNA unit within the linear double-stranded RNA molecule has 18 to 24 nucleotides and, additionally, the gene silencing activity is not affected by inverted orientation of an siRNA.
摘要翻译：线性双链RNA分子，其包含两个或更多个连续或趋向连接的短干扰RNA（siRNA），每个短干扰RNA减少一个不同靶基因的表达;以及重组表达载体，其包含表达线性双链RNA的双链DNA序列，提供了双链RNA分子。线性双链RNA分子或重组表达载体可用于减少细胞中靶基因表达的方法，该方法包括将线性双链RNA分子或重组表达载体引入细胞，由此编码 siRNA靶向不同的基因并减少靶基因的表达。还证明当线性双链RNA分子内的每个siRNA单元具有18至24个核苷酸时，可以诱导有效的基因沉默活性，此外，基因沉默活性不受siRNA反向取向的影响。

45. 发明授权

US07785875B2 Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same 有权
标题翻译：编码能够结合各种HLA超型的HCV表位的多核苷酸，包含其的免疫原性组合物和使用其诱导HCV特异性免疫应答的方法
公开(公告)号：US07785875B2
公开(公告)日：2010-08-31
申请号：US12289766
申请日：2008-11-03
申请人： Yu Kyeong Hwang , Okjae Lim , Hyejin Chung
发明人： Yu Kyeong Hwang , Okjae Lim , Hyejin Chung
IPC分类号： C12N15/00 , C07H21/00 , A61K31/7088 , A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , A61K2039/55516 , A61K2039/55527 , C12N2770/24222 , C12N2770/24234
摘要： There are provided a polynucleotide encoding HCV epitopes, an immunogenic composition including same, and a method of inducing an HCV-specific immune response using same.
摘要翻译：提供了编码HCV表位的多核苷酸，包含其的免疫原性组合物，以及使用它们诱导HCV特异性免疫应答的方法。

46. 发明申请

US20100209491A1 METHOD FOR ENHANCING SERUM STABILITY AND LOWERING IMMUNE RESPONSE OF SIRNA DOWN-REGULATING GENE EXPRESSION OF HBV OR HCV 审中-公开
标题翻译：用于增强血清稳定性和降低SIRNA下调HBV基因表达的免疫应答方法
公开(公告)号：US20100209491A1
公开(公告)日：2010-08-19
申请号：US12678469
申请日：2008-05-08
申请人： Soo In Kim , Duckhyang Shin , Hyeon Lee , Meehyein Kim , Doo-Hong Park , Yeup Yoon
发明人： Soo In Kim , Duckhyang Shin , Hyeon Lee , Meehyein Kim , Doo-Hong Park , Yeup Yoon
IPC分类号： A61K31/713 , C07H21/02 , A61K9/127 , A61P31/20
CPC分类号： C07H21/02 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2320/51 , C12N2320/53 , C12N2310/3521
摘要： A method for enhancing the serum stability and lowering the immunostimulatory property of a small interfering ribonucleic acid (siRNA) which mediates RNA interference (RNAi) against a viral gene expression of hepatitis B virus (HBV) or hepatitis C virus (HCV) is provided.
摘要翻译：提供了一种提高针对乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）的病毒基因表达介导RNA干扰（RNAi）的小干扰核糖核酸（siRNA）的血清稳定性和降低免疫刺激性的方法。

47. 发明申请

US20080138394A1 Composite For Liver-Specific Delivery and Release of Therapeutic Nucleic Acids or Drugs 审中-公开
标题翻译：用于肝脏特异性递送和释放治疗性核酸或药物的复合物
公开(公告)号：US20080138394A1
公开(公告)日：2008-06-12
申请号：US11741287
申请日：2007-04-27
申请人： Meehyein KIM , Soo In Kim , Duckhyang Shin , Mahnhoon Park
发明人： Meehyein KIM , Soo In Kim , Duckhyang Shin , Mahnhoon Park
IPC分类号： A61K9/127 , A61K31/7088
CPC分类号： A61K31/7088 , A61K9/1272
摘要： The inventive composite having a nanoscale particle size can specifically deliver therapeutic nucleic acids or drugs to the liver and selectively release them into hepatic cells to manifest potent therapeutic effects without inducing any enzymatic abnormalities or pathological damage to the normal liver function, when administered together with the therapeutic agents.
摘要翻译：具有纳米尺度粒度的本发明复合材料可以将治疗性核酸或药物特异性递送至肝脏并选择性地将它们释放到肝细胞中以显示出有效的治疗效果，而不引起任何酶促异常或对正常肝功能的病理损伤，当与治疗剂。

