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1. 发明授权

US06927359B2 Pulsed fiber laser cutting system for medical implants 失效
标题翻译：用于医疗植入物的脉冲光纤激光切割系统
公开(公告)号：US06927359B2
公开(公告)日：2005-08-09
申请号：US10369358
申请日：2003-02-18
申请人： Klaus Kleine , Stephen Jones , Brad Whitney , Yu-Chun Ku , Jason Fox
发明人： Klaus Kleine , Stephen Jones , Brad Whitney , Yu-Chun Ku , Jason Fox
IPC分类号： A61F2/90 , B23K26/16 , B23K26/38
CPC分类号： B23K26/18 , A61F2/91 , B23K26/06 , B23K26/0622 , B23K26/064 , B23K26/08 , B23K26/123 , B23K26/14 , B23K26/142 , B23K26/1436 , B23K26/1438 , B23K26/146 , B23K26/1476 , B23K26/16 , B23K26/38 , B23K2101/06 , B23K2103/05 , B23K2103/42 , B23K2103/50
摘要： An improved expandable stent for implantation in a body lumen, such as an artery, and an improved method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cut cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements, the elements having a rectangular cross-section from cut-to-cut. The individual radially expandable cylindrical elements are disposed in an undulating pattern. The stent is manufactured by direct laser cutting from a single metal tube using a finely focused laser beam originating from a diode pumped fiber laser with an external pulse generator and passing through a coaxial gas jet structure to impinge on the working surface of the tube as the linear and rotary velocity of the tube is precisely controlled. To optimize the cut, the laser parameters may be adjusted and/or the laser pulse may be shaped.
摘要翻译：用于植入体腔（例如动脉）中的改进的可扩张支架，以及用于使其从单一管道制成的改进方法。支架由多个径向可膨胀的切割的圆柱形元件组成，其大体上在公共轴线上对齐并由一个或多个互连元件互连，所述元件具有从切割到切割的矩形横截面。各个可径向扩张的圆柱形元件以波形图案设置。支架通过使用来自具有外部脉冲发生器的二极管泵浦光纤激光器的精细聚焦激光束从单个金属管直接激光切割制造，并且穿过同轴气体射流结构以撞击管的工作表面管的线性和旋转速度被精确控制。为了优化切割，可以调整激光参数和/或激光脉冲的形状。

2. 发明申请

US20050035101A1 Pulsed fiber laser cutting system for medical implants 审中-公开
公开(公告)号：US20050035101A1
公开(公告)日：2005-02-17
申请号：US10946223
申请日：2004-09-21
申请人： Stephen Jones , Klaus Kleine , Brad Whitney , Yu-Chun Ku , Jason Fox
发明人： Stephen Jones , Klaus Kleine , Brad Whitney , Yu-Chun Ku , Jason Fox
IPC分类号： A61F2/90 , B23K26/16 , B23K26/38
CPC分类号： B23K26/18 , A61F2/91 , B23K26/06 , B23K26/0622 , B23K26/064 , B23K26/08 , B23K26/123 , B23K26/14 , B23K26/142 , B23K26/1436 , B23K26/1438 , B23K26/146 , B23K26/1476 , B23K26/16 , B23K26/38 , B23K2101/06 , B23K2103/05 , B23K2103/42 , B23K2103/50
摘要： An improved expandable stent for implantation in a body lumen, such as an artery, and an improved method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cut cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements, the elements having a rectangular cross-section from cut-to-cut. The individual radially expandable cylindrical elements are disposed in an undulating pattern. The stent is manufactured by direct laser cutting from a single metal tube using a finely focused laser beam originating from a diode pumped fiber laser with an external pulse generator and passing through a coaxial gas jet structure to impinge on the working surface of the tube as the linear and rotary velocity of the tube is precisely controlled. To optimize the cut, the laser parameters may be adjusted and/or the laser pulse may be shaped.

