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41. 发明申请

US20060173184A1 Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase 有权
公开(公告)号：US20060173184A1
公开(公告)日：2006-08-03
申请号：US11321710
申请日：2005-12-29
申请人： Richard Apodaca , J. Breitenbucher , Kanaka Pattabiraman , Mark Seierstad , Wei Xiao
发明人： Richard Apodaca , J. Breitenbucher , Kanaka Pattabiraman , Mark Seierstad , Wei Xiao
IPC分类号： C07D403/02
CPC分类号： C07D295/195 , C07D207/335 , C07D209/08 , C07D209/14 , C07D209/82 , C07D211/16 , C07D213/38 , C07D213/56 , C07D213/61 , C07D213/75 , C07D215/12 , C07D215/18 , C07D239/42 , C07D241/42 , C07D295/20 , C07D295/215 , C07D307/79 , C07D307/81 , C07D317/46 , C07D317/58 , C07D319/16 , C07D319/18 , C07D333/58 , C07D333/60 , C07D401/12 , C07D405/12 , C07D417/12
摘要： Certain piperazinyl and piperidinyl urea compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).

42. 发明授权

US07071191B2 Non-imidazole aryloxypiperidines 有权
公开(公告)号：US07071191B2
公开(公告)日：2006-07-04
申请号：US09922619
申请日：2001-08-06
申请人： Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Chandravadan R. Shah , Wei Xiao
发明人： Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Chandravadan R. Shah , Wei Xiao
IPC分类号： A61K31/5375 , C07D413/12
CPC分类号： C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要： Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.

43. 发明申请

US20050216462A1 System and method for a snapshot query during database recovery 有权
标题翻译：数据库恢复期间快照查询的系统和方法
公开(公告)号：US20050216462A1
公开(公告)日：2005-09-29
申请号：US10812188
申请日：2004-03-29
申请人： Wei Xiao
发明人： Wei Xiao
IPC分类号： G06F7/00
CPC分类号： G06F17/30533 , G06F11/1471 , G06F11/2074 , G06F17/30362 , G06F17/30371 , Y10S707/99938 , Y10S707/99944 , Y10S707/99953
摘要： A method of performing a snapshot query in a database undergoing recovery allows access to the database during rollback or undo operations. The method includes allowing the query to detect whether a redo lock is present on a data item and if so, waiting until subsequent rollback operations release the lock. If another user has placed an exclusive lock on a data item of the database, the query may continue by reading a version of the data item form the version store. In an embodiment where a mirror database is used for recovery, the constant redo operations have an associated version store. Upon failover to the mirror database, queries may begin during the undo phase of recovery by allowing a query to read the version store of redo operations.
摘要翻译：在正在进行恢复的数据库中执行快照查询的方法允许在回滚或撤消操作期间访问数据库。该方法包括允许查询检测数据项上是否存在重做锁，如果是，则等待直到后续回滚操作释放锁。如果另一用户已经对数据库的数据项放置了排他锁，则可以通过从版本存储器读取数据项的版本来继续查询。在使用镜像数据库进行恢复的实施例中，常数重做操作具有关联的版本存储。在故障切换到镜像数据库时，可以在恢复的撤消阶段期间开始查询，方法是允许查询读取重做操作的版本存储。

44. 发明授权

US06884803B2 Phenylalkynes 有权
标题翻译：苯基炔
公开(公告)号：US06884803B2
公开(公告)日：2005-04-26
申请号：US10307870
申请日：2002-12-02
申请人： Richard Apodaca , Wei Xiao , Jill A. Jablonowski
发明人： Richard Apodaca , Wei Xiao , Jill A. Jablonowski
IPC分类号： C07D295/12 , A61K31/444 , A61K31/4453 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/08 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/28 , A61P27/14 , A61P27/16 , A61P37/08 , A61P43/00 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/66 , C07D213/38 , C07D215/06 , C07D215/12 , C07D239/42 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/12 , C07D471/10 , C07D491/10 , C07D491/113 , C07D403/06 , A61K31/495 , A61P25/24 , C07D295/04
CPC分类号： C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/38 , C07D215/06 , C07D273/00 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/12 , C07D471/10 , C07D491/10
摘要： Disclosed are substituted phenylalkynes of formula (I), wherein R1, R2, R3, R4, R5 and n are as defined, compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译：公开了式（I）的取代的苯基炔，其中R 1，R 2，R 3，R 4， R 5和n如上所定义，含有它们的组合物，以及制备和使用它们来治疗组胺介导的病症的方法。

