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41. 发明申请

US20090035839A1 Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof 有权
标题翻译：用于生产白藜芦醇或其寡聚或糖苷结合衍生物的代谢工程细胞
公开(公告)号：US20090035839A1
公开(公告)日：2009-02-05
申请号：US12081571
申请日：2008-04-17
申请人： Michael Katz , Hans Peter Smits , Jochen Forster , Jens Bredal Nielsen
发明人： Michael Katz , Hans Peter Smits , Jochen Forster , Jens Bredal Nielsen
IPC分类号： C12N1/00
CPC分类号： C12P7/22 , A23C3/08 , A61K31/05 , C12N9/0042 , C12N9/0073 , C12N9/1029 , C12N9/1037 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/42 , C12P23/00 , C12Y106/02004 , C12Y114/13011 , C12Y203/01074 , C12Y403/01005 , C12Y602/01012 , C12Y604/01002 , Y02A50/473 , Y02P20/52
摘要： A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.
摘要翻译：通过苯丙氨酸氨裂解酶（PAL）从苯丙氨酸产生反式肉桂酸，肉桂酸4-羟化酶（C4H）的途径产生白藜芦醇的重组微生物从所述反式肉桂酸，4-香豆酸 - 辅酶A产生4-香豆酸连接酶（4CL）从所述4-香豆酸生成4-香豆酰CoA，白藜芦醇合酶（VST）从所述4-香豆酰CoA或其中L-苯丙氨酸或酪氨酸 - 氨裂解酶（PAL / TAL）产生白藜芦醇 4-香豆酸，4-香豆酸-CaA连接酶（4CL）从所述4-香豆酸生成4-香豆酰CoA，白藜芦醇合酶（VST）从所述4-香豆酰CoA产生所述白藜芦醇。微生物可以是酵母，真菌或细菌，包括酿酒酵母，大肠杆菌，乳酸乳球菌，黑曲霉或米曲霉。

42. 发明申请

US20080071053A1 Vapochromic Coordination Polymers for Use in Analyte Detection 有权
标题翻译：用于分析物检测的色相配位聚合物
公开(公告)号：US20080071053A1
公开(公告)日：2008-03-20
申请号：US11577299
申请日：2005-10-17
申请人： Julie Lefebvre , Michael Katz , Daniel Leznoff
发明人： Julie Lefebvre , Michael Katz , Daniel Leznoff
IPC分类号： C08G79/00 , G01J3/28 , G01J3/46 , G01N7/14
CPC分类号： C07F1/005 , G01N31/22 , Y10T436/196666 , Y10T436/25875
摘要： This application relates to vaprochromic coordination polymers useful for analyte detection. The vapochromism may be observed by visible color changes, changes in luminescence, and/or spectroscopic changes in the infrared (IR) signature. One or more of the above chromatic changes may be relied upon to identify a specific analyte, such as a volatile organic compound or a gas. The chromatic changes may be reversible to allow for successive analysis of different analytes using the same polymer. The polymer has the general formula MW[M′X(Z)Y]N wherein M and M′ are the same or different metals capable of forming a coordinate complex with the Z moiety; Z is selected from the group consisting of halides, pseudohalides, thiolates, alkoxides and amides; W is between 1-6; X and Y are between 1-9; and N is between 1-5. Optionally, an organic ligand may be bound to M. In alternative embodiments of the invention M may be a transition metal, such as Cu and Zn, M′ may be a metal such as Au, Ag, Hg and Cu, and Z may be a pseuodohalide, such as CN, SCN, SeCN, TeCN, OCN, CNO and NNN. In one particular embodiment a new class of [Metal(CN)2]-based coordination polymers with vapochromic properties is described, such as Cu[Au(CN)2]2 and Zn[Au(CN)2]2 polymers.
摘要翻译：本申请涉及可用于分析物检测的色素配位聚合物。可以通过可见的颜色变化，发光的变化和/或红外（IR）特征中的光谱变化来观察到紫外分析。上述色度变化中的一种或多种可以依赖于鉴定特定分析物，例如挥发性有机化合物或气体。色度变化可以是可逆的，以允许使用相同聚合物连续分析不同的分析物。聚合物具有通式MW [M'X（Z）Y] N，其中M和M'是与Z部分形成配位络合物的相同或不同的金属; Z选自卤化物，拟卤化物，硫醇盐，醇盐和酰胺; W在1-6之间; X和Y在1-9之间; N为1-5。任选地，有机配体可以结合到M.在本发明的备选实施方案中，M可以是过渡金属，例如Cu和Zn，M'可以是金属，例如Au，Ag，Hg和Cu，Z可以是一种pseuodohalide，如CN，SCN，SeCN，TeCN，OCN，CNO和NNN。在一个具体的实施方案中，描述了一类具有色相性质的[金属（CN）2]基配位聚合物，例如Cu [Au（CN）2] 2和Zn [Au（CN）2] 2聚合物）。

