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41. 发明授权

US08394779B2 Methods of modulating angiogenesis via TRPV4 有权
标题翻译：通过TRPV4调节血管生成的方法
公开(公告)号：US08394779B2
公开(公告)日：2013-03-12
申请号：US12996069
申请日：2009-06-04
申请人： Donald E. Ingber , Charles K. Thodeti
发明人： Donald E. Ingber , Charles K. Thodeti
IPC分类号： C12N15/11
CPC分类号： C12N15/1138 , A61K31/70 , A61K31/713 , A61K45/06 , C07K16/2842 , C12N2310/14 , G01N33/5064
摘要： The present invention relates to methods of inhibiting capillary endothelial (CE) cell migration, the formation of CE networks and angiogenesis, and uses thereof for the purpose of treating angiogenesis-related diseases and disorders, particularly when the diseases or disorders are directly related aberrant angiogenesis. Inhibition is achieved by inhibiting TRPV4 activity, such as the levels of TRPV4 expression, calcium influx through TRPV4, and/or the intracellular signaling from TRPV4 via β1 integrin activation.
摘要翻译：本发明涉及抑制毛细血管内皮细胞迁移，CE网络形成和血管生成的方法及其用于治疗血管发生相关疾病和病症的用途，特别是当疾病或病症直接相关异常血管生成。通过抑制TRPV4活性，例如通过TRPV4的TRPV4表达的水平，通过TRPV4的内流，和/或来自TRPV4的细胞内信号传导通过整合素的激活来实现抑制。

42. 发明申请

US20090322783A1 Method and apparatus for displaying information 有权
标题翻译：用于显示信息的方法和装置
公开(公告)号：US20090322783A1
公开(公告)日：2009-12-31
申请号：US12379000
申请日：2009-02-20
申请人： Donald E. Ingber , Sui Huang , Gabriel S. Eichler
发明人： Donald E. Ingber , Sui Huang , Gabriel S. Eichler
IPC分类号： G09G5/00
CPC分类号： G06T11/60
摘要： A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles each corresponding to a representative reference element; mapping observed elements onto the spatial layout of tiles of representative reference elements; assigning a respective value to each respective tile of the spatial layout of the representative elements; and displaying an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information. The apparatus includes a tiler forming a spatial layout of tiles, each corresponding to a representative reference element; a comparator mapping observed elements onto said spatial layout of tiles of representative reference elements; an assigner assigning a respective value to each respective tile of said spatial layout of representative reference elements; and a display displaying an image of the spatial layout of tiles of representative reference elements.
摘要翻译：一种显示大量信息的方法。该方法包括以下步骤：形成各自对应于代表参考元素的瓦片的空间布局; 将观察到的元素映射到代表参考元素的瓦片的空间布局上; 将相应的值分配给代表元素的空间布局的每个相应瓦片; 并显示代表性元素的瓦片的空间布局的图像。每个瓦片包括代表性元素的原子属性。本发明还涉及一种显示大量信息的装置。该装置包括形成瓦片的空间布局的分片器，每个对应于代表参考元件; 将观察到的元素映射到代表性参考元素的瓦片的所述空间布局上的比较器; 分配器，将代表参考元素的所述空间布局的相应值分配给相应的值; 以及显示代表参考元素的瓦片的空间布局的图像的显示器。

