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41. 发明申请

US20070093869A1 Device, system, and method for contracting tissue in a mammalian body 审中-公开
标题翻译：用于在哺乳动物体内收缩组织的装置，系统和方法
公开(公告)号：US20070093869A1
公开(公告)日：2007-04-26
申请号：US10560986
申请日：2004-06-21
申请人： Eliot Bloom , Nareak Douk , Nasser Rafiee
发明人： Eliot Bloom , Nareak Douk , Nasser Rafiee
IPC分类号： A61B17/08
CPC分类号： A61B17/068 , A61B17/0644 , A61B17/10 , A61B2017/00243 , A61B2017/0641 , A61B2017/081 , A61F2/2445
摘要： A device, a system and a method for contracting tissue in a mammalian body. The contracting device comprises a body and a plurality of legs radially splayed there from. Each leg includes a snap-acting spring tip. When a force is applied to the device, the tips operate to transform the device from a deployment state into a treatment state. Each leg may also be bent at one or more deformation elements in response to the application of force. The system comprises a contracting device slidably received within a delivery catheter. The method of contracting tissue in a mammalian body comprises delivering a contracting device in a lumen of a catheter proximate a treatment area, releasing the contracting device from the catheter, positioning legs of the contracting device on tissue to be contracted, exerting a force on the contracting device, transforming the device into a treatment state, and reducing a compass of the tissue in response to the attainment of the treatment state.
摘要翻译：用于在哺乳动物体内收缩组织的装置，系统和方法。收缩装置包括主体和在其上径向张开的多个腿。每个腿包括弹性弹簧尖。当力施加到设备时，提示操作以将设备从部署状态转换成处理状态。响应于施加力，每个腿也可以在一个或多个变形元件处弯曲。该系统包括可滑动地容纳在输送导管内的收缩装置。在哺乳动物身体中收缩组织的方法包括将收缩装置输送到靠近治疗区域的导管的内腔中，将收缩装置从导管释放，将收缩装置的腿定位在要收缩的组织上，在其上施加力收缩装置，将装置转化为治疗状态，以及响应于治疗状态的实现而减少组织的罗盘。

42. 发明申请

US20070027533A1 Cardiac valve annulus restraining device 审中-公开
标题翻译：心脏瓣膜环带限制装置
公开(公告)号：US20070027533A1
公开(公告)日：2007-02-01
申请号：US11193674
申请日：2005-07-28
申请人： Nareak Douk
发明人： Nareak Douk
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2433 , A61F2/2466 , A61F2250/001
摘要： A catheter based system for treating mitral valve regurgitation includes a restraining device having a flexible member, a plurality of movable anchor members attached to the outer surface of the flexible member, and an adjustment filament attached to the ends of the flexible member. One embodiment of the invention includes a method for attaching a flexible restraining device to the annulus of a mitral valve, and adjusting the length of the adjustment filament attached to the flexible member of the restraining device, thereby reshaping the mitral valve annulus so that the anterior and posterior leaflets of the mitral valve close during ventricular contraction.
摘要翻译：用于治疗二尖瓣反流的基于导管的系统包括具有柔性构件的限制装置，附接到柔性构件的外表面的多个可移动锚固构件和附接到柔性构件的端部的调节细丝。本发明的一个实施例包括一种用于将柔性约束装置附接到二尖瓣环的方法，以及调节附着在约束装置的柔性构件上的调节细丝的长度，从而重新形成二尖瓣环，使前并且在心室收缩期间二尖瓣的后小叶关闭。

43. 发明授权

US06911036B2 Guidewire apparatus for temporary distal embolic protection 失效
公开(公告)号：US06911036B2
公开(公告)日：2005-06-28
申请号：US10099399
申请日：2002-03-15
申请人： Nareak Douk , Nasser Rafiee , Peter G. Strickler , Matt S. Poole , Ellen M. Jennings
发明人： Nareak Douk , Nasser Rafiee , Peter G. Strickler , Matt S. Poole , Ellen M. Jennings
IPC分类号： A61B17/221 , A61B17/00 , A61B17/12 , A61B17/22 , A61F2/01 , A61M25/01 , A61M29/00
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/1204 , A61B17/12109 , A61B17/12172 , A61B2017/1205 , A61B2017/22038 , A61B2017/22045 , A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0071 , A61M25/09025 , A61M2025/09008 , A61M2025/09183 , A61M2025/1015
摘要： A guidewire apparatus for use during percutaneous catheter interventions, such as angioplasty or stent deployment. A protection element comprising a filter or an occluder is mounted near the distal end of a steerable guidewire, which guides a therapeutic catheter. The guidewire apparatus comprises a hollow shaft movably disposed about a core wire and, optionally, a slippery liner interfitted there between. The shaft and core wire control relative displacement of the ends of the protection element, causing transformation of the protection element between a deployed configuration and a collapsed configuration.

