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1. 发明授权

US07267938B2 Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks 有权
标题翻译：使用包括三维排列的通道网络的微流体标记的表面图案化
公开(公告)号：US07267938B2
公开(公告)日：2007-09-11
申请号：US10654587
申请日：2003-09-02
申请人： Janelle R. Anderson , Daniel T. Chiu , Noo Li Jeon , Sui Huang , Ravindra Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Noo Li Jeon , Sui Huang , Ravindra Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
IPC分类号： C12Q1/00 , C12N11/00 , C12N11/02 , C12M1/00 , C07K17/00 , C07K17/02
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively “ink” different regions of the stamp with different materials.
摘要翻译：本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。用于制造所公开的系统的方法可以提供拓扑复杂和改进的微流体系统的方便的途径。微流体系统可以包括其中流体流动路径的三维排列的网络，其中包括在交叉点处的交叉点处的交叉或不在其他通道上的通道，而没有物理交叉点。微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，该图案可以将多种材料结合或沉积到表面上。本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。

2. 发明授权

US06686184B1 Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks 有权
标题翻译：使用包括三维排列的通道网络的微流体标记的表面图案化
公开(公告)号：US06686184B1
公开(公告)日：2004-02-03
申请号：US09578562
申请日：2000-05-25
申请人： Janelle R. Anderson , Daniel T. Chiu , Noo-Li Jeon , Sui Huang , Ravi Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Noo-Li Jeon , Sui Huang , Ravi Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
IPC分类号： C12N1100
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： Microfluidic systems and methods are provided for fabricating complex patterns of materials, such as proteins, inorganic materials or cells, on surfaces. Complex, discontinuous patterns on surfaces can be formed incorporating or depositing multiple materials. A stamp structure has a flow path containing a series of interconnected channels. The channels include a first channel within an interior of the stamp structure, a second channel within a stamping surface of the structure defining a pattern, and a channel fluidically interconnecting the first and second channels. After contacting the stamp with a surface, a fluid is introduced into the flow path so that the fluid contacts the surface to form a pattern. In another embodiment, the stamp structure has two non-fluidically interconnected first and second flow paths defining first and second patterns of channels to produce non-continuous first and second patterns on a surface.
摘要翻译：提供微流体系统和方法用于在表面上制造复杂的材料图案，例如蛋白质，无机材料或细胞。可以形成结合或沉积多种材料的表面上的复杂的不连续图案。邮票结构具有包含一系列互连通道的流路。通道包括印模结构内部的第一通道，限定图案的结构的冲压表面内的第二通道以及流体地互连第一和第二通道的通道。在将印模与表面接触之后，将流体引入流动路径中，使得流体接触表面以形成图案。在另一个实施例中，印模结构具有限定第一和第二图案通道的两个非流体互连的第一和第二流动路径，以在表面上产生不连续的第一和第二图案。

