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41. 发明授权

US09023767B2 γ-Secretase substrates and methods of use 有权
标题翻译： γ-分泌酶底物和使用方法
公开(公告)号：US09023767B2
公开(公告)日：2015-05-05
申请号：US12776141
申请日：2010-05-07
申请人： Christopher Chad Shelton , Yuan Tian , Yueming Li
发明人： Christopher Chad Shelton , Yuan Tian , Yueming Li
IPC分类号： C40B30/04 , C07K14/47 , G01N33/542 , G01N33/573
CPC分类号： G01N33/573 , C07K14/4711 , G01N33/542 , G01N2333/4709 , G01N2333/948 , G01N2500/02 , G01N2800/2814 , G01N2800/2821
摘要： Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase.
摘要翻译：基于各种APP同种型的修饰或片段的多肽底物，基于这些底物的使用的测定方法以及用于鉴定γ-分泌酶活性抑制剂的筛选方法。测定方法和筛选方法适用于高通量多孔板测定装置。在许多实施方案中，底物多肽被标记以便于检测，和/或可以结合其本身被标记的特异性配体。通常，标记物具有高度的特异性和高灵敏度的检测。这些特征使得使用标记底物的测定和筛选方法特别适用于高通量测定形式。本公开进一步基于A＆bgr的亚序列基序识别小多肽; 这在本文中显示为γ-分泌酶活性的有效抑制剂。

42. 发明申请

US20100310605A1 ANTI-HCV VACCINE AND PREPARATION METHODS AND USES THEREOF 审中-公开
标题翻译：抗HCV疫苗及其制备方法及其用途
公开(公告)号：US20100310605A1
公开(公告)日：2010-12-09
申请号：US12809132
申请日：2007-12-18
申请人： Lai Wei , Yuan Tian
发明人： Lai Wei , Yuan Tian
IPC分类号： A61K39/29 , A61P31/14
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234
摘要： An anti-HCV vaccine, which is prepared through recombination of an NS gene in series, including NS3/NS4 and NS4/NS5, with an adenovirus vector. The preparation methods and uses of the anti-HCV vaccine.
摘要翻译：通过将NS基因（包括NS3 / NS4和NS4 / NS5）与腺病毒载体重组而制备的抗HCV疫苗。抗HCV疫苗的制备方法和用途。

43. 发明申请

US20080004287A1 Substituted Piperidines that Increase P53 Activity and the Uses Thereof 有权
标题翻译：增加P53活性及其用途的替代哌啶子
公开(公告)号：US20080004287A1
公开(公告)日：2008-01-03
申请号：US11769030
申请日：2007-06-27
申请人： Yao Ma , Brian Lahue , Gerald Shipps , Yaolin Wang , Stephane Bogen , Matthew Voss , Latha Nair , Yuan Tian , Ronald Doll , Zhuyan Guo , Corey Strickland , Rumin Zhang , Mark McCoy , Weidong Pan , Elise Siegel , Craig Gibeau
发明人： Yao Ma , Brian Lahue , Gerald Shipps , Yaolin Wang , Stephane Bogen , Matthew Voss , Latha Nair , Yuan Tian , Ronald Doll , Zhuyan Guo , Corey Strickland , Rumin Zhang , Mark McCoy , Weidong Pan , Elise Siegel , Craig Gibeau
IPC分类号： A61K31/497 , A61P43/00 , C07D401/14
CPC分类号： C07D409/14 , C07D401/06 , C07D401/14
摘要： In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明公开了作为HDM2蛋白的抑制剂的新化合物，制备这些化合物的方法，包含一种或多种这样的化合物的药物组合物，治疗，预防，抑制与HDM2相关的一种或多种疾病的方法蛋白质或P53使用这些化合物或药物组合物。

