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41. 发明申请

US20160258011A1 Surface Stabilization of Biosensors 审中-公开
标题翻译：生物传感器表面稳定
公开(公告)号：US20160258011A1
公开(公告)日：2016-09-08
申请号：US15061273
申请日：2016-03-04
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Phil WAGGONER , James A. BALL , Wolfgang HINZ , Michael L. MINTO , Scott PARKER , David M. COX , Alexander MASTROIANNI , Jeremy GRAY , Marc GLAZER , Kimberly GORRELL
IPC分类号： C12Q1/68 , G01N27/414
摘要： A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
摘要翻译：传感器装置包括基板，设置在基板上的半导体器件，具有表面电极结构的半导体器件和形成在表面电极结构上的糖类涂层。在使用前可以除去糖衣。该半导体器件还可以包括一个阱以及可选地布置在阱中的珠。

42. 发明申请

US20160137762A1 Hydrophilic Polymeric Particles and Methods for Making and Using Same 审中-公开
公开(公告)号：US20160137762A1
公开(公告)日：2016-05-19
申请号：US15005420
申请日：2016-01-25
申请人： LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
发明人： Geir FONNUM , Grete Irene MODAHL , Nini Hofsloekken KJUS , Astrid Evenroed MOLTEBERG , Diem Thuy Thi TRAN , Jo AASERUD , M. Talha GOKMEN , Steven M. MENCHEN , Carl FULLER , Luisa ANDRUZZI , Wolfgang HINZ
IPC分类号： C08F130/08 , C08F6/24 , C08J9/20
CPC分类号： C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
摘要： A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.

43. 发明申请

US20160097095A1 Hydrophilic Polymeric Particles and Methods for Making and Using Same 有权
公开(公告)号：US20160097095A1
公开(公告)日：2016-04-07
申请号：US14970241
申请日：2015-12-15
申请人： LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
发明人： Geir FONNUM , Grete Irene MODAHL , Nini Hofslokken KJUS , Astrid Evenroed MOLTEBERG , Diem TRAN , Jo AASERUD , Talha M. GOKMEN , Steven M. MENCHEN , Carl FULLER , Luisa ANDRUZZI , Wolfgang HINZ
IPC分类号： C12Q1/68 , G01N27/414
CPC分类号： C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
摘要： A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.

44. 发明申请

US20140217477A1 ELECTRIC FIELD DIRECTED LOADING OF MICROWELL ARRAY 有权
标题翻译： MICROWELL阵列的电场方向装载
公开(公告)号：US20140217477A1
公开(公告)日：2014-08-07
申请号：US14244849
申请日：2014-04-03
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Kristopher BARBEE , John F. DAVIDSON , Wolfgang HINZ , Shifeng LI , James BUSTILLO
IPC分类号： G01N27/414
CPC分类号： G01N27/4473 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00704 , B01J2219/00722 , C12Q1/6874 , G01N27/4145 , G01N27/4148 , G01N27/44743
摘要： An apparatus includes a device substrate including an array of sensors. Each sensor of the array of sensors can include a electrode structure disposed at a surface of the device substrate. The apparatus further includes a wall structure overlying the surface of the device substrate and defining an array of wells at least partially corresponding with the array of sensors. The well structure including an electrode layer and an insulative layer.
摘要翻译：一种装置包括包括传感器阵列的装置基板。传感器阵列的每个传感器可以包括设置在器件基板的表面处的电极结构。该装置还包括覆盖在装置基板的表面上的壁结构，并且限定至少部分对应于传感器阵列的一组阱阵列。阱结构包括电极层和绝缘层。

45. 发明申请

US20140191292A1 METHODS AND SYSTEMS FOR POINT OF USE REMOVAL OF SACRIFICIAL MATERIAL 有权
标题翻译：使用移除材料的方法和系统
公开(公告)号：US20140191292A1
公开(公告)日：2014-07-10
申请号：US13734696
申请日：2013-01-04
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Christina INMAN , Alexander MASTROIANNI , Wolfgang HINZ , Shifeng LI , Scott BENSON
IPC分类号： H01L27/105 , H01L21/8234
CPC分类号： H01L21/31105 , G01N27/4145 , H01L21/31144
摘要： A method of manufacturing a sensor, the method including forming an array of chemically-sensitive field effect transistors (chemFETs), depositing a dielectric layer over the chemFETs in the array, depositing a protective layer over the dielectric layer, etching the dielectric layer and the protective layer to form cavities corresponding to sensing surfaces of the chemFETs, and removing the protective layer. The method further includes, etching the dielectric layer and the protective layer together to form cavities corresponding to sensing surfaces of the chemFETs. The protective layer is at least one of a polymer, photoresist material, noble metal, copper oxide, and zinc oxide. The protective layer is removed using at least one of sodium hydroxide, organic solvent, aqua regia, ammonium carbonate, hydrochloric acid, acetic acid, and phosphoric acid.
摘要翻译：一种制造传感器的方法，所述方法包括形成化学敏感场效应晶体管阵列（chemFET），在阵列中的chemFET上沉积电介质层，在电介质层上沉积保护层，蚀刻电介质层和保护层以形成对应于chemFET的感测表面的空腔，以及去除保护层。该方法还包括：将电介质层和保护层一起蚀刻以形成对应于chemFET的感测表面的空腔。保护层是聚合物，光致抗蚀剂材料，贵金属，氧化铜和氧化锌中的至少一种。使用氢氧化钠，有机溶剂，王水，碳酸铵，盐酸，乙酸和磷酸中的至少一种除去保护层。

