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41. 发明申请

US20070004046A1 Detection of analytes 审中-公开
标题翻译：检测分析物
公开(公告)号：US20070004046A1
公开(公告)日：2007-01-04
申请号：US11173122
申请日：2005-07-01
申请人： Nicholas Abbott
发明人： Nicholas Abbott
IPC分类号： G01N33/00 , C12Q1/00 , G02F1/13
CPC分类号： G01N33/5308 , B82Y15/00 , B82Y30/00 , G01N21/6428 , G01N33/54373 , G01N2021/6417 , G01N2430/10 , Y10T436/163333
摘要： The present invention relates to the field of detection of analytes, and in particular to detection of organophosphates using a liquid crystal assay format and a variety of analytes in stand-off detection formats utilizing liquid crystals as part of reporting system. The present devices find use in detecting cumulative exposure to organophosphates in the aerosol phase.
摘要翻译：本发明涉及分析物的检测领域，特别涉及使用液晶测定形式的检测有机磷酸盐，以及利用液晶作为报告系统的一部分的间断检测形式的各种分析物。本发明的装置用于检测气溶胶相中有机磷酸盐的累积暴露。

42. 发明授权

US06277489B1 Support for high performance affinity chromatography and other uses 失效
标题翻译：支持高性能亲和层析等用途
公开(公告)号：US06277489B1
公开(公告)日：2001-08-21
申请号：US09205750
申请日：1998-12-04
申请人： Nicholas Abbott , Pieter Stroeve , Timothy B. Dubrovsky , Zhizhong Hou
发明人： Nicholas Abbott , Pieter Stroeve , Timothy B. Dubrovsky , Zhizhong Hou
IPC分类号： B32B516
CPC分类号： B82Y30/00 , B01D15/1821 , B01D15/34 , B01D15/3804 , B01J20/0233 , B01J20/286 , B01J20/3236 , B01J20/3244 , B01J20/3248 , B01J20/3289 , B01J2219/00497 , B01J2220/54 , B05D1/185 , B05D2350/65 , B82Y40/00 , G01N33/54313 , G01N33/544 , G01N33/552 , G01N33/553 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998 , Y10T428/31678
摘要： Multilayered particulate materials are formed by coating a particulate substrate with a metal and adsorbing an organic layer comprising a recognition moiety onto the metal film. The recognition moiety interacts with an analyte of interest allowing for its detection, purification, etc. Suitable recognition moieties can be selected from a range of species including, small molecules, polymers and biomolecules and the like. The novel particulate materials of the invention can be utilized in an array of methods including, ion-exchange, ion-selective ion-exchange, assays, affinity dialysis, size exclusion dialysis, as supports in solid phase synthesis, combinatorial synthesis and screening of compound libraries and the like.
摘要翻译：通过用金属涂覆颗粒基材并将包含识别部分的有机层吸附到金属膜上来形成多层颗粒材料。识别部分与感兴趣的分析物相互作用，允许其检测，纯化等。合适的识别部分可以选自包括小分子，聚合物和生物分子等的一系列物质。本发明的新型颗粒材料可用于一系列方法，包括离子交换，离子选择性离子交换，测定，亲和透析，尺寸排阻透析，固相合成中的载体，组合合成和化合物的筛选图书馆等。