44. 发明申请

US20070131562A1 Method and apparatus for planarizing a substrate with low fluid consumption 审中-公开
标题翻译：用于以低流体消耗平坦化基板的方法和装置
公开(公告)号：US20070131562A1
公开(公告)日：2007-06-14
申请号：US11298643
申请日：2005-12-08
申请人： Zhihong Wang , Ming-Kuei Tseng , Yuan Tian , Yongqi Hu , Stan Tsai
发明人： Zhihong Wang , Ming-Kuei Tseng , Yuan Tian , Yongqi Hu , Stan Tsai
IPC分类号： B23H3/00
CPC分类号： B23H5/08 , B24B37/04 , B24B57/02 , C25D5/06 , C25D5/08 , C25D7/12 , C25D17/001
摘要： The embodiments of the invention generally relate to a method and apparatus for processing a substrate with reduced fluid consumption. Embodiments of the invention may be beneficially utilized in chemical mechanical and electrochemical mechanical polishing processes, among other processes where conservation of a processing fluid disposed on a rotating pad is desirable. In one embodiment, a processing fluid delivery arm assembly is provided that includes a nozzle assembly supported at a distal end of an arm. The nozzle assembly includes a nozzle that is adjustable to control the delivery of fluid exiting therefrom in two planes relative to the arm. In another embodiment, processing fluid in the form of electrolyte fills holes formed at least partially through the pad as they enter the wet zone, and a current is driven through the electrolyte, filling the holes between a substrate and an electrode disposed below the surface of the pad.
摘要翻译：本发明的实施例一般涉及用于处理具有减少的流体消耗的基板的方法和装置。本发明的实施例可以有利地用于化学机械和电化学机械抛光工艺以及其它工艺中，其中设置在旋转焊盘上的处理流体的保护是期望的。在一个实施例中，提供了一种处理流体输送臂组件，其包括支撑在臂的远端处的喷嘴组件。喷嘴组件包括可调节的喷嘴，以控制从相对于臂的两个平面离开的流体的输送。在另一个实施方案中，电解液形式的处理流体在其进入湿区时填充至少部分地通过焊盘形成的孔，并且电流驱动通过电解质，填充基板和设置在下表面之下的电极之间的孔垫

45. 发明申请

US20070037563A1 Method and system for downloading data to mobile terminals and for implementing data sharing between mobile terminals 有权
标题翻译：用于将数据下载到移动终端并实现移动终端之间的数据共享的方法和系统
公开(公告)号：US20070037563A1
公开(公告)日：2007-02-15
申请号：US11502845
申请日：2006-08-11
申请人： Pengliang Yang , Yuan Tian , Yongsheng Zhu , Hui Zhao
发明人： Pengliang Yang , Yuan Tian , Yongsheng Zhu , Hui Zhao
IPC分类号： H04M3/00
CPC分类号： H04L67/06 , H04L67/04 , H04L67/104 , H04L67/1044 , H04L67/1074 , H04W8/20
摘要： The invention discloses a method and system for downloading data to mobile terminals, a mobile terminal that utilizes the method, and a method and a system for implementing data sharing between mobile terminals. The method for data downloading includes: dividing data to be downloaded into multiple data task segments by a master mobile terminal, and allocating the data task segments to one or more mobile terminals; downloading the data by the mobile terminals in accordance with the allocated data task segments; judging by the master mobile terminal whether there are any data task segments that have not been downloaded; and if yes, allocating the data task segments to at least one mobile terminal that has finished downloading data task segment; and if no, terminating the download procedure. The system for data downloading includes: a server, at least a master mobile terminal, and at least a slave mobile terminal.
摘要翻译：本发明公开了一种向移动终端下载数据的方法和系统，利用该方法的移动终端，以及用于实现移动终端之间数据共享的方法和系统。用于数据下载的方法包括：由主移动终端将要下载的数据划分为多个数据任务段，并将数据任务段分配给一个或多个移动终端; 根据分配的数据任务段，由移动终端下载数据; 由主移动终端判断是否存在尚未下载的任何数据任务段; 如果是，则将数据任务段分配给已完成下载数据任务段的至少一个移动终端; 如果否，终止下载过程。用于数据下载的系统包括：服务器，至少主移动终端和至少从属移动终端。