44. 发明申请

US20050070995A1 Compliant venous graft 有权
标题翻译：合并静脉移植
公开(公告)号：US20050070995A1
公开(公告)日：2005-03-31
申请号：US10834360
申请日：2004-04-28
申请人： Peter Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael Wolf
发明人： Peter Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael Wolf
IPC分类号： A61F2/06 , A61F2/24 , A61F2/90 , A61L27/14 , A61L27/36
CPC分类号： A61F2/06 , A61F2/90 , A61L27/14 , A61L27/3625
摘要： A venous graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a vein segment carried within and having an ablumenal surface in contact with and supported by the tubular support, the venous graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.
摘要翻译：用于替换动脉的一部分的静脉移植物和制造移植物的方法。移植物包括柔性的，弹性的，大体上管状的外部支撑件和承载在管状支撑件内并具有与管状支撑件接触并由其支撑的缩小表面的静脉段，静脉移植物能够以模拟径向顺应性的方式弹性径向膨胀的动脉。

45. 发明申请

US20050004553A1 Sheath catheter having variable over-the-wire length and methods of use 审中-公开
标题翻译：护套导管具有可变的线上长度和使用方法
公开(公告)号：US20050004553A1
公开(公告)日：2005-01-06
申请号：US10610817
申请日：2003-07-02
申请人： Nareak Douk
发明人： Nareak Douk
IPC分类号： A61B17/12 , A61F2/00 , A61F2/01 , A61F2/06 , A61M25/00
CPC分类号： A61M25/0021 , A61B17/12022 , A61B2017/00991 , A61B2017/1205 , A61F2/01 , A61F2002/011 , A61F2002/9528 , A61F2250/0065 , A61M2025/0004 , A61M2025/0175
摘要： A sheath catheter includes a positioning wire fixedly attached at its distal end to a distal tube. A proximal tube is slidably disposed on the positioning wire proximal of the distal tube and sized so that the distal tube may be nested therein. In one embodiment, a series of coordinating stops are fixed on the tubes so that the distal tube can slide back and forth within the proximal tube but cannot be extracted from the proximal tube. As such, the over-the-wire length of the catheter can be varied. In another embodiment, an additional telescoping portion can be added between the distal tube and the proximal tube for greater control over the length of the sheath catheter. In this embodiment, the tubes are sized so that the middle tube may be nested within the proximal tube and the distal tube may be nested in the middle tube.
摘要翻译：护套导管包括定位线，其定位线在其远端固定连接到远端管。近端管可滑动地设置在远端管的近端的定位线上并且尺寸使得远端管可嵌套在其中。在一个实施例中，一系列协调止动件固定在管上，使得远端管能够在近端管内来回滑动，但不能从近侧管中抽出。因此，可以改变导管的线上长度。在另一个实施例中，可以在远端管和近端管之间添加附加的伸缩部分，以更好地控制护套导管的长度。在该实施例中，管的尺寸使得中管可以嵌套在近端管内，并且远端管可以嵌套在中管中。

46. 发明授权

US09364324B2 Infundibular reducer device delivery system and related methods 有权
标题翻译：漏斗式减速器装置输送系统及相关方法
公开(公告)号：US09364324B2
公开(公告)日：2016-06-14
申请号：US12358388
申请日：2009-01-23
申请人： Nasser Rafiee , Morgan House , Nareak Douk , Philipp Bonhoeffer
发明人： Nasser Rafiee , Morgan House , Nareak Douk , Philipp Bonhoeffer
IPC分类号： A61F2/24 , A61F2/95
CPC分类号： A61F2/2427 , A61F2/2418 , A61F2/2436 , A61F2002/9522 , A61F2250/0039 , A61M5/007 , A61M25/0043 , A61M2025/0057
摘要： Described is a delivery system for minimally invasive delivery of a self-expandable stent to a body lumen, and particularly delivery of a prosthetic valve to the right ventricular outflow tract. Also described is a method of loading a stent onto such a delivery system, and a method of delivering a self-expandable stent to a desired anatomic site.
摘要翻译：描述了用于将自扩张支架微创递送到体腔的输送系统，特别是将人工瓣膜输送到右心室流出道。还描述了将支架装载到这种递送系统上的方法，以及将自扩张支架递送到期望的解剖部位的方法。