46. 发明申请

US20130338046A1 METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS 有权
公开(公告)号：US20130338046A1
公开(公告)日：2013-12-19
申请号：US13909290
申请日：2013-06-04
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Jonathan M. ROTHBERG , Wolfgang HINZ , Kim L. JOHNSON
IPC分类号： G01N27/414
CPC分类号： C12Q1/6869 , C12Q1/6874 , G01N27/414 , G01N27/4145 , G01N27/4148 , H01L21/306 , H01L24/18 , H01L24/20 , H01L24/82 , H01L27/088 , H01L29/78 , H01L2224/04105 , H01L2224/16 , H01L2224/76155 , H01L2224/82102 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01012 , H01L2924/01013 , H01L2924/01015 , H01L2924/01019 , H01L2924/0102 , H01L2924/01023 , H01L2924/01024 , H01L2924/01027 , H01L2924/01029 , H01L2924/0103 , H01L2924/01033 , H01L2924/01046 , H01L2924/01047 , H01L2924/01052 , H01L2924/01056 , H01L2924/01059 , H01L2924/01073 , H01L2924/01074 , H01L2924/01075 , H01L2924/01082 , H01L2924/1306 , H01L2924/13091 , H01L2924/14 , H01L2924/1433 , H01L2924/19041 , H01L2924/19042 , H01L2924/19043 , H01L2924/30105 , H01L2924/3011 , H01L2924/3025 , C12Q2565/607 , C12Q2565/301 , C12Q2533/101 , H01L2924/00
摘要： Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

47. 发明申请

US20130324421A1 METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS 有权
公开(公告)号：US20130324421A1
公开(公告)日：2013-12-05
申请号：US13966184
申请日：2013-08-13
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Jonathan M. ROTHBERG , Wolfgang HINZ , Kim L. JOHNSON , James BUSTILLO , John LEAMON , Jonathan SCHULTZ
IPC分类号： G01N27/414
CPC分类号： C12Q1/6874 , B01L3/502761 , B01L2300/046 , B01L2300/0663 , B01L2300/0851 , B01L2400/086 , C12Q1/6869 , G01N27/4145 , G01N27/4148 , C12Q2565/607 , C12Q2565/301 , C12Q2565/629
摘要： Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates.

48. 发明申请

US20130280813A1 METHODS AND APPARATUS FOR DETECTING MOLECULAR INTERACTIONS USING FET ARRAYS 审中-公开
标题翻译：使用FET阵列检测分子相互作用的方法和装置
公开(公告)号：US20130280813A1
公开(公告)日：2013-10-24
申请号：US13922484
申请日：2013-06-20
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Jonathan ROTHBERG , Wolfgang HINZ
IPC分类号： G01N27/26
CPC分类号： C12Q1/6825 , C12Q1/6869 , C12Q1/6874 , G01N27/26 , G01N27/4145 , G01N27/4148 , G01N33/54373 , G01N33/6818 , H01L29/78 , H01L29/788 , H01L2924/01006
摘要： Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes.
摘要翻译：提供了与用于分析物检测和测量的大规模FET阵列相关的方法和装置。可以使用基于提高测量灵敏度和精度的改进的FET像素和阵列设计的传统CMOS处理技术来制造ChemFET（例如，ISFET）阵列，并且同时促进显着小的像素尺寸和致密阵列。改进的阵列控制技术提供了从大型和密集阵列的快速数据采集。可以使用这样的阵列来检测各种化学和/或生物过程中各种分析物类型的存在和/或浓度变化。

49. 发明公开

US20240201126A1 METHODS AND APPARATUS FOR MEASURING ANALYTES 审中-公开
公开(公告)号：US20240201126A1
公开(公告)日：2024-06-20
申请号：US18536131
申请日：2023-12-11
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： James BUSTILLO , Mark J. MILGREW , Wolfgang HINZ , John LEAMON , John DAVIDSON , Martin HUBER , Antoine M. VAN OIJEN , Jonathan ROTHBERG
IPC分类号： G01N27/414 , C12Q1/6869 , C12Q1/6874 , H01L21/82
CPC分类号： G01N27/4145 , C12Q1/6869 , C12Q1/6874 , G01N27/4148 , H01L21/82
摘要： Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

50. 发明公开

US20240159702A1 METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS 审中-公开
公开(公告)号：US20240159702A1
公开(公告)日：2024-05-16
申请号：US18353017
申请日：2023-07-14
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Jonathan M. ROTHBERG , Wolfgang HINZ , Kim L. JOHNSON , James BUSTILLO
IPC分类号： G01N27/414 , C12Q1/6818 , C12Q1/6874 , G01N33/543 , H01L27/088 , H01L29/78
CPC分类号： G01N27/4148 , C12Q1/6818 , C12Q1/6874 , G01N27/4145 , G01N33/54373 , G01N33/5438 , H01L27/088 , H01L29/78 , H01L29/42324 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01073 , H01L2924/14 , H01L2924/1433 , Y10T436/22
摘要： Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

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