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41. 发明申请

US20060271170A1 Stent with flexible sections in high strain regions 审中-公开
标题翻译：在高应变区域具有柔性部分的支架
公开(公告)号：US20060271170A1
公开(公告)日：2006-11-30
申请号：US11141834
申请日：2005-05-31
申请人： David Gale , Klaus Kleine , Anthony Abbate , Svava Atladottir , Stephen Pacetti
发明人： David Gale , Klaus Kleine , Anthony Abbate , Svava Atladottir , Stephen Pacetti
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2250/0029
摘要： A stent for treating a bodily lumen with a flexible section in a high strain region is disclosed. A flexible section may be selectively positioned to reduce an amount of strain in the high strain region when subjected to the applied stress during use to inhibit or prevent fracturing in the high strain region.
摘要翻译：公开了一种用于在高应变区域中用柔性部分处理身体管腔的支架。柔性部分可以选择性地定位成在使用过程中受到施加的应力时，在高应变区域中减小应变量，以抑制或防止高应变区域中的断裂。

42. 发明申请

US20060135985A1 Vulnerable plaque modification methods and apparatuses 审中-公开
标题翻译：易损斑块修饰方法和装置
公开(公告)号：US20060135985A1
公开(公告)日：2006-06-22
申请号：US11022548
申请日：2004-12-21
申请人： Daniel Cox , Jeffrey Ellis , Jeong Lee , Klaus Kleine , Alan Tannier
发明人： Daniel Cox , Jeffrey Ellis , Jeong Lee , Klaus Kleine , Alan Tannier
IPC分类号： A61M29/00
CPC分类号： A61F2/91 , A61B2017/22081 , A61F2/07 , A61F2/915 , A61F2/958 , A61F2002/075 , A61F2002/825 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2220/005 , A61F2230/0013 , A61F2230/0078 , A61F2250/0018 , A61F2250/0039 , A61F2250/0048 , A61M25/1002 , A61M2025/1052 , A61M2025/1059 , A61M2025/1072
摘要： A method including introducing an expandable body into a blood vessel at a point coextensive with a vulnerable plaque lesion, and expanding the expandable body from a first diameter to a different second diameter sufficient to modify the shape of an inner diameter of the blood vessel at the point coextensive with the lesion without rupturing the lesion. An apparatus including a cannula having a dimension suitable for insertion into a blood vessel and including an expandable body coupled thereto, the expandable body including a first outer diameter suitable for insertion through the blood vessel and a second outer diameter greater than the first diameter and having a maximum dimension to modify the shape of an inner diameter of the blood vessel and retain a same perimeter. A kit including a cannula including an expandable body and a stent. An expandable framework comprising a polymer material. An apparatus including an expandable body.
摘要翻译：一种方法，包括将可膨胀体引入到与易损斑块病变共同延伸的点处的血管中，以及将可膨胀体从第一直径扩大到不同的第二直径，以足以改变血管内径的形状点与病变共同延伸而不破坏病变。一种包括插管的装置，其具有适于插入血管并且包括与其连接的可扩张体的尺寸，所述可扩张体包括适于插入通过血管的第一外径和大于第一直径的第二外径，并且具有最大尺寸以改变血管内径的形状并保持相同的周边。一种套件，其包括包括可扩张体和支架的套管。包含聚合物材料的可膨胀骨架。一种包括可膨胀体的装置。

43. 发明申请

US20060058868A1 Compositions containing fast-leaching plasticizers for improved performance of medical devices 有权
标题翻译：含有快速浸出增塑剂的组合物可改善医疗器械的性能
公开(公告)号：US20060058868A1
公开(公告)日：2006-03-16
申请号：US10937975
申请日：2004-09-10
申请人： David Gale , Klaus Kleine , Anthony Abbate , Svava Atladottir , Stephen Pacetti
发明人： David Gale , Klaus Kleine , Anthony Abbate , Svava Atladottir , Stephen Pacetti
IPC分类号： A61F2/82 , A61F2/02 , B29C67/20
CPC分类号： A61L31/141
摘要： Medical implants containing a temporary plasticizer, methods of producing such implants, and methods of using the implants in treating a disease, or ameliorating one or more symptoms thereof, in a subject are provided.
摘要翻译：提供了包含临时增塑剂的医疗植入物，生产这种植入物的方法，以及使用植入物治疗疾病或改善其一种或多种症状的方法。

