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41. 发明申请

US20050283099A1 Method and device for preventing plaque formation in coronary arteries 失效
标题翻译：用于预防冠状动脉斑块形成的方法和装置
公开(公告)号：US20050283099A1
公开(公告)日：2005-12-22
申请号：US11203756
申请日：2005-08-15
申请人： Qingsheng Zhu , Avram Scheiner , Julio Spinelli
发明人： Qingsheng Zhu , Avram Scheiner , Julio Spinelli
IPC分类号： A61N1/05 , A61N1/32 , A61H1/02
CPC分类号： A61N1/326 , A61N1/0587
摘要： A method and device for preventing plaque build-up in a coronary artery includes providing an electrical field generating device, and generating an electrical field in the coronary artery to prevent plaque build-up in the coronary artery. The method further includes sensing the heart rhythm and generating the electrical field after a depolarization wave in the heart. The electrical field is generated by circuitry, in one embodiment implanted circuitry, connected to leads which are epicardially or intracardially positioned on the heart.
摘要翻译：用于防止冠状动脉斑块积聚的方法和装置包括提供电场产生装置，并且在冠状动脉中产生电场以防止冠状动脉中的斑块积聚。该方法还包括感测心脏节律并在心脏中去极化波之后产生电场。电场由电路产生，在一个实施例中，植入电路连接到心外膜或心内置于心脏上的引线。

42. 发明授权

US06915163B2 Apparatus and method for testing and adjusting a bipolar stimulation configuration 有权
公开(公告)号：US06915163B2
公开(公告)日：2005-07-05
申请号：US10634202
申请日：2003-08-05
申请人： Julio C. Spinelli , Qingsheng Zhu
发明人： Julio C. Spinelli , Qingsheng Zhu
IPC分类号： A61N1/362 , A61N1/37 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/371
摘要： A system and method for measuring the capture threshold of a bipolar lead in order to determine an appropriate value for the stimulus pulse energy to be used with the lead by a cardiac rhythm management device. An appropriate bipolar stimulating configuration can also be determined. The method is particularly useful in testing bipolar leads used to excite the left ventricle such as when delivering cardiac resynchronization therapy.

43. 发明申请

US20050137640A1 Adaptive safety pacing 有权
标题翻译：适应性安全起搏
公开(公告)号：US20050137640A1
公开(公告)日：2005-06-23
申请号：US10952345
申请日：2004-09-28
申请人： Scott Freeberg , Michael Lyden , Qingsheng Zhu
发明人： Scott Freeberg , Michael Lyden , Qingsheng Zhu
IPC分类号： A61N1/362 , A61N1/37
CPC分类号： A61N1/3712
摘要： Methods and systems involve adjusting an energy used for safety pacing based on the capture threshold. The safety pacing energy may be adjusted prior to a capture threshold test. During the capture threshold test, backup safety paces are delivered using the adjusted pacing energy. Following suspension of automatic capture verification, the device may enter a suspension mode. During the suspension mode, safety pacing pulses are delivered using a pacing energy adjusted based on capture threshold.
摘要翻译：方法和系统包括根据捕获阈值调整用于安全起搏的能量。可以在捕获阈值测试之前调整安全起搏能量。在捕获阈值测试期间，使用调整的起搏能量传送备用安全步伐。在停止自动捕获验证之后，设备可能进入暂停模式。在悬架模式下，使用基于捕获阈值调整的起搏能量来传送安全起搏脉冲。

44. 发明申请

US20050137490A1 Apparatus and method for outputting heart sounds 有权
标题翻译：用于输出心音的装置和方法
公开(公告)号：US20050137490A1
公开(公告)日：2005-06-23
申请号：US11037276
申请日：2005-01-18
申请人： Avram Scheiner , Qingsheng Zhu , Arthur Olive , Don Villalta
发明人： Avram Scheiner , Qingsheng Zhu , Arthur Olive , Don Villalta
IPC分类号： A61B5/00 , A61B5/042 , A61B5/044 , A61B5/0452 , A61B7/02 , A61B5/02
CPC分类号： A61B7/04 , A61B5/0002 , A61B5/0031 , A61B5/04012 , A61B5/04014 , A61B5/0402 , A61B5/042 , A61B5/044 , A61B5/0452 , A61B5/1118 , A61B5/742 , A61B7/023 , G06F19/00
摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.
摘要翻译：用于输出心音的装置包括可植入系统和外部系统。可植入系统包括用于产生表示检测到的心音的感测信号的传感器，接口电路和用于接收感测信号的控制电路，产生表示心音的数据，以及经由接口电路将数据发送到外部系统。外部系统包括用于与可植入系统进行通信的接口电路，以及用于接收表示心脏声音的数据的控制电路，以及用于产生使输出设备产生表示声音的输出的控制信号。可植入系统还可以包括用于检测心脏电信号的传感器。在这种情况下，还输出表示心电信号的输出。

