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1. 发明申请

US20100238441A1 DEVICE FOR IMAGING THE INTERIOR OF AN OPTICALLY TURBID MEDIUM AND RECEPTACLE UNIT FOR SUCH A DEVICE 有权
标题翻译：用于成像用于这种装置的光学涡卷介质和插座单元的内部的装置
公开(公告)号：US20100238441A1
公开(公告)日：2010-09-23
申请号：US12682939
申请日：2008-10-13
申请人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
发明人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
IPC分类号： G01N21/49 , G01N21/00
CPC分类号： G01N21/4795 , A61B5/0073 , A61B5/0091 , A61B5/4312 , A61B2562/146 , G01N2021/1787 , G01N2201/0826 , G01N2201/0833
摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.
摘要翻译：提供了用于对光学混浊介质的内部成像的装置（1）。该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

2. 发明授权

US09488574B2 Device for imaging the interior of an optically turbid medium and receptacle unit for such a device 有权
标题翻译：用于对用于这种装置的光学混浊介质和插座单元的内部进行成像的装置
公开(公告)号：US09488574B2
公开(公告)日：2016-11-08
申请号：US12682939
申请日：2008-10-13
申请人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
发明人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
IPC分类号： G01N21/47 , A61B5/00 , G01N21/17
CPC分类号： G01N21/4795 , A61B5/0073 , A61B5/0091 , A61B5/4312 , A61B2562/146 , G01N2021/1787 , G01N2201/0826 , G01N2201/0833
摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.
摘要翻译：提供了用于对光学混浊介质的内部成像的装置（1）。该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

3. 发明申请

US20100030084A1 DIFFUSE OPTICAL TOMOGRAPHY WITH MARKERS CONTAINING FLUORESCENT MATERIAL 审中-公开
公开(公告)号：US20100030084A1
公开(公告)日：2010-02-04
申请号：US12514589
申请日：2007-11-12
申请人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
发明人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
IPC分类号： A61B6/00 , G06K9/00
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N21/6456
摘要： The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.

4. 发明申请

US20110026851A1 METHOD FOR RECONSTRUCTING A FLUORESCENT IMAGE OF THE INTERIOR OF A TURBID MEDIUM AND DEVICE FOR IMAGING THE INTERIOR OF A TURBID MEDIUM 有权
标题翻译：用于重建涡轮介质内部的荧光图像的方法和用于成像涡轮介质的内部的装置
公开(公告)号：US20110026851A1
公开(公告)日：2011-02-03
申请号：US12933887
申请日：2009-03-20
申请人： Ronny Ziegler , Andy Ziegler , Tim Nielsen
发明人： Ronny Ziegler , Andy Ziegler , Tim Nielsen
IPC分类号： G06K9/40 , G01J1/58
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N21/6428
摘要： A method for reconstructing a fluorescence image of the interior of a turbid medium is provided. The method comprises the step: accommodating a turbid medium (1) to which a fluorescent contrast agent has been administered in a measurement volume (4). The fluorescent contrast agent is capable of emitting light in a first range of wavelengths upon irradiation with light. The method further comprises: performing attenuation measurements at a plurality of different wavelengths (λi, . . . λk) by subsequently irradiating the turbid medium (1) with light from a plurality of different source positions and detecting light emanating from the turbid medium (1) in a plurality of detection positions for each source position; reconstructing absorption properties (μa(r, λ)) as a function of the position in the interior of the turbid medium (1) for the plurality of different wavelengths from the attenuation measurements; calculating absorption properties as a function of the position in the interior of the turbid medium (1) for wavelengths of the first range of wavelengths; performing a fluorescence measurement by subsequently irradiating the turbid medium (1) with light causing the fluorescent contrast agent to emit light in the first range of wavelengths from the plurality of source positions and detecting the light emanating from the fluorescent contrast agent in the plurality of detection positions for each source position; and reconstructing a fluorescence image of the spatial distribution of the fluorescent contrast agent in the interior of the turbid medium (1) from the fluorescence measurement using the calculated absorption properties.
摘要翻译：提供了一种用于重建浑浊介质内部的荧光图像的方法。该方法包括以下步骤：在测量体积（4）中容纳已投与荧光造影剂的混浊介质（1）。荧光造影剂能够在照射光时在第一波长范围内发光。该方法还包括：通过随后用来自多个不同源位置的光照射混浊介质（1）并检测从浑浊介质（1）发出的光，在多个不同波长（λ1，...λk）下执行衰减测量）在每个源位置的多个检测位置中; 根据衰减测量，重建作为多个不同波长的混浊介质（1）内部位置的函数的吸收特性（μa（r，λ））; 计算作为第一波长范围波长的混浊介质（1）内部位置的函数的吸收特性; 通过随后用引起荧光对比剂的光在多个源位置的第一波长范围内发射光，并在多个检测中检测从荧光对比剂发出的光，进行荧光测量每个来源职位的职位; 以及使用所计算的吸收特性，从所述荧光测量重建所述浑浊介质（1）内的所述荧光造影剂的空间分布的荧光图像。

