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41. 发明申请

US20070191269A1 Medicament comprising ptx3, alone or in combination with tsg-6, for treating degenerative diseases of cartilage and bone and treating female infertility 审中-公开
标题翻译：包含单独或与tsg-6组合的ptx3的药物用于治疗软骨和骨的退行性疾病并治疗女性不育症
公开(公告)号：US20070191269A1
公开(公告)日：2007-08-16
申请号：US10584295
申请日：2004-12-21
申请人： Alberto Mantovani , Paolo Carminati , Barbara Bottazzi
发明人： Alberto Mantovani , Paolo Carminati , Barbara Bottazzi
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K2300/00
摘要： The use of pentraxin PTX3 and of its combination with TSG-6 for the preparation of a medicament for the treatment of bone or cartilage diseases and for the treatment of female infertility is described.
摘要翻译：描述了使用pentraxin PTX3及其与TSG-6的组合来制备用于治疗骨或软骨疾病和治疗女性不孕症的药物。

42. 发明授权

US06741162B1 Power line networking apparatus and method 有权
标题翻译：电力线网络设备及方法
公开(公告)号：US06741162B1
公开(公告)日：2004-05-25
申请号：US09678983
申请日：2000-10-04
申请人： Frank Sacca , Alberto Mantovani
发明人： Frank Sacca , Alberto Mantovani
IPC分类号： H04M1104
CPC分类号： H04B3/56 , H04B2203/5425 , H04B2203/5445 , H04B2203/5483 , H04B2203/5491
摘要： An apparatus for carrying electrical data signals and electrical power over a power line is disclosed. The apparatus includes a data processing device, a power supply, and a data signal transceiver. The apparatus also includes an interference filter coupled to the power line and to the power supply and configured to reject electromagnetic interference. A coupling circuit that is electromagnetically coupled to the power line is also disclosed. The coupling circuit is configured to transmit and receive data signals carried through the power line. The coupling circuit is coupled to the data signal transceiver. The data signal transceiver is configured to transmit and receive the data signals to and from the data processing device.
摘要翻译：公开了一种通过电力线承载电气数据信号和电力的装置。该装置包括数据处理装置，电源和数据信号收发器。该装置还包括耦合到电力线和电源并被配置为抑制电磁干扰的干扰滤波器。还公开了电磁耦合到电力线的耦合电路。耦合电路被配置为发送和接收通过电力线承载的数据信号。耦合电路耦合到数据信号收发器。数据信号收发器被配置为向数据处理装置发送数据信号并从数据处理装置接收数据信号。

43. 发明授权

US06534534B1 Pharmaceutical composition active in reducing production of MCP-1 protein 有权
标题翻译：药物组合物有效减少MCP-1蛋白的产生
公开(公告)号：US06534534B1
公开(公告)日：2003-03-18
申请号：US09463666
申请日：2000-04-27
申请人： Angelo Guglielmotti , Alberto Mantovani
发明人： Angelo Guglielmotti , Alberto Mantovani
IPC分类号： A61K31415
CPC分类号： A61K31/415
摘要： The present application relates to a method of treating atherosclerosis by administering to a patient a compound of formula: and/or salts thereof with pharmaceutically acceptable organic or inorganic bases.
摘要翻译：本申请涉及一种治疗动脉粥样硬化的方法，其通过向药物学上可接受的有机或无机碱施用式（II）化合物和/或其盐。

44. 发明授权

US06431655B1 Breaker device for removing the tops of columns 有权
标题翻译：用于去除柱顶部的断路器装置
公开(公告)号：US06431655B1
公开(公告)日：2002-08-13
申请号：US09669630
申请日：2000-09-26
申请人： Alberto Mantovani
发明人： Alberto Mantovani
IPC分类号： B28D126
CPC分类号： B28D1/222 , E02D9/005
摘要： The breaker device for removing the tops of columns comprises a support structure composed of a plurality identical chain elements reciprocally linked by link couplings to form a closed chain which can surround a column which is to be topped. Each chain element bears a jackhammer provided with a plurality of interchangeable breaker punches, of varying lengths. Each chain element exhibits a plurality of holes which are distanced from the link couplings and which are for linking the chain elements. Each hole is aligned with a corresponding hole of an adjacent chain element. A pin is used for blocking adjacent chain elements in predetermined positions. The invention is useful for breaking the stop of a reinforced-concrete column without damaging the reinforcement elements thereof. The device can be adapted to columns having different diameters.
摘要翻译：用于移除柱的顶部的断路器装置包括由多个相同的链条元件构成的支撑结构，所述多个相同的链条元件通过连杆联轴器往复地连接以形成围绕待顶部的柱的闭合链。每个链条带有一个装有多个可变长度的可互换的断路器冲头的手提锤。每个链条元件具有多个与链接联接器间隔开的孔，并且用于链接链条元件。每个孔与相邻链条元件的相应孔对齐。销用于在预定位置阻挡相邻的链条元件。本发明对于破坏钢筋混凝土柱的停止而不损害其增强元件是有用的。该装置可以适应于具有不同直径的柱。

