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1. 发明申请

US20110008885A1 LINEAR DOUBLE-STRANDED RNA MOLECULE INTERFERING WITH DIFFERENT TARGET GENES 审中-公开
标题翻译：线性双链RNA分子与不同目标基因的干扰
公开(公告)号：US20110008885A1
公开(公告)日：2011-01-13
申请号：US12667738
申请日：2008-07-07
申请人： Meehyein Kim , Duckhyang Shin , Hyeon Lee , Soo In Kim , Yeup Yoon
发明人： Meehyein Kim , Duckhyang Shin , Hyeon Lee , Soo In Kim , Yeup Yoon
IPC分类号： C12N5/071 , C07H21/02 , C12N15/63
CPC分类号： C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/51
摘要： A linear double-stranded RNA molecule, which comprises two or more consecutively or convergently linked short interfering RNAs (siRNAs) each reducing the expression of one of different target genes, and a recombinant expression vector comprising double-stranded DNA sequence expressing the linear double-stranded RNA molecule are provided. The linear double-stranded RNA molecule or the recombinant expression vector is useful for a method of reducing expression of target genes in a cell, the method comprising introducing the linear double-stranded RNA molecule or the recombinant expression vector into the cell, whereby the encoded siRNAs target different genes and reduce expression of the target genes. It was also proved that effective gene silencing activity can be induced when each siRNA unit within the linear double-stranded RNA molecule has 18 to 24 nucleotides and, additionally, the gene silencing activity is not affected by inverted orientation of an siRNA.
摘要翻译：线性双链RNA分子，其包含两个或更多个连续或趋向连接的短干扰RNA（siRNA），每个短干扰RNA减少一个不同靶基因的表达;以及重组表达载体，其包含表达线性双链RNA的双链DNA序列，提供了双链RNA分子。线性双链RNA分子或重组表达载体可用于减少细胞中靶基因表达的方法，该方法包括将线性双链RNA分子或重组表达载体引入细胞，由此编码 siRNA靶向不同的基因并减少靶基因的表达。还证明当线性双链RNA分子内的每个siRNA单元具有18至24个核苷酸时，可以诱导有效的基因沉默活性，此外，基因沉默活性不受siRNA反向取向的影响。

2. 发明申请

US20100209491A1 METHOD FOR ENHANCING SERUM STABILITY AND LOWERING IMMUNE RESPONSE OF SIRNA DOWN-REGULATING GENE EXPRESSION OF HBV OR HCV 审中-公开
标题翻译：用于增强血清稳定性和降低SIRNA下调HBV基因表达的免疫应答方法
公开(公告)号：US20100209491A1
公开(公告)日：2010-08-19
申请号：US12678469
申请日：2008-05-08
申请人： Soo In Kim , Duckhyang Shin , Hyeon Lee , Meehyein Kim , Doo-Hong Park , Yeup Yoon
发明人： Soo In Kim , Duckhyang Shin , Hyeon Lee , Meehyein Kim , Doo-Hong Park , Yeup Yoon
IPC分类号： A61K31/713 , C07H21/02 , A61K9/127 , A61P31/20
CPC分类号： C07H21/02 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2320/51 , C12N2320/53 , C12N2310/3521
摘要： A method for enhancing the serum stability and lowering the immunostimulatory property of a small interfering ribonucleic acid (siRNA) which mediates RNA interference (RNAi) against a viral gene expression of hepatitis B virus (HBV) or hepatitis C virus (HCV) is provided.
摘要翻译：提供了一种提高针对乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）的病毒基因表达介导RNA干扰（RNAi）的小干扰核糖核酸（siRNA）的血清稳定性和降低免疫刺激性的方法。