5. 发明授权

US08520921B2 Method for reconstructing a fluorescent image of the interior of a turbid medium and device for imaging the interior of a turbid medium 有权
标题翻译：用于重建浑浊介质内部的荧光图像的方法和用于对浑浊介质的内部进行成像的装置
公开(公告)号：US08520921B2
公开(公告)日：2013-08-27
申请号：US12933887
申请日：2009-03-20
申请人： Ronny Ziegler , Andy Ziegler , Tim Nielsen
发明人： Ronny Ziegler , Andy Ziegler , Tim Nielsen
IPC分类号： G06K9/00
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N21/6428
摘要： A method for reconstructing a fluorescence image of the interior of a turbid medium is provided. The method comprises the step: accommodating a turbid medium (1) to which a fluorescent contrast agent has been administered in a measurement volume (4). The fluorescent contrast agent is capable of emitting light in a first range of wavelengths upon irradiation with light. The method further comprises: performing attenuation measurements at a plurality of different wavelengths (λi, . . . , λk) by subsequently irradiating the turbid medium (1) with light from a plurality of different source positions and detecting light emanating from the turbid medium (1) in a plurality of detection positions for each source position; reconstructing absorption properties (μa(r, λ) as a function of the position in the interior of the turbid medium (1) for the plurality of different wavelengths from the attenuation measurements; calculating absorption properties as a function of the position in the interior of the turbid medium (1) for wavelengths of the first range of wavelengths; performing a fluorescence measurement by subsequently irradiating the turbid medium (1) with light causing the fluorescent contrast agent to emit light in the first range of wavelengths from the plurality of source positions and detecting the light emanating from the fluorescent contrast agent in the plurality of detection positions for each source position; and reconstructing a fluorescence image of the spatial distribution of the fluorescent contrast agent in the interior of the turbid medium (1) from the fluorescence measurement using the calculated absorption properties.
摘要翻译：提供了一种用于重建浑浊介质内部的荧光图像的方法。该方法包括以下步骤：在测量体积（4）中容纳已投与荧光造影剂的混浊介质（1）。荧光造影剂能够在照射光时在第一波长范围内发光。该方法还包括：通过随后用来自多个不同源位置的光照射浑浊介质（1）并检测从浑浊介质发出的光，以多个不同波长（兰德，兰布克）进行衰减测量 1）在每个源位置的多个检测位置; 根据衰减测量重建吸收性质（mu（r，λ））作为多个不同波长的混浊介质（1）内部的位置的函数;计算作为内部位置的函数的吸收特性用于波长第一波长范围的混浊介质（1）;通过随后用引起荧光对比剂的光在多个源位置发射第一波长范围内的光来照射浑浊介质来进行荧光测量以及在每个源位置的多个检测位置中检测从荧光对比剂发出的光;以及从所述荧光测量中使用所述荧光测量重建所述浑浊介质（1）内的荧光对比剂的空间分布的荧光图像，使用计算吸收性能。

