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1. 发明申请

US20090076111A1 Methods for improving glycemic control in humans 审中-公开
标题翻译：改善人体血糖控制的方法
公开(公告)号：US20090076111A1
公开(公告)日：2009-03-19
申请号：US11975192
申请日：2007-10-18
申请人： Steve S. Lee , Richard B. Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Shi Zhou
发明人： Steve S. Lee , Richard B. Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Shi Zhou
IPC分类号： A61K31/197 , A61P3/00 , A61K31/4172
CPC分类号： A61K31/198 , A61K31/401 , A61K31/4745 , A61K36/48 , A61K2300/00
摘要： The present invention is directed to methods for improving glycemic control in humans and animals comprising the step of administering a composition comprising an amino acid content including 4-hydroxyisoleucine in an amount between about 60% and about 70% of a total weight of the amino acid content, together with one or more amino acids selected from the group consisting of glutamate, aspartate, arginine, cysteine, threonine, serine, glycine, alanine, valine, methionine, isoleucine, and histidine (inclusive of any chemical salts, anhydrides, or isomers of any of the foregoing), in addition to, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Fasting blood glucose and glucose tolerance were studied in normal human subjects, in human subjects diagnosed with Metabolic Syndrome X, and in diabetic rats by means of dosing the subjects with compositions comprising 4-hydroxyisoleucine in an amount between about 20% and about 30% of the total weight of the composition, wherein improving glycemic control in standard glucose tolerance tests.
摘要翻译：本发明涉及用于改善人和动物血糖控制的方法，包括以下步骤：施用含有包含4-羟基异亮氨酸的氨基酸含量的组合物，其量为氨基酸总重量的约60％至约70％含有一种或多种选自谷氨酸，天冬氨酸，精氨酸，半胱氨酸，苏氨酸，丝氨酸，甘氨酸，丙氨酸，缬氨酸，甲硫氨酸，异亮氨酸和组氨酸的氨基酸（包括任何化学盐，酸酐或异构体除了生物碱，糖苷，挥发性油，皂角苷，皂甙元，甘露聚糖，类黄酮，脂肪酸，维生素和维生素，矿物质和碳水化合物之外。在正常人受试者，诊断为代谢综合征X的人类受试者中以及在糖尿病大鼠中通过给受试者给予包含4-羟基异亮氨酸的组合物的空腹血糖和葡萄糖耐量在约20％至约30％之间的量组合物的总重量，其中改善标准葡萄糖耐量试验中的血糖控制。

2. 发明申请

US20050053679A1 Methods for supporting metabolism and transportation of glucose and carbohydrates into muscle 审中-公开
标题翻译：支持葡萄糖和碳水化合物进入肌肉的代谢和运输的方法
公开(公告)号：US20050053679A1
公开(公告)日：2005-03-10
申请号：US10902219
申请日：2004-07-29
申请人： Steve Lee , Richard Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Zhou
发明人： Steve Lee , Richard Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Zhou
IPC分类号： A61K35/78
CPC分类号： A61K36/48
摘要： Methods for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells are taught. Preferably, the methods include the step of administering a composition of bio-active compounds further including 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, and gamma-aminobutyrate. In one presently preferred embodiment of the present invention, the bio-active compounds are extracted from fenugreek seeds. The methods of the present invention preferably include a composition of bio-active compounds with between about 10% and 70% of 4-hydroxyisoleucine and between about 20% and 40% of the amino acids. In presently preferred embodiments of the present invention, methods may work independently of or synergistically with insulin to stimulate the activity of glucose transport receptors located in muscle. More particularly, methods of the present invention may stimulate the activity of glucose transport receptor type 4.
摘要翻译：教导促进和支持葡萄糖和碳水化合物进入肌肉细胞的代谢和转运的方法。优选地，所述方法包括施用进一步包含4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸的氨基酸的生物活性化合物组合物的步骤，缬氨酸，甲硫氨酸，异亮氨酸，亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，赖氨酸，组氨酸和γ-氨基丁酸酯。在本发明的一个目前优选的实施方案中，从葫芦巴种子中提取生物活性化合物。本发明的方法优选包括具有约10％至70％的4-羟基异亮氨酸和约20％至40％的氨基酸的生物活性化合物的组合物。在本发明目前优选的实施方案中，方法可以与胰岛素独立地或协同地起作用以刺激位于肌肉中的葡萄糖转运受体的活性。更具体地，本发明的方法可以刺激4型葡萄糖转运受体的活性。

