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    • 42. 发明授权
    • Probes and methods for detection of Escheridia coli and antibiotic resistance
    • 用于检测大肠杆菌和抗生素耐药性的探针和方法
    • US07763426B2
    • 2010-07-27
    • US11743071
    • 2007-05-01
    • David A. HaakeBernard M. ChurchillJoseph C. LiaoMarc A. SuchardYang LiMitra Mastali
    • David A. HaakeBernard M. ChurchillJoseph C. LiaoMarc A. SuchardYang LiMitra Mastali
    • C12Q1/68C07H21/02C07H21/04
    • C12Q1/689
    • Described are probes and methods for detecting pathogens and antibiotic resistance of a specimen. The method comprises contacting the specimen with a growth medium; and lysing the specimen to release nucleic acid molecules from the specimen. The lysate of the specimen is contacted with a capture probe immobilized on a substrate, wherein the capture probe comprises an oligonucleotide that specifically hybridizes with a first target nucleic acid sequence region of ribosomal RNA. The lysate is in contact with a detector probe that comprises a detectably labeled oligonucleotide that specifically hybridizes with a second target nucleic acid sequence region of ribosomal RNA. The presence or absence of labeled oligonucleotide complexed with the substrate is determined. Detection of labeled oligonucleotide complexed with the substrate is indicative of the presence of pathogen. Performing the method in the presence and absence of an antibiotic permits detection of antibiotic resistance.
    • 描述了用于检测样品的病原体和抗生素抗性的探针和方法。 该方法包括使样品与生长培养基接触; 并裂解样品以从样品中释放核酸分子。 将样品的裂解物与固定在底物上的捕获探针接触,其中捕获探针包含与核糖体RNA的第一靶核酸序列区特异性杂交的寡核苷酸。 裂解物与检测器探针接触,检测器探针包含与核糖体RNA的第二靶核酸序列区特异性杂交的可检测标记的寡核苷酸。 确定与底物复合的标记寡核苷酸的存在或不存在。 与底物复合的标记寡核苷酸的检测表明存在病原体。 在存在和不存在抗生素的情况下进行该方法可以检测抗生素耐药性。
    • 44. 发明申请
    • TRANSMISSION GATE-BASED SPIN-TRANSFER TORQUE MEMORY UNIT
    • 基于传输门控的转子转矩记忆单元
    • US20100008134A1
    • 2010-01-14
    • US12170549
    • 2008-07-10
    • Yiran ChenHai LiHongyue LiuYong LuYang Li
    • Yiran ChenHai LiHongyue LiuYong LuYang Li
    • G11C11/00G11C7/00
    • G11C11/1657G11C11/1659G11C11/1675Y10S977/935
    • A transmission gate-based spin-transfer torque memory unit is described. The memory unit includes a magnetic tunnel junction data cell electrically coupled to a bit line and a source line. A NMOS transistor is in parallel electrical connection with a PMOS transistor and they are electrically connected with the source line and the magnetic tunnel junction data cell. The magnetic tunnel junction data cell is configured to switch between a high resistance state and a low resistance state by passing a polarized write current through the magnetic tunnel junction data cell. The PMOS transistor and the NMOS transistor are separately addressable so that a first write current in a first direction flows through the PMOS transistor and a second write current in a second direction flows through the NMOS transistor.