45. 发明授权

US6081586A Modem having a programmable universal data access arrangement 有权
标题翻译：调制解调器具有可编程通用数据访问装置
公开(公告)号：US6081586A
公开(公告)日：2000-06-27
申请号：US193113
申请日：1998-11-16
申请人： Raphael Rahamim , Thomas Grey Beutler , Nuno F. Paulino , Alberto Mantovani , Jacques Mathe
发明人： Raphael Rahamim , Thomas Grey Beutler , Nuno F. Paulino , Alberto Mantovani , Jacques Mathe
IPC分类号： H04M20060101 , H04M1/00 , H04M11/00 , H04M11/06
CPC分类号： H04M1/738
摘要： A modem utilizing a DAA having line side circuitry including a telephone network interface and system side circuitry including a host system interface, the line side circuitry and the system side circuitry being separated by a high voltage isolation barrier. A CODEC is provided in the line side circuitry, such that encoded information generated by the CODEC, as well as information for decoding by the CODEC, are communicated across the high voltage isolation barrier. These communications are accomplished in a digital manner. In an alternate embodiment of the invention, the line side circuitry of the modem further includes programmable detection and measurement circuitry that is programmable to measure electrical characteristics (e.g., tip/ring voltage and loop current) of the telephone line interface connection and is capable of corresponding adjustments to enable compliance with applicable regulations. The system is software programmable via control signals sent across the high voltage isolation barrier to establish electrical parameters corresponding to a specific country where the equipment may be used.
摘要翻译：利用具有线路侧电路的DAA的调制解调器，该线路侧电路包括电话网络接口和包括主机系统接口的系统侧电路，所述线路侧电路和所述系统侧电路被高电压隔离屏障隔开。在行侧电路中提供CODEC，使得由CODEC生成的编码信息以及由CODEC解码的信息跨越高电压隔离屏障传送。这些通信是以数字方式完成的。在本发明的替代实施例中，调制解调器的线路侧电路还包括可编程检测和测量电路，其可编程以测量电话线接口连接的电特性（例如尖端/环电压和回路电流），并且能够相应的调整，以符合适用的法规。该系统可通过跨高压隔离屏障发送的控制信号进行软件编程，以建立与可能使用设备的特定国家相对应的电气参数。

46. 发明授权

US5739282A Interleukin-1 antagonist 失效
标题翻译：白细胞介素-1拮抗剂
公开(公告)号：US5739282A
公开(公告)日：1998-04-14
申请号：US476860
申请日：1995-06-07
申请人： Francesco Colotta , Marta Muzio , Alberto Mantovani
发明人： Francesco Colotta , Marta Muzio , Alberto Mantovani
IPC分类号： C12N15/09 , A61K38/00 , A61K38/20 , A61P7/06 , A61P29/00 , A61P31/04 , A61P35/02 , A61P37/00 , C07K5/083 , C07K14/54 , C12N5/10 , C12N15/12 , C12N15/24 , C12N15/25 , C12N15/85 , C07K14/47 , C12N15/11
CPC分类号： C07K14/54 , A61K38/00
摘要： It is described a new interleukin-1 antagonist active both against IL-1.alpha. and IL-1.beta., a new DNA sequence encoding the Il-1 antagonist and the method for obtaining a IL-1 antagonist by the recombinant DNA technique; it is also described the prophylactic, therapeutic and diagnostic use of such new IL-1 antagonist in pathologies deriving from the IL-1 production.
摘要翻译：描述了针对IL-1α和IL-1β的新型白细胞介素-1拮抗剂，编码II-1拮抗剂的新DNA序列和通过重组DNA技术获得IL-1拮抗剂的方法; 还描述了这种新的IL-1拮抗剂在来自IL-1产生的病理学中的预防，治疗和诊断用途。