3. 发明申请

US20050238738A1 Methods for deriving, isolating, and/or extracting amino acid compositions from Fenugreek seed 有权
标题翻译：从葫芦巴种子得到，分离和/或提取氨基酸组合物的方法
公开(公告)号：US20050238738A1
公开(公告)日：2005-10-27
申请号：US11069747
申请日：2005-03-01
申请人： Steve Lee , Richard Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Zhou
发明人： Steve Lee , Richard Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Zhou
IPC分类号： A61K36/286 , A61K36/48 , A61K36/55 , A61K36/88 , A61K36/8962 , A61K36/9066 , A61K35/78
CPC分类号： A61K36/48 , A61K36/286 , A61K36/55 , A61K36/88 , A61K36/8962 , A61K36/9066 , A61K2300/00
摘要： The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.
摘要翻译：本发明涉及包含4-羟基异亮氨酸和一种或多种选自氨基酸，生物碱，糖苷，挥发性油，皂角苷，皂甙元，甘露聚糖，类黄酮，脂肪酸，维生素和/或其中的一种或多种化合物的生物活性化合物的新组合物，维生素，矿物质和碳水化合物。优选地，生物活性化合物的新组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸，缬氨酸，甲硫氨酸，异亮氨酸，亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，脯氨酸，赖氨酸，组氨酸和γ-氨基丁酸。生物活性化合物的组合物优选包括约10％至约70％的4-羟基异亮氨酸和约20％至约40％的其它氨基酸。本发明的新型组合物的生物活性化合物可以从胡芦巴种子中衍生，分离和/或提取。从葫芦巴种子提取生物活性化合物的优选方法包括以下步骤：（1）提供多种葫芦巴种子; （2）准备葫芦巴种子; （3）从葫芦巴种子中提取生物活性化合物的新组合物，其中包括初步提取步骤和二次提取步骤。已经发现生物活性化合物的组合有助于恢复人和动物中的健康能量平衡，帮助体重管理工作，以及通过协助身体更有效地利用现有的（例如，，内源性）胰岛素。

4. 发明申请

US20050233013A1 Methods for enhancing the transport of glucose for balancing blood sugar levels 审中-公开
标题翻译：用于增强血糖运输以平衡血糖水平的方法
公开(公告)号：US20050233013A1
公开(公告)日：2005-10-20
申请号：US11068734
申请日：2005-03-01
申请人： Steve Lee , Richard Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Zhou
发明人： Steve Lee , Richard Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Zhou
IPC分类号： A61K31/198 , A61K31/401 , A61K31/405 , A61K31/4172 , A61K35/78
CPC分类号： A61K31/401 , A61K31/202 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/4172 , A61K31/436 , A61K31/44 , A61K31/4425 , A61K31/445 , A61K31/495 , A61K36/48 , A61K45/06 , A61K2236/39 , A61K31/198 , A61K2300/00
摘要： The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.
摘要翻译：本发明涉及包含4-羟基异亮氨酸和一种或多种选自氨基酸，生物碱，糖苷，挥发性油，皂角苷，皂甙元，甘露聚糖，类黄酮，脂肪酸，维生素和/或其中的一种或多种化合物的生物活性化合物的新组合物，维生素，矿物质和碳水化合物。优选地，生物活性化合物的新组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸，缬氨酸，甲硫氨酸，异亮氨酸，亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，脯氨酸，赖氨酸，组氨酸和γ-氨基丁酸。生物活性化合物的组成优选包括约10％至约70％的4-羟基异亮氨酸和约20％至约40％的其它氨基酸。本发明的新型组合物的生物活性化合物可以从胡芦巴种子中衍生，分离和/或提取。从葫芦巴种子提取生物活性化合物的优选方法包括以下步骤：（1）提供多种葫芦巴种子; （2）准备葫芦巴种子; （3）从葫芦巴种子中提取生物活性化合物的新组合物，其中包括初步提取步骤和二次提取步骤。已经发现生物活性化合物的组合有助于恢复人和动物中的健康能量平衡，帮助体重管理工作，以及通过协助身体更有效地利用现有的（例如，，内源性）胰岛素。

5. 发明授权

US07645466B2 Methods for deriving, isolating, and/or extracting amino acid compositions from Fenugreek seed 有权
标题翻译：从葫芦巴种子得到，分离和/或提取氨基酸组合物的方法
公开(公告)号：US07645466B2
公开(公告)日：2010-01-12
申请号：US11069747
申请日：2005-03-01
申请人： Steve S. Lee , Richard B. Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing S. Zhou
发明人： Steve S. Lee , Richard B. Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing S. Zhou
IPC分类号： A61K36/48
CPC分类号： A61K36/48 , A61K36/286 , A61K36/55 , A61K36/88 , A61K36/8962 , A61K36/9066 , A61K2300/00
摘要： The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, omithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds.
摘要翻译：本发明涉及包含4-羟基异亮氨酸和一种或多种选自氨基酸，生物碱，糖苷，挥发性油，皂角苷，皂甙元，甘露聚糖，类黄酮，脂肪酸，维生素和/或其中的一种或多种化合物的生物活性化合物的新组合物，维生素，矿物质和碳水化合物。优选地，生物活性化合物的新组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸，缬氨酸，甲硫氨酸，异亮氨酸，亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，脯氨酸，赖氨酸，组氨酸和γ-氨基丁酸。生物活性化合物的组成优选包括约10％至约70％的4-羟基异亮氨酸和约20％至约40％的其它氨基酸。本发明的新型组合物的生物活性化合物可以从胡芦巴种子中衍生，分离和/或提取。