3. 发明授权

US07494482B2 Methods and apparatus for application of micro-mechanical forces to tissues 有权
标题翻译：将微机械力施加到组织的方法和装置
公开(公告)号：US07494482B2
公开(公告)日：2009-02-24
申请号：US10146472
申请日：2002-05-15
申请人： Dennis P. Orgill , Quentin Gavin Eichbaum , Sui Huang , Chao-Wei Hwang , Donald E. Ingber , Vishal Saxena , Evan Stuart Garfein
发明人： Dennis P. Orgill , Quentin Gavin Eichbaum , Sui Huang , Chao-Wei Hwang , Donald E. Ingber , Vishal Saxena , Evan Stuart Garfein
IPC分类号： A61F2/00 , A61F13/00 , A61F2/06
CPC分类号： A61M1/0088 , A61B2017/00747 , A61B2090/401 , A61F13/00 , A61F13/00008 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00987 , A61F2002/286 , A61F2002/30062 , A61F2002/30955 , A61F2013/00174 , A61F2013/00221 , A61F2013/00327 , A61F2013/00365 , A61F2013/0054 , A61F2013/00574 , A61F2013/00927 , A61F2210/0004 , A61L15/42 , A61L15/425 , A61M1/0023
摘要： Methods and devices for transmitting micromechanical forces locally to induce surface convolutions into tissues on the millimeter to micron scale for promoting wound healing are presented. These convolutions induce a moderate stretching of individual cells, stimulating cellular proliferation and elaboration of natural growth factors without increasing the size of the wound. Micromechanical forces can be applied directly to tissue, through biomolecules or the extracellular matrix. This invention can be used with biosensors, biodegradable materials and drug delivery systems. This invention will also be useful in pre-conditioned tissue-engineering constructs in vitro. Application of this invention will shorten healing times for wounds and reduce the need for invasive surgery.
摘要翻译：提出了用于传递微机械力局部地诱导表面卷积到毫米至微米级的组织以促进伤口愈合的方法和装置。这些卷积诱导单个细胞的适度拉伸，刺激细胞增殖和自然生长因子的制备而不增加伤口的大小。微机械力可以通过生物分子或细胞外基质直接施用于组织。本发明可用于生物传感器，可生物降解材料和药物递送系统。本发明也可用于体外预处理组织工程构建体。本发明的应用将缩短伤口的愈合时间并减少对侵入性手术的需要。

4. 发明授权

US06888543B2 Method and apparatus for displaying information 失效
标题翻译：用于显示信息的方法和装置
公开(公告)号：US06888543B2
公开(公告)日：2005-05-03
申请号：US10435660
申请日：2003-05-09
申请人： Donald E. Ingber , Sui Huang , Gabriel Eichler
发明人： Donald E. Ingber , Sui Huang , Gabriel Eichler
IPC分类号： G06T11/60 , G06T17/00
CPC分类号： G06T11/60
摘要： A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles each corresponding to a representative reference element; mapping observed elements onto the spatial layout of tiles of representative reference elements; assigning a respective value to each respective tile of the spatial layout of the representative elements; and displaying an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information. The apparatus includes a tiler forming a spatial layout of tiles, each corresponding to a representative reference element; a comparator mapping observed elements onto said spatial layout of tiles of representative reference elements; an assigner assigning a respective value to each respective tile of said spatial layout of representative reference elements; and a display displaying an image of the spatial layout of tiles of representative reference elements.
摘要翻译：一种显示大量信息的方法。该方法包括以下步骤：形成各自对应于代表参考元素的瓦片的空间布局; 将观察到的元素映射到代表参考元素的瓦片的空间布局上; 将相应的值分配给代表元素的空间布局的每个相应瓦片; 并显示代表性元素的瓦片的空间布局的图像。每个瓦片包括代表性元素的原子属性。本发明还涉及一种显示大量信息的装置。该装置包括形成瓦片的空间布局的分片器，每个对应于代表参考元件; 将观察到的元素映射到代表性参考元素的瓦片的所述空间布局上的比较器; 分配器，将代表参考元素的所述空间布局的相应值分配给相应的值; 以及显示代表参考元素的瓦片的空间布局的图像的显示器。

5. 发明申请

US20090322783A1 Method and apparatus for displaying information 有权
标题翻译：用于显示信息的方法和装置
公开(公告)号：US20090322783A1
公开(公告)日：2009-12-31
申请号：US12379000
申请日：2009-02-20
申请人： Donald E. Ingber , Sui Huang , Gabriel S. Eichler
发明人： Donald E. Ingber , Sui Huang , Gabriel S. Eichler
IPC分类号： G09G5/00
CPC分类号： G06T11/60
摘要： A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles each corresponding to a representative reference element; mapping observed elements onto the spatial layout of tiles of representative reference elements; assigning a respective value to each respective tile of the spatial layout of the representative elements; and displaying an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information. The apparatus includes a tiler forming a spatial layout of tiles, each corresponding to a representative reference element; a comparator mapping observed elements onto said spatial layout of tiles of representative reference elements; an assigner assigning a respective value to each respective tile of said spatial layout of representative reference elements; and a display displaying an image of the spatial layout of tiles of representative reference elements.
摘要翻译：一种显示大量信息的方法。该方法包括以下步骤：形成各自对应于代表参考元素的瓦片的空间布局; 将观察到的元素映射到代表参考元素的瓦片的空间布局上; 将相应的值分配给代表元素的空间布局的每个相应瓦片; 并显示代表性元素的瓦片的空间布局的图像。每个瓦片包括代表性元素的原子属性。本发明还涉及一种显示大量信息的装置。该装置包括形成瓦片的空间布局的分片器，每个对应于代表参考元件; 将观察到的元素映射到代表性参考元素的瓦片的所述空间布局上的比较器; 分配器，将代表参考元素的所述空间布局的相应值分配给相应的值; 以及显示代表参考元素的瓦片的空间布局的图像的显示器。