6. 发明申请

US20080273655A1 Imaging Method with Back Projection 失效
标题翻译：具有反投影的成像方法
公开(公告)号：US20080273655A1
公开(公告)日：2008-11-06
申请号：US11570896
申请日：2005-06-24
申请人： Tim Nielsen , Andy Ziegler , Thomas Koehler , Roland Proksa
发明人： Tim Nielsen , Andy Ziegler , Thomas Koehler , Roland Proksa
IPC分类号： A61B6/00 , G06K9/00
CPC分类号： G06T11/006 , A61B6/027 , G06T2211/421 , Y10S378/901
摘要： The invention relates to an imaging method, especially a computerized tomography method, with which an object is penetrated by rays from different directions and measured values, which depend upon the intensity of the rays after penetrating the object, are acquired by a detector unit. From these measured values, an object image is reconstructed by means of back projection of measured-value-dependent back projection values. Therein, the object image is divided into overlapping, quasi-spherically symmetric image segments, each being defined by an image value and a quasi-spherically symmetric base function. Furthermore, during the back projection, the back projection values are added in proportions to the image values, wherein the proportion of a back projection value, which is added during the back projection to an image value, is dependent on a proportionality factor, which is equal to the average value of the line integrals of the base function belonging to the respective image value along those rays that have generated the measured value, on which the respective back projection value is dependent.
摘要翻译：本发明涉及一种成像方法，特别是计算机断层摄影方法，其中物体被来自不同方向的光线穿透，并且测量值取决于穿透物体之后的光线的强度，由检测器单元获取。从这些测量值，通过背投影测量值依赖的反投影值重建对象图像。其中，对象图像被划分为重叠的准球形对称图像片段，每个片段由图像值和准球形对称的基本功能定义。此外，在背投影期间，反投影值以与图像值成比例的方式相加，其中在后投影中添加的反投影值与图像值的比例取决于比例因子，即比例因子等于属于相应图像值的基本功能的线积分的平均值，沿着相应的背投影值依赖于已经产生测量值的那些射线。

7. 发明授权

US07672424B2 Image reconstruction with voxel dependent interpolation 有权
标题翻译：用体素依赖插值进行图像重建
公开(公告)号：US07672424B2
公开(公告)日：2010-03-02
申请号：US11575902
申请日：2005-09-22
申请人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Roland Proksa , Dominic J. Heuscher
发明人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Roland Proksa , Dominic J. Heuscher
IPC分类号： A61B6/00
CPC分类号： G06T11/006
摘要： A radiographic imaging apparatus includes a radiation detector (16) and a radiation source (12) which projects a non-parallel beam of radiation into field of view (14). A footprint of each voxel (v) which is projected on the detector (16) is corrected based on the position of the voxel (v) in the field of view (14) in relation to the radiation detector (16) and the radiation source (12). The contributions from substantially parallel redundant projections are further combined based on a fractional distance frac from a center point (82) of the voxel (v) to a center of each of the adjacent redundant projections.
摘要翻译：放射线照相成像装置包括辐射检测器（16）和辐射源（12），其将非平行辐射束投射到视场（14）中。基于在视场（14）中相对于放射线检测器（16）的体素（v）的位置和辐射源（v）来校正投影在检测器（16）上的每个体素（v）的足迹（12）。基于从体素（v）的中心点（82）到每个相邻冗余投影的中心的分数距离压裂进一步组合基本上平行的冗余投影的贡献。