44. 发明申请

US20050035101A1 Pulsed fiber laser cutting system for medical implants 审中-公开
公开(公告)号：US20050035101A1
公开(公告)日：2005-02-17
申请号：US10946223
申请日：2004-09-21
申请人： Stephen Jones , Klaus Kleine , Brad Whitney , Yu-Chun Ku , Jason Fox
发明人： Stephen Jones , Klaus Kleine , Brad Whitney , Yu-Chun Ku , Jason Fox
IPC分类号： A61F2/90 , B23K26/16 , B23K26/38
CPC分类号： B23K26/18 , A61F2/91 , B23K26/06 , B23K26/0622 , B23K26/064 , B23K26/08 , B23K26/123 , B23K26/14 , B23K26/142 , B23K26/1436 , B23K26/1438 , B23K26/146 , B23K26/1476 , B23K26/16 , B23K26/38 , B23K2101/06 , B23K2103/05 , B23K2103/42 , B23K2103/50
摘要： An improved expandable stent for implantation in a body lumen, such as an artery, and an improved method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cut cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements, the elements having a rectangular cross-section from cut-to-cut. The individual radially expandable cylindrical elements are disposed in an undulating pattern. The stent is manufactured by direct laser cutting from a single metal tube using a finely focused laser beam originating from a diode pumped fiber laser with an external pulse generator and passing through a coaxial gas jet structure to impinge on the working surface of the tube as the linear and rotary velocity of the tube is precisely controlled. To optimize the cut, the laser parameters may be adjusted and/or the laser pulse may be shaped.

45. 发明授权

US08191501B2 Apparatus for selectively coating a medical article 有权
标题翻译：用于选择性地涂敷医疗用品的装置
公开(公告)号：US08191501B2
公开(公告)日：2012-06-05
申请号：US12616651
申请日：2009-11-11
申请人： Syed F. A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
发明人： Syed F. A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
IPC分类号： B05B5/00
CPC分类号： B05D1/32 , B05B12/20 , B05B13/0442 , B05D1/02 , Y10T428/13
摘要： A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article.
摘要翻译：用于在涂覆过程中遮蔽支架的掩模可以包括掩模体，其具有由掩模体遮蔽的支架图案的负图案或近似负图案。用于选择性地涂覆医疗用品的预定部分的设备可以包括涂料组合物的分配器，掩模，用于在面罩和医疗制品之间产生相对运动的装置。

46. 发明申请

US20070228023A1 Pulsed Synchronized Laser Cutting of Stents 审中-公开
标题翻译：脉冲同步激光切割支架
公开(公告)号：US20070228023A1
公开(公告)日：2007-10-04
申请号：US11278131
申请日：2006-03-30
申请人： Klaus Kleine , William Fox , Scott Palley
发明人： Klaus Kleine , William Fox , Scott Palley
IPC分类号： B23K26/38
CPC分类号： B23K26/0823 , A61F2/91 , B23K26/0626
摘要： A system for pulsed synchronized laser cutting of stents and/or other medical products includes a numerical controller and a machine for moving a tube of material during cutting. A pulsed fiber laser is configured to cut the tube into, for example, a stent, the numerical controller being in communication with the machine and configured to send movement control information to the machine. The numerical controller may also receive movement speed information from the machine. The numerical controller is also in communication with the pulsed fiber laser and is configured to send pulse control information to the pulsed fiber laser. The numerical controller is configured to cause average laser power to decrease by decreasing frequency of laser pulses as stent cutting speed decreases, and to cause average laser power to increase by increasing frequency of laser pulses as stent cutting speed increases.
摘要翻译：用于支架和/或其他医疗产品的脉冲同步激光切割的系统包括数字控制器和用于在切割期间移动材料管的机器。脉冲光纤激光器被配置为将管切割成例如支架，数字控制器与机器通信并被配置为向机器发送运动控制信息。数值控制器还可以从机器接收移动速度信息。数字控制器还与脉冲光纤激光器通信，并配置为向脉冲光纤激光器发送脉冲控制信息。数值控制器被配置为通过降低激光脉冲的频率来降低平均激光功率，因为支架切割速度降低，并且由于支架切割速度增加，激光脉冲的频率增加导致平均激光功率增加。

47. 发明申请

US20070045255A1 Laser induced plasma machining with an optimized process gas 审中-公开
标题翻译：用优化的工艺气体激光诱导等离子体加工
公开(公告)号：US20070045255A1
公开(公告)日：2007-03-01
申请号：US11210349
申请日：2005-08-23
申请人： Klaus Kleine , Scott Palley
发明人： Klaus Kleine , Scott Palley
IPC分类号： B23K10/00 , B23K26/38
CPC分类号： B23K26/38 , A61F2/91 , B23K26/0624 , B23K2103/42 , B23K2103/50
摘要： Embodiments of methods of laser machining that include inducing formation of a plasma plume from a process gas through interaction of the gas with a laser beam are disclosed. The methods may include removing material from the substrate by interaction of the induced plasma plume with the substrate. The process gas may be optimized to achieve a desired machining effect.
摘要翻译：公开了激光加工方法的实施例，其包括通过气体与激光束的相互作用从工艺气体引起等离子体羽流的形成。所述方法可以包括通过诱导的等离子体羽流与衬底的相互作用从衬底去除材料。可以优化处理气体以实现期望的加工效果。