45. 发明申请

US20050085487A1 Heterocyclic compounds 审中-公开
标题翻译：杂环化合物
公开(公告)号：US20050085487A1
公开(公告)日：2005-04-21
申请号：US10961247
申请日：2004-10-08
申请人： Nicholas Carruthers , Wenying Chai , Curt Dvorak , James Edwards , Cheryl Grice , Jill Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer Kreisberg , Annette Kwok , Timothy Lovenberg , Kiev Ly , Barbara Pio , Chandravadan Shah , Siquan Sun , Robin Thurmond , Jianmei Wei , Wei Xiao
发明人： Nicholas Carruthers , Wenying Chai , Curt Dvorak , James Edwards , Cheryl Grice , Jill Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer Kreisberg , Annette Kwok , Timothy Lovenberg , Kiev Ly , Barbara Pio , Chandravadan Shah , Siquan Sun , Robin Thurmond , Jianmei Wei , Wei Xiao
IPC分类号： C07D307/84 , A61K31/496 , A61P1/04 , A61P7/00 , A61P9/06 , A61P17/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D209/42 , C07D401/12 , C07D403/06 , A61K31/454 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： C07D401/12 , A61K31/496 , C07D209/42
摘要： Heterocyclic compounds and methods of making them and using them.
摘要翻译：杂环化合物及其制备方法和使用方法。

46. 发明授权

US06587881B1 Software server usage governor 有权
标题翻译：软件服务器使用总监
公开(公告)号：US06587881B1
公开(公告)日：2003-07-01
申请号：US09289054
申请日：1999-04-09
申请人： Sameet Agarwal , Wei Xiao , Michael Zwilling
发明人： Sameet Agarwal , Wei Xiao , Michael Zwilling
IPC分类号： G06F1516
CPC分类号： G06F9/505 , G06F11/3433 , G06F11/3438 , G06F11/3452 , G06F2201/87 , G06F2201/88
摘要： A system and method for controlling usage of a particular software program in a computer network environment is disclosed. The invention operates by controlling the throughput of the software as it executes on a server computer. In particular, the invention monitors the number of active requests to the software. If the number of active requests exceeds a predefined number, the software throughput on the server (e.g., requests completed per minute) is artificially restricted. As such, the present invention continues to allow further connections to the software but intentionally restricts further use by inhibiting the throughput for all connections to the software. Preferably, the present invention continues to allow the predefined number of active requests to be exceeded, but as more requests are made, the overall performance of software progressively degrades.
摘要翻译：公开了一种用于控制计算机网络环境中特定软件程序的使用的系统和方法。本发明通过在服务器计算机上执行时控制软件的吞吐量来操作。特别地，本发明监视对软件的活动请求的数量。如果活动请求的数量超过预定义的数量，则服务器上的软件吞吐量（例如，每分钟完成的请求）被人为限制。因此，本发明继续允许与软件的进一步连接，而是有意地通过禁止对软件的所有连接的吞吐量来限制进一步的使用。优选地，本发明继续允许超过预定数量的活动请求，但是随着更多请求，软件的整体性能逐渐降低。

47. 发明申请

US20140221406A1 QUINAZOLINE-7-ETHER COMPOUNDS AND METHODS OF USE 有权
标题翻译：喹唑啉-7-醚化合物及其使用方法
公开(公告)号：US20140221406A1
公开(公告)日：2014-08-07
申请号：US14118200
申请日：2012-05-17
申请人： Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
发明人： Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
IPC分类号： C07D405/12 , C07D493/04
CPC分类号： C07D405/12 , C07D493/04
摘要： The invention provides quinazoline-7-ether derivatives, particularly 4-anilinyl-6-butenamido-quinazoline-7-ether derivatives that are inhibitors of the receptor protein tyrosine kinases (RTK). The compounds are useful in the treatment of diseases and disorders where RTK activity is implicated such as a hyperproliferative diseases (e.g., cancer). Also provided are methods of preparation of the quinazoline derivatives and methods of use as therapeutic agents alone or in a drug combination.
摘要翻译：本发明提供了喹唑啉-7-醚衍生物，特别是作为受体蛋白酪氨酸激酶（RTK）抑制剂的4-苯乙烯基-6-丁烯酰氨基 - 喹唑啉-7-醚衍生物。所述化合物可用于治疗涉及RTK活性的疾病和病症，例如过度增殖性疾病（例如癌症）。还提供了制备喹唑啉衍生物的方法和单独使用或作为药物组合用作治疗剂的方法。

