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    • 41. 发明授权
    • Percutaneous absorption preparation
    • 经皮吸收制剂
    • US5618555A
    • 1997-04-08
    • US430384
    • 1995-04-28
    • Shoichi TokudaKazuhisa NinomiyaYasuhiro FukushimaShigeyuki WatanabeMitsuru OchiaiMutsuo OkumuraYuko Hosokawa
    • Shoichi TokudaKazuhisa NinomiyaYasuhiro FukushimaShigeyuki WatanabeMitsuru OchiaiMutsuo OkumuraYuko Hosokawa
    • A61K9/00A61K9/70A61K31/485A61K47/14A61P25/04A61F13/00
    • A61K9/7061A61K31/485A61K47/14A61K9/0014Y10S514/946
    • A percutaneous absorption preparation which is excellent in the skin penetration of a non-narcotic analgesic buprenorphine and can sustain a high blood level in a stable state over a long period of time is provided. The percutaneous absorption preparation for administrating buprenorphine hydrochloride and/or buprenorphine, which comprises a support having on one surface thereof a plaster layer containing a pressure-sensitive adhesive, buprenorphine hydrochloride and/or buprenorphine, and a penetration enhancer, wherein the penetration enhancer comprises a combination of a monoglyceride of a fatty acid having 6 to 8 carbon atoms and isopropyl myristate, and the plaster layer contains at least 10% by weight of a monoglyceride off fatty acid having 6 to 8 carbon atoms and at least 5% by weight off isopropyl myristate, with the proviso that the content of the whole penetration enhancer ranges from 25 to 50% by weight. The combined use of the fatty acid monoglyceride and isopropyl myristate as a penetration enhancer synergistically elevates skin penetration of buprenorphine hydrochloride and/or buprenorphine.
    • 提供了一种在非麻醉性止痛丁丙诺啡的皮肤渗透性优异并能够长期稳定地维持高血液水平的经皮吸收制剂。 用于施用盐酸丁丙诺非和/或丁丙诺啡的经皮吸收制剂,其包含在其一个表面上具有含有压敏粘合剂,盐酸丁丙诺非和/或丁丙诺啡的膏药的支持物和渗透促进剂,其中所述渗透促进剂包含 具有6至8个碳原子的脂肪酸的单酸甘油酯和肉豆蔻酸异丙酯的组合,所述膏药层含有至少10重量%的具有6至8个碳原子的单酸甘油酯脱脂肪酸和至少5重量%的异丙基 肉豆蔻酸酯,条件是全部渗透促进剂的含量为25至50重量%。 将脂肪酸单甘油酯和肉豆蔻酸异丙酯作为渗透促进剂的组合使用协同地提高了丁丙诺啡盐酸盐和/或丁丙诺啡的皮肤渗透。
    • 43. 发明申请
    • STRUCTURE FOR SUPPRESSING FLOW VIBRATION OF INSTRUMENTATION GUIDE TUBE
    • 用于抑制仪表导管流动振动的结构
    • US20100091929A1
    • 2010-04-15
    • US12527484
    • 2009-02-22
    • Nobuki UdaShigeyuki WatanabeKazuo HirotaHideyuki SakataHideyuki MoritaMakoto NakajimaChikara KurimuraToshio Ichikawa
    • Nobuki UdaShigeyuki WatanabeKazuo HirotaHideyuki SakataHideyuki MoritaMakoto NakajimaChikara KurimuraToshio Ichikawa
    • G21C17/10
    • G21C17/10G21C3/322G21C17/08
    • An upper hole 37A and a lower hole 37B are provided at two positions, namely, upper and lower portions, of a side surface of a guide tube 27, and a thimble tube 22 is pressed against an inner circumferential surface of the guide tube 27, by a differential pressure between coolant inside and outside the upper hole 37A and the lower hole 37B. It is preferable that an upper pressure adjustment hole and a lower pressure adjustment hole are provided at two positions, namely, upper and lower portions, of a side surface of an upper core support column 21, and a coolant flowing into the guide tube from an upper end of the guide tube flows out to the outside from inside the guide tube through a gap between the thimble tube and the upper hole, and also flows out to the outside from inside the upper core support column through the upper pressure adjustment hole, and a coolant flowing into the guide tube from a lower end of the guide tube flows out to the outside from inside the guide tube through a gap between the thimble tube and the lower hole, and also flows out to the outside from inside the upper core support column through the lower pressure adjustment hole.
