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    • 47. 发明授权
    • Processes for producing &bgr;-halogeno-&agr;-amino-carboxylic acids and phenylcysteine derivatives and intermediates thereof
    • 制备β-卤代-α-氨基 - 羧酸和苯基半胱氨酸衍生物的方法及其中间体
    • US06372941B1
    • 2002-04-16
    • US09582461
    • 1999-08-16
    • Koki YamashitaKenji InoueKoichi KinoshitaYasuyoshi UedaHiroshi Murao
    • Koki YamashitaKenji InoueKoichi KinoshitaYasuyoshi UedaHiroshi Murao
    • C07C22900
    • C07C227/16C07C319/14Y02P20/55C07C323/58C07C323/59C07C229/20
    • An industrially advantageous method of producing &bgr;-halogeno-&agr;-aminocarboxylic acids is provided. Methods are also provided of producing optically active N-protected-S-phenylcysteines having high optical purity and of intermediates thereof, respectively, in which the above production method is utilized. A method of producing &bgr;-halogeno-&agr;-aminocarboxylic acids or salts thereof is disclosed which comprises halogenating the hydroxyl group of a &bgr;-hydroxy-&agr;-aminocarboxylic acid (in which the basicity of the amino group in &agr;-position is not masked by the presence of a substituent on said amino group) or a salt thereof with an acid with a halogenating agent. A method of producing optically active N-protected-S-phenylcysteines represented by the general formula (3) or salts thereof is further disclosed which comprises applying the above production method to optically active serine or a salt thereof and then carrying out treatment with an amino-protecting agent and reaction with thiophenol under a basic condition.
    • 提供了产生β-卤代-α-氨基羧酸的工业上有利的方法。 还提供了分别制备具有高光学纯度的光学活性N-保护的S-苯基半胱氨酸及其中间体的方法,其中使用上述制备方法.1。制备β-卤代-α-氨基羧酸或其盐的方法 其中包括将β-羟基-α-氨基羧酸的羟基(其中在所述氨基上不存在取代基的α-位置上的氨基的碱性)或其盐与卤素化反应 具有卤化剂的酸。 进一步公开了制备由通式(3)表示的光学活性N-保护的S-苯基半胱氨酸或其盐的方法,其包括将上述制备方法应用于光学活性丝氨酸或其盐,然后用氨基 保护剂和与苯硫酚在基本条件下的反应。
    • 50. 发明授权
    • Process for producing L-allysine acetals
    • 生产L-赖氨酸乙缩醛的方法
    • US06174707B1
    • 2001-01-16
    • US09202901
    • 1999-03-04
    • Naoaki TaokaTakehiko MatsumotoKenji Inoue
    • Naoaki TaokaTakehiko MatsumotoKenji Inoue
    • G01N3853
    • C12P7/40C12P13/04C12P41/006
    • The present invention has for its object to provide a method for producing an L-allysine acetal which involves a fewer steps and is efficient. This invention relates to method for producing an L-allysine acetal which comprises; converting a D,L-allysine acetal of the following general formula (1) (wherein R1 and R2 are the same or different, and each of them represents an alkyl group having 1 to 8 carbon atoms, or they combinedly form a ring and represent an alkylene group having 2 to 8 carbon atoms) to a mixture of a 2-oxo-6,6-dialkoxyhexanoic acid of the following general formula (2) (wherein R1 and R2 are as defined above) and an L-allysine acetal of the following general formula (3) (wherein R1 and R2 are as defined above) by reacting in the presence of an enzyme capable of stereoselective oxidative deamination of D-amino acids and; isolating said L-allysine acetal after said converting.
    • 本发明的目的是提供一种生产L-赖氨酸缩醛的方法,该方法涉及较少的步骤并且是有效的。本发明涉及L-赖氨酸缩醛的制备方法,其包括:将D,L-烯丙基乙缩醛 的下述通式(1)(其中,R 1和R 2相同或不同,它们各自表示碳原子数1〜8的烷基,或者它们组合形成环,表示碳原子数2〜8的亚烷基 原子)与下述通式(2)的2-氧代-6,6-二烷氧基己酸(其中R 1和R 2如上定义)和下列通式(3)的L-烯丙基缩醛的混合物 其中R1和R2如上所定义)通过在能够进行D-氨基酸的立体选择性氧化脱氨作用的酶存在下反应;和在所述转化后分离所述L-赖氨酸缩醛。