45. 发明授权

US06909916B2 Cardiac rhythm management system with arrhythmia classification and electrode selection 有权
公开(公告)号：US06909916B2
公开(公告)日：2005-06-21
申请号：US10027800
申请日：2001-12-20
申请人： Julio C. Spinelli , Qingsheng Zhu , Jeffrey E. Stahmann , Andrew P. Kramer
发明人： Julio C. Spinelli , Qingsheng Zhu , Jeffrey E. Stahmann , Andrew P. Kramer
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3684
摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.

46. 发明授权

US06473649B1 Rate management during automatic capture verification 有权
标题翻译：自动捕获验证期间的费率管理
公开(公告)号：US06473649B1
公开(公告)日：2002-10-29
申请号：US09470269
申请日：1999-12-22
申请人： Mark Gryzwa , Qingsheng Zhu
发明人： Mark Gryzwa , Qingsheng Zhu
IPC分类号： A61N137
CPC分类号： A61N1/3712 , Y10S128/901
摘要： An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient's heart and suitable for use during capture verification. The device of the present invention may operate in an automatic capture verification mode, wherein an electrocardiogram signal of a patient's heart is received and used by the device to determine whether a stimulation pulse evokes a response by the patient's heart. The device suspends the automatic capture verification mode and/or adjust the detection threshold dependent upon detected and/or measured noise, a determined amplitude of evoked response, a determined modulation in the evoked response, or detected and/or measured artifact. Further, the sensing circuit of the rhythm management device of the present invention reduces afterpotentials that result due to delivery of the stimulation pulses.
摘要翻译：一种植入式心律管理装置，其能够自动检测患者心脏的内在和诱发反应并适于在捕获验证期间使用。本发明的装置可以在自动捕获验证模式下操作，其中由装置接收并使用患者心脏的心电图信号，以确定刺激脉冲是否引起患者心脏的反应。取决于检测到的和/或测量的噪声，所确定的诱发响应幅度，诱发响应中的确定调制，或检测到的和/或测量的伪影，该装置暂停自动捕获验证模式和/或调整检测阈值。此外，本发明的节律管理装置的感测电路减少了由于刺激脉冲的传送而导致的后电位。

47. 发明授权

US06275731B1 Pseudo-fusion management during automatic capture verification 有权
标题翻译：自动捕获验证期间的伪融合管理
公开(公告)号：US06275731B1
公开(公告)日：2001-08-14
申请号：US09474193
申请日：1999-12-29
申请人： Qingsheng Zhu , Jungkuk Kim , Arthur Olive , Jan-Pieter Heemels
发明人： Qingsheng Zhu , Jungkuk Kim , Arthur Olive , Jan-Pieter Heemels
IPC分类号： A61N1365
CPC分类号： A61N1/3712
摘要： A method for reducing the affects of intrinsic detection latency in a cardiac rhythm management device, wherein said method is initiated immediately prior to delivering a stimulation pulse to the heart tissue. A coincidence of intrinsic and cardiac rhythm management initiated stimulus or the delivery of a stimulation pulse proximate the time of an intrinsic event due to intrinsic detection latency may results in delivery of unnecessary backup stimulus and/or imprecise determination of a pacing threshold. When stimulating the heart, the timing sequence for delivering a stimulation pulse typically depends upon the timing of a previous intrinsic or device initiated event. Further, the method of the present invention reduces the affects of intrinsic detection latency thereby facilitating improved detection of capture and determination of capture threshold for minimizing power consumption while assuring therapeutic efficacy.
摘要翻译：一种减轻心律管理装置中内在检测延迟的影响的方法，其中所述方法在将刺激脉冲传递到心脏组织之前立即开始。由于内在的检测潜伏期，固有和心律管理发起的刺激或接近内在事件时间的刺激脉冲的传递的巧合可能导致递送不必要的备份刺激和/或不精确地确定起搏阈值。当刺激心脏时，用于递送刺激脉冲的定时序列通常取决于先前的固有或设备启动事件的时序。此外，本发明的方法减少了内在检测潜能的影响，从而有助于提高捕获捕获阈值的检测和捕获阈值的确定，以最大限度地降低功耗，同时确保治疗效果。