48. 发明申请

US20070038290A1 Fiber reinforced composite stents 审中-公开
标题翻译：纤维增强复合支架
公开(公告)号：US20070038290A1
公开(公告)日：2007-02-15
申请号：US11205254
申请日：2005-08-15
申请人： Bin Huang , David Gale , Srinivasan Sridharan , Joseph Callol , Klaus Kleine , Syed Hossainy , Timothy Limon , Anthony Abbate
发明人： Bin Huang , David Gale , Srinivasan Sridharan , Joseph Callol , Klaus Kleine , Syed Hossainy , Timothy Limon , Anthony Abbate
IPC分类号： A61F2/88 , A61F2/90 , B29C47/20
CPC分类号： A61F2/915 , A61F2/04 , A61F2/06 , A61F2/90 , A61F2/91 , A61F2002/072 , A61F2002/91508 , A61F2002/91575 , A61F2210/0004 , A61F2210/0009 , A61F2210/0076 , A61F2220/005 , A61F2230/0013 , A61F2250/0098 , A61L31/129 , B23K26/402 , B23K26/50 , B23K2103/42 , B23K2103/50 , B29C43/02 , B29C45/0001 , B29C45/0005 , B29C45/0055 , B29C48/0022 , B29C48/022 , B29C48/09 , B29C48/10 , B29C48/18 , B29C48/2886 , B29C53/566 , B29C53/583 , B29C59/02 , B29C59/021 , B29C2043/028 , B29K2101/00 , B29K2105/12 , B29K2267/043 , B29K2995/0056 , B29K2995/006 , B29L2023/003 , B29L2031/7546 , D03D3/02
摘要： Polymeric composite stents reinforced with fibers for implantation into a bodily lumen are disclosed.
摘要翻译：公开了用纤维增强的用于植入体腔的聚合复合支架。

49. 发明申请

US20060224226A1 In-vivo radial orientation of a polymeric implantable medical device 审中-公开
标题翻译：聚合物可植入医疗装置的体内径向取向
公开(公告)号：US20060224226A1
公开(公告)日：2006-10-05
申请号：US11096342
申请日：2005-03-31
申请人： Bin Huang , Klaus Kleine , David Gale
发明人： Bin Huang , Klaus Kleine , David Gale
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2002/9155 , A61F2002/91575 , A61F2230/0013
摘要： A method and system for treating a bodily lumen with an implantable medical device, such as a stent, are disclosed. The device may be disposed within a bodily lumen and radially expanded by circumferentially deforming a tube-like section of the device. The deforming section may expand the lumen and the deformed section may support the lumen.
摘要翻译：公开了一种用可植入医疗装置（例如支架）治疗身体管腔的方法和系统。该装置可以设置在体腔中并且通过使装置的管状部分周向变形而径向扩张。变形部分可以扩张内腔，并且变形的部分可以支撑管腔。

50. 发明授权

US06521865B1 Pulsed fiber laser cutting system for medical implants 有权
标题翻译：用于医疗植入物的脉冲光纤激光切割系统
公开(公告)号：US06521865B1
公开(公告)日：2003-02-18
申请号：US09882590
申请日：2001-06-14
申请人： Stephen Jones , Klaus Kleine , Brad Whitney
发明人： Stephen Jones , Klaus Kleine , Brad Whitney
IPC分类号： B23K2638
CPC分类号： B23K26/142 , A61F2/91 , B23K26/1438 , B23K26/146 , B23K26/1476 , B23K26/16 , B23K26/38 , B23K2101/06 , B23K2103/05 , B23K2103/42 , B23K2103/50
摘要： An improved expandable stent for implantation in a body lumen, such as an artery, and an improved method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cut cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements, the elements having a rectangular cross-section from cut-to-cut. The individual radially expandable cylindrical elements are disposed in an undulating pattern. The stent is manufactured by direct laser cutting from a single metal tube using a finely focused laser beam originating from a diode pumped fiber laser with an external pulse generator and passing through a coaxial gas jet structure to impinge on the working surface of the tube as the linear and rotary velocity of the tube is precisely controlled.
摘要翻译：用于植入体腔（例如动脉）中的改进的可扩张支架，以及用于使其从单一管道制成的改进方法。支架由多个径向可膨胀的切割的圆柱形元件组成，其大体上在公共轴线上对齐并由一个或多个互连元件互连，所述元件具有从切割到切割的矩形横截面。各个可径向扩张的圆柱形元件以波形图案设置。支架通过使用来自具有外部脉冲发生器的二极管泵浦光纤激光器的精细聚焦激光束从单个金属管直接激光切割制造，并且穿过同轴气体射流结构以撞击管的工作表面管的线性和旋转速度被精确控制。

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