48. 发明授权

US07285277B2 Anticancer agent 失效
标题翻译：抗癌剂
公开(公告)号：US07285277B2
公开(公告)日：2007-10-23
申请号：US11162817
申请日：2005-09-23
申请人： Jang-Seong Kim , Jin-Hyung Ahn , Hyun-Kyung Yu , Ho-Jeong Lee , Doo-Hong Park , Yeup Yoon
发明人： Jang-Seong Kim , Jin-Hyung Ahn , Hyun-Kyung Yu , Ho-Jeong Lee , Doo-Hong Park , Yeup Yoon
IPC分类号： A61K39/00 , A61K38/03
CPC分类号： A61K38/1709
摘要： The present application discloses a method of reducing tumor growth that includes contacting the tumor with a tumor growth reducing effective amount of a composition comprising LK8 or LK68 protein or a functionally equivalent amino acid variant thereof and a pharmaceutically acceptable carrier thereof to a subject having tumor.
摘要翻译：本申请公开了一种减少肿瘤生长的方法，其包括使肿瘤与具有肿瘤生长的有效量的包含LK8或LK68蛋白或其功能等同的氨基酸变体和其药学上可接受的载体的组合物接触肿瘤。

49. 发明授权

US07118905B2 Nucleic acid encoding angiogenesis inhibitor 有权
标题翻译：核酸编码血管生成抑制剂
公开(公告)号：US07118905B2
公开(公告)日：2006-10-10
申请号：US10849961
申请日：2004-05-19
申请人： Jihoon Chang , Jang Seong Kim , Eun Jeong Park , Jung-sun Yum , Soo-il Chung
发明人： Jihoon Chang , Jang Seong Kim , Eun Jeong Park , Jung-sun Yum , Soo-il Chung
IPC分类号： C12N1/20 , C12N15/09 , C12N15/63 , C07H21/04
CPC分类号： C07K14/4703 , A61K38/00
摘要： The present invention provides a novel angiogenesis inhibitor, LK68 whose amino acid sequence is identical with the human apolipoprotein (a) kringle domains IV36, IV37 and V38, a cDNA sequence encoding the LK68, a recombinant expression vector comprising the cDNA, a recombinant microorganism transformed with the recombinant expression vector and a novel use of the LK68 as an anticancer agent and a method for treating angiogenesis-mediated disease. LK68, LK6, LK7 and LK8 exhibit inhibitory activities on the cultured endothelial cell proliferation as well as on the endothelial cell migration. LK68 and its single kringles also inhibit the normal development of capillaries in the chick embryo chorioallantoic membrane (CAM). It was also showed that systemic administration of LK68 causes the inhibition of primary tumor growth, which is correlated with a suppression of tumor-induced angiogenesis. Accordingly, LK68 protein, its single kringles or their functional equivalents may be applied for the development of a potent anti-cancer agent, which is highly effective for angiogenesis-mediated diseases covering cancer, rheumatoid arthritis, psoriasis, ocular angiogenic disease, etc.
摘要翻译：本发明提供了一种新型的血管生成抑制剂LK68，其氨基酸序列与人载脂蛋白（a）三环结构域IV36，IV37和V38相同，编码LK68的cDNA序列，包含cDNA的重组表达载体，转化的重组微生物用重组表达载体和LK68作为抗癌剂的新用途和治疗血管生成介导的疾病的方法。 LK68，LK6，LK7和LK8表现出对培养的内皮细胞增殖以及内皮细胞迁移的抑制活性。 LK68及其单克隆也抑制鸡胚绒毛尿囊膜（CAM）毛细血管的正常发育。还表明，LK68的全身给药导致原发性肿瘤生长的抑制，其与抑制肿瘤诱导的血管发生相关。因此，LK68蛋白，其单克隆或其功能等同物可用于开发有效的抗癌剂，其对于涵盖癌症，类风湿性关节炎，牛皮癣，眼血管生成疾病等的血管生成介导的疾病是非常有效的。

50. 发明申请

US20060013823A1 ANTICANCER AGENT 失效
标题翻译： ANTICANCER代理
公开(公告)号：US20060013823A1
公开(公告)日：2006-01-19
申请号：US11162817
申请日：2005-09-23
申请人： Jang-Seong KIM , Jin-Hyung AHN , Hyun-Kyung YU , Ho-Jeong LEE , Doo-Hong PARK , Yeup YOON
发明人： Jang-Seong KIM , Jin-Hyung AHN , Hyun-Kyung YU , Ho-Jeong LEE , Doo-Hong PARK , Yeup YOON
IPC分类号： A61K39/00 , C07H21/04 , C07K14/82
CPC分类号： A61K38/1709
摘要： The present application discloses a method of reducing tumor growth that includes contacting the tumor with a tumor growth reducing effective amount of a composition comprising LK8 or LK68 protein or a functionally equivalent amino acid variant thereof and a pharmaceutically acceptable carrier thereof to a subject having tumor.
摘要翻译：本申请公开了一种减少肿瘤生长的方法，其包括使肿瘤与具有肿瘤生长的有效量的包含LK8或LK68蛋白或其功能等同的氨基酸变体和其药学上可接受的载体的组合物接触肿瘤。

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