43. 发明申请

US20090220932A1 DEVICE AND METHOD FOR COMBINED MICROFLUIDIC-MICROMAGNETIC SEPARATION OF MATERIAL IN CONTINUOUS FLOW 有权
标题翻译：用于连续流动的材料的微流控 - 微生物分离的装置和方法
公开(公告)号：US20090220932A1
公开(公告)日：2009-09-03
申请号：US12088975
申请日：2006-10-06
申请人： Donald E. Ingber , Shannon Xia , Tom P. Hunt , Robert M. Westervelt
发明人： Donald E. Ingber , Shannon Xia , Tom P. Hunt , Robert M. Westervelt
IPC分类号： A01N1/02 , B01J19/00 , C12M1/00 , G01N1/18 , C12N13/00
CPC分类号： A61M1/3618 , A61M1/36 , A61M2205/0244 , A61M2206/11 , B01L3/502761 , B01L2200/0636 , B01L2200/0668 , B01L2300/06 , B01L2300/0864 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N2015/149 , Y10T436/25375
摘要： A miniaturized, integrated, microfluidic device pulls materials bound to magnetic particles from one laminar flow path to another by applying a local magnetic field gradient. The device removes microbial and mammalian cells from flowing biological fluids without any wash steps. A microfabricated high-gradient magnetic field concentrator (HGMC) is integrated at one side of a microfluidic channel. When magnetic particles are introduced into one flow path, they remain limited to that flow path. When the HGMC is magnetized, the magnetic beads are pulled from the initial flow path into the collection stream, thereby cleansing the fluid. The microdevice allows large numbers of beads and materials to be sorted simultaneously, has no capacity limit, does not lose separation efficiency as particles are removed, and is useful for cell separations from blood and other biological fluids. This on-chip separator allows cell separations to be performed in the field outside of hospitals and laboratories.
摘要翻译：小型化，集成的微流体装置通过施加局部磁场梯度将与磁性颗粒结合的材料从一个层流路径拉到另一层。该装置在没有任何洗涤步骤的情况下除去微生物和哺乳动物细胞流动的生物流体。微加工的高梯度磁场集中器（HGMC）集成在微流体通道的一侧。当磁性颗粒被引入一个流动路径时，它们仍然限于该流动路径。当HGMC被磁化时，将磁珠从初始流动路径拉入收集流，从而清洁流体。微型装置允许大量的珠粒和材料同时分选，没有容量限制，在颗粒被去除时不会失去分离效率，并且可用于从血液和其它生物流体中分离细胞。这种片上分离器允许在医院和实验室外的实地进行细胞分离。

44. 发明授权

US06686184B1 Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks 有权
标题翻译：使用包括三维排列的通道网络的微流体标记的表面图案化
公开(公告)号：US06686184B1
公开(公告)日：2004-02-03
申请号：US09578562
申请日：2000-05-25
申请人： Janelle R. Anderson , Daniel T. Chiu , Noo-Li Jeon , Sui Huang , Ravi Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Noo-Li Jeon , Sui Huang , Ravi Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
IPC分类号： C12N1100
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： Microfluidic systems and methods are provided for fabricating complex patterns of materials, such as proteins, inorganic materials or cells, on surfaces. Complex, discontinuous patterns on surfaces can be formed incorporating or depositing multiple materials. A stamp structure has a flow path containing a series of interconnected channels. The channels include a first channel within an interior of the stamp structure, a second channel within a stamping surface of the structure defining a pattern, and a channel fluidically interconnecting the first and second channels. After contacting the stamp with a surface, a fluid is introduced into the flow path so that the fluid contacts the surface to form a pattern. In another embodiment, the stamp structure has two non-fluidically interconnected first and second flow paths defining first and second patterns of channels to produce non-continuous first and second patterns on a surface.
摘要翻译：提供微流体系统和方法用于在表面上制造复杂的材料图案，例如蛋白质，无机材料或细胞。可以形成结合或沉积多种材料的表面上的复杂的不连续图案。邮票结构具有包含一系列互连通道的流路。通道包括印模结构内部的第一通道，限定图案的结构的冲压表面内的第二通道以及流体地互连第一和第二通道的通道。在将印模与表面接触之后，将流体引入流动路径中，使得流体接触表面以形成图案。在另一个实施例中，印模结构具有限定第一和第二图案通道的两个非流体互连的第一和第二流动路径，以在表面上产生不连续的第一和第二图案。