3. 发明授权

US06521865B1 Pulsed fiber laser cutting system for medical implants 有权
标题翻译：用于医疗植入物的脉冲光纤激光切割系统
公开(公告)号：US06521865B1
公开(公告)日：2003-02-18
申请号：US09882590
申请日：2001-06-14
申请人： Stephen Jones , Klaus Kleine , Brad Whitney
发明人： Stephen Jones , Klaus Kleine , Brad Whitney
IPC分类号： B23K2638
CPC分类号： B23K26/142 , A61F2/91 , B23K26/1438 , B23K26/146 , B23K26/1476 , B23K26/16 , B23K26/38 , B23K2101/06 , B23K2103/05 , B23K2103/42 , B23K2103/50
摘要： An improved expandable stent for implantation in a body lumen, such as an artery, and an improved method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cut cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements, the elements having a rectangular cross-section from cut-to-cut. The individual radially expandable cylindrical elements are disposed in an undulating pattern. The stent is manufactured by direct laser cutting from a single metal tube using a finely focused laser beam originating from a diode pumped fiber laser with an external pulse generator and passing through a coaxial gas jet structure to impinge on the working surface of the tube as the linear and rotary velocity of the tube is precisely controlled.
摘要翻译：用于植入体腔（例如动脉）中的改进的可扩张支架，以及用于使其从单一管道制成的改进方法。支架由多个径向可膨胀的切割的圆柱形元件组成，其大体上在公共轴线上对齐并由一个或多个互连元件互连，所述元件具有从切割到切割的矩形横截面。各个可径向扩张的圆柱形元件以波形图案设置。支架通过使用来自具有外部脉冲发生器的二极管泵浦光纤激光器的精细聚焦激光束从单个金属管直接激光切割制造，并且穿过同轴气体射流结构以撞击管的工作表面管的线性和旋转速度被精确控制。

4. 发明授权

US09561351B2 Drug delivery spiral coil construct 有权
标题翻译：药物输送螺旋线圈构造
公开(公告)号：US09561351B2
公开(公告)日：2017-02-07
申请号：US11445079
申请日：2006-05-31
申请人： Klaus Kleine , David C. Gale , Fozan El-Nounou , Syed F. A. Hossainy , Florian Ludwig
发明人： Klaus Kleine , David C. Gale , Fozan El-Nounou , Syed F. A. Hossainy , Florian Ludwig
IPC分类号： A61M31/00 , A61F2/88
CPC分类号： A61M31/002 , A61F2/88 , A61F2/885 , A61F2250/0039 , A61F2250/0067
摘要： An implantable medical device is disclosed having a helical construct including a set of spiral coils for local in vivo application of a therapeutic substance in a biological lumen. The helical construct is configured to apply less than 0.75 Bar of pressure to the biological lumen wall. The helical construct can have at least two sets of spiral coils having opposing helical directions. The device can be used for the treatment of vascular disorders such as restenosis and vulnerable plaque.
摘要翻译：公开了一种植入式医疗装置，其具有螺旋构造，其包括用于在生物腔内局部体内施用治疗物质的一组螺旋线圈。螺旋结构被配置为向生物腔壁施加小于0.75巴的压力。螺旋结构可以具有至少两组具有相反螺旋方向的螺旋线圈。该装置可用于治疗血管疾病如再狭窄和易损斑块。

5. 发明授权

US08894900B2 Stent with flexible sections in high strain regions 有权
标题翻译：在高应变区域具有柔性部分的支架
公开(公告)号：US08894900B2
公开(公告)日：2014-11-25
申请号：US12247164
申请日：2008-10-07
申请人： David C. Gale , Klaus Kleine , Anthony J. Abbate , Svava Maria Atladottir , Stephen Pacetti
发明人： David C. Gale , Klaus Kleine , Anthony J. Abbate , Svava Maria Atladottir , Stephen Pacetti
IPC分类号： B29C70/74
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2250/0029
摘要： A stent for treating a bodily lumen with a flexible section in a high strain region is disclosed. A flexible section may be selectively positioned to reduce an amount of strain in the high strain region when subjected to the applied stress during use to inhibit or prevent fracturing in the high strain region.
摘要翻译：公开了一种用于在高应变区域中用柔性部分处理身体管腔的支架。柔性部分可以选择性地定位成在使用过程中受到施加的应力时，在高应变区域中减小应变量，以抑制或防止高应变区域中的断裂。

6. 发明授权

US08373090B2 Method and apparatus to prevent stent damage caused by laser cutting 失效
标题翻译：防止激光切割引起的支架损伤的方法和装置
公开(公告)号：US08373090B2
公开(公告)日：2013-02-12
申请号：US12554764
申请日：2009-09-04
申请人： David C. Gale , Yunbing Wang , Svava Maria Atladottir , Klaus Kleine
发明人： David C. Gale , Yunbing Wang , Svava Maria Atladottir , Klaus Kleine
IPC分类号： B23K26/14
CPC分类号： B23K26/38 , A61F2/91 , B23K26/0823 , B23K26/14 , B23K26/147 , B23K26/702 , B23K2101/06 , B23K2103/42 , B23K2103/50 , B26D2003/285 , B26D2003/288 , Y10T83/0596 , Y10T83/748
摘要： Apparatus, method and system for cutting a polymeric stent including the use of a polymeric mandrel as a laser shielding device. The polymeric mandrel is allowed to roll freely within a polymeric tube that is cut into a polymeric stent.
摘要翻译：用于切割聚合物支架的装置，方法和系统，包括使用聚合物心轴作为激光屏蔽装置。允许聚合物心轴在切割成聚合物支架的聚合物管内自由滚动。

