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41. 发明申请

US20050100580A1 Hydrophilic coated medical device 审中-公开
标题翻译：亲水涂层医疗器械
公开(公告)号：US20050100580A1
公开(公告)日：2005-05-12
申请号：US10965584
申请日：2004-10-14
申请人： Thomas Osborne , Andrew Hoffa , Bruce Gingles , Jason Urbanski
发明人： Thomas Osborne , Andrew Hoffa , Bruce Gingles , Jason Urbanski
IPC分类号： A61F2/02 , A61F2/06 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L29/14 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/00 , A61L2300/606
摘要： A medical device comprises a main body, a therapeutic agent and a radiation-curable hydrophilic coating. The hydrophilic coating allows for easy insertion of medical devices, which may include catheters, cannulae, stents, wire guides, and the like. The medical device may include more than one therapeutic agent.
摘要翻译：医疗装置包括主体，治疗剂和可辐射固化的亲水涂层。亲水涂层允许容易地插入医疗装置，医疗装置可以包括导管，套管，支架，线导板等。医疗装置可以包括多于一种治疗剂。

42. 发明申请

US20130191391A1 PERSONALIZATION ENGINE FOR BUILDING A DYNAMIC CLASSIFICATION DICTIONARY 有权
标题翻译：个性化发动机建立动态分类词典
公开(公告)号：US20130191391A1
公开(公告)日：2013-07-25
申请号：US13555823
申请日：2012-07-23
申请人： Tushar Pradhan , Thomas Osborne , John Potter
发明人： Tushar Pradhan , Thomas Osborne , John Potter
IPC分类号： G06F17/30
CPC分类号： G06F17/30011 , G06F17/30598 , G06F17/30699 , G06F17/30707
摘要： A dynamic classification dictionary is built for use in profiling and targeting users for additional relevant content. Behavioral data is gathered from user activity, and user documents and actions are categorized. Author-generated document classification information is analyzed and assigned a first taxonomic noun to characterize the document. User-generated tags characterizing a portion of the document are assigned a second taxonomic noun. Search terms that resulted in the user accessing the document are identified and assigned a third taxonomic noun. Attributes related to the manner in which the document was accessed are evaluated and assigned a fourth taxonomic noun. The document is processed using pattern rules to extract a fifth taxonomic noun. The taxonomic nouns are aggregated into a composite set of taxonomic nouns, and the dynamic classification dictionary is build by storing the composite set of taxonomic nouns.
摘要翻译：动态分类字典被构建用于对用户进行分析和定位以获得更多的相关内容。从用户活动中收集行为数据，并对用户文档和操作进行分类。作者生成的文档分类信息被分析并分配了第一个分类名词来表征文档。表征文档的一部分的用户生成的标签被分配了第二个分类名词。导致用户访问该文档的搜索字词被识别并分配了第三个分类名词。与文件访问方式相关的属性进行评估并分配第四个分类名词。使用模式规则处理文档以提取第五个分类名词。分类名词汇总成一个复合的分类名词，动态分类词典是通过存储复合的分类名词来构建的。

43. 发明申请

US20110066615A1 PERSONALIZATION ENGINE FOR BUILDING A USER PROFILE 有权
标题翻译：用于构建用户配置文件的个性化引擎
公开(公告)号：US20110066615A1
公开(公告)日：2011-03-17
申请号：US12607584
申请日：2009-10-28
申请人： Tushar PRADHAN , Thomas Osborne , John Potter
发明人： Tushar PRADHAN , Thomas Osborne , John Potter
IPC分类号： G06F17/30
CPC分类号： G06F17/30011 , G06F17/30598 , G06F17/30699 , G06F17/30707
摘要： Users of electronic documents are classified for profiling and targeting of additional relevant content. Behavioral data is gathered from user registration information and user activity, and user documents and actions are categorized. Registration information is combined with collaborative and editorial data to provide user profile information. Author-generated document classification information is analyzed and assigned a first taxonomic noun to characterize the document. User-generated tags characterizing a portion of the document are assigned a second taxonomic noun. Search terms that resulted in the user accessing the document are identified and assigned a third taxonomic noun. Attributes related to how the document was accessed are evaluated and assigned a fourth taxonomic noun. The document is processed using pattern rules to extract a fifth taxonomic noun. The taxonomic nouns are aggregated to determine a composite set of taxonomic nouns, and the user is categorized using the taxonomic nouns, and/or the author-generated classification.
摘要翻译：电子文件的用户被分类为其他相关内容的分析和定位。从用户注册信息和用户活动中收集行为数据，并对用户文档和操作进行分类。注册信息与协作和编辑数据相结合，以提供用户简档信息。作者生成的文档分类信息被分析并分配了第一个分类名词来表征文档。表征文档的一部分的用户生成的标签被分配了第二个分类名词。导致用户访问该文档的搜索字词被识别并分配了第三个分类名词。与文档访问相关的属性被评估并分配了第四个分类名词。使用模式规则处理文档以提取第五个分类名词。分类学名词被聚合以确定一组复合的分类名词，用户使用分类名词和/或作者生成的分类进行分类。

