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41. 发明申请

US20050003345A1 Synthetic antigens for the detection of antibodies to hepatitis C virus 审中-公开
公开(公告)号：US20050003345A1
公开(公告)日：2005-01-06
申请号：US10822871
申请日：2004-04-13
申请人： Robert Deleys , Dirk Pollet , Geert Maertens , Hugo Van Heuverswijn
发明人： Robert Deleys , Dirk Pollet , Geert Maertens , Hugo Van Heuverswijn
IPC分类号： A61K38/00 , A61K38/04 , A61K38/12 , A61K39/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/02 , C07K14/10 , C07K14/18 , C07K16/00 , C07K17/00 , C12Q1/70 , G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S436/82 , Y10S530/826
摘要： Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific assays for the detection of antibodies to HCV, for the detection of HCV antigens, or as immunogens.

42. 发明授权

US06613333B1 Immunodominant human T-cell epitopes of hepatitis C virus 失效
标题翻译：丙型肝炎病毒的免疫显性人类T细胞表位
公开(公告)号：US06613333B1
公开(公告)日：2003-09-02
申请号：US08974690
申请日：1997-11-19
申请人： Geert Leroux-Roels , Robert Deleys , Geert Maertens
发明人： Geert Leroux-Roels , Robert Deleys , Geert Maertens
IPC分类号： A61K3929
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2770/24222 , C12N2770/36022 , Y10S530/806 , Y10S530/826
摘要： The present invention relates to a polypeptide of about 8 to about 100 amino acids comprising or consisting of at least 8 contiguous amino acids selected from the core, and/or the NS3 regions of the HCV polyprotein, with said contiguous amino acids containing a T-cell stimulating epitope.
摘要翻译：本发明涉及约8至约100个氨基酸的多肽，其包含或由选自HCV多蛋白的核心和/或NS3区域的至少8个连续氨基酸组成，所述连续氨基酸含有T- 细胞刺激表位。

43. 发明授权

US5910404A Synthetic antigens for the detection of antibodies to hepatitis C virus 失效
公开(公告)号：US5910404A
公开(公告)日：1999-06-08
申请号：US466975
申请日：1995-06-06
申请人： Robert J. Deleys , Dirk Pollet , Geert Maertens , Hugo Van Heuverswijn
发明人： Robert J. Deleys , Dirk Pollet , Geert Maertens , Hugo Van Heuverswijn
IPC分类号： A61K38/00 , A61K38/04 , A61K38/12 , A61K39/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/02 , C07K14/10 , C07K14/18 , C07K16/00 , C07K17/00 , C12Q1/70 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/576
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S436/82 , Y10S530/826
摘要： Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific assays for the detection of antibodies to HCV, for the detection of HCV antigens, or as immunogens.

44. 发明授权

US5846704A Process for typing of HCV isolates 失效
标题翻译： HCV分离株的分型方法
公开(公告)号：US5846704A
公开(公告)日：1998-12-08
申请号：US256568
申请日：1994-07-18
申请人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
发明人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
IPC分类号： C12N15/09 , C07H21/04 , C12N15/40 , C12Q1/02 , C12Q1/68 , C12Q1/70 , C12N9/34
CPC分类号： C12Q1/707 , C12Q1/6834
摘要： A method of genotyping of HCV isolates using probes targeting sequences from the 5- untranslated region of HCV.
摘要翻译： PCT No.PCT / EP93 / 03325 Sec。 371日期：1994年7月18日 102（e）1994年7月18日PCT 1993年11月26日PCT公布。公开号WO94 / 12670 日期1994年6月9日使用来自HCV的5-非翻译区的序列的探针对HCV分离株进行基因分型的方法。

45. 发明授权

US07855052B2 Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents 失效
标题翻译：丙型肝炎病毒基因型的序列及其作为治疗和诊断剂的用途
公开(公告)号：US07855052B2
公开(公告)日：2010-12-21
申请号：US11606236
申请日：2006-11-30
申请人： Geert Maertens , Lieven Stuyver
发明人： Geert Maertens , Lieven Stuyver
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04 , C12N15/33 , C12N15/11 , C12N15/34 , C12N15/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2770/24222
摘要： The present application discloses and claims polynucleic acids relating to and/or containing HCV polynucleic acid sequences.
摘要翻译：本申请公开并要求涉及和/或含有HCV多核酸序列的多核酸。

