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41. 发明授权

US6106469A Method and apparatus for reducing undesired multiple-echo signal in ultrasound imaging 失效
标题翻译：用于减少超声成像中不需要的多重回波信号的方法和装置
公开(公告)号：US6106469A
公开(公告)日：2000-08-22
申请号：US299002
申请日：1999-04-26
申请人： Takao Suzuki , Hisashi Hagiwara , Hiroshi Fukukita
发明人： Takao Suzuki , Hisashi Hagiwara , Hiroshi Fukukita
IPC分类号： A61B8/00 , G01S7/52 , G01S15/89
CPC分类号： G01S15/894 , G01S7/52026
摘要： First 1-sound-line received signals are successively generated from an output signal of a transducer. One is selected from among the generated first 1-sound-line received signals as a 1-sound-line received signal of interest. Second 1-sound-line received signals are selected from among the generated first 1-sound-line received signals. The second 1-sound-line received signals include a 1 -sound-line received signal preceding the 1-sound-line received signal of interest and also a 1-sound-line received signal following the 1-sound-line received signal of interest. The second 1-sound-line received signals are averaged into a mean 1-sound-line received signal which corresponds to an undesired multiple-echo signal. The mean 1-sound-line received signal is subtracted from the 1-sound-line received signal of interest to remove the undesired multiple-echo signal from the 1-sound-line received signal of interest.
摘要翻译：从换能器的输出信号连续生成第一个1声线接收信号。从所生成的第一1-声线接收信号中选择一个作为感兴趣的1-声线接收信号。从生成的第一1声线接收信号中选择第2个1声线接收信号。第二个1声线接收信号包括在感兴趣的1声线接收信号之前的1声线接收信号，以及跟随感兴趣的1-声线接收信号之后的1-声线接收信号。第二个1声线接收信号被平均为对应于不期望的多回波信号的平均1声线接收信号。从感兴趣的1声线接收信号中减去平均1声线接收信号，以从感兴趣的1声线接收信号中去除不想要的多回波信号。

42. 发明授权

US5261407A Ultrasonic doppler blood-flow meter 失效
标题翻译：超声波多普勒血流计
公开(公告)号：US5261407A
公开(公告)日：1993-11-16
申请号：US796596
申请日：1991-11-22
申请人： Mori Nishigaki , Hiroshi Fukukita , Hisashi Hagiwara , Junichiro Ninomiya
发明人： Mori Nishigaki , Hiroshi Fukukita , Hisashi Hagiwara , Junichiro Ninomiya
IPC分类号： A61B8/06 , G01P5/00 , G01S15/89 , H03F1/30 , H03G3/34
CPC分类号： H03G3/34 , G01S15/8979 , H03F1/303
摘要： There is provided an ultrasonic Doppler blood-flow meter which can suppress the occurrence of unwanted frequency components by suppressing the jump of signal to thereby produce images of high quality A DC feedback circuit is provided which negatively feeds back a Doppler deviated signal produced from an integrator to the input thereof. The feedback amount of the DC feedback circuit is changed in synchronism with the timing for switching between the B-mode transmission/reception sequence and the Doppler mode sequence to prevent a jump of a signal at the commencement of the Doppler mode. The feedback amount of the DC feedback circuit is made to be different for the gate moving sequence and the Doppler mode sequence, thereby preventing a jump of a transient signal due to a discontinuous input signal at the commencement of the Doppler mode.

43. 发明申请

US20100323432A1 SAMPLE PROCESSING DEVICE FOR MICROCHIP 审中-公开
标题翻译：用于微型计算机的样品处理装置
公开(公告)号：US20100323432A1
公开(公告)日：2010-12-23
申请号：US12677419
申请日：2008-09-05
申请人： Minoru Asogawa , Hisashi Hagiwara , Tohru Hiramatsu
发明人： Minoru Asogawa , Hisashi Hagiwara , Tohru Hiramatsu
IPC分类号： C12M1/34 , B01L3/00
CPC分类号： B01L3/5027 , B01F11/0071 , B01F13/0059 , B01L3/50273 , B01L7/52 , B01L2300/0809 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2300/163 , B01L2400/0481 , B01L2400/0487 , B01L2400/0666 , G01N35/00029 , G01N2035/00544
摘要： A sample processing device for a microchip, including: a sample vessel for packing a sample therein; and a reaction vessel which is continuous with the sample vessel through a channel, and to which the sample is sequentially delivered to be packed and mixed therein, in which the sample is repeatedly delivered between the sample vessel and the reaction vessel through the channel so that the sample is stirred and mixed.
摘要翻译：一种用于微芯片的样品处理装置，包括：用于在其中包装样品的样品容器; 以及反应容器，其通过通道与样品容器连续，并且将样品依次递送到其中进行填充和混合，其中通过通道将样品重复地输送到样品容器和反应容器之间，使得将样品搅拌并混合。