    • 描述基于传输门的自旋转移转矩存储单元。 存储单元包括电耦合到位线和源极线的磁性隧道结数据单元。 NMOS晶体管与PMOS晶体管并联电连接,并且它们与源极线和磁性隧道结数据单元电连接。 磁隧道结数据单元被配置为通过使极化写入电流通过磁性隧道结数据单元在高电阻状态和低电阻状态之间切换。 PMOS晶体管和NMOS晶体管可单独寻址,使得第一方向上的第一写入电流流过PMOS晶体管,并且第二方向的第二写入电流流过NMOS晶体管。
    • 45. 发明申请
    • ORGANIC LIGHT EMITTING DEVICE AND FABRICATION METHOD THEREOF
    • 有机发光装置及其制造方法
    • US20090267499A1
    • 2009-10-29
    • US12427846
    • 2009-04-22
    • Yong QiuLian DuanYang LiGuohui Zhang
    • Yong QiuLian DuanYang LiGuohui Zhang
    • H01J1/62B05D5/06
    • H01L51/5092H01L51/5221H01L2251/558
    • The present invention provides an organic light emitting device and a fabrication method thereof, comprising a substrate, an anode layer formed on said substrate, an organic function layer formed on said anode layer, and a cathode layer formed on said organic function layer, characterized in that, further comprising a cathode interface modification layer between said organic function layer and said cathode layer, wherein said cathode interface modification layer contains a compound AxByCz, A is an element of Group IA or IIA, B is an element of Group IIIA or VA, C is a hydrogen element, and 1≦x≦2, y ∈ [0,1], 1≦z≦4. In the present invention, the cathode interface modification layer is formed after forming a light emitting layer, the cathode interface modification layer contains a compound AxByCz, the electron injection ability at the cathode interface can be improved by adding the cathode interface modification layer, and hence the device performance can be significantly improved. At the same time, the process feasibility of the material is good during the fabrication, and thus the yield of the device can be further improved.
    • 本发明提供了一种有机发光器件及其制造方法,包括:衬底,形成在所述衬底上的阳极层,形成在所述阳极层上的有机功能层,以及形成在所述有机功能层上的阴极层,其特征在于: 还包括在所述有机功能层和所述阴极层之间的阴极界面改性层,其中所述阴极界面改性层含有化合物AxByCz,A是IAA或IIA族的元素,B是IIIA或VA族的元素, C是氢元素,1 <= x <= 2,y∈[0,1],1 <= z <= 4。 在本发明中,在形成发光层之后形成阴极界面改性层,阴极界面改性层含有化合物AxByCz,通过添加阴极界面改性层可以提高阴极界面处的电子注入能力,因此 器件性能可以显着提高。 同时,在制造过程中材料的工艺可行性良好,从而可以进一步提高装置的产量。
    • 47. 发明申请
    • Aggregate personal computer system
    • 综合个人电脑系统
    • US20080320501A1
    • 2008-12-25
    • US11821754
    • 2007-06-25
    • Yang LiLifeng WangJian WangChao Li
    • Yang LiLifeng WangJian WangChao Li
    • G06F13/00
    • G06F9/4411G06F9/45537
    • Described is an aggregate computer system that operates by sharing devices of networked computing machines. A consumer machine uses a real device of a producer machine as a virtual device, by coupling the real driver of the real device over the network to a virtual driver of the consumer machine. Each machine may include an aggregate device manager that manages the virtual devices, and/or an aggregate connection manager that processes communications received over at least two different types of networks. Each machine may include a virtual bus and virtual bus driver that simulates a physical connection of a remote device to that machine via a bus. Upon receiving a request to plug-in a virtual device, the consumer machines queries for information of the device, and loads a virtual driver based on the device information when received. The consumer machine may query by sending plug-and-play events to the virtual bus.
