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41. 发明申请

US20130170618A1 DIFFERENTIAL PHASE-CONTRAST IMAGING WITH IMPROVED SAMPLING 有权
标题翻译：具有改进的采样的差分相位对比成像
公开(公告)号：US20130170618A1
公开(公告)日：2013-07-04
申请号：US13819764
申请日：2011-08-26
申请人： Thomas Koehler
发明人： Thomas Koehler
IPC分类号： G21K1/06 , G01N23/04
CPC分类号： G21K1/067 , A61B6/032 , A61B6/4035 , A61B6/4291 , A61B6/484 , G01N23/04 , G21K1/02 , G21K2207/005
摘要： The present invention relates to differential phase-contrast imaging of an object. For increasing spatial resolution of an X-ray imaging system (2) the size of a detector pixel element (8) may be considered a limiting factor. Accordingly, it may be beneficial to increase the resolution of an apparatus (38) for phase-contrast imaging without further reducing the area of an individual pixel element (8). Accordingly, an apparatus (38) for phase-contrast imaging with improved sampling is provided, comprising an X-ray source (4), a first grating element G1 (24), a second grating element G2 (26) and an X-ray detector element (6) comprising a plurality of detector pixel elements (8), each detector pixel element (8) having a pixel area A. An object to be imagined (14) is arrangeable between the X-ray source (4) and the X-ray detector element (6). The first grating element G1 (24) as well as the second grating element G2 (26) are arrangeable between the X-ray source (4) and the X-ray detector element (6). The X-ray source (4), the first grating element G1 (24), the second grating element G2 (26) and the X-ray detector (6) are operatively coupled for acquisition of a phase-contrast image of the object (14). At least one of the first grating element G1 (24) and the second grating element G2 (26) comprise a first area A1 having a first grating pitch p1 and a second area A2 having a second grating pitch p2 different from the first grating pitch.
摘要翻译：本发明涉及物体的差分相位对比成像。为了增加X射线成像系统的空间分辨率（2），检测器像素元件（8）的尺寸可以被认为是限制因素。因此，增加用于相位对比成像的装置（38）的分辨率可能是有益的，而不进一步减小单个像素元件（8）的面积。因此，提供了一种用于具有改进采样的相位对比成像的装置（38），包括X射线源（4），第一光栅元件G1（24），第二光栅元件G2（26）和X射线检测器元件（6）包括多个检测器像素元件（8），每个检测器像素元件（8）具有像素区域A.要想象的物体（14）可布置在X射线源（4）和 X射线检测元件（6）。第一光栅元件G1（24）以及第二光栅元件G2（26）可布置在X射线源（X）和X射线探测元件（6）之间。 X射线源（4），第一光栅元件G1（24），第二光栅元件G2（26）和X射线检测器（6）可操作地耦合以获取对象的相位差图像 14）。第一光栅元件G1（24）和第二光栅元件G2（26）中的至少一个包括具有第一光栅间距p1的第一区域A1和具有与第一光栅间距不同的第二光栅间距p2的第二区域A2。

42. 发明授权

US08406840B2 Spatially resolved oxymetry 有权
标题翻译：空间解析氧化测定
公开(公告)号：US08406840B2
公开(公告)日：2013-03-26
申请号：US12066561
申请日：2006-09-07
申请人： Tim Nielsen , Thomas Koehler
发明人： Tim Nielsen , Thomas Koehler
IPC分类号： A61B5/00
CPC分类号： A61B5/0073 , A61B5/14551 , A61B5/1495
摘要： In optical tomography, a calibration of the data may be necessary for image reconstruction. According to an exemplary embodiment of the present invention, the object of interest is used for calibration, wherein the image data is acquired during a highly oxygenated phase of the object of interest and wherein the calibration data is acquired during a low oxygenated phase of the object of interest. This may provide for an improved calibration, resulting in improved image quality.
摘要翻译：在光学层析成像中，图像重构可能需要校准数据。根据本发明的示例性实施例，感兴趣的对象被用于校准，其中在感兴趣对象的高度充氧阶段期间获取图像数据，并且其中在对象的低氧合期期间获取校准数据出于兴趣。这可以提供改进的校准，导致改善的图像质量。

