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41. 发明授权

US07337000B2 Selection of cardiac signal features detected in multiple classification intervals for cardiac pacing response classification 有权
标题翻译：选择心脏起搏反应分类的多个分类间隔检测到的心脏信号特征
公开(公告)号：US07337000B2
公开(公告)日：2008-02-26
申请号：US11116525
申请日：2005-04-28
申请人： Scott A. Meyer , Yanting Dong , Kevin John Stalsberg
发明人： Scott A. Meyer , Yanting Dong , Kevin John Stalsberg
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61B5/0452 , A61B5/7264 , A61N1/362 , A61N1/371
摘要： Cardiac devices and methods involve the detection of cardiac signals features in adjacent classification intervals. Portions of the cardiac signal features detected in adjacent classification intervals are associated and are used to classify the cardiac response to a pacing pulse. Associating the portions of the cardiac signal features may be based on expected signal morphology.
摘要翻译：心脏装置和方法涉及在相邻分类间隔中检测心脏信号特征。在相邻分类间隔中检测到的心脏信号特征的部分相关联并且用于将心脏反应分类到起搏脉冲。关联心脏信号特征的部分可以基于预期的信号形态。

42. 发明授权

US08831727B2 Methods and systems for managing fusion and noise in cardiac pacing response classification 有权
标题翻译：用于管理心脏起搏反应分类中的融合和噪声的方法和系统
公开(公告)号：US08831727B2
公开(公告)日：2014-09-09
申请号：US13618486
申请日：2012-09-14
申请人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
发明人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
IPC分类号： A61N1/362 , A61B5/00 , A61N1/37 , A61B5/0452
CPC分类号： A61N1/371 , A61B5/0452 , A61B5/7203 , A61B5/7217 , A61B5/7264
摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.
摘要翻译：用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。融合/噪声管理过程包括在相对高的能量级别进行起搏，直到在融合之后检测到捕获，不确定或可能错误的起搏响应分类。可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

43. 发明申请

US20110245890A1 METHOD AND APPARATUS FOR PACING SAFETY MARGIN 有权
标题翻译：防治安全隐患的方法和装置
公开(公告)号：US20110245890A1
公开(公告)日：2011-10-06
申请号：US13071680
申请日：2011-03-25
申请人： Amy Jean Brisben , Shibaji Shome , Kenneth N. Hayes , Yanting Dong , Aaron R. McCabe , Scott A. Meyer , Kevin John Stalsberg
发明人： Amy Jean Brisben , Shibaji Shome , Kenneth N. Hayes , Yanting Dong , Aaron R. McCabe , Scott A. Meyer , Kevin John Stalsberg
IPC分类号： A61N1/08 , A61N1/362
CPC分类号： A61N1/36585 , A61N1/3712
摘要： An apparatus comprises a cardiac signal sensing circuit, a pacing therapy circuit, and a controller circuit. The controller circuit includes a safety margin calculation circuit. The controller circuit initiates delivery of pacing stimulation energy to the heart using a first energy level, changes the energy level by at least one of: a) increasing the energy from the first energy level until detecting that the pacing stimulation energy induces stable capture, or b) reducing the energy from the first energy level until detecting that the stimulation energy fails to induce capture, and continues changing the stimulation energy level until confirming stable capture or the failure of capture. The safety margin calculation circuit calculates a safety margin of pacing stimulation energy using at least one of a determined stability of a parameter associated with evoked response and a determined range of energy levels corresponding to stable capture or intermittent failure of capture.
摘要翻译：一种装置包括心脏信号感测电路，起搏治疗电路和控制器电路。控制器电路包括安全裕度计算电路。控制器电路使用第一能级开始向心脏传送起搏刺激能量，通过以下至少一种来改变能量水平：a）从第一能量级增加能量直到检测到起搏刺激能量引起稳定的捕获，或 b）减少来自第一能级的能量，直到检测到刺激能量不能诱导捕获，并且继续改变刺激能量水平，直到确认捕获稳定或捕获失败为止。安全裕度计算电路使用与诱发反应相关联的参数的确定的稳定性以及与捕获的稳定捕获或间歇性故障相对应的能量水平的确定范围中的至少一个来计算起搏刺激能量的安全裕度。