7. 发明授权

US08066762B2 Assembly for manufacturing an implantable polymeric medical device 有权
标题翻译：用于制造可植入聚合物医疗装置的组件
公开(公告)号：US08066762B2
公开(公告)日：2011-11-29
申请号：US12579359
申请日：2009-10-14
申请人： Svava Maria Atladottir , David C. Gale , Klaus Kleine
发明人： Svava Maria Atladottir , David C. Gale , Klaus Kleine
IPC分类号： A61F2/06 , B29C35/08
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2240/001 , A61L31/04 , A61L31/14
摘要： A polymeric tube is positioned on a polymeric mandrel and then laser cut to form an implantable medical device, such as a stent. The method reduces contamination of the inner surface of the stent, which would be caused if conventional glass or metal mandrels are used, while simultaneously reducing damage to the inner surface of the stent due to the shielding effect of the polymeric mandrel.
摘要翻译：聚合物管定位在聚合物心轴上，然后激光切割以形成可植入的医疗装置，例如支架。该方法减少了支架内表面的污染，如果使用传统的玻璃或金属心轴，则会由于聚合物心轴的屏蔽作用而同时减少对支架内表面的损伤。

8. 发明授权

US07740791B2 Method of fabricating a stent with features by blow molding 有权
标题翻译：通过吹塑制造具有特征的支架的方法
公开(公告)号：US07740791B2
公开(公告)日：2010-06-22
申请号：US11479111
申请日：2006-06-30
申请人： Klaus Kleine , David C. Gale
发明人： Klaus Kleine , David C. Gale
IPC分类号： H05B6/00
CPC分类号： B29C49/0073 , A61F2/844 , A61F2/91 , A61F2/915 , A61F2210/0004 , A61F2230/0067 , A61F2230/0069 , A61F2240/001 , A61F2250/0068 , B29C49/4278 , B29C49/48 , B29C49/54 , B29C2049/0089 , B29C2793/009 , B29K2067/046 , B29K2995/0056 , B29L2031/7534
摘要： The invention provides a method of manufacturing a stent, the method comprising: disposing a polymeric tube into a cylindrical mold, the cylindrical mold having a variable diameter along a portion of the inside surface of the mold; radially expanding the tube by blowing a gas or liquid into the cylindrical mold, the outside surface of the tube conforming to the variable diameter portion of the outside surface of the mold, causing the radially expanded tube to have a variable diameter along the conformed length of the tube; and fabricating a stent from the expanded tube.
摘要翻译：本发明提供了一种制造支架的方法，所述方法包括：将聚合物管设置在圆柱形模具中，所述圆柱形模具沿着所述模具的内表面的一部分具有可变直径; 通过将气体或液体吹送到圆柱形模具中，使管的外表面与模具的外表面的可变直径部分相符，使得径向膨胀的管具有沿着合适的长度的可变直径管子并从扩张管制造支架。

9. 发明申请

US20100137471A1 Compositions Containing Fast-Leaching Plasticizers For Improved Performance Of Medical Devices 审中-公开
标题翻译：包含快速浸出增塑剂的组合物可改善医疗器械的性能
公开(公告)号：US20100137471A1
公开(公告)日：2010-06-03
申请号：US12651300
申请日：2009-12-31
申请人： David C. Gale , Klaus Kleine , Anthony J. Abbate , Svava Maria Atladottir , Stephen D. Pacetti
发明人： David C. Gale , Klaus Kleine , Anthony J. Abbate , Svava Maria Atladottir , Stephen D. Pacetti
IPC分类号： A61L27/14
CPC分类号： A61L31/141
摘要： Medical implants containing a temporary plasticizer, methods of producing such implants, and methods of using the implants in treating a disease, or ameliorating one or more symptoms thereof, in a subject are provided.
摘要翻译：提供了包含临时增塑剂的医疗植入物，生产这种植入物的方法，以及使用植入物治疗疾病或改善其一种或多种症状的方法。

10. 发明申请

US20100055295A1 Apparatus and Method for Selectively Coating a Medical Article 有权
标题翻译：选择性涂覆医疗用品的设备和方法
公开(公告)号：US20100055295A1
公开(公告)日：2010-03-04
申请号：US12616651
申请日：2009-11-11
申请人： Syed F.A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
发明人： Syed F.A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
IPC分类号： B05D7/00 , B05C11/00
CPC分类号： B05D1/32 , B05B12/20 , B05B13/0442 , B05D1/02 , Y10T428/13
摘要： A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article.
摘要翻译：用于在涂覆过程中遮蔽支架的掩模可以包括掩模体，其具有由掩模体遮蔽的支架图案的负图案或近似负图案。用于选择性地涂覆医疗用品的预定部分的设备可以包括涂料组合物的分配器，掩模，用于在面罩和医疗制品之间产生相对运动的装置。

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