46. 发明授权

US07129337B1 Sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents 失效
标题翻译：丙型肝炎病毒基因型序列及其作为预防，治疗和诊断剂的用途
公开(公告)号：US07129337B1
公开(公告)日：2006-10-31
申请号：US08836075
申请日：1995-10-23
申请人： Geert Maertens , Lieven Stuyver
发明人： Geert Maertens , Lieven Stuyver
IPC分类号： C12Q1/68 , C07H21/02 , A61K39/29
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , C12N2770/24222
摘要： The present invention relates to new genomic nucleotide sequences and amino acid sequences corresponding to the coding region of these genomes. The invention relates to new HCV types and subtypes sequences which are different from the known HCV types and subtypes sequences. More particularly, the present invention relates to new HCV type 7 sequences, new HCV type 9 sequences, new HCV type 10 and new HCV type 11 sequences. Also, the present invention relates to new HCV type 1 sequences of subtypes 1d, 1e, 1f and 1g; new HCV type 2 sequences of subtypes 2e, 2f, 2g, 2h, 2i, 2k and 2l; new HCV type 3 sequences of subtype 3g, new HCV type 4 sequences of subtypes 4k, 4l and 4m; a process for preparing them, and their use for diagnosis, prophylaxis and therapy. More particularly, the present invention provides new type-specific sequences of the Core, the E1 and the NS5 regions of new HCV types 7, 9, 10 and 11, as well as of new variants (subtypes) of HCV types 1, 2, 3 and 4. These new HCV sequences are useful to diagnose the presence of HCV type 1, and/or type 2, and/or type 3, and/or type 4, and/or type 7, and/or type 9, and/or type 10, and/or type 11 genotypes or serotypes in a biological sample. Moreover, the availability of these new type-specific sequences can increase the overall sensitivity of HCV detection and should also prove to be useful for prophylactic and therapeutic purposes.
摘要翻译：本发明涉及对应于这些基因组的编码区的新的基因组核苷酸序列和氨基酸序列。本发明涉及与已知的HCV类型和亚型序列不同的新的HCV类型和亚型序列。更具体地，本发明涉及新的HCV 7型序列，新型HCV 9型序列，新型HCV 10型和新型HCV 11型序列。此外，本发明涉及新型的1型，1e型，1型和1型的HCV型1型序列; 亚型2e，2f，2g，2h，2i，2k和2l的新HCV 2型序列; 亚型3g的新HCV 3型序列，亚型4k，4l和4m的新型HCV 4型序列; 它们的制备过程及其在诊断，预防和治疗中的应用。更具体地，本发明提供新型HCV 7型，9型，10型和11型的核心，E1和NS5区域的新型特异性序列，以及HCV类型1,2和2的新变体（亚型）这些新的HCV序列可用于诊断HCV 1型和/或2型和/或3型和/或4型和/或7型和/或9型的存在，以及 /或10型，和/或11型基因型或血清型。此外，这些新型特异性序列的可用性可以提高HCV检测的总体灵敏度，并且还应证明可用于预防和治疗目的。

47. 发明授权

US06689368B1 Immunodominant human T-cell epitopes of hepatitis C virus 失效
标题翻译：丙型肝炎病毒的免疫显性人类T细胞表位
公开(公告)号：US06689368B1
公开(公告)日：2004-02-10
申请号：US08974685
申请日：1997-11-19
申请人： Geert Leroux-Roels , Robert Deleys , Geert Maertens
发明人： Geert Leroux-Roels , Robert Deleys , Geert Maertens
IPC分类号： A61K3929
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2770/24222 , C12N2770/36022 , Y10S530/806 , Y10S530/826
摘要： The present invention relates to a polypeptide of about 8 to about 100 amino acids comprising or consisting of at least 8 contiguous amino acids selected from the core, and/or the NS3 regions of the HCV polyprotein, with said contiguous amino acids containing a T-cell stimulating epitope.
摘要翻译：本发明涉及约8至约100个氨基酸的多肽，其包含或由选自HCV多蛋白的核心和/或NS3区域的至少8个连续氨基酸组成，所述连续氨基酸含有T- 细胞刺激表位。