44. 发明申请

US20100262207A1 Methods and Systems for Managing Fusion and Noise in Cardiac Pacing Response Classification 有权
标题翻译：心脏起搏反应分类融合与噪声管理方法与系统
公开(公告)号：US20100262207A1
公开(公告)日：2010-10-14
申请号：US12822480
申请日：2010-06-24
申请人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
发明人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
IPC分类号： A61N1/08
CPC分类号： A61N1/371 , A61B5/0452 , A61B5/7203 , A61B5/7217 , A61B5/7264
摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.
摘要翻译：用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。融合/噪声管理过程包括在相对高的能量级别进行起搏，直到在融合之后检测到捕获，不确定或可能错误的起搏响应分类。可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

45. 发明授权

US07711424B2 Selection of cardiac signal features detected in multiple classification intervals for cardiac pacing response classification 有权
标题翻译：选择心脏起搏反应分类的多个分类间隔检测到的心脏信号特征
公开(公告)号：US07711424B2
公开(公告)日：2010-05-04
申请号：US12070004
申请日：2008-02-14
申请人： Scott A. Meyer , Yanting Dong , Kevin John Stalsberg
发明人： Scott A. Meyer , Yanting Dong , Kevin John Stalsberg
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61B5/0452 , A61B5/7264 , A61N1/362 , A61N1/371
摘要： Cardiac devices and methods involve the detection of cardiac signals features in adjacent classification intervals. Portions of the cardiac signal features detected in adjacent classification intervals are associated and are used to classify the cardiac response to a pacing pulse. Associating the portions of the cardiac signal features may be based on expected signal morphology.
摘要翻译：心脏装置和方法涉及在相邻分类间隔中检测心脏信号特征。在相邻分类间隔中检测到的心脏信号特征的部分相关联并且用于将心脏反应分类到起搏脉冲。关联心脏信号特征的部分可以基于预期的信号形态。

46. 发明申请

US20090163973A1 Cardiac Signal Template Generation Using Waveform Clustering 审中-公开
标题翻译：使用波形聚类的心脏信号模板生成
公开(公告)号：US20090163973A1
公开(公告)日：2009-06-25
申请号：US12396267
申请日：2009-03-02
申请人： Scott A. Meyer , Yanting Dong
发明人： Scott A. Meyer , Yanting Dong
IPC分类号： A61N1/362
CPC分类号： A61B5/04525 , A61N1/371
摘要： Cardiac devices and methods using cardiac waveform clustering for template generation are described. A method of characterizing a cardiac response involves delivering pacing pulses to heart, the pulses having an energy greater than a capture threshold. Cardiac signals are sensed following the pulses. Cardiac signal characteristics, waveforms, and/or features are clustered into a plurality of clusters. A cardiac response template is formed using one or more of the plurality of clusters.
摘要翻译：描述了使用心脏波形聚类用于模板生成的心脏装置和方法。表征心脏反应的方法包括将起搏脉冲输送到心脏，脉冲具有大于捕获阈值的能量。在脉冲之后感测到心脏信号。心脏信号特征，波形和/或特征被聚集成多个聚类。使用所述多个簇中的一个或多个来形成心脏反应模板。

47. 发明授权

US07529578B2 Multi channel approach to capture verification 失效
标题翻译：捕获验证的多渠道方法
公开(公告)号：US07529578B2
公开(公告)日：2009-05-05
申请号：US11180937
申请日：2005-07-12
申请人： Yanting Dong , Scott A. Meyer , Qingsheng Zhu
发明人： Yanting Dong , Scott A. Meyer , Qingsheng Zhu
IPC分类号： A61B5/04
CPC分类号： A61N1/371 , A61B5/04525 , A61B5/7217 , A61B5/7264
摘要： Methods and systems involve classifying the cardiac response to pacing using a multi-channel approach. Multiple cardiac response signals are sensed via multiple sense channels. Each sense channel comprises a distinct combination of electrodes and sensing circuitry. The cardiac response to the pacing pulse is classified based on the morphology of the cardiac response signals. Classifying the cardiac response involves discriminating between capture, fusion, non-capture, and non-capture with intrinsic activity.
摘要翻译：方法和系统包括使用多通道方法对心脏起搏应答进行分类。通过多个感测通道感测多个心脏反应信号。每个感测通道包括电极和感测电路的不同组合。基于心脏反应信号的形态对起搏脉搏的心脏反应进行分类。分类心脏反应包括区分捕获，融合，非捕获和非捕获与内在活动。