44. 发明申请

US20070276354A1 Introducer Sheath and Method for Making 审中-公开
标题翻译：介绍者护套和制作方法
公开(公告)号：US20070276354A1
公开(公告)日：2007-11-29
申请号：US10581330
申请日：2005-07-15
申请人： Thomas Osborne
发明人： Thomas Osborne
IPC分类号： A61M25/16
CPC分类号： A61M25/0012 , A61M25/0662 , B29C48/05 , B29C48/09 , B29C48/19 , B29C48/20
摘要： An introducer sheath and a method of manufacturing an introducer sheath. The introducer comprises a first polymeric sleeve having a first striped extrusion arranged in a generally helical pattern along the first sleeve. A second polymeric sleeve is positioned over and bonded to the first polymeric sleeve, the second polymeric sleeve comprising a second striped extrusion that is arranged in a generally helical pattern along the second sleeve. The first and second polymeric sleeves are axially aligned such that the second striped extrusion is superposed over the first striped extrusion to define a generally braid-like configuration. The introducer sheath can optionally include an inner liner disposed within a lumen of the first polymeric sleeve, and/or a coil fitted over the inner liner, such that the first polymeric sleeve is bonded to the inner liner between turns of the coil.
摘要翻译：导引鞘和制造导引鞘的方法。引导器包括第一聚合物套筒，该第一聚合物套筒具有沿着第一套筒布置成大致螺旋形图案的第一条状挤压件。第二聚合物套管定位在第一聚合物套筒之上并且结合到第一聚合物套筒上，第二聚合物套筒包括沿着第二套筒布置成大致螺旋形图案的第二条纹挤出件。第一和第二聚合物套筒被轴向对齐，使得第二条纹挤出物叠加在第一条纹挤出物上以限定大致辫状构型。引导器护套可以可选地包括设置在第一聚合物套筒的内腔内的内衬和/或安装在内衬上的线圈，使得第一聚合物套筒在线圈的匝之间结合到内衬。

45. 发明申请

US20070244440A1 Medical device with expandable tip 审中-公开
标题翻译：具有可扩展尖端的医疗设备
公开(公告)号：US20070244440A1
公开(公告)日：2007-10-18
申请号：US11728528
申请日：2007-03-26
申请人： Dharmendra Pal , Thomas Osborne
发明人： Dharmendra Pal , Thomas Osborne
IPC分类号： A61M29/00 , A61M5/178 , A61M25/00
CPC分类号： A61M25/0074 , A61M25/0068
摘要： A catheter for use with at least two different sizes of wire guides is described. The catheter includes a wire guide lumen sized to receive a first wire guide of a first diameter. The catheter may also include a tip lumen that extends in a distal direction from a first opening in communication with the wire guide lumen to a second opening. The first opening is sized to receive the first wire guide, and the second opening is sized to receive a second wire guide of a smaller diameter than the first wire guide. The catheter also includes one or more longitudinal expansion features capable of radially expanding the tip lumen to receive a wire guide of a diameter up to the first diameter through the second opening. An adapter that may be attached to the catheter by a medical professional is also described.
摘要翻译：描述了与至少两种不同尺寸的导线器一起使用的导管。导管包括尺寸适于接收第一直径的第一线引导件的线引导腔。导管还可以包括尖端腔，其从远离方向延伸，与第一开口连通，该第一开口与导线管腔连通到第二开口。第一开口的尺寸被设计成接收第一线引导件，并且第二开口的尺寸被设计成接纳直径小于第一线引导件的第二线引导件。该导管还包括一个或多个纵向膨胀特征，其能够径向扩张尖端内腔，以通过第二开口接纳直径直到第一直径的线引导件。还描述了可由医学专业人员附接到导管的适配器。