43. 发明授权

US08178355B2 Detection of vapor phase compounds by changes in physical properties of a liquid crystal 有权
标题翻译：通过液晶物理性质的变化来检测气相化合物
公开(公告)号：US08178355B2
公开(公告)日：2012-05-15
申请号：US12560076
申请日：2009-09-15
申请人： Bharat Acharya , Avijit Sen , Nicholas Abbott , Kurt Kupcho
发明人： Bharat Acharya , Avijit Sen , Nicholas Abbott , Kurt Kupcho
IPC分类号： G01N33/497 , G01N21/19 , G01N21/41 , G01N27/02 , G01N27/72
CPC分类号： G01N33/497 , B82Y30/00 , G01N21/77 , G01N27/227 , G01N31/22 , G01N33/0037 , G01N2033/4975 , Y02A50/245 , Y10T436/15 , Y10T436/175383 , Y10T436/177692 , Y10T436/178459 , Y10T436/179228 , Y10T436/182 , Y10T436/184 , Y10T436/200833 , Y10T436/202499 , Y10T436/204165
摘要： The present invention relates to the field of detection of components in gas phase, and in particular to detection of nitric oxide exhaled as a component of breath, using a liquid crystal assay format and a device utilizing liquid crystals as part of a reporting system.
摘要翻译：本发明涉及气相中组分的检测领域，特别涉及使用液晶测定格式检测作为呼吸成分呼出的一氧化氮，以及利用液晶作为报告系统的一部分的装置。

44. 发明授权

US08062853B2 Polyelectrolyte multilayer films at liquid-liquid interfaces 有权
标题翻译：液 - 液界面聚电解质多层膜
公开(公告)号：US08062853B2
公开(公告)日：2011-11-22
申请号：US12685209
申请日：2010-01-11
申请人： Nicholas Abbott , Nathan A. Lockwood , Katie D. Cadwell , Frank Caruso , Elvira Tjipto
发明人： Nicholas Abbott , Nathan A. Lockwood , Katie D. Cadwell , Frank Caruso , Elvira Tjipto
IPC分类号： G01N33/53
CPC分类号： C08J5/20 , G01N21/6428
摘要： The present invention is directed to methods for providing a polyelectrolyte multilayer film at a liquid-liquid interface. Such methods include steps of sequentially-depositing layers of cationic and anionic polyelectrolytes at a liquid-liquid interface that is formed between immiscible first and second liquids whereby a polyelectrolyte multilayer film is provided at the liquid-liquid interface. In certain preferred embodiments, the first liquid is an aqueous solution and the second liquid is a liquid crystal. In alternative embodiments, the first liquid is an aqueous solution and the second liquid is an oil. The invention further encompasses polyelectrolyte multilayer films provided by the disclosed methods as well as applications utilizing such materials.
摘要翻译：本发明涉及在液 - 液界面处提供聚电解质多层膜的方法。这样的方法包括在不混溶的第一和第二液体之间形成的液 - 液界面顺序地沉积阳离子和阴离子聚电解质层，由此在液 - 液界面处提供聚电解质多层膜。在某些优选实施方案中，第一液体是水溶液，第二液体是液晶。在替代实施例中，第一液体是水溶液，第二液体是油。本发明还包括通过所公开的方法提供的聚电解质多层膜以及利用这种材料的应用。

45. 发明申请

US20070104612A1 Detecting interactions at biomimetic interfaces with liquid crystals 有权
标题翻译：用液晶检测仿生界面处的相互作用
公开(公告)号：US20070104612A1
公开(公告)日：2007-05-10
申请号：US11523319
申请日：2006-09-19
申请人： Nicholas Abbott , Jeffrey Brake
发明人： Nicholas Abbott , Jeffrey Brake
IPC分类号： G01N21/00 , G02F1/13 , G01N33/53
CPC分类号： C09K19/00 , C09K2019/528 , G01N33/54366 , Y10S436/805 , Y10T428/10 , Y10T428/1059 , Y10T428/1095
摘要： A method of forming a liquid crystal device, includes: contacting an aqueous solution comprising a surfactant and a receptor molecule with a top surface of a liquid crystal. The liquid crystal is in a holding compartment of a substrate, and the receptor molecule is adsorbed on the top surface of the liquid crystal forming an interface between the liquid crystal and the aqueous solution. The receptor molecule is different than the surfactant. A method of detecting a compound in a flowing stream includes passing an aqueous solution over a top surface of a liquid crystal in a holding compartment of a substrate. The method also includes determining whether a change in the orientation of the liquid crystal occurs as the aqueous solution is passed over the top surface of the liquid crystal. A change in the orientation of the liquid crystal indicates the presence of the compound in the flowing stream.
摘要翻译：形成液晶装置的方法包括：将包含表面活性剂和受体分子的水溶液与液晶的顶表面接触。液晶位于基板的保持室中，受体分子被吸附在液晶的顶面上，形成液晶与水溶液的界面。受体分子与表面活性剂不同。在流动物流中检测化合物的方法包括将水溶液通过基板的保持室中的液晶的顶表面。该方法还包括确定当水溶液通过液晶的顶表面时是否发生液晶的取向的变化。液晶的取向的变化表示化合物在流动流中的存在。