6. 发明申请

US20050233014A1 Methods for affecting homeostasis and metabolism in a mammalian body 审中-公开
标题翻译：影响哺乳动物体内的体内平衡和代谢的方法
公开(公告)号：US20050233014A1
公开(公告)日：2005-10-20
申请号：US11069836
申请日：2005-03-01
申请人： Steve Lee , Richard Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Zhou
发明人： Steve Lee , Richard Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Zhou
IPC分类号： A61K31/198 , A61K36/48 , A61K35/78
CPC分类号： A61K31/198 , A61K36/48 , A61K2300/00
摘要： The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.
摘要翻译：本发明涉及包含4-羟基异亮氨酸和一种或多种选自氨基酸，生物碱，糖苷，挥发性油，皂角苷，皂甙元，甘露聚糖，类黄酮，脂肪酸，维生素和/或其中的一种或多种化合物的生物活性化合物的新组合物，维生素，矿物质和碳水化合物。优选地，生物活性化合物的新组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸，缬氨酸，甲硫氨酸，异亮氨酸，亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，脯氨酸，赖氨酸，组氨酸和γ-氨基丁酸。生物活性化合物的组成优选包括约10％至约70％的4-羟基异亮氨酸和约20％至约40％的其它氨基酸。本发明的新型组合物的生物活性化合物可以从胡芦巴种子中衍生，分离和/或提取。从葫芦巴种子提取生物活性化合物的优选方法包括以下步骤：（1）提供多种葫芦巴种子; （2）准备葫芦巴种子; （3）从葫芦巴种子中提取生物活性化合物的新组合物，其中包括初步提取步骤和二次提取步骤。已经发现生物活性化合物的组合有助于恢复人和动物中的健康能量平衡，帮助体重管理工作，以及通过协助身体更有效地利用现有的（例如，，内源性）胰岛素。

7. 发明申请

US20050226948A1 Methods for enhancing the transport of glucose into muscle 审中-公开
标题翻译：增强葡萄糖输送到肌肉中的方法
公开(公告)号：US20050226948A1
公开(公告)日：2005-10-13
申请号：US11068733
申请日：2005-03-01
申请人： Steve Lee , Richard Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Zhou
发明人： Steve Lee , Richard Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Zhou
IPC分类号： A61K31/198 , A61K31/401 , A61K31/4745 , A61K36/48 , A61K35/78
CPC分类号： A61K31/4745 , A61K31/198 , A61K31/401 , A61K36/48 , A61K2300/00
摘要： The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.
摘要翻译：本发明涉及包含4-羟基异亮氨酸和一种或多种选自氨基酸，生物碱，糖苷，挥发性油，皂角苷，皂甙元，甘露聚糖，类黄酮，脂肪酸，维生素和/或其中的一种或多种化合物的生物活性化合物的新组合物，维生素，矿物质和碳水化合物。优选地，生物活性化合物的新组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸，缬氨酸，甲硫氨酸，异亮氨酸，亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，脯氨酸，赖氨酸，组氨酸和γ-氨基丁酸。生物活性化合物的组合物优选包括约10％至约70％的4-羟基异亮氨酸和约20％至约40％的其它氨基酸。本发明的新型组合物的生物活性化合物可以从胡芦巴种子中衍生，分离和/或提取。从葫芦巴种子提取生物活性化合物的优选方法包括以下步骤：（1）提供多种葫芦巴种子; （2）准备葫芦巴种子; （3）从葫芦巴种子中提取生物活性化合物的新组合物，其中包括初步提取步骤和二次提取步骤。已经发现生物活性化合物的组合有助于恢复人和动物中的健康能量平衡，帮助体重管理工作，以及通过协助身体更有效地利用现有的（例如，，内源性）胰岛素。