    • 描述了通过共享网络计算机的设备来操作的聚合计算机系统。 消费者机器使用生产者机器的真实设备作为虚拟设备,通过将真实设备的真实驱动器通过网络耦合到消费者机器的虚拟驱动器。 每个机器可以包括管理虚拟设备的聚合设备管理器和/或处理通过至少两种不同类型的网络接收的通信的聚合连接管理器。 每个机器可以包括虚拟总线和虚拟总线驱动器,其通过总线模拟远程设备到该机器的物理连接。 在接收到插入虚拟设备的请求时,消费者机器查询设备的信息,并且在接收时基于设备信息加载虚拟驱动程序。 消费者可以通过向虚拟总线发送即插即用事件进行查询。
    • 49. 发明申请
    • Salivary Mrna Profiling, Biomarkers and Related Methods and Kits of Parts
    • 唾液Mrna分析,生物标志物及相关方法和试剂盒
    • US20080280772A1
    • 2008-11-13
    • US10589788
    • 2005-02-17
    • David T.W. WongMaie A.R. St. JohnYang Li
    • David T.W. WongMaie A.R. St. JohnYang Li
    • C40B30/04C12Q1/68
    • G01N33/57488C12Q1/6886G01N33/5017G01N33/6893
    • A method to detect a biomarker in saliva wherein the biomarker is an extracellular mRNA, comprises detecting the extracellular mRNA in the cell-free saliva; transcriptome analysis of saliva comprises detecting a transcriptome pattern in the cell-free saliva; a method to detect genetic alterations in an organ or in a gene in the organ by analyzing saliva, comprises detecting a transcriptome pattern and/or the mRNA profiling of the gene in cell-free saliva; a method to diagnose an oral or systemic pathology disease or disorder in a subject, comprises: detecting profile of a biomarker associated with the pathology disease or disorder, in particular mRNA and/or protein, in cell-free saliva and/or serum; kits comprising identifier for at least one biomarker for performing at least one of the methods; and use of salivary biomarker salivary and/or serum mRNAs as biomarkers for oral and/or systemic pathology, disease or disorder.
    • 检测唾液中生物标志物的方法,其中生物标志物是细胞外mRNA,包括检测无细胞唾液中的细胞外mRNA; 唾液的转录组分析包括检测无细胞唾液中的转录组图谱; 通过分析唾液来检测器官或器官中基因变异的方法,包括检测无细胞唾液中基因的转录组模式和/或mRNA谱图; 用于诊断受试者的口腔或全身病理学疾病或病症的方法包括:在无细胞唾液和/或血清中检测与病理学疾病或病症特别是mRNA和/或蛋白质相关的生物标志物的谱图; 试剂盒包括用于至少一种生物标志物的标识符,用于执行至少一种方法; 并且使用唾液生物标志物唾液和/或血清mRNA作为口服和/或全身病理学,疾病或病症的生物标志物。
    • 50. 发明授权
    • Access control to shared resources
    • 对共享资源的访问控制
    • US07373338B2
    • 2008-05-13
    • US10784919
    • 2004-02-24
    • Simon G. ThompsonZhu TanYang LiNick Giles
    • Simon G. ThompsonZhu TanYang LiNick Giles
    • G06F7/00
    • G06F17/30734G06F17/3089G06F21/6227Y10S707/99933Y10S707/99935
    • Controlled access is provided to a shared resource 23 such as an ontology (knowledge database) in order to maintain its quality without restraining the ability of users 21a, 21b, 21c . . . to contribute to that resource.An edit and query function 26 is used to determine the validity and consistency of individual contributions. The results of these checks and the level of contribution made by individual users to the information resource is used to produce a rating for each user of the resource, which is stored (24a, 24b . . . ) for use in prioritise and manage future contributions to the resource 23, provide metadata on the resource and to prioritise access control 28 to the resource.When a new contribution is made by a user a threshold of approval can be set before it is accepted into the main database 23. This threshold is based on the sum of the ratings points of the original contributor and of users that give their assent to the inclusion of that contribution.
    • 将控制访问提供给诸如本体(知识数据库)的共享资源23,以便在不限制用户21a,21b,21c的能力的情况下保持其质量。 。 。 为该资源做出贡献。 编辑和查询功能26用于确定个人贡献的有效性和一致性。 这些检查的结果和个人用户对信息资源的贡献程度被用于为资源的每个用户产生一个评级,该资源被存储(24a,24b ...)以用于优先和管理 对资源23的未来贡献提供资源上的元数据并且优先考虑资源的访问控制28。 当用户作出新的贡献时,可以在将其批准进入主数据库23之前设置批准阈值。 这个阈值是基于原始贡献者和同意列入该捐款的用户的评分数之和。