48. 发明授权

US07392088B2 Capture detection for multi-chamber pacing 有权
标题翻译：捕获检测多腔起搏
公开(公告)号：US07392088B2
公开(公告)日：2008-06-24
申请号：US11116563
申请日：2005-04-28
申请人： Yanting Dong , Scott A. Meyer , Kevin John Stalsberg
发明人： Yanting Dong , Scott A. Meyer , Kevin John Stalsberg
IPC分类号： A61N1/368
CPC分类号： A61N1/3712 , A61N1/3684
摘要： Multi-chamber pacing may result in capture of one chamber, capture of multiple chambers, fusion, or non-capture. Approaches for detecting various capture conditions during multi-chamber pacing are described. Pacing pulses are delivered to left and right heart chambers during a cardiac cycle. A cardiac electrogram signal is sensed following the delivery of the pacing pulses. Left chamber capture only, right chamber capture only, and bi-chamber capture may be distinguished based on characteristics of the cardiac electrogram signal. Multi-chamber capture detection may be implemented using detection windows having dimensions of time and amplitude. The detection windows are associated with expected features, such as expected signal peaks, under a particular capture condition. The cardiac electrogram signal features are compared to detection windows to determine the capture condition.
摘要翻译：多腔起搏可能导致一个腔室的捕获，多个腔室的捕获，融合或非捕获。描述了在多室起搏期间检测各种捕获条件的方法。在心动周期期间，起搏脉冲被传送到左心室和右心室。在起搏脉冲输送之后感测心电图信号。仅左室捕获，右室捕获，双室捕获可以基于心电图信号的特征来区分。可以使用具有时间和幅度尺寸的检测窗来实现多室捕获检测。检测窗口与特定捕获条件下的预期特征（例如期望的信号峰值）相关联。将心电图信号特征与检测窗口进行比较以确定捕获条件。

49. 发明授权

US09020596B2 Management of fusion beat detection during capture threshold determination 有权
标题翻译：捕获阈值确定期间融合搏动检测的管理
公开(公告)号：US09020596B2
公开(公告)日：2015-04-28
申请号：US13546820
申请日：2012-07-11
申请人： Shibaji Shome , Yanting Dong , Aaron R. McCabe
发明人： Shibaji Shome , Yanting Dong , Aaron R. McCabe
IPC分类号： A61N1/37
CPC分类号： A61N1/3712
摘要： An improved technique is described for dealing with the detection of fusion beats when capture verification is performed by a cardiac pacing device such as during a capture threshold determination procedure. Schemes for classifying heart beats may misclassify beats as fusion beats due to feature/morphology changes in the test electrogram waveform that may occur even when capture is achieved.
摘要翻译：描述了一种改进的技术，用于处理在心脏起搏装置执行捕获验证时，例如在捕获阈值确定过程期间的融合节拍的检测。分类心脏跳动的方案可能由于测试电描记图波形中的特征/形态变化而将节拍错误分类为融合节拍，即使实现捕获也可能发生。

50. 发明授权

US08805497B2 Titrated intermittent pacing therapy 有权
标题翻译：滴定间歇起搏治疗
公开(公告)号：US08805497B2
公开(公告)日：2014-08-12
申请号：US12573533
申请日：2009-10-05
申请人： Yanting Dong , Shantha Arcot-Krishnamurthy , Allan C. Shuros , David L. Whitehouse
发明人： Yanting Dong , Shantha Arcot-Krishnamurthy , Allan C. Shuros , David L. Whitehouse
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3688
摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing but may also be hazardous. Described herein is a method and system that uses measures of a patient's heart rate or exertion level to control the duty cycles of intermittent pre-excitation pacing.
摘要翻译：心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。这种异常收缩负责预激励起搏的所需心脏保护作用，但也可能是危险的。这里描述了一种方法和系统，其使用患者心率或运动水平的测量来控制间歇性预激发起搏的占空比。

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