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    • 44. 发明申请
    • FLUID SAMPLE TRANSPORT DEVICE WITH REDUCED DEAD VOLUME FOR PROCESSING, CONTROLLING AND/OR DETECTING A FLUID SAMPLE
    • 具有减少死亡体积的流体样品运输装置用于处理,控制和/或检测流体样品
    • US20090130766A1
    • 2009-05-21
    • US12298951
    • 2007-04-23
    • Johannes Wilhelmus Weekamp
    • Johannes Wilhelmus Weekamp
    • G01N33/48B01L3/00G01N1/00
    • B01L3/50273B01L3/502707B01L3/502738B01L7/52B01L2200/143B01L2300/0627B01L2300/0645B01L2300/0816B01L2300/1822B01L2300/1827B01L2400/0478B01L2400/0481B01L2400/0655Y10T436/25Y10T436/2575
    • The present invention relates to a fluid sample transport device (1) with reduced dead volume for processing, controlling and/or detecting a fluid sample (3), comprising: a substrate (2), wherein the upper surface of said substrate (2) comprises at least one processing, controlling and/or detecting element (19); at least one flexible membrane (4), wherein the flexible membrane (5) is arranged on the upper surface of said substrate (2); at least one plunger (5) and/or actuating element (9) for actuating an up and/or down movement of the flexible membrane (4) to cause a fluid flow and/or to stop a fluid flow; at least one cover plate (6) arranged on the upper outer surface or lower outer surface of the flexible membrane (4), wherein the cover plate (6) comprises at least one through going hole (10) and/or cut-out (10) for receiving a plunger (5) and/or actuating element (9), so that movement of said plunger (5) and/or actuating element (9) causes a pump and/or valve action of the adjacent arranged flexible membrane area to cause a fluid flow between the upper surface of said substrate (2) and the lower surface of said flexible membrane (4); and wherein at least one channel (7) to direct the fluid sample (3) flow on the substrate (2) is temporally formed by the flexible membrane.
    • 本发明涉及一种流体样品输送装置(1),其具有减少的死体积用于处理,控制和/或检测流体样品(3),包括:基底(2),其中所述基底(2)的上表面, 包括至少一个处理,控制和/或检测元件(19); 至少一个柔性膜(4),其中所述柔性膜(5)布置在所述基底(2)的上表面上; 至少一个柱塞(5)和/或致动元件(9),用于致动柔性膜(4)的向上和/或向下运动以引起流体流动和/或停止流体流动; 至少一个盖板(6),布置在柔性膜(4)的上外表面或下外表面上,其中盖板(6)包括至少一个通孔(10)和/或切口 10),用于接收柱塞(5)和/或致动元件(9),使得所述柱塞(5)和/或致动元件(9)的运动导致相邻布置的柔性膜区域的泵和/或阀动作 在所述基板(2)的上表面和所述柔性膜(4)的下表面之间引起流体流动; 并且其中引导流体样品(3)的至少一个通道(7)在衬底(2)上流动,由柔性膜在时间上形成。
    • 47. 发明授权
    • Electrowetting device
    • 电动搅拌装置
    • US08854739B2
    • 2014-10-07
    • US13499918
    • 2010-09-29
    • Stein KuiperJohannes Wilhelmus Weekamp
    • Stein KuiperJohannes Wilhelmus Weekamp
    • G02B1/06G02B26/00G02B3/14
    • G02B3/14G02B26/005
    • The invention relates to an electrowetting-on-dielectric device (200). This is an electro wetting device comprising one or more cells, wherein each cell comprises an electrowetting composition of first and second immiscible fluids, the first fluid being an electrolytic solution (240), a first electrode (230), separated from the electrowetting composition by a dielectric (231), and a voltage source (260) for applying an operating voltage difference between the first electrode (230) and the electrolytic solution to operate the electrowetting device. According to the invention, the first electrode (230) of the electrowetting-on-dielectric device (200) comprises a valve metal, and the electrolytic solution (240) is capable of anodizing the valve metal to form a metal oxide at the operating voltage difference. This provides the electrowetting-on-dielectric device (200) with self-repairing properties thereby preventing breakdown of the dielectric. As a result, the electrowetting device can be operated at a low voltage, and it has an improved reliability.
