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41. 发明申请

US20140154043A1 MICROPLATE HANDLING SYSTEMS AND RELATED COMPUTER PROGRAM PRODUCTS AND METHODS 审中-公开
标题翻译：微处理器系统及相关计算机程序产品及方法
公开(公告)号：US20140154043A1
公开(公告)日：2014-06-05
申请号：US14027781
申请日：2013-09-16
申请人： Steven A. Hofstadler , Jared J. Drader , Jose R. Gutierrez , Paul J. Gleason , Rex O. Bare , Robert D. Miller , Jeffrey C. Smith , Kevin S. Oberkramer , Ronald K. Bergold
发明人： Steven A. Hofstadler , Jared J. Drader , Jose R. Gutierrez , Paul J. Gleason , Rex O. Bare , Robert D. Miller , Jeffrey C. Smith , Kevin S. Oberkramer , Ronald K. Bergold
IPC分类号： G01N35/02
CPC分类号： G01N35/028 , G01N35/0095 , G01N2035/0425
摘要： Systems, computer program products, and methods useful for handling or managing microplates are provided.
摘要翻译：提供了用于处理或管理微孔板的系统，计算机程序产品和方法。

42. 发明授权

US08550694B2 Mixing cartridges, mixing stations, and related kits, systems, and methods 失效
标题翻译：混合墨盒，搅拌站以及相关工具包，系统和方法
公开(公告)号：US08550694B2
公开(公告)日：2013-10-08
申请号：US12560982
申请日：2009-09-16
申请人： Steven A. Hofstadler , Jared J. Drader , Jose R. Gutierrez , Rex O. Bare , Robert D. Miller , Jeffrey C. Smith
发明人： Steven A. Hofstadler , Jared J. Drader , Jose R. Gutierrez , Rex O. Bare , Robert D. Miller , Jeffrey C. Smith
IPC分类号： B01F7/04 , B01F11/00 , B01F7/00 , B01F15/00 , B01F15/06
CPC分类号： B01F7/00233 , B01F7/00291 , B01F7/004 , B01F7/04 , B01F11/0088 , B01F11/0091 , B01F13/002 , B01F13/003 , B01F13/08 , B01F13/1013 , B01F13/1022 , B01F15/00207 , B01F15/00467 , B01F15/0048 , B01F15/065 , B01F2015/00649 , B01F2015/062 , B01F2215/0032 , B01F2215/0037 , C12Q1/6806
摘要： Cartridges useful for mixing materials, such as fluidic materials are provided. A cartridge typically includes a body structure having surfaces that define a cavity with upper and lower portions. A rotatable member generally extends along a horizontal axis in the upper portion of the cavity. One or more protrusions typically extend outward from the rotatable member and into the lower portion of the cavity, and are configured to mix the material when the material is disposed in the cavity. Related mixing stations, systems, kits, and methods are also provided.
摘要翻译：提供了用于混合材料（如流体材料）的墨盒。盒通常包括具有限定具有上部和下部的空腔的表面的主体结构。可旋转构件通常沿着空腔的上部中的水平轴线延伸。一个或多个突起通常从可旋转构件向外延伸并且进入空腔的下部，并且被配置为当材料设置在空腔中时混合材料。还提供了相关的混合站，系统，试剂盒和方法。

43. 发明申请

US20130059372A1 SAMPLE PROCESSING UNITS, SYSTEMS, AND RELATED METHODS 失效
标题翻译：样品加工单元，系统和相关方法
公开(公告)号：US20130059372A1
公开(公告)日：2013-03-07
申请号：US13595189
申请日：2012-08-27
申请人： Steven A. Hofstadler , Jared J. Drader , Jose R. Gutierrez , Paul J. Gleason , Rex O. Bare , Robert D. Miller , Jeffrey C. Smith
发明人： Steven A. Hofstadler , Jared J. Drader , Jose R. Gutierrez , Paul J. Gleason , Rex O. Bare , Robert D. Miller , Jeffrey C. Smith
IPC分类号： C12M1/40 , G01N9/00 , G01N33/00 , G01N1/00 , H01J49/26 , G01N27/04 , G01K13/12 , G01L19/00 , G01F23/00
CPC分类号： G01N1/10 , G01N1/02 , G01N35/0098 , G01N35/025 , G01N2035/00524
摘要： Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.
摘要翻译：提供了用于混合和净化材料（如流体材料）的样品处理单元。样品处理单元通常包括被配置为容纳包含磁响应颗粒的样品和相对于容器处于基本固定位置的一个或多个磁体的容器。样品处理单元还通常包括输送机构，其构造成将容器输送到与磁体磁连通的位置，例如使得当添加其它材料时，具有捕获的分析物的磁响应颗粒可以保留在容器内到和/或从容器中取出。此外，样品处理单元还通常包括旋转机构，其被配置为旋转容器，例如以实现设置在容器内的样品材料的混合。还提供了相关的载体机构，样品处理站，系统和方法。