8. 发明授权

US07338675B2 Fenugreek seed bio-active compositions and methods for extracting same 有权
标题翻译：葫芦巴种子生物活性成分及其提取方法
公开(公告)号：US07338675B2
公开(公告)日：2008-03-04
申请号：US10434444
申请日：2003-05-07
申请人： Steve S. Lee , Richard B. Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Shi Zhou
发明人： Steve S. Lee , Richard B. Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Shi Zhou
IPC分类号： A01N65/00 , A01N37/30 , A01N37/12
CPC分类号： A61K36/48
摘要： A composition of bio-active compounds and methods for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells. Preferably, the composition of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine and gamma-amino butyrate. In one presently preferred embodiment of the present invention, the bio-active compounds are extracted from fenugreek seeds. A method for extracting a composition of bio-active compounds from fenugreek seeds is also disclosed, wherein the method comprises the steps of: (1) providing a plurality of fenugreek seeds; (2) preparing the fenugreek seeds; and (3) extracting a composition of bio-active compounds from the fenugreek seeds, wherein the bio-active compounds comprise 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine and gamma-amino butyrate. The composition of bio-active compounds and methods for extraction of same preferably include between about 10% and 70% of 4-hydroxyisoleucine and between about 20% and 40% of the amino acids.
摘要翻译：生物活性化合物的组合物和促进和支持葡萄糖和碳水化合物进入肌肉细胞的代谢和转运的方法。优选地，生物活性化合物的组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸，缬氨酸，甲硫氨酸，异亮氨酸，亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，赖氨酸，组氨酸和γ-氨基丁酸酯。在本发明的一个目前优选的实施方案中，从葫芦巴种子中提取生物活性化合物。还公开了从葫芦巴种子提取生物活性化合物的组合物的方法，其中所述方法包括以下步骤：（1）提供多种葫芦巴种子; （2）准备葫芦巴种子; （3）从葫芦巴种子提取生物活性化合物的组合物，其中所述生物活性化合物包含4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸，缬氨酸，甲硫氨酸，异亮氨酸，亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，赖氨酸，组氨酸和γ-氨基丁酸。生物活性化合物的组成和其提取方法优选包括约10％至70％的4-羟基异亮氨酸和约20％至40％的氨基酸。

9. 发明申请

US20050048147A1 Compositions and methods for weight management 审中-公开
标题翻译：组合和重量管理方法
公开(公告)号：US20050048147A1
公开(公告)日：2005-03-03
申请号：US10902220
申请日：2004-07-29
申请人： Steve Lee , Richard Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Zhou
发明人： Steve Lee , Richard Hynson , Ke-Qin Zhang , Wu-Zhou Li , Jing Zhou
IPC分类号： A61K35/78
CPC分类号： A61K36/48
摘要： Compositions and methods for promoting weight management are taught by the present invention. Preferably, the methods include the step of administering a composition of bio-active compounds further including 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, and gamma-aminobutyrate. In one presently preferred embodiment of the present invention, the bio-active compounds are extracted from fenugreek seeds. The methods of the present invention preferably include a composition of bio-active compounds with between about 10% and 70% of 4-hydroxyisoleucine and between about 20% and 40% of the amino acids. In presently preferred embodiments of the present invention, methods may work independently of or synergistically with insulin to stimulate the activity of glucose transport receptors located in muscle. More particularly, methods of the present invention may stimulate the activity of glucose transport receptor type 4. In another presently preferred embodiment of the present invention, a method for weight management includes the steps of: (1) performing a weight management analysis on an individual experiencing nutritional and metabolic deficiencies which impact proper metabolism of glucose and carbohydrates; (2) extracting a composition of bio-active compounds from fenugreek; and (3) administering the composition of bio-active compounds from fenugreek in an amount effective to enhance muscle glucose transportation within the body of the individual.
摘要翻译：用于促进体重管理的组合物和方法由本发明教导。优选地，所述方法包括施用进一步包含4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸的氨基酸的生物活性化合物组合物的步骤，缬氨酸，甲硫氨酸，异亮氨酸，亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，赖氨酸，组氨酸和γ-氨基丁酸酯。在本发明的一个目前优选的实施方案中，从葫芦巴种子中提取生物活性化合物。本发明的方法优选包括具有约10％至70％的4-羟基异亮氨酸和约20％至40％的氨基酸的生物活性化合物的组合物。在本发明目前优选的实施方案中，方法可以与胰岛素独立地或协同地起作用以刺激位于肌肉中的葡萄糖转运受体的活性。更具体地，本发明的方法可以刺激4型葡萄糖转运受体的活性。在本发明的另一个目前优选的实施方案中，一种体重管理方法包括以下步骤：（1）对个体进行体重管理分析遇到影响葡萄糖和碳水化合物正确代谢的营养和代谢缺陷; （2）从葫芦巴提取生物活性化合物的组成; 和（3）以有效增强个体体内肌肉葡萄糖转运量的量从葫芦巴管理生物活性化合物的组合物。

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