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    • 41. 发明授权
    • Symmetrical triazine derivatives
    • 对称三嗪衍生物
    • US07311897B2
    • 2007-12-25
    • US10804676
    • 2004-03-19
    • Thomas EhlisStefan MüllerPascal Hayoz
    • Thomas EhlisStefan MüllerPascal Hayoz
    • A61Q17/04A61Q19/00A61K8/00
    • C07D251/24A61K8/4966A61Q17/04
    • Disclosed is the use of the compounds of formula wherein A is a radical of formula R1 and R5 independently from each other are hydrogen; C1-C18alkyl; or C6-C12aryl; R2, R3 and R4 independently from each other are hydrogen; or a radical of formula wherein, in formula (1a), at least one of the radicals R2, R3 and R4 are a radical of formula (1c); R6, R7, R8, R9 and R10 independently from each other are hydrogen; hydroxy; halogen; C1-C18alkyl; C1-C18alkoxy; C6-C12aryl; biphenylyl; C6-C12aryloxy; C1-C18alkylthio; carboxy; —COOM; C1-C18-alkylcarboxyl; aminocarbonyl; or mono- or di-C1-C18alkylamino; C1-C10acylamino; —COOH; M is an alkali metal ion; x is 1 or 2; and y is a number from 2 to 10; for the protection of human and animal hair and skin against the damaging effect of UV radiation. The compounds of formula (1) are high effective UV absorbers for cosmetic formulations aund can be—depending on their physical properties be used in micronized or soluble form.
    • 公开了下式化合物的用途,其中A是式R 1和R 5的基团彼此独立地是氢; C 1 -C 18烷基; 或C 6 -C 12 - 芳基; R 2,R 3和R 4彼此独立地是氢; 或式(1a)的基团,其中在式(1a)中,基团R 2,R 3和R 4中的至少一个为 式(1c)的基团; R 6,R 7,R 8,R 9和R 10独立地是 彼此是氢; 羟基; 卤素; C 1 -C 18烷基; C 1 -C 18烷氧基; C 6 -C 12芳基; 联苯基 C 6 -C 12芳氧基; C 1 -C 18烷硫基; 羧基; -COOM; C 1 -C 18 - 烷基羧基; 氨基羰基; 或单或二-C 1 -C 18烷基氨基; C 1 -C 10酰基氨基; -COOH; M是碱金属离子; x为1或2; y为2〜10的数; 用于保护人体和动物毛发和皮肤免受紫外线辐射的破坏作用。 式(1)的化合物是用于化妆品制剂的高效UV吸收剂,可以取决于它们以微粉化或可溶形式使用的物理性质。
    • 42. 发明授权
    • Use of benzotriazole UV absorbers
    • 苯并三唑紫外线吸收剂的使用
    • US07179924B2
    • 2007-02-20
    • US11046913
    • 2005-01-31
    • Thomas Ehlis
    • Thomas Ehlis
    • C07D249/04
    • C08K5/3475A61K8/4966A61Q17/04C07D249/20
    • The use of benzotriazole UV absorbers of formula wherein A is a radical of formula B is a radical of formula R1, R2, R3, R4, R5 and R6 are each independently of the others hydrogen, C1–C16 alkyl; C5–C7cycloalkyl; halogen; R9 is hydrogen, C1–C12alkyl; or C5–C7cycloalkyl; R7, R8 and R10 are each independently of the others hydrogen, C1C12alkyl, C5–C7cycloalkyl, C1–C12hydroxyalkyl; X is halogen; a radical of formula (1s)  sulfate, phosphate, lactate, citrate, tartrate; R11 is C1–C12alkyl; or C5–C7cycloalkyl; R12 and R13 are each independently of the other hydrogen; or C1–C5alkyl; x is from 0 to 10; and y is from 1 to 20; in the cosmetic treatment of human hair for protection against UV radiation is described.