44. 发明申请

US20090202391A1 MICRO PASSAGE CHIP AND FLUID TRANSFERRING METHOD 有权
标题翻译：微通道芯片和流体传输方法
公开(公告)号：US20090202391A1
公开(公告)日：2009-08-13
申请号：US12307403
申请日：2007-07-04
申请人： Hisashi Hagiwara , Yoshinori Mishina
发明人： Hisashi Hagiwara , Yoshinori Mishina
IPC分类号： B01J19/00 , F17D3/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01J2219/00889 , B01J2219/00891 , B01L3/50273 , B01L2200/12 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/12 , B01L2400/0481 , B01L2400/0633 , B01L2400/0672 , F04B43/043 , Y10T137/0318 , Y10T137/0324 , Y10T137/0352 , Y10T137/0396 , Y10T137/1624 , Y10T428/24612
摘要： There is provided by the present invention a novel micro passage chip having such a structure that a fluid can be transferred without using a physical or mechanical squeezing means that is applied from above the substrate of the micro passage chip. The micro passage chip of the present invention comprises at least a first substrate, a second substrate, and an intermediate substrate interposed between the first substrate and the second substrate and is characterized in that a first non-adhesive thin-film layer is formed on at least one of the mating sides of the first substrate and the intermediate substrate and at least one port for fluids that is in contact with the first non-adhesive thin-film layer and which is open to the outer surface of the first substrate is provided in any position on the first non-adhesive thin-film layer, and that at least a portion of a second non-adhesive thin-film layer whose length is either the same as or different from that of the first non-adhesive thin-film layer is formed on at least one of the mating sides of the second substrate and the intermediate substrate such that it lies either above or under the first non-adhesive thin-film layer, with the intermediate substrate lying in between, and a pressurizing port that is in contact with the second non-adhesive thin-film layer and which is open to the outer surface of the first or the second substrate is provided in at least one area on the second non-adhesive thin-film layer.
摘要翻译：本发明提供了一种新颖的微通道芯片，具有这样一种结构，可以在不使用从微通道芯片的基板上方施加的物理或机械挤压装置的情况下传送流体。本发明的微通道芯片至少包括插入在第一基板和第二基板之间的第一基板，第二基板和中间基板，其特征在于，在第一基板，第二基板和第二基板之间形成第一非粘性薄膜层第一基板和中间基板的配合侧中的至少一个以及与第一非粘合薄膜层接触并且与第一基板的外表面开口的流体的至少一个端口设置在在第一非粘合薄膜层上的任何位置，以及长度与第一非粘性薄膜层的长度相同或不同的第二非粘性薄膜层的至少一部分形成在第二基板和中间基板的至少一个配合侧上，使得其位于第一非粘合薄膜层的上方或下方，中间基板位于其间，并且在第二非粘合薄膜层上的至少一个区域上设置与第二非粘合薄膜层接触且与第一或第二基板的外表面开口的加压口。