48. 发明授权

US09480848B2 Advanced patient management with environmental data 有权
标题翻译：高级患者管理与环境数据
公开(公告)号：US09480848B2
公开(公告)日：2016-11-01
申请号：US13185121
申请日：2011-07-18
申请人： John Hatlestad , Jeffrey E. Stahmann , Qingsheng Zhu
发明人： John Hatlestad , Jeffrey E. Stahmann , Qingsheng Zhu
IPC分类号： A61B5/00 , A61N1/372 , G06F19/00
CPC分类号： A61B5/0031 , A61B5/0022 , A61B5/0205 , A61B5/0537 , A61B5/0816 , A61B5/091 , A61B5/1118 , A61B7/04 , A61B2560/0247 , A61B2560/0252 , A61B2560/0257 , A61N1/37252 , A61N1/37282 , G06F19/00 , G06F19/3418 , G16H40/63 , G16H50/30
摘要： Systems, devices and methods for using environmental data to manage health care are disclosed. One aspect is an advanced patient management system. In various embodiments, the system includes at least one implantable medical device (IMD) to acquire at least one IMD parameter indicative of patient wellness, means to acquire at least one environmental parameter from at least one external source, and means to correlate the at least one parameter indicative of patient wellness and the at least one environmental parameter to assist with patient health care decisions. Other aspects and embodiments are provided herein.
摘要翻译：公开了使用环境数据来管理医疗保健的系统，设备和方法。一个方面是先进的患者管理系统。在各种实施例中，系统包括至少一个可植入医疗装置（IMD），以获取指示患者健康的至少一个IMD参数，从至少一个外部源获取至少一个环境参数的手段，以及至少将指示患者健康的一个参数和用于协助患者医疗保健决定的至少一个环境参数。本文提供了其它方面和实施例。

49. 发明授权

US09265950B2 Contractility modulation based on impedance signal 有权
标题翻译：基于阻抗信号的收缩调制
公开(公告)号：US09265950B2
公开(公告)日：2016-02-23
申请号：US12152099
申请日：2008-05-12
申请人： Qingsheng Zhu , Julio C. Spinelli
发明人： Qingsheng Zhu , Julio C. Spinelli
IPC分类号： A61N1/00 , A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A cardiac rhythm management system detects edema. In response to an episode of detected edema, it initiates or adjusts a cardiac resynchronization therapy and/or a cardiac contractility modulation (CCM) therapy.
摘要翻译：心律管理系统检测水肿。响应于检测到的水肿发作，其启动或调整心脏再同步治疗和/或心脏收缩调节（CCM）治疗。

50. 发明授权

US08812105B2 Circuit-based devices and methods for pulse control of endocardial pacing in cardiac rhythm management 有权
标题翻译：基于电路的心脏心律管理脉搏控制心脏起搏的装置和方法
公开(公告)号：US08812105B2
公开(公告)日：2014-08-19
申请号：US13282163
申请日：2011-10-26
申请人： Qingsheng Zhu , Daniel Felipe Ortega
发明人： Qingsheng Zhu , Daniel Felipe Ortega
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： Tools and methods are particularly suited for certain cardiac conditions involving use of a catheter for pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by generating pulses for delivery to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. In one embodiment, an implantable pulse generator includes circuitry for generating pacing profiles, with signals of opposite polarities, specifically selected for delivery on electrodes at a site near the septal wall of a right ventricle of the heart.
摘要翻译：工具和方法特别适合于某些心脏状况，包括使用导管将右心室和左心室从右心室中的引线起搏，例如为了促进用于再同步的机械和/或电同步收缩。某些方面涉及起搏和/或作图，通过产生用于递送到心脏部位的脉搏，用于改善心脏功能，例如通过QRS宽度，分级，晚期LV激活时间，游离壁和间隔壁的机械同步性，有效吞吐量/ 压力或其组合。在一个实施例中，可植入脉冲发生器包括用于产生具有相反极性的信号的起搏曲线的电路，其具体选择用于在靠近心脏右心室隔壁的位置处的电极上传送。

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