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    • 41. 发明申请
    • Methods for affecting homeostasis and metabolism in a mammalian body
    • 影响哺乳动物体内的体内平衡和代谢的方法
    • US20050233014A1
    • 2005-10-20
    • US11069836
    • 2005-03-01
    • Steve LeeRichard HynsonKe-Qin ZhangWu-Zhou LiJing Zhou
    • Steve LeeRichard HynsonKe-Qin ZhangWu-Zhou LiJing Zhou
    • A61K31/198A61K36/48A61K35/78
    • A61K31/198A61K36/48A61K2300/00
    • The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.
    • 本发明涉及包含4-羟基异亮氨酸和一种或多种选自氨基酸,生物碱,糖苷,挥发性油,皂角苷,皂甙元,甘露聚糖,类黄酮,脂肪酸,维生素和/或其中的一种或多种化合物的生物活性化合物的新组合物, 维生素,矿物质和碳水化合物。 优选地,生物活性化合物的新组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸,天冬氨酸,苏氨酸,丝氨酸,谷氨酸,脯氨酸,甘氨酸,丙氨酸,半胱氨酸,缬氨酸,甲硫氨酸,异亮氨酸, 亮氨酸,色氨酸,苯丙氨酸,鸟氨酸,脯氨酸,赖氨酸,组氨酸和γ-氨基丁酸。 生物活性化合物的组成优选包括约10%至约70%的4-羟基异亮氨酸和约20%至约40%的其它氨基酸。 本发明的新型组合物的生物活性化合物可以从胡芦巴种子中衍生,分离和/或提取。 从葫芦巴种子提取生物活性化合物的优选方法包括以下步骤:(1)提供多种葫芦巴种子; (2)准备葫芦巴种子; (3)从葫芦巴种子中提取生物活性化合物的新组合物,其中包括初步提取步骤和二次提取步骤。 已经发现生物活性化合物的组合有助于恢复人和动物中的健康能量平衡,帮助体重管理工作,以及通过协助身体更有效地利用现有的(例如, ,内源性)胰岛素。
    • 42. 发明申请
    • Methods for enhancing the transport of glucose into muscle
    • 增强葡萄糖输送到肌肉中的方法
    • US20050226948A1
    • 2005-10-13
    • US11068733
    • 2005-03-01
    • Steve LeeRichard HynsonKe-Qin ZhangWu-Zhou LiJing Zhou
    • Steve LeeRichard HynsonKe-Qin ZhangWu-Zhou LiJing Zhou
    • A61K31/198A61K31/401A61K31/4745A61K36/48A61K35/78
    • A61K31/4745A61K31/198A61K31/401A61K36/48A61K2300/00
    • The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.
    • 本发明涉及包含4-羟基异亮氨酸和一种或多种选自氨基酸,生物碱,糖苷,挥发性油,皂角苷,皂甙元,甘露聚糖,类黄酮,脂肪酸,维生素和/或其中的一种或多种化合物的生物活性化合物的新组合物, 维生素,矿物质和碳水化合物。 优选地,生物活性化合物的新组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸,天冬氨酸,苏氨酸,丝氨酸,谷氨酸,脯氨酸,甘氨酸,丙氨酸,半胱氨酸,缬氨酸,甲硫氨酸,异亮氨酸, 亮氨酸,色氨酸,苯丙氨酸,鸟氨酸,脯氨酸,赖氨酸,组氨酸和γ-氨基丁酸。 生物活性化合物的组合物优选包括约10%至约70%的4-羟基异亮氨酸和约20%至约40%的其它氨基酸。 本发明的新型组合物的生物活性化合物可以从胡芦巴种子中衍生,分离和/或提取。 从葫芦巴种子提取生物活性化合物的优选方法包括以下步骤:(1)提供多种葫芦巴种子; (2)准备葫芦巴种子; (3)从葫芦巴种子中提取生物活性化合物的新组合物,其中包括初步提取步骤和二次提取步骤。 已经发现生物活性化合物的组合有助于恢复人和动物中的健康能量平衡,帮助体重管理工作,以及通过协助身体更有效地利用现有的(例如, ,内源性)胰岛素。
    • 43. 发明申请
    • Compositions and methods for glycogen synthesis
    • 糖原合成的组成和方法
    • US20050176827A1
    • 2005-08-11
    • US10926849
    • 2004-08-26
    • Steve LeeRichard HynsonBrent RubySteven Gaskill
    • Steve LeeRichard HynsonBrent RubySteven Gaskill
    • A61K31/198C08B20060101
    • A61K36/48
    • A composition of bio-active compounds and methods for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells, promoting muscle function and growth, promoting glycogen synthesis, enhancing glucose disposal, stimulating pancreatic beta cells, promoting metabolic recovery, promoting muscle recovery, promoting lean body mass, and promoting fat burning. Preferably, the composition of bio-active compounds includes a combination of 4-hydroxyisoleucine with at least one amino acid selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, gamma-amino butyrate and tyrosine. In one presently preferred embodiment of the present invention, the combination is derived, isolated, and/or extracted from fenugreek seeds. Methods for using a novel composition of bio-active compounds from fenugreek seed for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells, promoting muscle function and growth, promoting glycogen synthesis, enhancing glucose disposal, stimulating pancreatic beta cells, promoting metabolic recovery, promoting muscle recovery, promoting lean body mass, and promoting fat burning are also disclosed, wherein methods comprise the steps of: (1) providing an effective amount of a composition of bio-active compounds derived, isolated, and/or extracted from fenugreek seeds; and (2) administering the composition to a human or animal.