43. 发明授权

US08385621B2 Method for reconstruction images and reconstruction system for reconstructing images 有权
标题翻译：重建图像和重建图像重构系统的方法
公开(公告)号：US08385621B2
公开(公告)日：2013-02-26
申请号：US12296116
申请日：2007-03-15
申请人： Thomas Koehler , Peter Forthmann
发明人： Thomas Koehler , Peter Forthmann
IPC分类号： G06K9/20 , G06T1/00
CPC分类号： G06T11/005 , A61B6/027 , G06T7/30 , G06T2207/30004
摘要： A reconstruction method for an image of an object, the reconstruction method comprising receiving a first projection data set representing information about said object, receiving a second projection data set representing information about said object, reconstructing a first image of said object using the first projection data set, reconstructing a second image of said object using the second projection data set, performing a registration between the first image and the second image, and fusing the first image and the second image to said image of said object, wherein the first projecting data set and the second projecting data set are achieved by using a single radiation type.
摘要翻译：一种用于对象的图像的重建方法，所述重建方法包括接收表示关于所述对象的信息的第一投影数据集，接收表示关于所述对象的信息的第二投影数据集，使用所述第一投影数据重建所述对象的第一图像使用所述第二投影数据集重建所述对象的第二图像，执行所述第一图像和所述第二图像之间的对准，以及将所述第一图像和所述第二图像融合到所述对象的所述图像，其中，所述第一投影数据集并且通过使用单个辐射类型来实现第二投影数据集。

44. 发明授权

US08306183B2 Detection setup for X-ray phase contrast imaging 有权
标题翻译： X射线相位成像检测设置
公开(公告)号：US08306183B2
公开(公告)日：2012-11-06
申请号：US12744070
申请日：2008-11-19
申请人： Thomas Koehler
发明人： Thomas Koehler
IPC分类号： G01N23/02
CPC分类号： A61B6/00 , A61B6/032 , A61B6/06 , A61B6/4291 , A61B6/484
摘要： The invention relates to a method and a device for generating phase contrast X-ray images of an object (1). The device comprises an X-ray source (10) that may for example be realized by a spatially extended emitter (11) behind a grating (G0). A diffractive optical element (DOE), for example a phase grating (G1), generates an interference pattern (I) from the X-radiation that has passed the object (1), and a spectrally resolving X-ray detector (30) is used to measure this interference pattern behind the DOE. Using the information obtained for different wavelengths/energies of X-radiation, the phase shift induced by the object can be reconstructed.
摘要翻译：本发明涉及一种用于产生对象（1）的相差X射线图像的方法和装置。该装置包括例如可以由光栅（G0）后面的空间扩展的发射器（11）实现的X射线源（10）。衍射光学元件（DOE），例如相位光栅（G1），从已经通过物体（1）的X射线产生干涉图案（I），光谱分辨X射线检测器（30）是用于测量DOE背后的干扰模式。使用对于X射线的不同波长/能量获得的信息，可以重建由对象引起的相移。

45. 发明授权

US08250336B2 Method, system and computer program product for storing external device result data 失效
标题翻译：用于存储外部设备结果数据的方法，系统和计算机程序产品
公开(公告)号：US08250336B2
公开(公告)日：2012-08-21
申请号：US12036695
申请日：2008-02-25
申请人： Chung-Lung Kevin Shum , Brian D. Barrick , Thomas Koehler , Aaron Tsai
发明人： Chung-Lung Kevin Shum , Brian D. Barrick , Thomas Koehler , Aaron Tsai
IPC分类号： G06F13/00
CPC分类号： G06F12/084 , G06F9/30043 , G06F9/3824 , G06F9/383 , G06F9/3879
摘要： A method, system, and computer program product for storing result data from an external device. The method includes receiving the result data from the external device, the receiving at a system. The result data is stored into a store data buffer. The store data buffer is utilized by the system to contain store data normally generated by the system. A special store instruction is executed to store the result data into a memory on the system. The special store instruction includes a store address. The executing includes performing an address calculation of the store address based on provided instruction information, and updating a memory location at the store address with contents of the store data buffer utilizing a data path utilized by the system to store data normally generated by the system.
摘要翻译：一种用于从外部设备存储结果数据的方法，系统和计算机程序产品。该方法包括从外部设备接收结果数据，在系统接收。结果数据存储到存储数据缓冲区中。存储数据缓冲器被系统用于包含通常由系统生成的存储数据。执行特殊存储指令以将结果数据存储到系统中的存储器中。特殊商店指令包括商店地址。所述执行包括基于所提供的指示信息执行所述存储地址的地址计算，以及利用所述系统利用的用于存储由所述系统正常生成的数据的数据路径来更新所述存储数据缓冲器的存储位置。

