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41. 发明授权

US09132275B2 Automatic determination of chronotropic incompetence using atrial pacing at rest 有权
标题翻译：使用心房起搏静息自动确定时间性无能力
公开(公告)号：US09132275B2
公开(公告)日：2015-09-15
申请号：US13290362
申请日：2011-11-07
申请人： Yinghong Yu , Donald L. Hopper , Jiang Ding , James O. Gilkerson
发明人： Yinghong Yu , Donald L. Hopper , Jiang Ding , James O. Gilkerson
IPC分类号： A61N1/36 , A61N1/368
CPC分类号： A61N1/3682
摘要： An apparatus comprises an implantable cardiac signal sensing circuit that provides an electrical cardiac signal representative of cardiac activity of a subject, an implantable therapy circuit that delivers electrical pacing stimulation energy to a heart of a subject, and a controller circuit. The controller circuit includes a chronotropic incompetence detection circuit that initiates pacing of an atrium of the subject at a rate higher than a device-indicated rate or a sensed intrinsic rate, monitor the AV interval, initiates an increase in the pacing rate while continuing the monitoring of the AV interval, calculates a change in AV intervals between a highest paced rate used in the monitoring and a lowest paced rate used in the monitoring, and indicates that the AV intervals are evidence of chronotropic incompetence when the calculated change in the AV intervals exceeds a specified threshold AV interval change value.
摘要翻译：一种装置包括可植入心脏信号感测电路，其提供代表受试者的心脏活动的电心脏信号，将对该对象的心脏发出电起搏刺激能量的可植入治疗电路以及控制器电路。控制器电路包括一个变时无能检测电路，其以高于设备指示速率或感测到的固有频率的速率启动对象的心房起搏，监视AV间隔，启动起搏速率的增加，同时继续监视计算AV监视中使用的最高起搏速率和监视中使用的最低起搏速度之间的AV间隔的变化，并且指示AV间隔是当计算出的AV间隔的变化超过时间间隔无能力的证据指定的阈值AV间隔变化值。

42. 发明授权

US08805503B2 Method and apparatus for optimizing electrical stimulation parameters using heart rate variability 有权
标题翻译：使用心率变异优化电刺激参数的方法和装置
公开(公告)号：US08805503B2
公开(公告)日：2014-08-12
申请号：US12699457
申请日：2010-02-03
申请人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
发明人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/362
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/368
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于评估用于选择近似最佳参数值的多个参数值。

43. 发明申请

US20130190636A1 OPTIMIZATION OF LV AND RV LEAD PLACEMENT BASED ON ELECTRICAL DELAYS 有权
标题翻译：基于电延迟优化LV和RV导线放置
公开(公告)号：US20130190636A1
公开(公告)日：2013-07-25
申请号：US13552996
申请日：2012-07-19
申请人： Shibaji Shome , Pramodsingh Hirasingh Thakur , Yinghong Yu , Keith L. Herrmann , Aaron R. McCabe , Jiang Ding
发明人： Shibaji Shome , Pramodsingh Hirasingh Thakur , Yinghong Yu , Keith L. Herrmann , Aaron R. McCabe , Jiang Ding
IPC分类号： A61B5/0456 , A61B5/04
CPC分类号： A61B5/0456 , A61B5/04012 , A61N1/3684 , A61N1/3686 , A61N1/3702 , A61N1/37247 , A61N1/3918
摘要： A system comprises a cardiac signal sensing and a processing circuit. The cardiac signal sensing circuit senses a first cardiac signal segment that includes a QRS complex and a second cardiac signal segment that includes a fiducial indicative of local ventricular activation. The processor circuit includes a site activation timer circuit configured to determine a time duration between a fiducial of the QRS complex of the first cardiac signal segment and the fiducial of the second cardiac signal segment. The processor circuit is configured to generate, using the determined time duration, an indication of optimality of placement of one or more electrodes for delivering therapy and provide the indication to at least one of a user or process.
摘要翻译：一种系统包括心脏信号感测和处理电路。心脏信号感测电路感测包括QRS复合物的第一心脏信号片段和包括指示局部心室激活的基准的第二心脏信号片段。处理器电路包括站点激活定时器电路，其被配置为确定第一心脏信号段的QRS复合体的基准点与第二心脏信号段的基准点之间的持续时间。处理器电路被配置为使用所确定的持续时间来生成用于递送治疗的一个或多个电极的放置的最佳化的指示，并向至少一个用户或过程提供指示。

44. 发明授权

US08483825B2 AV delay features 有权
标题翻译： AV延迟功能
公开(公告)号：US08483825B2
公开(公告)日：2013-07-09
申请号：US12336064
申请日：2008-12-16
申请人： Yinghong Yu , Jiang Ding
发明人： Yinghong Yu , Jiang Ding
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61B5/0452 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： At least one of a left intraventricular conduction defect, a right intraventricular conduction defect, or no intraventricular conduction defect can be detected using received intrinsic cardiac information from a subject, and a first atrioventricular (AV) delay can be calculated using a first relationship if the left intraventricular conduction defect or no intraventricular conduction defect is detected, or a second AV delay can be calculated using a second relationship if the right intraventricular conduction defect is detected.
摘要翻译：可以使用来自受试者的接收的固有心脏信息来检测左室内传导缺陷，右心室内传导缺陷或无心室内传导缺陷中的至少一个，并且可以使用第一关系来计算第一房室（AV）延迟，如果如果检测到右心室传导缺陷，则检测到左心室内传导缺陷或无心室传导缺陷，或者可以使用第二关系计算第二AV延迟。