    • 生物活性化合物的组合物和促进和支持葡萄糖和碳水化合物进入肌细胞的代谢和转运,促进肌肉功能和生长,促进糖原合成,增强葡萄糖处置,刺激胰腺β细胞,促进代谢恢复,促进肌肉的方法 恢复,促进瘦体重,促进脂肪燃烧。 优选地,生物活性化合物的组合物包括4-羟基异亮氨酸与至少一种选自精氨酸,天冬氨酸,苏氨酸,丝氨酸,谷氨酸,脯氨酸,甘氨酸,丙氨酸,半胱氨酸,缬氨酸,甲硫氨酸, 异亮氨酸,亮氨酸,色氨酸,苯丙氨酸,鸟氨酸,赖氨酸,组氨酸,γ-氨基丁酸和酪氨酸。 在本发明的一个目前优选的实施方案中,从葫芦巴种子中衍生,分离和/或提取该组合。 使用来自葫芦巴种子的生物活性化合物的新组合物的方法,用于促进和支持葡萄糖和碳水化合物向肌肉细胞的代谢和转运,促进肌肉功能和生长,促进糖原合成,增强葡萄糖处置,刺激胰腺β细胞,促进 还公开了代谢恢复,促进肌肉恢复,促进瘦体重和促进脂肪燃烧,其中方法包括以下步骤:(1)提供有效量的衍生,分离和/或提取的生物活性化合物的组合物 来自葫芦巴种子; 和(2)将组合物给予人或动物。
    • 49. 发明授权
    • Refractory discharge device with separate external reinforcement member
    • 具有独立外部加固构件的冲击放电装置
    • US5092500A
    • 1992-03-03
    • US651623
    • 1991-02-07
    • Udo WeberErnst LuhrsenAlbert OttSteve Lee
    • Udo WeberErnst LuhrsenAlbert OttSteve Lee
    • B22D11/10B22D41/50B22D41/54
    • B22D41/505
    • A refractory discharge device includes an immersion nozzle formed substantially of carbon-bonded magnesium oxide or carbon-bonded aluminum oxide or fused quartz. The immersion nozzle has therethrough a discharge passage and has an outer surface and an outlet end. An external reinforcement member is formed entirely separately from the immersion nozzle from a zirconium oxide material that is directly bonded without any carbon and by burning at a high temperature. The external reinforcement member is attached to the outer surface of the outer surface of the immersion nozzle at a position such that during use the external reinforcement member will extend above and below a casting powder covering of molten metal into which the refractory discharge device will be immersed.
    • 耐火材料放电装置包括基本上由碳键合的氧化镁或碳键合的氧化铝或熔融石英形成的浸渍喷嘴。 浸入式喷嘴通过排出通道并具有外表面和出口端。 外部加强件与浸没式喷嘴完全不同于直接接合而没有碳并且在高温下燃烧的氧化锆材料。 外部加强构件在浸入式喷嘴的外表面的外表面上的一个位置处,使得在使用期间外部加强构件将在熔融金属的铸造粉末覆盖物的上方和下方延伸,耐火材料放电装置将浸入其中 。