48. 发明授权

US08598202B2 Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase 有权
标题翻译：芳基 - 羟乙基氨基 - 嘧啶和三嗪作为脂肪酸酰胺水解酶的调节剂
公开(公告)号：US08598202B2
公开(公告)日：2013-12-03
申请号：US12378734
申请日：2009-02-18
申请人： Richard Apodaca , J. Guy Breitenbucher , Alison L. Chambers , Xiaohu Deng , Natalie A. Hawryluk , John M. Keith , Neelakandha S. Mani , Jeffrey E. Merit , Joan M. Pierce , Mark Seierstad , Wei Xiao
发明人： Richard Apodaca , J. Guy Breitenbucher , Alison L. Chambers , Xiaohu Deng , Natalie A. Hawryluk , John M. Keith , Neelakandha S. Mani , Jeffrey E. Merit , Joan M. Pierce , Mark Seierstad , Wei Xiao
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/42 , C07D239/47 , C07D239/48 , C07D251/22 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12
摘要： Certain aryl-hydroxyethylamino-pyrimidine and triazine compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.
摘要翻译：描述了某些芳基 - 羟乙基氨基 - 嘧啶和三嗪化合物，其可用作FAAH抑制剂。这些化合物可用于治疗由脂肪酰胺水解酶（FAAH）活性介导的疾病状态，病症和病症的药物组合物和方法，例如焦虑症，疼痛，炎症，睡眠障碍，进食障碍，能量代谢紊乱，和运动障碍（例如多发性硬化）。还公开了合成这些化合物的方法。

49. 发明申请

US20130005687A1 IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 有权
标题翻译： TRPV1的咪唑啉酮，氧杂双环和三唑基咪嗪调节剂
公开(公告)号：US20130005687A1
公开(公告)日：2013-01-03
申请号：US13611936
申请日：2012-09-12
申请人： Bryan James Branstetter , J. Guy Breitenbucher , Alec D. Lebsack , Jing Liu , Jason C. Rech , Wei Xiao
发明人： Bryan James Branstetter , J. Guy Breitenbucher , Alec D. Lebsack , Jing Liu , Jason C. Rech , Wei Xiao
IPC分类号： C07D513/04 , A61K31/519 , C07D239/48 , A61K31/5377 , C07D473/34 , A61K31/52 , C07D473/24 , C07D473/18 , C07D473/16 , C07F7/10 , A61K31/695 , A61P29/00 , A61P27/16 , A61P11/00 , A61P1/00 , A61P13/00 , A61P7/00 , A61P25/00 , A61P17/04 , A61P19/02 , A61P11/10 , A61P11/06 , C07D498/04
CPC分类号： C07D513/04 , A61K31/497 , A61K31/519 , A61K31/5377 , C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34 , C07D498/04
摘要： Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.
摘要翻译：描述了一些TRPV1调节的咪唑并，恶唑并噻唑并噻吩并嘧啶化合物。所述化合物可用于治疗由TRPV1活性介导的疾病状态，病症和状况的药物组合物和方法，例如疼痛，关节炎，瘙痒，咳嗽，哮喘或炎症性肠病。

50. 发明申请

US20120179025A1 CT AND MRI SYNCHRONOUS DETECTION POSITIONING NEEDLE 失效
标题翻译： CT和MRI同步检测定位针
公开(公告)号：US20120179025A1
公开(公告)日：2012-07-12
申请号：US13377044
申请日：2011-04-25
申请人： Dedong Ma , Wei Xiao , Qingshi Zeng , Ying Xing , Hongxiu Lu
发明人： Dedong Ma , Wei Xiao , Qingshi Zeng , Ying Xing , Hongxiu Lu
IPC分类号： A61B5/055 , A61M5/00 , A61B6/03
CPC分类号： A61B5/0035 , A61B5/055 , A61B6/032 , A61B6/12 , A61B17/3403 , A61B90/10 , A61B90/37 , A61B2017/3405 , A61B2090/3954 , A61B2090/3966 , A61B2090/3995 , A61M5/427 , A61M5/46
摘要： Disclosed is a CT and MRI synchronous detection positioning needle. The needle comprises a silicone tube which is internally provided with a guide needle; the two sides of the guide needle are provided with hollow cavities; each hollow cavity is internally provided with membranes dividing the hollow cavity into a plurality of small chambers which are filled with liquid, wherein a CT contrast agent is filled in a plurality of small chambers at one side of the guide needle, and an MRI contrast agent is filled in a plurality of small chambers at the other side of the guide needle. In the invention, specially designed silicone positioning needles are implanted in vivo, and synchronous comparison of different image data and pathological data is implemented by means of multi-plane reconstruction technology, so the CT and MRI synchronous detection positioning needle can be widely applied to experimental study on tumors.
摘要翻译：公开了一种CT和MRI同步检测定位针。该针包括内部设置有引导针的硅胶管; 引导针的两侧设有中空腔; 每个中空腔内部设置有将中空腔分成多个填充有液体的小室的膜，其中CT造影剂填充在引导针一侧的多个小室中，并且MRI造影剂被填充在引导针的另一侧的多个小室中。在本发明中，特别设计的硅胶定位针植入体内，通过多平面重建技术实现不同图像数据和病理数据的同步比较，CT和MRI同步检测定位针可广泛应用于实验研究肿瘤。

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