6. 发明授权

US07834884B2 Method and apparatus for displaying information 有权
标题翻译：用于显示信息的方法和装置
公开(公告)号：US07834884B2
公开(公告)日：2010-11-16
申请号：US12379000
申请日：2009-02-20
申请人： Donald E. Ingber , Sui Huang , Gabriel Eichler
发明人： Donald E. Ingber , Sui Huang , Gabriel Eichler
IPC分类号： G06T11/20 , G09G5/22 , G09G5/00 , A01N1/00 , G06F17/00 , A61B5/00
CPC分类号： G06T11/60
摘要： A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles each corresponding to a representative reference element; mapping observed elements onto the spatial layout of tiles of representative reference elements; assigning a respective value to each respective tile of the spatial layout of the representative elements; and displaying an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information. The apparatus includes a tiler forming a spatial layout of tiles, each corresponding to a representative reference element; a comparator mapping observed elements onto said spatial layout of tiles of representative reference elements; an assigner assigning a respective value to each respective tile of said spatial layout of representative reference elements; and a display displaying an image of the spatial layout of tiles of representative reference elements.
摘要翻译：一种显示大量信息的方法。该方法包括以下步骤：形成各自对应于代表参考元素的瓦片的空间布局; 将观察到的元素映射到代表参考元素的瓦片的空间布局上; 将相应的值分配给代表元素的空间布局的每个相应瓦片; 并显示代表性元素的瓦片的空间布局的图像。每个瓦片包括代表性元素的原子属性。本发明还涉及一种显示大量信息的装置。该装置包括形成瓦片的空间布局的分片器，每个对应于代表参考元件; 将观察到的元素映射到代表性参考元素的瓦片的所述空间布局上的比较器; 分配器，将代表参考元素的所述空间布局的相应值分配给相应的值; 以及显示代表参考元素的瓦片的空间布局的图像的显示器。

7. 发明申请

US20080174610A1 Method and apparatus for displaying information 审中-公开
标题翻译：用于显示信息的方法和装置
公开(公告)号：US20080174610A1
公开(公告)日：2008-07-24
申请号：US11890286
申请日：2007-08-03
申请人： Donald E. Ingber , Sui Huang , Gabriel S. Eichler
发明人： Donald E. Ingber , Sui Huang , Gabriel S. Eichler
IPC分类号： G09G5/00
CPC分类号： G06T11/60
摘要： A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles each corresponding to a representative reference element; mapping observed elements onto the spatial layout of tiles of representative reference elements; assigning a respective value to each respective tile of the spatial layout of the representative elements; and displaying an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information. The apparatus includes a tiler forming a spatial layout of tiles, each corresponding to a representative reference element; a comparator mapping observed elements onto said spatial layout of tiles of representative reference elements; an assigner assigning a respective value to each respective tile of said spatial layout of representative reference elements; and a display displaying an image of the spatial layout of tiles of representative reference elements.
摘要翻译：一种显示大量信息的方法。该方法包括以下步骤：形成各自对应于代表参考元素的瓦片的空间布局; 将观察到的元素映射到代表参考元素的瓦片的空间布局上; 将相应的值分配给代表元素的空间布局的每个相应瓦片; 并显示代表性元素的瓦片的空间布局的图像。每个瓦片包括代表性元素的原子属性。本发明还涉及一种显示大量信息的装置。该装置包括形成瓦片的空间布局的分片器，每个对应于代表参考元件; 将观察到的元素映射到代表性参考元素的瓦片的所述空间布局上的比较器; 分配器，将代表参考元素的所述空间布局的相应值分配给相应的值; 以及显示代表参考元素的瓦片的空间布局的图像的显示器。