3. 发明申请

US20060097228A1 Continuous synthetic process of phosphor in supercritical water and apparatus being used therein 审中-公开
标题翻译：超临界水中的荧光粉连续合成工艺及其中使用的设备
公开(公告)号：US20060097228A1
公开(公告)日：2006-05-11
申请号：US11271099
申请日：2005-11-10
申请人： Jae Lee , Chang Lee , Hyeon Lee , Jung In , Man Han
发明人： Jae Lee , Chang Lee , Hyeon Lee , Jung In , Man Han
IPC分类号： C09K11/08 , B01J19/00
CPC分类号： B01J19/2415 , B01J3/008 , B01J2219/00159 , Y02P20/544
摘要： The present invention relates to a method of continuously producing a phosphor at a supercritical water (SCW) condition and an apparatus used in the method. A phosphor produced according to the method of the present invention has similar luminosity to a phosphor produced according to a conventional solid-state method and the size and shape of particles thereof is also uniform. Accordingly, a phosphor according to the method of the present invention is applicable in various fields such as plasma display (PDP) and field emission display (FED). Also, in the method of producing a phosphor according to the present invention, the total reaction time is within about one minute, which is shorter than in the solid-state method. Also, since a separate heat processing process is not needed to obtain crystallized particles, it is efficient in aspects of time and energy.
摘要翻译：本发明涉及在超临界水（SCW）条件下连续生产荧光体的方法和该方法中使用的装置。根据本发明的方法制造的荧光体具有与根据常规固态方法制造的荧光体相似的亮度，并且其颗粒的尺寸和形状也是均匀的。因此，根据本发明的方法的荧光体可应用于等离子体显示（PDP）和场发射显示（FED）等各种领域。此外，在本发明的荧光体的制造方法中，总反应时间在比固态方法短的约1分钟内。此外，由于不需要单独的热处理工艺来获得结晶颗粒，因此在时间和能量方面是有效的。

4. 发明授权

US08628956B2 Expression vector suitable for expression of a coding sequence for gene therapy 有权
标题翻译：适用于表达基因治疗编码序列的表达载体
公开(公告)号：US08628956B2
公开(公告)日：2014-01-14
申请号：US13423474
申请日：2012-03-19
申请人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
发明人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
IPC分类号： C12N15/63 , C12N15/113 , C07H21/04
CPC分类号： C12N15/63
摘要： Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.
摘要翻译：提供了具有转录调节元件的新组合的基因治疗的表达载体，其包括启动子，增强子，内含子，非翻译区（UTR）和基因座控制区（LCR）。表达载体能够持续表达肝组织特异性基因，因此可有效用于治疗血栓形成，血友病，肝癌等。

5. 发明申请

US20070254882A1 Sulfamide Derivatives and Pharmaceutical Composition for Upregulation of Lipid Metabolism Comprising Same 审中-公开
标题翻译：用于上调脂质代谢的磺酰胺衍生物和药物组合物
公开(公告)号：US20070254882A1
公开(公告)日：2007-11-01
申请号：US11571836
申请日：2005-07-14
申请人： Joong Cho , Tae Lee , Seonggu Ro , Jin Kim , Young Jeon , Dong Shin , Young-Lan Hyun , Gyu Yon , Young-Gwi Yoon , Eun Choi , Hyeon Lee , Chwang Pak
发明人： Joong Cho , Tae Lee , Seonggu Ro , Jin Kim , Young Jeon , Dong Shin , Young-Lan Hyun , Gyu Yon , Young-Gwi Yoon , Eun Choi , Hyeon Lee , Chwang Pak
IPC分类号： A61K31/421 , A61K31/4709 , A61K31/496 , A61K31/5377 , C07D215/58 , C07D263/32 , C07D413/12
CPC分类号： C07D263/32 , C07D409/04 , C07D413/12
摘要： The present invention relates to a novel sulfamide derivative, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for upregulation of lipid metabolism comprising same as an active ingredient.
摘要翻译：本发明涉及一种新型的磺酰胺衍生物，其药学上可接受的盐和用于上调脂质代谢的药物组合物，其包含其作为活性成分。