44. 发明授权

US08277422B2 Multi-chambered retractable safety syringe 有权
标题翻译：多腔可伸缩安全注射器
公开(公告)号：US08277422B2
公开(公告)日：2012-10-02
申请号：US12842885
申请日：2010-07-23
申请人： Richard B. Oliver , Daniel Thayer , Jeffrey Smith , Rex O. Bare
发明人： Richard B. Oliver , Daniel Thayer , Jeffrey Smith , Rex O. Bare
IPC分类号： A61M5/00
CPC分类号： A61M5/3234 , A61M2005/3151 , A61M2005/3224 , A61M2005/323 , A61M2005/3242
摘要： A retractable safety syringe may have a needle, needle holder, syringe body, and a plunger assembly. A proximal portion of the body and a piston of the plunger may define a vacuum chamber. The plunger assembly may comprise a distal piston and a proximal piston, with an intermediate chamber disposed between the two plungers. A vent through the syringe body pneumatically connects ambient air and the intermediate chamber allowing air to escape out of the intermediate chamber when a plunger assembly traversed toward the engaged position and allow air to be introduced into the intermediate chamber. A retraction force may be created by the vacuum chamber by traversing the plunger assembly to the engaged position. At the engaged position, the distal piston may engage the needle holder and the retraction force may retract the needle holder and needle into the syringe body to prevent accidental needle pricking and needle reuse.
摘要翻译：可伸缩的安全注射器可以具有针，针保持器，注射器主体和柱塞组件。主体的近端部分和柱塞的活塞可以限定真空室。柱塞组件可以包括远端活塞和近端活塞，其中设置在两个柱塞之间的中间室。通过注射器主体的通气气路连接环境空气和中间室，当柱塞组件朝向接合位置移动并允许空气被引入中间室时，允许空气从中间室逸出。通过将柱塞组件穿过接合位置，可以通过真空室产生回缩力。在接合位置，远端活塞可以接合针保持器，并且缩回力可以将针保持器和针缩回到注射器主体中，以防止意外针刺和针重复使用。

45. 发明授权

US08148163B2 Sample processing units, systems, and related methods 有权
公开(公告)号：US08148163B2
公开(公告)日：2012-04-03
申请号：US12561175
申请日：2009-09-16
申请人： Steven A. Hofstadler , Jared J. Drader , Jose R. Gutierrez , Paul J. Gleason , Rex O. Bare , Robert D. Miller , Jeffrey C. Smith
发明人： Steven A. Hofstadler , Jared J. Drader , Jose R. Gutierrez , Paul J. Gleason , Rex O. Bare , Robert D. Miller , Jeffrey C. Smith
IPC分类号： G01N27/00 , G01N27/72
CPC分类号： G01N1/10 , G01N1/02 , G01N35/0098 , G01N35/025 , G01N2035/00524
摘要： Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.