46. 发明申请

US20070198002A1 Implant retrieval assembly and method for retrieving an implant 有权
标题翻译：植入物检索组件和用于检索植入物的方法
公开(公告)号：US20070198002A1
公开(公告)日：2007-08-23
申请号：US11708235
申请日：2007-02-20
申请人： Jeffry Melsheimer , Thomas Osborne
发明人： Jeffry Melsheimer , Thomas Osborne
IPC分类号： A61B17/00
CPC分类号： A61B17/221 , A61B17/32056 , A61B17/3468 , A61B2017/0046 , A61B2017/00477 , A61B2017/2919
摘要： An implant retrieval frame for advancement of a retrieval device to snare an implant is disclosed. The frame comprises a first arm and a second arm. The first arm has a first handle end and a first pivot end. The second arm has a second handle end and a second pivot end. The second pivot end is connected to the first pivot end to define a pivot axis about which the first and second arm pivotally move. The frame further comprises a connector to which the retrieval device is attached. The connector is configured to cooperate with the first and second arms to translate pivotal movement of one of the first and second arms to linear movement of the retrieval device relative to the pivot point.
摘要翻译：公开了一种用于推进提取装置以圈套植入物的植入物检索框架。框架包括第一臂和第二臂。第一臂具有第一手柄端和第一枢转端。第二臂具有第二手柄端和第二枢转端。第二枢转端连接到第一枢转端以限定枢转轴线，第一和第二臂枢转运动。该框架还包括一个连接器，拾取装置附接到该连接器。连接器构造成与第一和第二臂配合以将第一和第二臂之一的枢转运动转换成相对于枢转点的线性运动。

47. 发明申请

US20070191927A1 Stent with orientation-dependent properties 有权
标题翻译：支架与取向相关的属性
公开(公告)号：US20070191927A1
公开(公告)日：2007-08-16
申请号：US11593908
申请日：2006-11-07
申请人： Jason Bowe , Thomas Osborne
发明人： Jason Bowe , Thomas Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/30136 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2230/0004 , A61F2230/0054
摘要： A method and device for implantation into a curved vessel is described. The device may be a stent with a generally curved configuration in its radially expanded state. The stent may have a first series of linkages located along a first side of the stent and a second series of linkages located along a second side of the stent. Both series of linkages interconnect structural elements of the stent. During deployment of the stent into a vessel, the second series of linkages undergo longitudinal expansion sufficient to produce a stent having a longer second side than a first side. This difference in longitudinal length between the second side and first side of the stent creates a curved configuration which conforms to the curvature of the vessel which it is implanted into.
摘要翻译：描述了用于植入弯曲容器的方法和装置。该装置可以是在其径向展开状态下具有大致弯曲构造的支架。支架可以具有沿着支架的第一侧定位的第一系列连杆，以及沿着支架的第二侧定位的第二系列连杆。两个系列的连接将支架的结构元件相互连接。在将支架部署到容器中期间，第二系列连接件经历纵向膨胀，足以产生具有比第一侧更长的第二侧的支架。支架的第二侧和第一侧之间的纵向长度差异产生符合被植入的血管的曲率的弯曲构型。

48. 发明申请

US20060235512A1 Valve device with inflatable chamber 有权
公开(公告)号：US20060235512A1
公开(公告)日：2006-10-19
申请号：US11394303
申请日：2006-03-30
申请人： Thomas Osborne , Jacob Flagle , John Brumleve
发明人： Thomas Osborne , Jacob Flagle , John Brumleve
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0026 , A61F2230/0095 , A61F2250/0003 , Y10T29/494
摘要： Prosthetic valve devices for implantation in body vessels are provided. The prosthetic valve device includes at least one flexible member that permits fluid flow in a first direction and substantially prevents fluid flow in a second. The valve device also includes an inflatable chamber at least partially attached to the flexible member. The inflatable chamber is adapted to receive inflating media and is adapted to contact the body vessel. A delivery system is also provided that includes a valve device and a delivery apparatus. The delivery apparatus includes a member adapted for filling the chamber of the valve device with inflating media. A related method of making the valve device is also provided.