45. 发明授权

US07331928B2 Ultrasonic doppler bloodstream measurement device 有权
标题翻译：超声多普勒血流测量装置
公开(公告)号：US07331928B2
公开(公告)日：2008-02-19
申请号：US10534959
申请日：2004-02-17
申请人： Takao Seki , Hisashi Hagiwara
发明人： Takao Seki , Hisashi Hagiwara
IPC分类号： A61B8/06 , A61B8/00
CPC分类号： A61B8/06
摘要： The present invention is for an ultrasonic Doppler blood flow measurement device with which high-speed computation is possible, even when a memory having the characteristic of different read/write speeds in the row direction and the column direction is used for the buffer memory when computing blood flow information, without being affected by the slower read/write speed. It is provided with a large capacity memory section 10 that is constituted by a memory that has a two-dimensional address space and different data read/write speeds in the row direction and the column direction of that address space, and that stores detection signals, a blood flow computation section 6 that calculates blood flow information from the detection signals, a small capacity memory section 12 that has the capacity of at least the data amount required for the blood flow computation section 6 to compute any one depth point of an object to be examined, and a large capacity memory control section 9 that performs data transfer from the large capacity memory section 10 to the small capacity memory section 12 in the row direction only.
摘要翻译：本发明是为了能够进行高速计算的超声波多普勒血流测定装置，即使在计算缓冲存储器时，在行方向和列方向上具有不同读/写速度特性的存储器被用于缓冲存储器血流信息，而不受较慢的读/写速度的影响。设置有大容量存储器部分10，其由具有二维地址空间和在该地址空间的行方向和列方向上的不同数据读/写速度的存储器构成，并且存储检测信号，根据检测信号计算血流信息的血流计算部6，至少具有血流计算部6所需的数据量的能力的小容量存储部12，计算对象的任意一个深度点以及大容量存储器控制部分9，其仅在行方向上执行从大容量存储器部分10到小容量存储器部分12的数据传送。

46. 发明授权

US06802815B2 Noninvasive continuous blood pressure measuring apparatus and a method of noninvasively measuring continuous blood pressure 失效
标题翻译：无创连续血压测量仪器和无创测量连续血压的方法
公开(公告)号：US06802815B2
公开(公告)日：2004-10-12
申请号：US10721083
申请日：2003-11-26
申请人： Kinya Hasegawa , Yushi Nishimura , Hisashi Hagiwara
发明人： Kinya Hasegawa , Yushi Nishimura , Hisashi Hagiwara
IPC分类号： A61B500
CPC分类号： A61B5/02133 , A61B5/021 , A61B5/02116 , A61B2562/0247 , A61B2562/043
摘要： One of pairs of an exciter and a sensor is selected in accordance with the detection signal which is derived from an exciter waveform induced in an artery transmitted therethrough. The pairs of exciters and sensors are arranged on a substrate in various formations. A/D converters are provided to respective detection signals. A frequency of the oscillation signal supplied to the exciter is controlled by various oscillation signal generation circuits. Bandpass filtering for extracting the exciter waveform, low-pass-filtering for extracting a natural blood pressure waveform, phase difference detection processes are provided by a microprocessor, wherein the bandpass filtering and low-pass-filtering processes may be replaced with a bandpass filter and a low pass filter, and their outputs are selected by a switching circuit and supplied to the microprocessor through one a/d converter. The frequency of the oscillation signal is controlled to an optimum frequency by detecting the detection signal and estimating the attenuation, dispersion, phase shift with respect to different frequency and by determining one of the different frequency in accordance with the estimation result. The waveform of the oscillation signal is controlled to an optimum waveform similarly.
摘要翻译：根据从通过其传输的动脉中感应的激励器波形导出的检测信号来选择一对激励器和传感器。激励器和传感器对被布置在各种形式的基板上。 A / D转换器被提供给相应的检测信号。提供给励磁机的振荡信号的频率由各种振荡信号发生电路控制。用于提取激励器波形的带通滤波器，用于提取自然血压波形的低通滤波，相位差检测处理由微处理器提供，其中带通滤波和低通滤波处理可以被带通滤波器代替，低通滤波器，其输出由开关电路选择，并通过一个a / d转换器提供给微处理器。通过检测检测信号并估计相对于不同频率的衰减，色散，相移以及根据估计结果确定不同频率之一，将振荡信号的频率控制到最佳频率。振荡信号的波形类似地被控制到最佳波形。