45. 发明授权

US09593160B2 Engineered microbe-targeting molecules and uses thereof 有权
标题翻译：工程微生物靶向分子及其用途
公开(公告)号：US09593160B2
公开(公告)日：2017-03-14
申请号：US14233553
申请日：2012-07-18
申请人： Donald E. Ingber , Michael Super , Jeffrey Charles Way , Mark J. Cartwright , Julia B. Berthet , Dinah R. Super , Martin M. Rottman , Alexander Watters
发明人： Donald E. Ingber , Michael Super , Jeffrey Charles Way , Mark J. Cartwright , Julia B. Berthet , Dinah R. Super , Martin M. Rottman , Alexander Watters
IPC分类号： C07K14/42 , C07K16/12 , A61K47/48 , G01N33/543 , G01N33/569
CPC分类号： C07K16/12 , A61K47/68 , A61K47/6815 , C07K14/42 , C07K2319/33 , G01N33/54353 , G01N33/56911 , G01N33/56916 , G01N33/56938 , G01N33/56961 , G01N2333/42 , G01N2333/4724 , Y02A50/53 , Y02A50/58
摘要： Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.
摘要翻译：本文描述了工程化的微生物靶向或微生物结合分子，包含其的试剂盒及其用途。微生物靶向或微生物结合分子的一些具体实施方案包括与Fc区的一部分连接的甘露糖结合凝集素或其片段的碳水化合物识别结构域。在一些实施方案中，微生物靶向分子或微生物结合分子可以与基底（例如磁性微珠）缀合，形成微生物靶向底物（例如，微生物靶向磁性微珠）。这样的微生物靶向分子和/或底物及其包含的试剂盒可以结合和/或捕获微生物和/或其微生物物质，因此可用于各种应用中，例如诊断和/或治疗感染由微生物引起，如受试者或任何环境表面的败血症。微生物靶向分子和/或底物可以在使用后通过用不溶于钙的低pH缓冲液或缓冲液洗涤而再生。

46. 发明授权

US07993905B2 Device containing cytophilic islands that adhere cells separated by cytophobic regions 失效
标题翻译：包含细胞吸附岛的装置，其附着由细胞疏植区域分离的细胞
公开(公告)号：US07993905B2
公开(公告)日：2011-08-09
申请号：US12166287
申请日：2008-07-01
申请人： Rahul Singhvi , Amit Kumar , George M. Whitesides , Donald E. Ingber , Gabriel P. Lopez , Daniel I. C. Wang , Gregory Stephanopoulos
发明人： Rahul Singhvi , Amit Kumar , George M. Whitesides , Donald E. Ingber , Gabriel P. Lopez , Daniel I. C. Wang , Gregory Stephanopoulos
IPC分类号： C12N1/00 , C12N11/00 , C12N11/08
CPC分类号： C12N1/00 , B01J19/0046 , B01J2219/00382 , B01J2219/00385 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B81B2201/0214 , B81C1/00206 , B81C2201/034 , B82Y5/00 , B82Y30/00 , C12N5/0068 , C12N5/067 , C12N2535/10 , C12Q1/02 , C40B60/14
摘要： The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).
摘要翻译：本发明提供一种用于将细胞粘附在特定和预定位置的装置以及相关方法。该装置包括限定表面的板和多个细胞亲和岛，其附着细胞，由细胞不粘附的细胞渗透区隔离，与细胞色素岛邻接。岛或区域或两者可以由自组装单层（SAM）形成。

47. 发明授权

US07834884B2 Method and apparatus for displaying information 有权
标题翻译：用于显示信息的方法和装置
公开(公告)号：US07834884B2
公开(公告)日：2010-11-16
申请号：US12379000
申请日：2009-02-20
申请人： Donald E. Ingber , Sui Huang , Gabriel Eichler
发明人： Donald E. Ingber , Sui Huang , Gabriel Eichler
IPC分类号： G06T11/20 , G09G5/22 , G09G5/00 , A01N1/00 , G06F17/00 , A61B5/00
CPC分类号： G06T11/60
摘要： A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles each corresponding to a representative reference element; mapping observed elements onto the spatial layout of tiles of representative reference elements; assigning a respective value to each respective tile of the spatial layout of the representative elements; and displaying an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information. The apparatus includes a tiler forming a spatial layout of tiles, each corresponding to a representative reference element; a comparator mapping observed elements onto said spatial layout of tiles of representative reference elements; an assigner assigning a respective value to each respective tile of said spatial layout of representative reference elements; and a display displaying an image of the spatial layout of tiles of representative reference elements.
摘要翻译：一种显示大量信息的方法。该方法包括以下步骤：形成各自对应于代表参考元素的瓦片的空间布局; 将观察到的元素映射到代表参考元素的瓦片的空间布局上; 将相应的值分配给代表元素的空间布局的每个相应瓦片; 并显示代表性元素的瓦片的空间布局的图像。每个瓦片包括代表性元素的原子属性。本发明还涉及一种显示大量信息的装置。该装置包括形成瓦片的空间布局的分片器，每个对应于代表参考元件; 将观察到的元素映射到代表性参考元素的瓦片的所述空间布局上的比较器; 分配器，将代表参考元素的所述空间布局的相应值分配给相应的值; 以及显示代表参考元素的瓦片的空间布局的图像的显示器。