    • 在引导管27的侧面的两个位置,即上下部分设置有上孔37A和下孔37B,并且将套管22压靠在引导管27的内周面上, 通过上部孔37A和下部孔37B的内部和外部的冷却剂之间的压力差。 优选的是,上压力调节孔和下压力调节孔设置在上芯支撑柱21的侧表面的两个位置,即上部和下部,以及从上部芯支撑柱21的侧表面流入导管的冷却剂 引导管的上端通过引导管和上孔之间的间隙从导管的内部流出到外部,并且还通过上压力调节孔从上芯支撑柱的内部流出到外部,并且 从引导管的下端流入引导管的冷却剂通过引导管和下孔之间的间隙从引导管的内部流出到外部,并且还从上部芯支撑体内部流出到外部 柱通过下压力调节孔。
    • 44. 发明申请
    • Infrared light irradiating lamp for vehicle
    • 车载红外线照明灯
    • US20080037269A1
    • 2008-02-14
    • US11890568
    • 2007-08-07
    • Yuji SugiyamaShigeyuki WatanabeShoichiro YokoiAtsushi SugimotoHideki Fukuchi
    • Yuji SugiyamaShigeyuki WatanabeShoichiro YokoiAtsushi SugimotoHideki Fukuchi
    • F21S8/10
    • F21S41/13F21V9/40
    • An infrared light irradiating lamp for a vehicle includes a projection lens disposed on an optical axis extending in a longitudinal direction of the vehicle; a light source bulb disposed behind a rear focal point of the projection lens such that a longitudinal direction of a filament is substantially orthogonal to the optical axis; a reflector for reflecting light emitted from the light source bulb in a forward direction close to the optical axis by setting the light source bulb as a first focal point of the reflector; and a filter driving unit disposed between the projection lens and the light source bulb. The filter driving unit comprising a movable shaft to be driven in a vertical direction. The infrared light irradiating lamp also includes a bracket comprising a tip portion and a base end; and a rotating shaft linking the movable shaft to the base end of the bracket, wherein a distance from the rotating shaft to the base end is less than a distance from the rotating shaft to the tip portion. The tip portions holds an infrared light transmitting filter. The infrared light transmitting filter is movable between a transmitting position in which light reflected by the reflector is intercepted and a retreating position in which the reflected light is not intercepted between the light source bulb and a second focal point of the reflector.
    • 一种用于车辆的红外线照射灯包括设置在沿车辆的纵向方向延伸的光轴上的投影透镜; 设置在所述投影透镜的后焦点之后的光源灯泡,使得灯丝的纵向方向基本上与所述光轴正交; 通过将所述光源灯泡设置为所述反射器的第一焦点来反射从所述光源灯泡发射的光在靠近所述光轴的前方向上反射的反射器; 以及布置在投影透镜和光源灯泡之间的滤光器驱动单元。 过滤器驱动单元包括沿垂直方向驱动的可动轴。 红外光照射灯还包括:托架,其包括尖端部分和基端部; 以及将可动轴连接到支架的基端的旋转轴,其中从旋转轴到基端的距离小于从旋转轴到尖端部分的距离。 尖端部分保持红外光透射滤光片。 红外光透射滤光器可在被反射器反射的光被遮挡的透射位置和反射光在光源灯泡与反射器的第二焦点之间不被截留的后退位置之间移动。