47. 发明授权

US06364836B1 Ultrasound diagnostic apparatus 失效
标题翻译：超声诊断仪
公开(公告)号：US06364836B1
公开(公告)日：2002-04-02
申请号：US09634857
申请日：2000-08-08
申请人： Hiroshi Fukukita , Morio Nishigaki , Hisashi Hagiwara
发明人： Hiroshi Fukukita , Morio Nishigaki , Hisashi Hagiwara
IPC分类号： A61B800
CPC分类号： G01S7/52066 , G01S7/52046 , G01S15/8979 , G10K11/346
摘要： An ultrasound diagnostic apparatus includes a probe which outputs RF signals. There are N phase detectors for converting the RF signals outputted from the probe into baseband signals In and Qn, where “N” denotes a first predetermined natural number and “n” denotes a second predetermined natural number set as 2≦n≦N. A reception beam former operates for processing the baseband signals In and Qn into a time-division-multiplexed signal. The reception beam former includes a device for multiplying the baseband signals In and Qn by phase shift data to generate multiplication-resultant signals, a device for delaying the multiplication-resultant signals to generate delay-resultant signals, and a device for combining the delay-resultant signals into the time-division-multiplexed signal.
摘要翻译：超声波诊断装置包括输出RF信号的探针。存在用于将从探测器输出的RF信号转换为基带信号In和Qn的N相检测器，其中“N”表示第一预定自然数，“n”表示设置为2 <= n

48. 发明授权

US06358212B1 Noninvasive continuous blood pressure measuring apparatus and a method of noninvasively measuring continuous blood pressure 失效
标题翻译：无创连续血压测量仪器和无创测量连续血压的方法
公开(公告)号：US06358212B1
公开(公告)日：2002-03-19
申请号：US09290394
申请日：1999-04-13
申请人： Kinya Hasegawa , Yushi Nishimura , Hisashi Hagiwara
发明人： Kinya Hasegawa , Yushi Nishimura , Hisashi Hagiwara
IPC分类号： A61B500
CPC分类号： A61B5/02133 , A61B5/021 , A61B5/02116 , A61B2562/0247 , A61B2562/043
摘要： One of pairs of an exciter and a sensor is selected in accordance with the detection signal which is derived from an exciter waveform induced in an artery transmitted therethrough. The pairs of exciters and sensors are arranged on a substrate in various formations. A/D converters are provided to respective detection signals. A frequency of the oscillation signal supplied to the exciter is controlled by various oscillation signal generation circuits. Bandpass filtering for extracting the exciter waveform, low-pass-filtering for extracting a natural blood pressure waveform, phase difference detection processes are provided by a microprocessor, wherein the bandpass filtering and low-pass-filtering processes may be replaced with a bandpass filter and a low pass filter, and their outputs are selected by a switching circuit and supplied to the microprocessor through one a/d converter. The frequency of the oscillation signal is controlled to an optimum frequency by detecting the detection signal and estimating the attenuation, dispersion, phase shift with respect to different frequency and by determining one of the different frequency in accordance with the estimation result. The waveform of the oscillation signal is controlled to an optimum waveform similarly.
摘要翻译：根据从通过其传输的动脉中感应的激励器波形导出的检测信号来选择一对激励器和传感器。激励器和传感器对被布置在各种形式的基板上。 A / D转换器被提供给相应的检测信号。提供给励磁机的振荡信号的频率由各种振荡信号发生电路控制。用于提取激励器波形的带通滤波器，用于提取自然血压波形的低通滤波，相位差检测处理由微处理器提供，其中带通滤波和低通滤波处理可以被带通滤波器代替，低通滤波器，其输出由开关电路选择，并通过一个a / d转换器提供给微处理器。通过检测检测信号并估计相对于不同频率的衰减，色散，相移以及根据估计结果确定不同频率之一，将振荡信号的频率控制到最佳频率。振荡信号的波形类似地被控制到最佳波形。