    • 使用下式的苯并三唑UV吸收剂其中A是式B的基团是式R 1,R 2,R 3, R 4,R 5和R 6各自独立地为氢,C 1 -C 3烷基, 烷基; C 5 -C 7环烷基; 卤素; R 9是氢,C 1 -C 12烷基; 或C 5 -C 7环烷基; R 7,R 8和R 10各自独立地为氢,C 1 -C 10烷基, C 1 -C 12烷基,C 5 -C 7环烷基,C 1 -C 12羟烷基,C 1 -C 12烷基, X是卤素; 硫酸盐,磷酸盐,乳酸盐,柠檬酸盐,酒石酸盐的式(1s)基团; R 11是C 1 -C 12烷基; 或C 5 -C 7环烷基; R 12和R 13各自独立地为氢; 或C 1 -C 5烷基; x为0〜10; y为1〜20; 在描述用于防止UV辐射的人发的美容处理中。
    • 45. 发明授权
    • Heat-sensitive coating compositions based on resorcinyl triazine derivatives
    • 基于间苯二酚三嗪衍生物的热敏涂料组合物
    • US08865620B2
    • 2014-10-21
    • US12529718
    • 2008-03-05
    • Allan Francis CunninghamThomas EhlisJean-Luc BirbaumPascal HayozKamalesh Pai Fondekar
    • Allan Francis CunninghamThomas EhlisJean-Luc BirbaumPascal HayozKamalesh Pai Fondekar
    • B41M5/333C09D5/26C08K5/3492C09D7/00
    • B41M5/3335B41M5/3336C08K5/3492C09D5/26C09D7/41Y10T428/24802
    • The present invention provides heat-sensitive coating compositions, which comprise a color developer of formula (1) or mixtures thereof wherein R1 can be hydrogen, C1-20-alkyl, C3-8-cycloalkyl, C2-10-alkenyl, aryl or SO3H, and R2 and R3 can be the same or different and can be hydrogen, halogen, C1-20-alkyl, C3-8-cyclo-alkyl, C2-10-alkenyl, aryl, OR6, NR7R8, SR9, SO3H or COOR10 and R4 and R5 can be the same or different, and can be hydrogen, halogen, C1-20-alkyl, C3-8-cyclo-alkyl, C2-10-alkenyl, aryl, OR6, NR7R8 or SR9, R6, R7, R8, R9 and R10 can be the same or different and can be hydrogen, C1-30-alkyl, C3-8-cycloalkyl, C2-10-alkenyl or aryl, wherein C1-20-alkyl can be unsubstituted or substituted with one or more C3-8-cycloalkyl, C2-10-alkenyl, phenyl, halogen, OR11, NR12R13, SR14, SO3H or COOR15, and aryl can be unsubstituted or substituted with one or more halogen, C1-10-alkyl, halogenated C1-10-alkyl, C3-8-cycloalkyl C2-10-alkenyl, phenyl, OR11, NR12R13, SR14, SO3H or COOR15, wherein R11, R12, R13, R14 and R15 can be the same or different and can be hydrogen, C1-10-alkyl, C3-8-cycloalkyl or C2-10-alkenyl, a process for the preparation of these compositions, a process of coating substrates with these compositions, substrates coated with these compositions, a process for preparing marked substrates using these compositions, marked substrates obtainable by the latter process, and certain color developers.