46. 发明申请

US20060219663A1 Metal CMP process on one or more polishing stations using slurries with oxidizers 审中-公开
标题翻译：使用具有氧化剂的浆料在一个或多个抛光站上进行金属CMP处理
公开(公告)号：US20060219663A1
公开(公告)日：2006-10-05
申请号：US11338146
申请日：2006-01-23
申请人： Shi-Ping Wang , Martin Wohlert , Alain Duboust , Renhe Jia , Feng Liu , Yuan Tian , Liang-Yuh Chen , Stan Tsai , Wei-Yung Hsu
发明人： Shi-Ping Wang , Martin Wohlert , Alain Duboust , Renhe Jia , Feng Liu , Yuan Tian , Liang-Yuh Chen , Stan Tsai , Wei-Yung Hsu
IPC分类号： C03C15/00 , H01L21/302 , B44C1/22 , H01L21/461
CPC分类号： H01L21/3212 , C09G1/02 , C23F3/04 , C23F3/06 , H01L21/32125 , H01L21/7684
摘要： Polishing compositions and methods for removing conductive materials and barrier materials from a substrate surface are provided. In one aspect, a full sequence electrochemical mechanical planarization technique is provided. In another aspect, a hybrid planarization technique using combination of at least one chemical mechanical polishing process and at least one electrochemical mechanical polishing process is provided. In addition, a multi-step polishing process for polishing a substrate surface using at least two oxidizers in one or more polishing composition is described. The polishing composition may be used in the full sequence or the hybrid planarization technique. The polishing compositions and methods described herein improve the effective removal rate of materials from the substrate surface with a reduction in planarization defects.
摘要翻译：提供了抛光组合物和从衬底表面去除导电材料和阻挡材料的方法。一方面，提供了全序列电化学机械平面化技术。在另一方面，提供了使用至少一种化学机械抛光工艺和至少一种电化学机械抛光工艺的组合的混合平面化技术。此外，描述了在一种或多种研磨组合物中使用至少两种氧化剂来研磨衬底表面的多步抛光方法。抛光组合物可以以全序或混合平面化技术使用。本文所述的抛光组合物和方法改善了材料从衬底表面的有效去除速率，同时减小了平坦化缺陷。

47. 发明申请

US20060183871A1 Biosensor membrane material 有权
标题翻译：生物传感器膜材料
公开(公告)号：US20060183871A1
公开(公告)日：2006-08-17
申请号：US11404528
申请日：2006-04-14
申请人： Robert Ward , Yuan Tian , W. Ward , Ellen Anderson , Jody House
发明人： Robert Ward , Yuan Tian , W. Ward , Ellen Anderson , Jody House
IPC分类号： C08G77/448 , C08G64/18
CPC分类号： C08G64/18 , C08G77/448 , C08G77/458
摘要： Embodiments of the present invention provide various multipolymers and permselective membranes for use with biosensors and other implantable medical devices and prostheses. Embodiments of the present invention may provide structural strength and integrity, and further may control the influx of glucose, oxygen and/or water. Embodiments of the present invention may, for example, minimize or reduce the influx of glucose by minimizing the percentage of hydrophilic segments, which in turn minimizes the percentage of water uptake and the degree of glucose transport.
摘要翻译：本发明的实施方案提供了用于生物传感器和其它可植入医疗装置和假体的各种多聚体和选择渗透膜。本发明的实施方案可以提供结构强度和完整性，并且还可以控制葡萄糖，氧气和/或水的流入。例如，本发明的实施方案可以通过使亲水段的百分比最小化来最小化或减少葡萄糖的流入，从而使吸水的百分比和葡萄糖转运的程度最小化。

48. 发明申请

US20060160803A1 Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity 失效
标题翻译：具有激酶抑制活性的辛酰胺和氢化己内酰胺衍生物
公开(公告)号：US20060160803A1
公开(公告)日：2006-07-20
申请号：US11332674
申请日：2006-01-12
申请人： Ruth Adams , Emily Calderwood , Alexandra Gould , Paul Greenspan , Matthew LaMarche , Yuan Tian , Tricia Vos
发明人： Ruth Adams , Emily Calderwood , Alexandra Gould , Paul Greenspan , Matthew LaMarche , Yuan Tian , Tricia Vos
IPC分类号： C07D413/02 , C07D403/02 , A61K31/5377 , A61K31/506 , A61K31/513
CPC分类号： C07D213/73 , C07D213/56 , C07D213/68 , C07D213/74 , C07D213/75 , C07D213/78 , C07D213/79 , C07D213/81 , C07D213/84 , C07D231/18 , C07D233/32 , C07D237/24 , C07D239/34 , C07D239/47 , C07D261/12 , C07D277/64 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D473/02 , C07D473/30 , C07D487/04
摘要： The present invention provides novel cinnamide compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的新颖的肉桂酰胺化合物。本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。