49. 发明授权

US06275447B1 Sound generating apparatus, a sound detection apparatus, an acoustic sensor, and an acoustic living body measuring apparatus 有权
标题翻译：声音产生装置，声音检测装置，声音传感器和声学生物体测量装置
公开(公告)号：US06275447B1
公开(公告)日：2001-08-14
申请号：US09247561
申请日：1999-02-10
申请人： Hiroshi Fukukita , Hisashi Hagiwara
发明人： Hiroshi Fukukita , Hisashi Hagiwara
IPC分类号： G03B4206
CPC分类号： G03B42/06
摘要： A sound generating apparatus or a sound detecting apparatus includes: a flexible substrate; and a plurality of bimorphs arranged on a surface of the flexible substrate in a direction at a predetermined interval, each of the bimorphs having input/output terminals. Each of the bimorphs has a rectangular shape and its longitudinal direction is perpendicular to the direction. The flexible substrate has a slit between successive two of the bimorphs. A width of the slit outside the bimorphs is wide. A buffering material covering surfaces of the flexible substrate with the bimorphs exposed or a cover covering the bimorphs with a space may be provided. The cover and the buffering material may have slit. A sound generating apparatus including a plurality of flexible substrates respectively supporting bimorphs may be provided. The flexible substrate may have a comb shape. An acoustic sensor includes the sound generating apparatus, the sound detection apparatus connected therebetween by a flexible substrate, wherein the flexible substrate may include a cable and a connector. A living body measuring apparatus includes the acoustic sensor, wherein phase shift between the sound signal induced by the bimorph and a reference drive signal is detected and a blood pressure is operated by the phase shift amount.
摘要翻译：发声装置或声音检测装置包括：柔性基板; 以及以预定间隔布置在柔性基板的表面上的多个双压电晶片，每个双压电晶片具有输入/输出端子。每个双压电晶片具有矩形，其纵向方向垂直于方向。柔性基板在连续两个双压电晶片之间具有狭缝。双压电晶片外侧的狭缝宽度很宽。可以提供覆盖柔性基板的表面的缓冲材料，其中露出双压电晶片或用空间覆盖双压电晶片。盖和缓冲材料可以具有狭缝。可以提供包括分别支撑双压电晶片的多个柔性衬底的发声装置。柔性基板可以具有梳形。声学传感器包括声音产生装置，声音检测装置通过柔性基板连接在其上，其中柔性基板可以包括电缆和连接器。生物体测量装置包括声传感器，其中检测由双压电晶片引起的声音信号与参考驱动信号之间的相移，并通过相移量操作血压。

50. 发明授权

US5311870A Ultrasonic Doppler imaging apparatus 失效
标题翻译：超声多普勒成像仪
公开(公告)号：US5311870A
公开(公告)日：1994-05-17
申请号：US878623
申请日：1992-05-05
申请人： Hiroshi Fukukita , Hisashi Hagiwara , Morio Nishigaki , Yasuhiro Nakamura
发明人： Hiroshi Fukukita , Hisashi Hagiwara , Morio Nishigaki , Yasuhiro Nakamura
IPC分类号： A61B8/06 , G01P5/00 , G01S15/58 , G01S15/89 , H03D3/00
CPC分类号： G01S15/582 , G01S15/8979 , H03D3/007 , H03D2200/005 , H03D2200/0062
摘要： An ultrasonic Doppler imaging apparatus emits ultrasonic pulse waves to an object body under test and provides information on blood flow in the body based on Doppler shifts of ultrasonic waves reflected back from the object body. The ultrasonic pulse waves emitted by a probe to the object body undergo Doppler shifts by being reflected by the blood stream, and the reflected ultrasonic waves received by the probe are decomposed with an A/D converter in synchronism with emission. The decomposed data are transformed into complex Doppler data through a quadrature addition/subtraction by quadrature addition/subtraction means. The complex Doppler data is subjected to frequency analysis through correlative computation or the like, and resulting data is stored in a frame memory and displayed. The apparatus is capable of measuring the Doppler shift frequency accurately.
摘要翻译：超声波多普勒成像装置向被检测物体发射超声波脉冲波，并且基于从物体反射回来的超声波的多普勒频移，提供关于体内血流量的信息。由探针发射到物体的超声脉冲波被血流反射而进行多普勒频移，并且由A / D转换器与发射同步地将由探头接收的反射的超声波分解。分解的数据通过正交加法/减法装置的正交加减法变换为复数多普勒数据。通过相关计算等对复数多普勒数据进行频率分析，将结果数据存储在帧存储器中并进行显示。该装置能够准确地测量多普勒频移频率。

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