47. 发明申请

US20160081830A1 POLYMERIC IMPLANT DELIVERY SYSTEM 审中-公开
公开(公告)号：US20160081830A1
公开(公告)日：2016-03-24
申请号：US14953542
申请日：2015-11-30
申请人： Nareak Douk , Rany Busold , Lee Core , Kicherl Ho , My Le , Timothy Walter Robinson , Sarah Kostanski , Benedict Shia , Jerry Brightbill
发明人： Nareak Douk , Rany Busold , Lee Core , Kicherl Ho , My Le , Timothy Walter Robinson , Sarah Kostanski , Benedict Shia , Jerry Brightbill
IPC分类号： A61F2/966 , A61F2/86 , A61F2/90
CPC分类号： A61F2/966 , A61F2/86 , A61F2/90 , A61F2002/826 , A61F2002/9505 , A61F2002/9522 , A61F2002/9665 , A61F2230/0054
摘要： Delivery systems for a polymeric tubular implant, kits that include such delivery systems, and methods of treating patients by implanting tubular implants using the delivery systems. The delivery systems include an inner shaft, an expandable member slidably disposed about the inner shaft and configured to receive the tubular implant, and a tubular outer shaft disposed about the inner shaft.

48. 发明授权

US09198783B2 Polymeric implant delivery system 有权
标题翻译：聚合物植入物输送系统
公开(公告)号：US09198783B2
公开(公告)日：2015-12-01
申请号：US13606962
申请日：2012-09-07
申请人： Nareak Douk , Rany Busold , Lee Core , Kicherl Ho , My Le , Timothy Walter Robinson , Sarah Kostanski , Benedict Shia , Jerry Brightbill
发明人： Nareak Douk , Rany Busold , Lee Core , Kicherl Ho , My Le , Timothy Walter Robinson , Sarah Kostanski , Benedict Shia , Jerry Brightbill
IPC分类号： A61F2/06 , A61F2/90 , A61F2/966 , A61F2/86 , A61F2/95 , A61F2/82
CPC分类号： A61F2/966 , A61F2/86 , A61F2/90 , A61F2002/826 , A61F2002/9505 , A61F2002/9522 , A61F2002/9665 , A61F2230/0054
摘要： Delivery systems for a polymeric tubular implant, kits that include such delivery systems, and methods of treating patients by implanting tubular implants using the delivery systems. The delivery systems include an inner shaft, an expandable member slidably disposed about the inner shaft and configured to receive the tubular implant, and a tubular outer shaft disposed about the inner shaft.
摘要翻译：用于聚合物管状植入物的递送系统，包括这种递送系统的试剂盒以及通过使用递送系统植入管状植入物来治疗患者的方法。输送系统包括内轴，可滑动地设置在内轴周围并构造成容纳管状植入物的可扩张构件以及围绕内轴设置的管状外轴。

49. 发明申请

US20120116495A1 Compliant Venous Graft 审中-公开
标题翻译：合并静脉移植
公开(公告)号：US20120116495A1
公开(公告)日：2012-05-10
申请号：US13351591
申请日：2012-01-17
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/90 , A61L27/14 , A61L27/3625
摘要： A venous graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a vein segment carried within and having an ablumenal surface in contact with and supported by the tubular support, the venous graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.
摘要翻译：用于替换动脉的一部分的静脉移植物和制造移植物的方法。移植物包括柔性的，弹性的，大体上管状的外部支撑件和承载在管状支撑件内并具有与管状支撑件接触并由其支撑的缩小表面的静脉段，静脉移植物能够以模拟径向顺应性的方式弹性径向膨胀的动脉。

50. 发明授权

US07998188B2 Compliant blood vessel graft 有权
标题翻译：符合血管移植
公开(公告)号：US07998188B2
公开(公告)日：2011-08-16
申请号：US11797648
申请日：2007-05-04
申请人： Peter Paul Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf , Paul Human
发明人： Peter Paul Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf , Paul Human
IPC分类号： A61F2/06
CPC分类号： A61B17/11 , A61B5/1076 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/95 , A61F2240/002
摘要： Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
摘要翻译：提供支架和使用支架的方法。本发明的支架为设置在其内的血管段提供外部支撑结构，其中支架能够以模仿动脉的顺应性的方式弹性径向扩张。支架可以由形成的针织或编织网形成，以便提供所需的顺应性。提供具有支架和设置在其内的静脉段的静脉移植物，其中移植物能够模拟动脉的顺应性。提供了选择小型化支架的方法和使用本发明的支架在缩小和平滑方面的方法。提供了用包括本发明的支架的静脉移植物代替动脉的一部分的方法。提供了使用本发明的支架在静脉移植物中减少植入静脉段内膜增生的方法。

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