48. 发明授权

US06548244B2 Process for typing HCV isolates 失效
标题翻译：分离HCV分离株的方法
公开(公告)号：US06548244B2
公开(公告)日：2003-04-15
申请号：US09899044
申请日：2001-07-06
申请人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
发明人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
IPC分类号： C12Q170
CPC分类号： C12Q1/707 , C12Q1/6834 , C12Q2563/131 , C12Q2545/101 , C12Q2525/101 , C12Q2531/113
摘要： The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: contacting said sample in which the ribonucleotides or deoxyribonucleotides have been made accessible, if need be, under suitable denaturation, with at least one probe from about 10 to about 40 nucleotides, with said probe being liable to hybridize to a region being in the domain extending from nucleotide at position −291 to nucleotide at position −66 of the 5′ untranslated region of one of the HCV isolates represented by their cDNA sequences, with said numbering of position beginning with the first ATG codon of the open reading frame encoding the HCV polyprotein, or with said probe being complementary to the above-defined probes, detecting the complexes possibly formed between said probe and the nucleotide sequence of the HCV isolate to be identified.
摘要翻译：本发明涉及用于对先前鉴定为HCV阳性的生物样品中存在的任何HCV分离物进行基因分型的方法，以及根据与其它HCV分离株的同源性百分比对所述分离物进行分类的方法，包括以下步骤：如果需要的话，核糖核苷酸或脱氧核糖核苷酸可以在合适的变性下与至少一个约10至约40个核苷酸的探针接触，所述探针易于与位置延伸的结构域延伸的区域杂交。 291到由其cDNA序列表示的HCV分离物之一的5'非翻译区的-66位的核苷酸，其中所述编号的位置开始于编码HCV多聚蛋白的开放阅读框的第一个ATG密码子，或与所述探针与上述定义的探针互补，检测可能形成于所述探针和HCV核苷酸序列之间的复合物分离鉴定。

49. 发明授权

US06287761B1 Synthetic antigens for the detection of antibodies to hepatitis C virus 失效
标题翻译：用于检测丙型肝炎病毒抗体的合成抗原
公开(公告)号：US06287761B1
公开(公告)日：2001-09-11
申请号：US09275265
申请日：1999-03-23
申请人： Robert J. Deleys , Dirk Pollet , Geert Maertens , Hugo Van Heuverswijn
发明人： Robert J. Deleys , Dirk Pollet , Geert Maertens , Hugo Van Heuverswijn
IPC分类号： G01N33576
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S436/82 , Y10S530/826
摘要： Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific assays for the detection of antibodies to HCV, for the detection of HCV antigens, or as immunogens.
摘要翻译：提供肽序列，其能够模拟HCV编码的蛋白质，用作筛选血液和血液制品以用于先前暴露于HCV的试剂。肽长度至少为5个氨基酸，可用于检测HCV抗体，检测HCV抗原或作为免疫原的各种特异性检测中。

50. 发明申请

US20120270208A1 SYNTHETIC ANTIGENS FOR THE DETECTION OF ANTIBODIES TO HEPATITIS C VIRUS 审中-公开
标题翻译：用于检测丙型肝炎病毒抗体的合成抗生素
公开(公告)号：US20120270208A1
公开(公告)日：2012-10-25
申请号：US13478377
申请日：2012-05-23
申请人： Robert J. DELEYS , Dirk Pollet , Geert Maertens , Hugo Van Heuverswjn
发明人： Robert J. DELEYS , Dirk Pollet , Geert Maertens , Hugo Van Heuverswjn
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S436/82 , Y10S530/826
摘要： Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific assays for the detection of antibodies to HCV, for the detection of HCV antigens, or as immunogens.
摘要翻译：提供肽序列，其能够模拟HCV编码的蛋白质，用作筛选血液和血液制品以用于先前暴露于HCV的试剂。肽长度至少为5个氨基酸，可用于检测HCV抗体，检测HCV抗原或作为免疫原的各种特异性检测中。

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