8. 发明申请

US20100303719A1 ANTI-CANCER COMPOUNDS 有权
标题翻译：抗癌化合物
公开(公告)号：US20100303719A1
公开(公告)日：2010-12-02
申请号：US12812114
申请日：2009-01-12
申请人： Sui Huang , John Norton , Daniel Appella , Mark Witschi
发明人： Sui Huang , John Norton , Daniel Appella , Mark Witschi
IPC分类号： A61K31/435 , C07D221/14 , A61K38/50 , A61K38/21 , A61K39/395 , A61K33/14 , A61K51/04 , A61K51/02 , A61K31/675 , A61P35/00 , A61P35/02
CPC分类号： C07D221/14 , A61K31/43 , A61K31/473 , A61K45/06 , A61K2300/00 , C07D217/24
摘要： The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.
摘要翻译：本发明涉及抗癌化合物，其发现方法及其治疗用途。特别地，本发明提供了已知的抗癌化合物阿米卡德和结构和功能相关化合物的类似物，以及使用这些化合物作为治疗剂来治疗与过度增殖相关的许多病症的方法。

9. 发明申请

US20050084852A1 Perinucleolar compartment as a cancer marker 审中-公开
标题翻译：周围隔室作为癌症标志物
公开(公告)号：US20050084852A1
公开(公告)日：2005-04-21
申请号：US10403422
申请日：2003-03-31
申请人： Sui Huang , Rajesh Kamath , David Spector , Ann Thor , Chen Wang
发明人： Sui Huang , Rajesh Kamath , David Spector , Ann Thor , Chen Wang
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/574
CPC分类号： G01N33/5011 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , G01N33/574
摘要： The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
摘要翻译：本发明涉及癌症诊断，预后和预测的组合物和方法，包括但不限于癌症标志物。特别地，本发明提供了作为癌症标记物的周围核隔室及其驻留分子。

10. 发明授权

US11497719B1 Cannabinoid composition and application of the same in preparing medicine for treating neurodegenerative diseases including parkinson's disease and alzheimer's disease 有权
公开(公告)号：US11497719B1
公开(公告)日：2022-11-15
申请号：US17586304
申请日：2022-01-27
申请人： Chendong Zou , Hei Tai , Guijiang Wang , Wan Xiao , Sui Huang
发明人： Chendong Zou , Hei Tai , Guijiang Wang , Wan Xiao , Sui Huang
IPC分类号： A61K31/05 , A61P25/16 , A61P25/28
摘要： Disclosed are a cannabinoid composition and an application of the same in preparing a medicine for treating neurodegenerative diseases, so as to solve the drawbacks of conventional medicines such as serious side effects and degraded therapeutic effect after long-term administration. The cannabinoid composition includes: cannabidiol and cannabigerol, a mass ratio of the cannabidiol to the cannabigerol ranging from 1:1 to 1:10, or from 1:0.3 to 1:0.5, or from 1:0.5 to 1:0.7, or from 1:07 to 1:1. The present disclosure adopts the experimental method of inducing differentiation of fibroblasts to dopaminergic neurons, wherein by observing the cell morphology, quantity, and relative expression level of DA-related factor of the differentiation-induced and cultured fibroblasts, and screening various common cannabinoids and different combinations thereof based on their impacts on inducing differentiation of the fibroblasts into dopaminergic neurons, it was found that the CBD+CBG combination offered an optimal effect in improving viability and dopamine-secreting capability of the dopaminergic neuronal cells; besides, the CBD+CBG combination is free of the addictive substance THC, which thus significantly reduces side effects and may be applied to prepare medicines for treating neurodegenerative diseases.

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