46. 发明申请

US20110320761A1 ADDRESS TRANSLATION, ADDRESS TRANSLATION UNIT DATA PROCESSING PROGRAM, AND COMPUTER PROGRAM PRODUCT FOR ADDRESS TRANSLATION 有权
标题翻译：地址翻译，地址转换单元数据处理程序和用于地址转换的计算机程序产品
公开(公告)号：US20110320761A1
公开(公告)日：2011-12-29
申请号：US13165013
申请日：2011-06-21
申请人： Ute Gaertner , Thomas Koehler
发明人： Ute Gaertner , Thomas Koehler
IPC分类号： G06F12/10
CPC分类号： G06F12/1027 , G06F12/0855
摘要： A lookup operation is performed in a translation look aside buffer based on a first translation request as current translation request, wherein a respective absolute address is returned to a corresponding requestor for the first translation request as translation result in case of a hit. A translation engine is activated to perform at least one translation table fetch in case the current translation request does not hit an entry in the translation look aside buffer, wherein the translation engine is idle waiting for the at least one translation table fetch to return data, reporting the idle state of the translation engine as lookup under miss condition and accepting a currently pending translation request as second translation request, wherein a lookup under miss sequence is performed in the translation look aside buffer based on said second translation request.
摘要翻译：在基于第一翻译请求的翻译旁边缓冲器中执行查找操作作为当前翻译请求，其中相应的绝对地址在命中情况下作为翻译结果返回给第一翻译请求的对应请求者。翻译引擎被激活以执行至少一个转换表提取，以防当前转换请求没有到达翻译旁边缓冲器中的条目，其中翻译引擎空闲等待至少一个转换表提取返回数据，将所述翻译引擎的空闲状态报告为在未命中条件下的查找，并接受当前待处理的转换请求作为第二转换请求，其中在所述翻译旁边缓冲器中基于所述第二翻译请求执行在未命中序列下的查找。

47. 发明申请

US20110182400A1 METHOD AND APPARATUS TO IMPROVE CT IMAGE ACQUISITION USING A DISPLACED GEOMETRY 有权
标题翻译：使用位移几何来改进CT图像采集的方法和装置
公开(公告)号：US20110182400A1
公开(公告)日：2011-07-28
申请号：US13120660
申请日：2009-10-05
申请人： Peter Forthmann , Thomas Koehler , Udo Van Stevendaal , Matthias Bertram , Steffen Wiesner , Colas Schretter
发明人： Peter Forthmann , Thomas Koehler , Udo Van Stevendaal , Matthias Bertram , Steffen Wiesner , Colas Schretter
IPC分类号： A61B6/03 , G01N23/04
CPC分类号： A61B6/032 , A61B5/107 , A61B6/027
摘要： A method and apparatus are provided to improve CT image acquisition using a displaced acquisition geometry. A CT apparatus may be used having a source (102) and a detector (104) transversely displaced from a center (114) of a field of view (118) during acquisition of the projection data. The amount of transverse displacement may be determined based on the size of the object (108). The source and the detector may be adjusted to vary the size of the transverse field of view. The first data set acquired by the detector may be reconstructed and used to simulate missing projection data that could not be acquired by the detector at each projection angle. The measured projection data and the simulated projection data may be used to obtain a second data set. The second data set may be compared to the first data set to produce a corrected data set.
摘要翻译：提供了一种方法和装置，用于改善使用位移采集几何形状的CT图像采集。可以使用CT装置，在获取投影数据期间具有从视场（118）的中心（114）横向移位的源（102）和检测器（104）。可以基于物体（108）的尺寸来确定横向位移量。源和检测器可以被调节以改变横向视场的大小。由检测器获取的第一数据集可以被重构并用于模拟在每个投影角度不能由检测器获取的丢失的投影数据。所测量的投影数据和模拟投影数据可用于获得第二数据集。可以将第二数据集与第一数据集进行比较以产生校正数据集。