46. 发明申请

US20060134656A1 Reduction of non-specific adsorption of biological agents on surfaces 审中-公开
标题翻译：减少生物制剂对表面的非特异性吸附
公开(公告)号：US20060134656A1
公开(公告)日：2006-06-22
申请号：US11137127
申请日：2005-05-25
申请人： Robert Hamers , Tami Clare , Nicholas Abbott , Brian Clare
发明人： Robert Hamers , Tami Clare , Nicholas Abbott , Brian Clare
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/34
CPC分类号： G01N33/54393 , A61M2205/0244 , G01N33/551
摘要： The present invention relates to surface-modified substrates that demonstrate reduced non-specific adsorption of biological agents. The substrates are silicon or carbon substrates having ethylene glycol oligomers covalently bound to at least one substrate surface. The substrates may be used in sensor devices, such as biochips, and in implantable medical devices in order to reduce the non-specific binding of biological agents.
摘要翻译：本发明涉及表现出降低生物制剂的非特异性吸附的表面改性底物。基底是具有共价结合至少一个基底表面的乙二醇低聚物的硅或碳基底。衬底可用于诸如生物芯片的传感器装置中，并且可用于可植入的医疗装置中，以便减少生物制剂的非特异性结合。

47. 发明申请

US20050260703A1 Biochemical blocking layer for liquid crystal assay 审中-公开
标题翻译：用于液晶测定的生化阻断层
公开(公告)号：US20050260703A1
公开(公告)日：2005-11-24
申请号：US10625869
申请日：2003-07-23
申请人： Nicholas Abbott , Seung-Ryeol Kim
发明人： Nicholas Abbott , Seung-Ryeol Kim
IPC分类号： G01N21/75 , G01N33/543 , G01N33/552 , G01N37/00 , C12P21/06
CPC分类号： G01N33/54366 , G01N33/54353 , G01N33/54373 , G01N33/552 , Y10T428/1018
摘要： A rubbed substrate structure for use in a liquid crystal assay device, includes: a biochemical blocking compound chemically immobilized on a surface of one side of a support forming a biochemical blocking layer; and a biomolecule recognition agent deposited on the side of the support containing the biochemical blocking layer. The biomolecule recognition agent includes a recognition site capable of selectively recognizing a target species to be detected by the liquid crystal assay device. Additionally, the surface of the side of the support containing the biochemical blocking layer is rubbed such that it possesses features that drive a uniform anchoring of liquid crystals when the liquid crystals contact the side of the support containing the biochemical blocking layer. A method for preparing a rubbed substrate structure for use in a liquid crystal assay device, optical cells for use in a liquid crystal assay, liquid crystal assay devices, kits for use in a liquid crystal assay, and methods for detecting the presence of a target species using a liquid crystal assay device are also disclosed.
摘要翻译：用于液晶测定装置的摩擦衬底结构包括：化学固定在形成生化阻断层的支持物一侧的表面上的生化封闭化合物; 和沉积在含有生化阻断层的载体侧上的生物分子识别剂。生物分子识别剂包括能够选择性地识别由液晶测定装置检测的靶物种的识别位点。此外，含有生化阻断层的载体的表面被摩擦，使得其具有当液晶接触包含生化阻断层的载体侧时驱动液晶的均匀锚定的特征。一种制备用于液晶测定装置的摩擦衬底结构的方法，用于液晶测定的光学单元，液晶测定装置，用于液晶测定的试剂盒以及用于检测靶的存在的方法还公开了使用液晶测定装置的物种。

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