    • 本发明涉及一种电润湿介电装置(200)。 这是一种包含一个或多个电池的电润湿装置,其中每个电池包括第一和第二不混溶流体的电润湿组合物,第一流体是电解溶液(240),第一电极(230),其与电润湿组合物分离, 电介质(231)和用于在第一电极(230)和电解液之间施加工作电压差以操作电润湿装置的电压源(260)。 根据本发明,电介质电介质器件(200)的第一电极(230)包括阀金属,并且电解溶液(240)能够在操作电压下阳极氧化阀金属以形成金属氧化物 区别。 这提供了具有自修复性能的电介质电介质器件(200),从而防止电介质的破坏。 结果,电润湿装置可以在低电压下操作,并且其可靠性提高。
    • 49. 发明申请
    • FLUID LENS WITH PRESSURE RELEASE SYSTEM
    • 带压力释放系统的流体镜
    • US20100277809A1
    • 2010-11-04
    • US12811831
    • 2009-01-12
    • Jan Frederik SuijverStein KuiperBernardus Hendrikus Wilhelmus HendriksSzabolcs DeladiAntonius Johannes Josephus RademakersCornelius Antonius Micolaas Maria Van Der VleutenJohannes Wilhelmus WeekampWaltherus Cornelis Jozef Bierhoff
    • Jan Frederik SuijverStein KuiperBernardus Hendrikus Wilhelmus HendriksSzabolcs DeladiAntonius Johannes Josephus RademakersCornelius Antonius Micolaas Maria Van Der VleutenJohannes Wilhelmus WeekampWaltherus Cornelis Jozef Bierhoff
    • G02B3/14A61B1/06
    • G02B7/008A61B1/0019G02B3/14G02B23/2407
    • Fluid lens system, e.g. for medical imaging or medical treatment, with a container enclosing a fluid arranged to refract incoming waves. A pressure release mechanism is in contact with the fluid so as to compensate changes in its volume due to thermal variations, e.g. during high temperature medical cleaning. This pressure release mechanism is positioned within a pathway of incoming waves. In preferred embodiments a fluid container connected via a tube to the fluid as a reservoir, is arranged within or outside the container, e.g. beyond an image sensor. Alternatively, an easily compressible body, e.g. a small closed metal bellows enclosing a gas, is positioned inside the fluid to absorb volume changes by compression. In both embodiments, the pressure release elements are preferably positioned in a peripheral part of the pathway of incoming waves to not affect performance of the lens. In another aspect, a fluid lens includes a container with an inner container part that fits inside an outer container part, wherein the inner container part is in rigid connection to at least a one boundary arranged for penetration of incoming waves. The pressure release mechanism is positioned within the outer container part, and it is in contact with the fluid so as to compensate changes in volume of the fluid due to thermal variations. In one embodiment the inner and outer container parts are arranged for relative one-dimensional movement and fluid tight interconnected. In another embodiment, a fluid filled cavity is formed between the inner and outer container parts, and this cavity houses a compressible body. The lens systems are suited for applications such as medical endoscopes, catheters and needles, optically as well as acoustically based.
    • 流体透镜系统,例如 用于医疗成像或医疗处理,容器包围布置成折射入射波的流体。 压力释放机构与流体接触,以便补偿由于热变化引起的体积变化,例如, 在高温医疗清洗过程中。 该压力释放机构位于入射波的通路内。 在优选实施例中,经由管连接到作为储存器的流体的流体容器设置在容器内或外部,例如, 超越图像传感器。 或者,容易压缩的主体,例如, 围绕气体的小封闭金属波纹管位于流体内部以通过压缩吸收体积变化。 在两个实施例中,压力释放元件优选地定位在入射波通路的周边部分中,从而不影响透镜的性能。 在另一方面,一种流体透镜包括具有内部容器部分的容器,该内部容器部分装配在外部容器部分内部,其中内部容器部分刚好连接至布置成用于穿透入射波的至少一个边界。 压力释放机构定位在外部容器部分内,并且与流体接触,以补偿由于热变化引起的流体体积的变化。 在一个实施例中,内部和外部容器部件布置用于相对一维运动并且流体密封互连。 在另一个实施例中,在内部和外部容器部分之间形成流体填充空腔,并且该空腔容纳可压缩体。 透镜系统适用于诸如医用内窥镜,导管和针的应用,光学和声学基础。