48. 发明申请

US20110150176A1 IMAGE PROCESSING WITH COMPUTER AIDED DETECTION AND/OR DIAGNOSIS 审中-公开
标题翻译：具有计算机辅助检测和/或诊断的图像处理
公开(公告)号：US20110150176A1
公开(公告)日：2011-06-23
申请号：US12675809
申请日：2008-09-05
申请人： Thomas Koehler , Rafael Wiemker
发明人： Thomas Koehler , Rafael Wiemker
IPC分类号： A61B6/03 , G06T7/00
CPC分类号： G06T7/0012 , G06T11/008 , G06T2207/10072 , G06T2207/30064
摘要： The invention relates to a method and an image processing device (10) for the evaluation of image raw-data of a body region generated with an imaging device like a CT scanner (30). From the image raw-data, a first image (ICAD) is reconstructed with a reconstruction module (12) according to reconstruction parameters (p) set optimally by a computer aided detection and/or diagnosis (CAD) module (13). This module can then evaluate an image (ICAD) that was reconstructed optimally according to its own requirements, for example with respect to image size and/or resolution, to find features of interest.
摘要翻译：本发明涉及一种用于评估由诸如CT扫描仪（30）的成像装置生成的身体区域的图像原始数据的方法和图像处理装置（10）。根据图像原始数据，根据由计算机辅助检测和/或诊断（CAD）模块（13）最佳设置的重建参数（p），利用重建模块（12）重建第一图像（ICAD）。然后，该模块可以根据其自己的要求（例如关于图像尺寸和/或分辨率）评估被最优化地重建的图像（ICAD），以找到感兴趣的特征。

49. 发明申请

US20100272322A1 CORRECTION FOR UN-VOLUNTARY RESPIRATORY MOTION IN CARDIAC CT 有权
标题翻译： CARDIAC CT中自愿呼吸运动的校正
公开(公告)号：US20100272322A1
公开(公告)日：2010-10-28
申请号：US12746301
申请日：2008-12-12
申请人： Thomas Koehler
发明人： Thomas Koehler
IPC分类号： G06K9/00
CPC分类号： A61B6/032 , A61B6/027 , A61B6/5217
摘要： A CT angiography apparatus (10) compensates for respiratory motion. During a helical scan, a radiation source (16) and a detector (18) generate data sets corresponding to a plurality of sub-volumes of a blood vessel over a plurality of cardiac cycles. Sub-volume data sets corresponding to a selected cardiac phase are reconstructed (40) into a plurality of sub-volume images (54′1, 54′2, 54′3). Characteristic points (561, 562, 563) in the sub-volume images are identified. A computer routine or processor (48) calculates a respiratory motion vector based on the identified characteristic points in a plurality of the sub-volume images. An image reconstruction routine or processor (50) reconstructs the original sub-volume data (36) in the selected cardiac phase into a volume image representation (50′) using the calculated respiratory motion vector.
摘要翻译： CT血管造影装置（10）补偿呼吸运动。在螺旋扫描期间，辐射源（16）和检测器（18）在多个心动周期上产生对应于血管的多个子体积的数据集。对应于所选心脏相位的子体数据集被重建（40）成多个子体积图像（54'1,54'2,54'3）。识别子体积图像中的特征点（561,562,563）。计算机程序或处理器（48）基于多个子体积图像中所识别的特征点来计算呼吸运动矢量。图像重建程序或处理器（50）使用所计算的呼吸运动矢量将所选择的心脏相位中的原始子体积数据（36）重建为体积图像表示（50'）。

50. 发明申请

US20100238441A1 DEVICE FOR IMAGING THE INTERIOR OF AN OPTICALLY TURBID MEDIUM AND RECEPTACLE UNIT FOR SUCH A DEVICE 有权
标题翻译：用于成像用于这种装置的光学涡卷介质和插座单元的内部的装置
公开(公告)号：US20100238441A1
公开(公告)日：2010-09-23
申请号：US12682939
申请日：2008-10-13
申请人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
发明人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
IPC分类号： G01N21/49 , G01N21/00
CPC分类号： G01N21/4795 , A61B5/0073 , A61B5/0091 , A61B5/4312 , A61B2562/146 , G01N2021/1787 , G01N2201/0826 , G01N2201/0833
摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.
摘要翻译：提供了用于对光学混浊介质的内部成像的装置（1）。该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

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