49. 发明申请

US20060046623A1 Method and apparatus for reduced wear polishing pad conditioning 失效
标题翻译：降低磨损抛光垫调理的方法和装置
公开(公告)号：US20060046623A1
公开(公告)日：2006-03-02
申请号：US11209167
申请日：2005-08-22
申请人： Yan Wang , Stan Tsai , Yongqi Hu , Feng Liu , Liang-Yuh Chen , Daxin Mao , Huyen Tran , Martin Wohlert , Renhe Jia , Yuan Tian
发明人： Yan Wang , Stan Tsai , Yongqi Hu , Feng Liu , Liang-Yuh Chen , Daxin Mao , Huyen Tran , Martin Wohlert , Renhe Jia , Yuan Tian
IPC分类号： B24B1/00
CPC分类号： B24B53/017 , B23H5/08
摘要： Embodiments of a conditioning head for in-situ conditioning and/or cleaning a processing pad of a CMP, ECMP, or other processing system are provided. In one embodiment, the conditioning head includes a brush disposed in a central cavity. A cleaning fluid is provided through the central cavity of the conditioning head to a processing pad. The brush spins and moves laterally across the surface of the processing pad. The cleaning solution dispensed through the conditioning head dissolves by-products of the processing operation while the brush gently wipes the processing pad. A lip of the conditioning head retains the cleaning fluid and cleaning waste, thereby minimizing contamination of the area outside of the conditioning head. The cleaning waste is removed from the processing pad via passages formed near the outer periphery of the conditioning head.
摘要翻译：提供了用于原位调理和/或清洁CMP，ECMP或其它处理系统的处理垫的调节头的实施例。在一个实施例中，调节头包括设置在中心腔中的刷子。清洁流体通过调节头的中心空腔设置到处理垫。刷子旋转并横向移动到处理垫的表面上。通过调节头分配的清洁溶液溶解处理操作的副产物，同时刷子轻轻地擦拭处理垫。调节头的唇缘保持清洁流体和清洁废物，从而最小化调节头外部区域的污染。清洁废物通过在调节头的外周附近形成的通道从处理垫移除。

50. 发明授权

US09051880B2 System and method for compressed gas fuel handling 有权
标题翻译：压缩气体燃料处理系统和方法
公开(公告)号：US09051880B2
公开(公告)日：2015-06-09
申请号：US13236510
申请日：2011-09-19
申请人： Wenjie Wu , Ping Yu , Yuan Tian , Zhiyong Chen
发明人： Wenjie Wu , Ping Yu , Yuan Tian , Zhiyong Chen
IPC分类号： G05D23/13 , F02C3/22 , F02C3/28 , F02C7/22 , F23K5/00
CPC分类号： F02C3/22 , F02C3/28 , F02C7/22 , F05D2220/722 , F05D2260/20 , F23K5/007 , F23K2401/10 , F23K2401/201 , F23K2900/05001 , Y02E20/16 , Y02E20/18 , Y02T50/675 , Y10T137/6416
摘要： A system includes a cooler configured to cool a first gas portion of a compressed gas fuel and discharge a cooled fluid. The cooled fluid comprises a cooled gas portion and a cooled liquid portion. The system also includes a separator configured to separate the cooled fluid into the cooled gas portion and the cooled liquid portion and a mixing tank configured to mix a second gas portion of the compressed gas fuel with the cooled gas portion in direct contact with one another to produce a superheated gas fuel. The superheated gas fuel comprises a degree of superheat above a lower threshold for a combustion system.
摘要翻译：系统包括冷却器，该冷却器构造成冷却压缩气体燃料的第一气体部分并排出冷却的流体。冷却的流体包括冷却的气体部分和冷却的液体部分。该系统还包括分离器，该分离器被构造成将冷却的流体分离成冷却的气体部分和冷却的液体部分;以及混合罐，其被配置成将压缩气体燃料的第二气体部分与冷却的气体部分彼此直接接触，产生过热气体燃料。过热气体燃料包括一个超过燃烧系统下限阈值的过热度。

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