    • 本发明提供热敏涂料组合物,其包含式(1)的显色剂或其混合物,其中R 1可以是氢,C 1-20烷基,C 3-8 - 环烷基,C 2-10 - 烯基,芳基或SO 3 H ,R2和R3可以相同或不同,可以是氢,卤素,C 1-20烷基,C 3-8 - 环烷基,C 2-10 - 烯基,芳基,OR 6,NR 7 R 8,SR 9,SO 3 H或COOR 10和 R4和R5可以相同或不同,可以是氢,卤素,C 1-20烷基,C 3-8 - 环烷基,C 2-10 - 烯基,芳基,OR 6,NR 7 R 8或SR 9,R 6,R 7,R 8 ,R 9和R 10可以相同或不同,并且可以是氢,C 1-30 - 烷基,C 3-8 - 环烷基,C 2-10 - 烯基或芳基,其中C 1-20 - 烷基可以是未取代的或被一个或多个 C 3-8 - 环烷基,C 2-10 - 烯基,苯基,卤素,OR 11,NR 12 R 13,SR 14,SO 3 H或COOR 15,芳基可以是未被取代的或被一个或多个卤素取代,C 1-10烷基,卤代C 1-10 - 烷基,C 3-8 - 环烷基C2-10 - 烯基,苯基,OR11,NR12R13,SR14,SO3H或COOR15,其中 在R 11,R 12,R 13,R 14和R 15可以相同或不同,可以是氢,C 1-10 - 烷基,C 3-8 - 环烷基或C 2-10 - 烯基,一种制备这些组合物的方法, 涂覆这些组合物的基材,用这些组合物涂布的基材,使用这些组合物制备标记的基材的方法,通过后一方法获得的标记的底物和某些显色剂。
    • 48. 发明授权
    • Amino substituted hydroxyphenyl benzophenone derivatives
    • 氨基取代羟苯基二苯甲酮衍生物
    • US07374749B2
    • 2008-05-20
    • US10537940
    • 2003-12-03
    • Jürg HaaseThomas EhlisElek BorsosStefan Müller
    • Jürg HaaseThomas EhlisElek BorsosStefan Müller
    • A61K8/44A61K8/49C07D277/66C07D313/12C07C233/73C07C233/69C07C233/78C07C229/52
    • C07D295/192A61K8/42A61K8/44A61K8/49A61K8/4973A61Q17/04C07C229/52C07C237/32C07C237/34C07C237/40C07C237/42C07D277/46C07D277/66C07D313/12
    • Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R1, and R2 independently from each other are; C1-C20alkyl; C2-C20-alkenyl; C3-C10cycloalkyl; C3-C10cycloalkenyl; or R1, and R2 together with the linking nitrogen atom form a 5- or 6-membered heterocyclic ring; n1 is a number from 1 to 4; when n1=1, R3 is a saturated or unsaturated heterocyclic radical; hydroxy-C1-C5alkyl; cyclohexyl optionally substituted with one or more C1-C5alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C1-C5alkylcarboxy; when n1 is 2, R3 is an alkylene-, cycloalkylene- or alkenylene radical which is optionally substituted by a carbonyl- or carboxy group; o R3 together with A forms a bivalent radical of the formula (Ia), wherein n2 is a number from 1 to 3; when n1 is 3, R3 is an alkanetriyl radical; when n1 is 4, R3 is an alkanetetrayl radical; A is —O—; or —N(R5)—; and R5 is hydrogen; C1-C5alkyl; or hydroxy-C1-C5alkyl. The compounds are useful as UV filters in sunscreen applications.
    • 描述了式(I)的氨基取代的羟基苯基二苯甲酮衍生物,其中R 1和R 2彼此独立地是; C 1 -C 20烷基; C 1 -C 20烷基; C 2 -C 20 - 烯基; C 3 -C 10环烷基; C 3 -C 10环烯基; 或R 1和R 2与连接氮原子一起形成5-或6-元杂环; n 1是1至4的数; 当n 1 = 1时,R 3 3是饱和或不饱和杂环基; 羟基-C 1 -C 5烷基; 任选被一个或多个C 1 -C 5烷基取代的环己基; 任选被杂环基取代的苯基,氨基羰基或C 1 -C 5烷基羧基; 当n 1是2时,R 3是任选被羰基或羧基取代的亚烷基 - 亚环烷基 - 或亚烯基; R 3与A一起形成式(Ia)的二价基团,其中n 2是1至3的数; 当n 1为3时,R 3为烷三基; 当n 1为4时,R 3为烷基乙酰基; A为-O- 或-N(R 5) - ; 并且R 5是氢; C 1 -C 5烷基; 或羟基-C 1 -C 5烷基。 这些化合物可用作防晒霜中的紫外线过滤器。
    • 49. 发明授权
    • Use of benzotriazole UV absorbers
    • 苯并三唑紫外线吸收剂的使用
    • US07129198B1
    • 2006-10-31
    • US11171309
    • 2005-06-30
    • Thomas Ehlis
    • Thomas Ehlis
    • C11D3/28
    • A61K8/4966A61Q17/04C07D249/20C08K5/3475
    • The use of benzotriazole UV absorbers of formula wherein A is a radical of formula B is a radical of formula R1, R2, R3, R4, R5 and R6 are each independently of the others hydrogen, C1–C16alkyl; C5–C7cycloalkyl; halogen;R9 is hydrogen, C1–C12alkyl; or C5–C7cycloalkyl;R7, R8 and R10 are each independently of the others hydrogen, C1–C12alkyl, C5–C7cycloalkyl, C1–C12hydroxyalkyl;X is halogen; a radical of formula sulfate, phosphate, lactate, citrate, tartrate; R11 is C1–C12alkyl; or C5–C7cycloalkyl; R12 and R13 are each independently of the other hydrogen; or C1–C5alkyl; x is from 0 to 10; and y is from 1 to 20; in the cosmetic treatment of human hair for protection against UV radiation is described.