46. 发明授权

US07972300B2 Syringe 有权
标题翻译：注射器
公开(公告)号：US07972300B2
公开(公告)日：2011-07-05
申请号：US11439802
申请日：2006-05-24
申请人： Jeffrey Smith , Daniel Thayer , Rex O. Bare
发明人： Jeffrey Smith , Daniel Thayer , Rex O. Bare
IPC分类号： A61M5/00 , A61M5/32
CPC分类号： A61M5/3234 , A61M2005/3224 , A61M2005/3242
摘要： A retractable needle safety syringe is provided having a braking mechanism. The braking mechanism may be disposed at a proximal portion of a syringe body of the syringe. The braking mechanism may comprise a brake member which is traversable between a braking position and a released position. At the braking position, fingers of the brake member frictionally engage an outer surface of the shaft of a plunger of the syringe. The frictional engagement counterbalances a retraction force that urges a piston of the syringe toward a retracted position. When the brake members are traversed to the released position, the fingers do not press against the outer surface of the shaft. As such, the retraction force may traverse the piston toward the retracted position and traverse a needle and needle holder into the body of the syringe.
摘要翻译：提供具有制动机构的伸缩针安全注射器。制动机构可以设置在注射器的注射器主体的近端部分。制动机构可以包括可在制动位置和释放位置之间移动的制动构件。在制动位置，制动部件的指状物摩擦地接合注射器的柱塞的轴的外表面。摩擦接合抵消了将注射器的活塞推向缩回位置的回缩力。当制动构件横穿到释放位置时，手指不会压在轴的外表面上。因此，缩回力可以朝向缩回位置移动活塞，并且将针和针保持器穿过注射器的主体。

47. 发明申请

US20100219336A1 IONIZATION PROBE ASSEMBLIES 有权
标题翻译：离子探针组件
公开(公告)号：US20100219336A1
公开(公告)日：2010-09-02
申请号：US12705352
申请日：2010-02-12
申请人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
发明人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
IPC分类号： H01J49/10 , H01J49/04 , H01J49/26 , F23D11/32
CPC分类号： H01J49/165 , C12Q1/6872 , G01N23/00 , G01R31/2812 , G01R31/2848 , G01R31/2853 , H01J27/02 , H01J49/0422 , H01J49/0431 , H01J49/0468
摘要： The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.
摘要翻译：本发明一般涉及样品离子化，并且提供电离探针组件，系统，计算机程序产品和用于此目的的方法。

48. 发明申请

US20100128558A1 MIXING CARTRIDGES, MIXING STATIONS, AND RELATED KITS, SYSTEMS, AND METHODS 失效
标题翻译：混合盒，混合站及相关工具，系统和方法
公开(公告)号：US20100128558A1
公开(公告)日：2010-05-27
申请号：US12560982
申请日：2009-09-16
申请人： Steven A. Hofstadler , Jared J. Drader , Jose R. Gutierrez , Rex O. Bare , Robert D. Miller , Jeffrey C. Smith
发明人： Steven A. Hofstadler , Jared J. Drader , Jose R. Gutierrez , Rex O. Bare , Robert D. Miller , Jeffrey C. Smith
IPC分类号： B01F7/04 , B01F7/02 , B01F15/00
CPC分类号： B01F7/00233 , B01F7/00291 , B01F7/004 , B01F7/04 , B01F11/0088 , B01F11/0091 , B01F13/002 , B01F13/003 , B01F13/08 , B01F13/1013 , B01F13/1022 , B01F15/00207 , B01F15/00467 , B01F15/0048 , B01F15/065 , B01F2015/00649 , B01F2015/062 , B01F2215/0032 , B01F2215/0037 , C12Q1/6806
摘要： Cartridges useful for mixing materials, such as fluidic materials are provided. A cartridge typically includes a body structure having surfaces that define a cavity with upper and lower portions. A rotatable member generally extends along a horizontal axis in the upper portion of the cavity. One or more protrusions typically extend outward from the rotatable member and into the lower portion of the cavity, and are configured to mix the material when the material is disposed in the cavity. Related mixing stations, systems, kits, and methods are also provided.
摘要翻译：提供了用于混合材料（如流体材料）的墨盒。盒通常包括具有限定具有上部和下部的空腔的表面的主体结构。可旋转构件通常沿着空腔的上部中的水平轴线延伸。一个或多个突起通常从可旋转构件向外延伸并且进入空腔的下部，并且被配置为当材料设置在空腔中时混合材料。还提供了相关的混合站，系统，试剂盒和方法。