43. 发明申请

US20060165463A1 Wireless keyboard for hand-held computers 审中-公开
标题翻译：手持电脑的无线键盘
公开(公告)号：US20060165463A1
公开(公告)日：2006-07-27
申请号：US10500693
申请日：2003-01-03
申请人： Michael Katz
发明人： Michael Katz
IPC分类号： B41J5/14
CPC分类号： H01H13/86 , G06F1/1632 , G06F3/0221 , G06F3/0231 , H01H2223/05
摘要： Prior collapsible keyboards for personal digital assistants are overly complex and require different connecting hard-ware for different handheld devices. The present invention provides a folding keyboard for a hand-held computer or other information processing devices which folds up simply and in a small size and which is useful for touch typists. It communicates with the handheld device by a wireless connection which allows a single keyboard to be used with multiple types of handheld devices.
摘要翻译：用于个人数字助理的现有可折叠键盘过于复杂，需要不同手持设备的不同连接硬件。本发明提供了一种用于手持式计算机的折叠键盘或其它简单且小型化的信息处理装置，这对于触摸打字机是有用的。它通过无线连接与手持设备进行通信，该无线连接允许单个键盘与多种类型的手持设备一起使用。

44. 发明申请

US20060057728A1 Method to prevent urine specimen and other specimen substitution in substance use screening 审中-公开
标题翻译：防止尿样和其他标本置换的物质使用方法
公开(公告)号：US20060057728A1
公开(公告)日：2006-03-16
申请号：US11225892
申请日：2005-09-14
申请人： Michael Katz , Elinore McCance-Katz
发明人： Michael Katz , Elinore McCance-Katz
IPC分类号： G01N37/00
CPC分类号： G01N33/493 , Y10T436/13
摘要： Substitution of specimens (such as urine specimens) may be detected and even prevented by adding randomization to the collection and routing of specimens. A test taker is required to ingest an ingestible entity the nature of which is concealed from the test taker and others participating in the collection of the sample. The test-taker and unauthorized personnel collecting and routing the specimen are uninformed about fluorescence behavior (or lack of fluorescence) expected for an unsubstituted specimen. The nature of the ingestible entity that a test-taker must take is randomized, and the nature of the ingestible entity is closely held, such as by using bar coding or by using a marker undetectable by the naked eye.
摘要翻译：样本的替代（如尿标本）可能会被检测到，甚至可以通过添加随机化进行标本的收集和路由来防止。测试人员需要摄取一个可摄取的实体，其性质被参加收集样品的测试者和其他人隐藏。测试人员和未经授权的人员收集和路由样本对于未取消标本的荧光行为（或缺乏荧光）是不知情的。受试者必须服用的可摄入实体的性质是随机的，可摄取实体的性质是紧密的，例如通过使用条形码或使用肉眼可以检测到的标记。