6. 发明申请

US20060128402A1 Method of implementing scatternet in wireless personal area network 审中-公开
标题翻译：在无线个域网中实现分布式互联网的方法
公开(公告)号：US20060128402A1
公开(公告)日：2006-06-15
申请号：US11271780
申请日：2005-11-14
申请人： Hyeon Lee , Jin Cho , Sun June , Kyu Youn , Yun Won , Tai Kwon
发明人： Hyeon Lee , Jin Cho , Sun June , Kyu Youn , Yun Won , Tai Kwon
IPC分类号： H04Q7/20
CPC分类号： H04W72/082 , H04W36/06 , H04W52/0216 , H04W52/0219 , H04W72/0453 , H04W84/20 , H04W92/02 , Y02D70/142 , Y02D70/144
摘要： The present invention relates to a method of implementing a scatternet over a plurality of piconets using different frequencies in a Wireless Personal Area Network (WPAN). In the scatternet implementation method of the present invention, a master of a first piconet transmits a scatternet request to a shared slave, and the shared slave switches a frequency thereof to a frequency of a second piconet and relays the scatternet request to a master of the second piconet. The master of the second piconet transmits scatternet approval to the shared slave. The shared slave switches the frequency to a frequency of the first piconet, relays the scatternet approval to the master of the first piconet, and is allocated resources, which do not overlap each other, by the masters of the first piconet and the second piconet. The shared slave switches frequencies and relays data between the first piconet and the second piconet while synchronizing with both the first piconet and the second piconet using allocated resources.
摘要翻译：本发明涉及一种在无线个人区域网（WPAN）中使用不同频率在多个微微网上实现分散网络的方法。在本发明的分散网络实现方法中，第一微微网的主机向共享从机发送分散网络请求，并且共享从机将其频率切换到第二微微网的频率，并将分散网络请求中继到主机第二微微网。第二个微微网的主机将共同的从站的互联网批准。共享从站将频率切换到第一微微网的频率，将分机互联网批准中继到第一微微网的主设备，并且由第一微微网和第二微微网的主设备分配不相互重叠的资源。共享从站在使用分配的资源与第一微微网和第二微微网同步时，切换频率并中继第一微微网和第二微微网之间的数据。

7. 发明授权

US08309698B2 Expression vector suitable for expression of a coding sequence for gene therapy 有权
标题翻译：适用于表达基因治疗编码序列的表达载体
公开(公告)号：US08309698B2
公开(公告)日：2012-11-13
申请号：US12867716
申请日：2008-02-14
申请人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
发明人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
IPC分类号： C07H21/04 , C12N15/63
CPC分类号： C12N15/63
摘要： Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.
摘要翻译：提供了具有转录调节元件的新组合的基因治疗的表达载体，其包括启动子，增强子，内含子，非翻译区（UTR）和基因座控制区（LCR）。表达载体能够持续表达肝组织特异性基因，因此可有效用于治疗血栓形成，血友病，肝癌等。

8. 发明授权

US08617875B2 Expression vector suitable for expression of a coding sequence for gene therapy 有权
标题翻译：适用于表达基因治疗编码序列的表达载体
公开(公告)号：US08617875B2
公开(公告)日：2013-12-31
申请号：US13423559
申请日：2012-03-19
申请人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
发明人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
IPC分类号： C12N15/63 , C12N15/113 , C07H21/04
CPC分类号： C12N15/63
摘要： Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.
摘要翻译：提供了具有转录调节元件的新组合的基因治疗的表达载体，其包括启动子，增强子，内含子，非翻译区（UTR）和基因座控制区（LCR）。表达载体能够持续表达肝组织特异性基因，因此可有效用于治疗血栓形成，血友病，肝癌等。

9. 发明授权

US08569051B2 Expression vector for gene therapy 有权
标题翻译：基因治疗的表达载体
公开(公告)号：US08569051B2
公开(公告)日：2013-10-29
申请号：US13423652
申请日：2012-03-19
申请人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
发明人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
IPC分类号： C12N15/63 , C12N15/113 , C07H21/04
CPC分类号： C12N15/63
摘要： Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.
摘要翻译：提供了具有转录调节元件的新组合的基因治疗的表达载体，其包括启动子，增强子，内含子，非翻译区（UTR）和基因座控制区（LCR）。表达载体能够持续表达肝组织特异性基因，因此可有效用于治疗血栓形成，血友病，肝癌等。

10. 发明申请

US20110045584A1 EXPRESSION VECTOR SUITABLE FOR EXPRESSION OF A CODING SEQUENCE FOR GENE THERAPY 有权
标题翻译：用于表达基因治疗编码序列的表达载体
公开(公告)号：US20110045584A1
公开(公告)日：2011-02-24
申请号：US12867716
申请日：2008-02-14
申请人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
发明人： Daekyung Koh , Kyuhyun Lee , Hyeon Lee , Seongtae Yun , Eui-Cheol Jo
IPC分类号： C12N15/63 , C07H21/04
CPC分类号： C12N15/63
摘要： Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.
摘要翻译：提供了具有转录调节元件的新组合的基因治疗的表达载体，其包括启动子，增强子，内含子，非翻译区（UTR）和基因座控制区（LCR）。表达载体能够持续表达肝组织特异性基因，因此可有效用于治疗血栓形成，血友病，肝癌等。

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