49. 发明申请

US20060200110A1 Introducer sheath 审中-公开
标题翻译：导引鞘
公开(公告)号：US20060200110A1
公开(公告)日：2006-09-07
申请号：US11366649
申请日：2006-03-02
申请人： D. Lentz , Thomas Osborne
发明人： D. Lentz , Thomas Osborne
IPC分类号： A61M25/00
CPC分类号： A61M25/0662 , A61L29/06 , A61M25/0045 , A61M25/005 , C08L77/00
摘要： An introducer sheath has an inner fluorocarbon liner, a reinforcing member disposed radially outwardly from the liner, and a polymeric intermediate layer positioned longitudinally over the reinforcing member and inner liner. A heat shrink layer formed of a block copolymer having cross-linked and non-cross-linked functional groups comprises an outer layer of the sheath. During for of the introducer sheath, the intermediate layer is melted and compressed in the heat shrink layer in a manner such that the inner surface of the intermediate layer bonds to the outer surface of the inner liner through spacings of the reinforcing member, and the outer surface of the intermediate layer bonds with non-cross-linked active functional groups of the heat shrink layer.
摘要翻译：引导器护套具有内部碳氟化合物衬垫，从衬套径向向外设置的加强构件以及纵向位于加强构件和内衬上的聚合物中间层。由具有交联和非交联官能团的嵌段共聚物形成的热收缩层包括外层的外层。在引导器护套期间，中间层在热收缩层中熔融并压缩，使得中间层的内表面通过加强构件的间隔与内衬的外表面结合，并且外层中间层的表面与热收缩层的非交联活性官能团结合。

50. 发明申请

US20060064036A1 Variable flexibility wire guide 审中-公开
标题翻译：可变弹性导线
公开(公告)号：US20060064036A1
公开(公告)日：2006-03-23
申请号：US10946416
申请日：2004-09-21
申请人： Thomas Osborne , Aaron Barr
发明人： Thomas Osborne , Aaron Barr
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M25/01 , A61M29/02 , A61M2025/09075
摘要： The present invention provides a wire guide having a wire core and a braided sheath. The wire core includes a proximal end and distal end, wherein the braided sheath is attached to the distal end of the wire core and serves as a flexible pulling section. The braided sheath is woven of a plurality of strands and may be made of various material based on the application, such as stainless steel, a shape memory alloy, or a radiopaque material. The wire guide has a flexible tip at the proximal end opposite the flexible pulling section. A stiff section is provided between the flexible tip and the flexible pulling section to allow manipulation of the wire guide through a body lumen. Proximate the distal end of the wire core a tapered section is provided to increase flexibility of the wire guide toward the distal end. The braided sheath is received over and attached to the wire core. In addition, a shoulder is provided in the wire core providing a smooth transition from the wire core to the braided section. The braided sheath extends from the shoulder beyond the distal end of the wire core.
摘要翻译：本发明提供一种具有线芯和编织护套的导线器。线芯包括近端和远端，其中编织的护套附接到线芯的远端并用作柔性牵引部分。编织的护套由多根股线编织，并且可以根据应用，例如不锈钢，形状记忆合金或不透射线的材料，由各种材料制成。线引导件在与柔性牵引部分相对的近端处具有柔性尖端。在柔性尖端和柔性牵引部分之间提供了一个坚硬的部分，以允许线引导件通过体腔的操纵。近似线芯的远端设置有锥形部分以增加导线器朝向远端的柔性。编织的护套被接收在线芯上并附着到线芯上。此外，在芯线中设置有肩部，其提供从线芯到编织部分的平滑过渡。编织护套从肩部延伸超过线芯的远端。

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