45. 发明申请

US20050256174A1 Raf kinase inhibitors 审中-公开
标题翻译： Raf激酶抑制剂
公开(公告)号：US20050256174A1
公开(公告)日：2005-11-17
申请号：US11149332
申请日：2005-06-10
申请人： Jill Wood , Hanno Wild , Daniel Rogers , John Lyons , Michael Katz , Yolanda Caringal , Robert Dally , Wendy Lee , Roger Smith , Cheri Blum
发明人： Jill Wood , Hanno Wild , Daniel Rogers , John Lyons , Michael Katz , Yolanda Caringal , Robert Dally , Wendy Lee , Roger Smith , Cheri Blum
IPC分类号： A61K31/38 , A61K31/381 , A61K31/416 , A61K31/433 , C07D207/34 , C07D307/68 , C07D333/38 , C07D333/42 , C07D409/00 , C07D409/12 , C07D417/12
CPC分类号： C07D207/34 , C07D307/68 , C07D333/38 , C07D409/12 , C07D417/12 , C07D471/04
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译：治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。

46. 发明授权

US06913936B2 Immunological test kit comprising an immunologically invisible peg copolymer conjugated to one or more immunologically reactive substances 失效
标题翻译：免疫测试试剂盒包含与一种或多种免疫反应性物质缀合的免疫不可见的聚合物共聚物
公开(公告)号：US06913936B2
公开(公告)日：2005-07-05
申请号：US09982265
申请日：2001-10-17
申请人： Bo Qiu , Guobao Zhang , Stanley Stein , Leonard H Sigal , Michael Brunner , Michael Katz
发明人： Bo Qiu , Guobao Zhang , Stanley Stein , Leonard H Sigal , Michael Brunner , Michael Katz
IPC分类号： G01N33/543 , G01N33/545 , C07K17/06 , C07K17/08 , G01N33/546
CPC分类号： G01N33/543 , Y10S436/811 , Y10S436/823
摘要： A novel compound comprising an immunologically invisible polyethylene glycol copolymer is used to carry one or more immunologically reactive substances. The novel compounds may be used as part of kits for immunological assays.
摘要翻译：包含免疫隐性聚乙二醇共聚物的新型化合物用于携带一种或多种免疫反应性物质。新化合物可用作免疫测定试剂盒的一部分。

47. 外观设计

USD444133S1 Folding computer 失效
公开(公告)号：USD444133S1
公开(公告)日：2001-06-26
申请号：US29094616
申请日：1998-10-06
申请人： Michael Katz
设计人： Michael Katz

48. 发明授权

US5562313A Threadless connector for electrical conduits 失效
标题翻译：用于电气导管的无螺纹连接器
公开(公告)号：US5562313A
公开(公告)日：1996-10-08
申请号：US344486
申请日：1994-11-22
申请人： Alexey Piniaev , Simon Litvin , Alexander Ljubomirsky , Alexey Zakharov , Alexey Mishin , Michael Valdman , Michael Katz
发明人： Alexey Piniaev , Simon Litvin , Alexander Ljubomirsky , Alexey Zakharov , Alexey Mishin , Michael Valdman , Michael Katz
IPC分类号： F16L21/08 , F16L17/04
CPC分类号： F16L21/08
摘要： A threadless connector for cable pipes or electrical conduit that includes two half-couplings having tightening flanges along their lateral edges or faces. Female and male necks and beads extend along the cooperating lateral faces to form longitudinal seals when the half-couplings are clamped together. Internal radial grooves located near the outer parts of both ends of the half-couplings cooperate with split compression rings the outer surface of which compresses against the conic grooves and the inner edges bite into the connected pipe sections to form radial seals therewith. The half-couplings can be either two separate congruent parts or joined along one edge as desired.
摘要翻译：用于电缆管道或电气导管的无螺纹连接器，包括两个半连接件，沿其横向边缘或表面具有紧固法兰。当半联轴器夹在一起时，母和颈颈和珠沿着协作的侧面延伸以形成纵向密封。位于半联轴器两端的外部部分附近的内部径向槽与分离的压缩环配合，其分离的压缩环的外表面压缩锥形槽，并且内边缘咬入连接的管段以与其形成径向密封。半联轴器可以是两个独立的一致部件，也可以根据需要沿一个边缘连接。