8. 发明申请

US20090202036A1 IMAGE RECONSTRUCTION WITH VOXEL DEPENDENT INTERPOLATION 有权
标题翻译：具有VOXEL依赖插值的图像重建
公开(公告)号：US20090202036A1
公开(公告)日：2009-08-13
申请号：US11575902
申请日：2005-09-22
申请人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Roland Proksa , Dominic J, Heuscher
发明人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Roland Proksa , Dominic J, Heuscher
IPC分类号： H05G1/60 , G06K9/00
CPC分类号： G06T11/006
摘要： A radiographic imaging apparatus includes a radiation detector (16) and a radiation source (12) which projects a non-parallel beam of radiation into field of view (14). A footprint of each voxel (v) which is projected on the detector (16) is corrected based on the position of the voxel (v) in the field of view (14) in relation to the radiation detector (16) and the radiation source (12). The contributions from substantially parallel redundant projections are further combined based on a fractional distance frac from a center point (82) of the voxel (v) to a center of each of the adjacent redundant projections.
摘要翻译：放射线照相成像装置包括辐射检测器（16）和辐射源（12），其将非平行辐射束投射到视场（14）中。基于在视场（14）中相对于放射线检测器（16）的体素（v）的位置和辐射源（v）来校正投影在检测器（16）上的每个体素（v）的足迹（12）。基于从体素（v）的中心点（82）到每个相邻冗余投影的中心的分数距离压裂进一步组合基本上平行的冗余投影的贡献。

9. 发明授权

US07570731B2 Imaging method with back projection 失效
标题翻译：具有反投影的成像方法
公开(公告)号：US07570731B2
公开(公告)日：2009-08-04
申请号：US11570896
申请日：2005-06-24
申请人： Tim Nielsen , Andy Ziegler , Thomas Koehler , Roland Proksa
发明人： Tim Nielsen , Andy Ziegler , Thomas Koehler , Roland Proksa
IPC分类号： A61B6/03
CPC分类号： G06T11/006 , A61B6/027 , G06T2211/421 , Y10S378/901
摘要： The invention relates to an imaging method, especially a computerized tomography method, with which an object is penetrated by rays from different directions and measured values, which depend upon the intensity of the rays after penetrating the object, are acquired by a detector unit. From these measured values, an object image is reconstructed by means of back projection of measured-value-dependent back projection values. Therein, the object image is divided into overlapping, quasi-spherically symmetric image segments, each being defined by an image value and a quasi-spherically symmetric base function. Furthermore, during the back projection, the back projection values are added in proportions to the image values, wherein the proportion of a back projection value, which is added during the back projection to an image value, is dependent on a proportionality factor, which is equal to the average value of the line integrals of the base function belonging to the respective image value along those rays that have generated the measured value, on which the respective back projection value is dependent.
摘要翻译：本发明涉及一种成像方法，特别是计算机断层摄影方法，其中物体被来自不同方向的光线穿透，并且测量值取决于穿透物体之后的光线的强度，由检测器单元获取。从这些测量值，通过背投影测量值依赖的反投影值重建对象图像。其中，对象图像被划分为重叠的准球形对称图像片段，每个片段由图像值和准球形对称的基本功能定义。此外，在背投影期间，反投影值以与图像值成比例的方式相加，其中在后投影中添加的反投影值与图像值的比例取决于比例因子，即比例因子等于属于相应图像值的基本功能的线积分的平均值，沿着相应的背投影值依赖于已经产生测量值的那些射线。

10. 发明申请

US20090060121A1 COMPUTED TOMOGRAPHY DATA ACQUISITION APPARATUS AND METHOD 审中-公开
标题翻译：计算机图形数据采集装置和方法
公开(公告)号：US20090060121A1
公开(公告)日：2009-03-05
申请号：US12293087
申请日：2007-03-05
申请人： Andy Ziegler , Tim Nielsen
发明人： Andy Ziegler , Tim Nielsen
IPC分类号： A61B6/00
CPC分类号： G01T1/2985 , A61B6/032 , A61B6/4014 , A61B6/482 , G01T1/1648
摘要： A computed tomography scanner includes a first (20) and a second (21) detector. The second detector (21) has a relatively higher spatial resolution and a relatively smaller field of view (204) than that of the first detector (20). Projection data generated by the detectors (20, 21) is combined and reconstructed so as to generate relatively high resolution volumetric data (318) indicative of a region of interest (314) in an object under examination.
摘要翻译：计算机断层扫描器包括第一检测器（20）和第二检测器（21）。第二检测器（21）具有比第一检测器（20）更高的空间分辨率和相对更小的视场（204）。由检测器（20,21）生成的投影数据被组合和重建，以便产生指示被检查物体中的感兴趣区域（314）的相对较高分辨率的体积数据（318）。

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