45. 发明授权

US08175703B2 Cardiac resynchronization therapy parameter optimization 有权
标题翻译：心脏再同步治疗参数优化
公开(公告)号：US08175703B2
公开(公告)日：2012-05-08
申请号：US11338935
申请日：2006-01-25
申请人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
发明人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36585 , A61N1/3684
摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.
摘要翻译：系统和方法涉及使用多个CRT优化过程来确定CRT参数。每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。可以基于返回的推荐参数的组合来确定CRT参数。可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

46. 发明授权

US08121685B2 Method and system for delivering cardiac resynchronization therapy with variable atrio-ventricular delay 有权
标题翻译：用心脏再同步治疗可变心房延迟的方法和系统
公开(公告)号：US08121685B2
公开(公告)日：2012-02-21
申请号：US12622602
申请日：2009-11-20
申请人： Jiang Ding , Yinghong Yu , Milton M. Morris
发明人： Jiang Ding , Yinghong Yu , Milton M. Morris
IPC分类号： A61N1/00
CPC分类号： A61N1/36585 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.
摘要翻译：起搏系统使用内在导电间隔计算最佳心脏再同步起搏参数。在各种实施例中，心室间隔延迟间隔的值各自被计算为内在房室间隔和反映室间传导延迟的参数的函数。反映室间传导延迟的参数的示例包括QRS宽度和右心室感觉和左心室感觉之间的间隔。

47. 发明授权

US08103345B2 Cardiac pacing using adjustable atrio-ventricular delays 有权
标题翻译：心脏起搏使用可调节的心房延迟
公开(公告)号：US08103345B2
公开(公告)日：2012-01-24
申请号：US12955218
申请日：2010-11-29
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio C. Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

48. 发明授权

US08041426B2 Selective resynchronization therapy optimization based on user preference 有权
标题翻译：基于用户偏好的选择性再同步治疗优化
公开(公告)号：US08041426B2
公开(公告)日：2011-10-18
申请号：US12565344
申请日：2009-09-23
申请人： Richard Fogoros , Jiang Ding , Yinghong Yu
发明人： Richard Fogoros , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method and system for calculating an atrio-ventricular delay interval based upon an inter-atrial delay exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may optimize the stroke volume exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may be blended with another atrio-ventricular delay interval that may optimize another performance characteristic, such as left ventricular contractility. Such blending may include finding an arithmetic mean, geometric mean, or weighted mean of two or more proposed atrio-ventricular delay intervals.
摘要翻译：一种用于根据患者心脏表现的心房间延迟来计算心房延迟间隔的方法和系统。上述的心室延迟间隔可以优化患者心脏展示的搏动量。上述房室延迟间隔可以与可以优化另一性能特征（例如左心室收缩力）的另一心房延迟间隔混合。这种混合可以包括找到两个或更多个提出的心房延迟间隔的算术平均值，几何平均值或加权平均值。

49. 发明授权

US08032214B2 Method and apparatus for optimizing ventricular synchrony during DDD resynchronization therapy using adjustable atrio-ventricular delays 有权
标题翻译：在使用可调节心室延迟的DDD再同步治疗期间优化心室同步的方法和装置
公开(公告)号：US08032214B2
公开(公告)日：2011-10-04
申请号：US12424136
申请日：2009-04-15
申请人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
发明人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/36564 , A61N1/368 , A61N1/3682
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟心室起搏脉冲的最佳时机。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

50. 发明授权

US07844330B2 Dynamic device therapy control for treating post myocardial infarction patients 有权
标题翻译：用于治疗心肌梗死后患者的动态装置治疗控制
公开(公告)号：US07844330B2
公开(公告)日：2010-11-30
申请号：US11689646
申请日：2007-03-22
申请人： Yinghong Yu , Jiang Ding , Joseph M. Pastore
发明人： Yinghong Yu , Jiang Ding , Joseph M. Pastore
IPC分类号： A61N1/362
CPC分类号： A61N1/365
摘要： A cardiac rhythm management system includes an implantable device executing a dynamic pacing algorithm after an myocardial infarction (MI) event. The dynamic pacing algorithm dynamically adjusts one or more pacing parameters based on a person's gross physical activity level. Examples of the one or more pacing parameters include atrioventricular pacing delays and pacing channels/sites. The dynamic pacing algorithm provides for improved hemodynamic performance when a person's metabolic need is high, and post MI remodeling control when the person's metabolic need is low.
摘要翻译：心律管理系统包括在心肌梗死（MI）事件之后执行动态起搏算法的可植入装置。动态起搏算法根据人的总身体活动水平动态调整一个或多个起搏参数。一个或多个起搏参数的示例包括房室起搏延迟和起搏通道/部位。当人的代谢需求高时，动态起搏算法提供改善的血液动力学性能，并且当人的代谢需求低时，进行MI重建控制。

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