    • 使用下式的苯并三唑UV吸收剂其中A是式B的基团是式R 1,R 2,R 3, R 4,R 5和R 6各自独立地为氢,C 1 -C 3烷基, 烷基; C 5 -C 7环烷基; 卤素; R 9是氢,C 1 -C 12烷基; 或C 5 -C 7环烷基; R 7,R 8和R 10各自独立地为氢,C 1 -C 3 C 12 -C 12烷基,C 5 -C 7环烷基,C 1 -C 12羟烷基,C 1 -C 12烷基, X是卤素; 硫酸盐,磷酸盐,乳酸盐,柠檬酸盐,酒石酸盐; R 11是C 1 -C 12烷基; 或C 5 -C 7环烷基; R 12和R 13各自独立地为氢; 或C 1 -C 5烷基; x为0〜10; y为1〜20; 在描述用于防止UV辐射的人发的美容处理中。
    • 50. 发明申请
    • Triazine derivatives as uv absorbers
    • 三嗪衍生物作为紫外线吸收剂
    • US20060153783A1
    • 2006-07-13
    • US10542467
    • 2004-01-13
    • Thomas EhlisDietmar HuglinElek Borsos
    • Thomas EhlisDietmar HuglinElek Borsos
    • A61K8/49C07D251/18C07D403/02
    • C07D251/18C07D251/20
    • The present invention relates to new compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, and R8 independently from each other are hydrogen; C1-C18alkyl; C2-C18alkenyl; C5-C7, cycloalkyl; C1-C6alkylene-C5-C7, cycloalkyl; R9 is hydrogen; C1-C18alkyl; C2-C18alkenyl; C5-C7cycloalkyl; C1-C6alkylene-C5-C7cycloalkyl; C6-C10aryl; A is —S—; —O— or —NR10—, wherein R10 has the same meanings as R9; X is COOR11; CONR12R13; SO3, R14; or SO2NR15R16, wherein R11, R12, R13, R14, R15, and R16, have independently from each other the same meanings as R9; to their preparation and to their use as UV absorbers in cosmetic and pharmaceutical formulations.
    • 本发明涉及新的式(I)化合物,其中R 1,R 2,R 3,R 4, R 5,R 6,R 7和R 8彼此独立地是氢 ; C 1 -C 18烷基; C 2 -C 18链烯基; C 5 -C 7环烷基,环烷基, C 1 -C 6亚烷基-C 5 -C 7亚烷基,环烷基; R 9是氢; C 1 -C 18烷基; C 2 -C 18链烯基; C 5 -C 7环烷基; C 1 -C 6亚烷基-C 5 -C 7环烷基; C 6 -C 10芳基; A是-S-; -O-或-NR 10 - ,其中R 10具有与R 9相同的含义; X是COOR 11; CONR 12 R 13; SO 3,R 14; 或其中R 11,R 12,R 12,R 12,R 12, R 13,R 14,R 15和R 16,彼此独立地具有与 R 9; 用于制备和用作化妆品和药物制剂中的UV吸收剂。