47. 发明授权

US09077236B2 Permanent magnet rotor for a rotary electric machine 有权
标题翻译：用于旋转电机的永磁转子
公开(公告)号：US09077236B2
公开(公告)日：2015-07-07
申请号：US13610409
申请日：2012-09-11
申请人： Alberto Mantovani
发明人： Alberto Mantovani
IPC分类号： H02K21/12 , H02K29/03 , H02K15/03 , H02K1/27
CPC分类号： H02K21/12 , H02K1/2773 , H02K1/278 , H02K15/03 , H02K29/03 , H02K2213/03
摘要： A permanent magnet rotor (3) for a rotary electric machine (1) comprises a rotor body (10) having a rotation axis (A) and a plurality of radial magnets (4), wherein the magnets (4) exhibit a head portion (5) located in proximity to an external surface (30) of the rotor body (10) and a base portion (6) facing towards the rotation axis (A). The base portion (6) of each magnet (4) has a width smaller than a width of the head portion (5).
摘要翻译：用于旋转电机（1）的永磁转子（3）包括具有旋转轴线（A）和多个径向磁体（4）的转子体（10），其中磁体（4）具有头部（ 5）位于转子体（10）的外表面（30）附近，以及基部（6）面向旋转轴线（A）。每个磁体（4）的基部（6）的宽度小于头部（5）的宽度。

48. 发明申请

US20110318760A1 METHOD FOR THE IN VITRO DIAGNOSIS OF AN AUTOIMMUNE RESPONSE ASSOCIATED WITH THE EXISTENCE OF AN ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES-ASSOCIATED VASCULITIS BY DETECTION OF ANTIBODIES DIRECTED AGAINST THE PENTRAXIN 3 ANTIGEN 审中-公开
标题翻译：通过检测针对PENTRAXIN 3抗原的抗体，与ANANEETROPHIL CYPOPLASMIC抗体相关的血管生成相关的自身免疫反应的体外诊断方法
公开(公告)号：US20110318760A1
公开(公告)日：2011-12-29
申请号：US13161158
申请日：2011-06-15
申请人： Pascale Jeannin , Yves Delneste , Alberto Mantovani
发明人： Pascale Jeannin , Yves Delneste , Alberto Mantovani
IPC分类号： G01N33/566
CPC分类号： G01N33/564 , G01N2333/4709 , G01N2333/4737 , G01N2800/328
摘要： A method for the in vitro diagnosis of an autoimmune immune response in an individual by detection, in a biological fluid from said individual, of antibodies directed against the pentraxin 3 (PTX3) antigen, characterized in that the presence of antibodies directed against the PTX3 antigen (anti-PTX3 antibodies) are determined in a biological fluid from the individual, and kits for implementing the method.
摘要翻译：一种通过在来自所述个体的生物流体中检测针对五倍体素3（PTX3）抗原的抗体体外诊断个体中自身免疫免疫应答的方法，其特征在于存在针对PTX3抗原的抗体（抗PTX3抗体）在来自个体的生物流体中测定，以及用于实施该方法的试剂盒。

49. 发明授权

US07858577B2 Use of the long pentraxin PTX3 for the treatment of diseases caused by an altered activation of the growth factor FGF-2 有权
标题翻译：使用长的pentraxin PTX3用于治疗由生长因子FGF-2的活化改变引起的疾病
公开(公告)号：US07858577B2
公开(公告)日：2010-12-28
申请号：US10416225
申请日：2001-11-08
申请人： Alberto Mantovani , Barbara Bottazzi , Marco Presta , Marco Rusnati
发明人： Alberto Mantovani , Barbara Bottazzi , Marco Presta , Marco Rusnati
IPC分类号： A61K38/00
CPC分类号： A61K45/06 , A61K38/1709 , A61K48/00 , A61K2300/00
摘要： The use of the long pentraxin PTX3 (PTX3) or one of its functional derivatives is described for the preparation of medicament which inhibits the biological activity of the growth factor FGF-2, useful for the prevention and treatment of diseases brought about by an altered activation of said growth factor FGF-2.
摘要翻译：描述了使用长五倍体PTX3（PTX3）或其功能性衍生物之一用于制备抑制生长因子FGF-2的生物活性的药物，其可用于预防和治疗由改变的活化引起的疾病的所述生长因子FGF-2。

50. 发明授权

US07550269B2 PTX3 as an early prognostic indicator of cardiovascular and cerebrovascular pathologies 有权
标题翻译： PTX3作为心血管和脑血管病变的早期预后指标
公开(公告)号：US07550269B2
公开(公告)日：2009-06-23
申请号：US11508960
申请日：2006-08-24
申请人： Roberto Latini , Giuseppi Peri , Alberto Mantovani , Aldo P. Maggioni
发明人： Roberto Latini , Giuseppi Peri , Alberto Mantovani , Aldo P. Maggioni
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/32 , G01N2800/324 , G01N2800/325
摘要： A method for the early determination of the risk of death or heart failure in infarction patients, and the risk of death, relapse or complications in ictus patients, the method being based on the determination of PTX3 from plasma or blood.
摘要翻译：一种早期确定梗死患者死亡或心力衰竭风险的方法，以及ictus患者死亡，复发或并发症的风险，该方法基于血浆或血液中PTX3的测定。

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