48. 发明申请

US20100203143A1 SYSTEMS AND METHODS FOR NANOMAGNETIC ACTUATION OF MOLECULAR CELL SIGNALING 有权
标题翻译：用于分子细胞信号的纳米分解的系统和方法
公开(公告)号：US20100203143A1
公开(公告)日：2010-08-12
申请号：US12595306
申请日：2008-04-09
申请人： Donald E. Ingber , Robert J. Mannix , Sanjay Kumar
发明人： Donald E. Ingber , Robert J. Mannix , Sanjay Kumar
IPC分类号： A61K9/14 , A61K39/395 , A61P35/00 , A61P9/06 , A61P5/00 , C12N13/00
CPC分类号： A61K41/0052 , A61K47/48507 , A61K47/6835 , A61N2/00 , Y10S977/904
摘要： The present invention relates to signaling mechanisms that transduce magnetic inputs into physiological cellular outputs. More particularly, the present invention relates to systems and methods for non-invasively controlling cellular signaling functions and behaviors by harnessing receptor-mediated and intracellular molecular-mediated signal transduction using nanomagnetic cellular switches.
摘要翻译：本发明涉及将磁输入转换成生理细胞输出的信号传导机制。更具体地，本发明涉及通过利用纳米磁性细胞开关利用受体介导和细胞内分子介导的信号转导来非侵入性地控制细胞信号传导功能和行为的系统和方法。

49. 发明申请

US20080174610A1 Method and apparatus for displaying information 审中-公开
标题翻译：用于显示信息的方法和装置
公开(公告)号：US20080174610A1
公开(公告)日：2008-07-24
申请号：US11890286
申请日：2007-08-03
申请人： Donald E. Ingber , Sui Huang , Gabriel S. Eichler
发明人： Donald E. Ingber , Sui Huang , Gabriel S. Eichler
IPC分类号： G09G5/00
CPC分类号： G06T11/60
摘要： A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles each corresponding to a representative reference element; mapping observed elements onto the spatial layout of tiles of representative reference elements; assigning a respective value to each respective tile of the spatial layout of the representative elements; and displaying an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information. The apparatus includes a tiler forming a spatial layout of tiles, each corresponding to a representative reference element; a comparator mapping observed elements onto said spatial layout of tiles of representative reference elements; an assigner assigning a respective value to each respective tile of said spatial layout of representative reference elements; and a display displaying an image of the spatial layout of tiles of representative reference elements.
摘要翻译：一种显示大量信息的方法。该方法包括以下步骤：形成各自对应于代表参考元素的瓦片的空间布局; 将观察到的元素映射到代表参考元素的瓦片的空间布局上; 将相应的值分配给代表元素的空间布局的每个相应瓦片; 并显示代表性元素的瓦片的空间布局的图像。每个瓦片包括代表性元素的原子属性。本发明还涉及一种显示大量信息的装置。该装置包括形成瓦片的空间布局的分片器，每个对应于代表参考元件; 将观察到的元素映射到代表性参考元素的瓦片的所述空间布局上的比较器; 分配器，将代表参考元素的所述空间布局的相应值分配给相应的值; 以及显示代表参考元素的瓦片的空间布局的图像的显示器。

50. 发明授权

US07267938B2 Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks 有权
标题翻译：使用包括三维排列的通道网络的微流体标记的表面图案化
公开(公告)号：US07267938B2
公开(公告)日：2007-09-11
申请号：US10654587
申请日：2003-09-02
申请人： Janelle R. Anderson , Daniel T. Chiu , Noo Li Jeon , Sui Huang , Ravindra Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Noo Li Jeon , Sui Huang , Ravindra Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
IPC分类号： C12Q1/00 , C12N11/00 , C12N11/02 , C12M1/00 , C07K17/00 , C07K17/02
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively “ink” different regions of the stamp with different materials.
摘要翻译：本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。用于制造所公开的系统的方法可以提供拓扑复杂和改进的微流体系统的方便的途径。微流体系统可以包括其中流体流动路径的三维排列的网络，其中包括在交叉点处的交叉点处的交叉或不在其他通道上的通道，而没有物理交叉点。微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，该图案可以将多种材料结合或沉积到表面上。本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。

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