49. 发明申请

US20090305315A1 HUBBED DUAL CANNULA DEVICE FOR CLOSED CONTAINER SAMPLING SYSTEMS 审中-公开
标题翻译：用于封闭式集装箱采样系统的双通道装置（HUBBED DUAL CANNULA DEVICE FOR CLOSED CONTAINER SAMPLING SYSTEMS）
公开(公告)号：US20090305315A1
公开(公告)日：2009-12-10
申请号：US12480476
申请日：2009-06-08
申请人： Kent Raphael Gandola , David Elliott Kaplan , Rex O. Bare , Christopher Johann Johnson
发明人： Kent Raphael Gandola , David Elliott Kaplan , Rex O. Bare , Christopher Johann Johnson
IPC分类号： C12Q1/56 , C12M1/26 , C12Q1/02
CPC分类号： B01L3/563 , A61M2039/0202 , B01L3/50825 , B01L2400/0487 , B01L2400/0694
摘要： The present invention provides a hubbed dual cannula device for extracting a fluid sample from a closed container. The device comprises a housing hub, two substantially parallel needles, a venting valve and a hydrophobic membrane, and may be used effectively to extract a fluid sample from a sealed container, such as a vacuum tube, without damaging the cellular components or activating platelets in the fluid sample. Also provided are methods for using the disclosed device to extract a fluid sample from a closed container and kits for measuring platelet aggregation using such a device.
摘要翻译：本发明提供了一种用于从密闭容器中提取流体样品的轮毂式双插管装置。该装置包括壳体毂，两个基本上平行的针，通气阀和疏水膜，并且可以有效地用于从诸如真空管的密封容器中提取流体样品，而不损坏细胞组分或激活血小板流体样品。还提供了使用所公开的装置从密封容器中提取流体样品的方法以及用于使用这种装置测量血小板聚集的试剂盒。

50. 发明授权

US5665653A Method for encapsulating an electrochemical sensor 失效
标题翻译：封装电化学传感器的方法
公开(公告)号：US5665653A
公开(公告)日：1997-09-09
申请号：US412705
申请日：1995-03-29
申请人： Rex O. Bare , Andy Scherer
发明人： Rex O. Bare , Andy Scherer
IPC分类号： G01N27/28 , H01L25/04 , H01L23/31 , H01L25/16
CPC分类号： G01N27/414 , H01L2224/48091
摘要： An electrochemical sensor assembly which allows a solution to make contact with an active sensing area of a sensor, while constraining the solution such that the fluid does not contact the sensor electronics and a method for fabricating such a sensor assembly. A sensor assembly is fabricated in accordance with a simple process, including: fabricating a master pattern which matches the external profile of an epoxy shell which will encapsulate a substrate upon which the sensors are mounted; forming a flexible tool (or mold) which conforms to the general profile of the master pattern; placing sensors together with any other desired electronic circuitry on a substrate (such as a printed circuit board or a ceramic pad to form a "hybrid"); pressing a number of electrical contact points on the hybrid and the active sensing area of each sensor on the substrate into contact with flexible protrusions of the flexible tool; and potting the hybrid. Due to the fact that the protrusions from the flexible tool are in contact with the hybrid and structures thereon, a seal is formed to prevent potting material from contacting and covering the predetermined areas of the hybrid covered by the protrusions from the flexible tool.
摘要翻译：一种电化学传感器组件，其允许溶液与传感器的主动感测区域接触，同时约束溶液，使得流体不接触传感器电子器件以及用于制造这种传感器组件的方法。根据简单的过程制造传感器组件，包括：制造匹配环氧树脂外壳的外部轮廓的主图案，其将封装安装有传感器的基板; 形成符合主图案的一般轮廓的柔性工具（或模具）; 将传感器与任何其它所需的电子电路放置在基板（例如印刷电路板或陶瓷垫以形成“混合”）上; 将混合物上的多个电接触点和基板上每个传感器的主动感测区域按压与柔性工具的柔性突起接触; 和灌封杂交。由于来自柔性工具的突起与其上的混合物和结构接触，形成密封件以防止灌封材料接触并覆盖由柔性工具由突起物覆盖的混合物的预定区域。

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