49. 发明授权

US4552857A Cathode coating with hydrogen-evolution catalyst and semi-conducting polymer 失效
标题翻译：具有析氢催化剂和半导体聚合物的阴极涂层
公开(公告)号：US4552857A
公开(公告)日：1985-11-12
申请号：US365185
申请日：1982-04-05
申请人： Michael Katz , Jean Hinden , Jurgen Gauger
发明人： Michael Katz , Jean Hinden , Jurgen Gauger
IPC分类号： C25B11/04 , C25B11/06 , C25B11/10 , H01M4/88 , B05D5/12
CPC分类号： C25B11/0489
摘要： A cathode coating comprises a catalyst for hydrogen evolution finely dispersed in a matrix consisting of an insoluble, semiconducting polymer which is formed in situ on an electrode support body. A bipolar electrode is provided with such a cathode coating on a support body consisting of a valve metal such as titanium.The cathode coating is formed by applying to the electrode support body a coating solution which contains an inorganic precursor compound for the hydrogen evolution catalyst and an organic precursor compound for forming the polymer matrix, drying and then thermally converting these precursors to a cathode coating adhering to the electrode support body.
摘要翻译：阴极涂层包括精细分散在由在电极支撑体上原位形成的不溶性半导体聚合物构成的基质中的析氢催化剂。双极电极在由诸如钛的阀金属组成的支撑体上设置有这样的阴极涂层。阴极涂层通过向电极支撑体施加包含用于析氢催化剂的无机前体化合物和用于形成聚合物基质的有机前体化合物的涂布溶液形成，干燥然后将这些前体热转化成附着于电极支撑体。

50. 发明授权

US4435313A Electrode with outer coating for effecting an electrolytic process and protective intermediate coating on a conductive base, and method of making same 失效
标题翻译：具有外部涂层的电极，用于在导电性基底上进行电解处理和保护性中间涂层及其制造方法
公开(公告)号：US4435313A
公开(公告)日：1984-03-06
申请号：US293381
申请日：1981-08-17
申请人： Michael Katz , Jean M. Hinden , Jurgen F. Gauger
发明人： Michael Katz , Jean M. Hinden , Jurgen F. Gauger
IPC分类号： C25B11/04 , C25B11/08 , C25B11/10 , C25B11/16 , C25C7/02
CPC分类号： C25B11/16 , C25B11/0489 , C25C7/02
摘要： An electrode with an outer coating for effecting an electrolytic process is provided with a protective intermediate coating consisting of a conducting insoluble polymer network formed in situ on a titanium base and containing a small amount of finely dispersed platinum group metal catalyst.A method of manufacturing the electrode comprises applying to the titanium base several layers of a solution containing a polymer precursor and a platinum metal compound which are thermally converted to the protective polymer coating, on which the outer coating is formed, more particularly by electrodepositing manganese dioxide or lead dioxide.The polymeric intermediate coating serves to protect the titanium base from oxidation, and to more particularly provide stable electrode performance with economical use of precious metal.
摘要翻译：具有用于进行电解处理的外涂层的电极具有由在钛基上原位形成并含有少量微细分散的铂族金属催化剂的导电不溶性聚合物网络组成的保护性中间涂层。制造电极的方法包括向钛基底施加几层含有聚合物前体和铂金属化合物的溶液，其被热转化成形成外涂层的保护性聚合物涂层，更特别地通过电沉积二氧化锰或二氧化铅。聚合物中间涂层用于保护钛基免受氧化，并且更具体地提供经济使用贵金属的稳定的电极性能。

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