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41. 发明授权

US08475388B2 Detection of disordered breathing 有权
标题翻译：检测无序呼吸
公开(公告)号：US08475388B2
公开(公告)日：2013-07-02
申请号：US12847711
申请日：2010-07-30
申请人： Quan Ni , John D. Hatlestad , Jesse W. Hartley , Jeffrey E. Stahmann , Jaeho Kim , Kent Lee
发明人： Quan Ni , John D. Hatlestad , Jesse W. Hartley , Jeffrey E. Stahmann , Jaeho Kim , Kent Lee
IPC分类号： A61B5/08
CPC分类号： A61B5/4818 , A61B5/0205 , A61B5/4806 , A61B5/4809 , A61B5/7264
摘要： Devices and methods for detecting disordered breathing involve determining that the patient is asleep and sensing one or more signals associated with disordered breathing indicative of sleep-disordered breathing while the patient is asleep. Sleep-disordered breathing is detected using the sensed signals associated with disordered breathing. The sensed signals associated with disordered breathing may also be used to acquire a respiration pattern of one or more respiration cycles. Characteristics of the respiration pattern are determined. The respiration pattern is classified as a disordered breathing episode based on the characteristics of the respiration pattern. One or more processes involved in the detection of disordered breathing are performed using an implantable device.
摘要翻译：用于检测无序呼吸的装置和方法涉及确定患者睡着并且感测与患者睡着时指示睡眠呼吸紊乱的无序呼吸相关联的一个或多个信号。使用与无序呼吸相关的感测信号来检测睡眠呼吸障碍。与无序呼吸相关联的感测信号也可用于获取一个或多个呼吸循环的呼吸模式。确定呼吸模式的特征。根据呼吸模式的特点，呼吸模式被分类为无序呼吸发作。使用可植入装置进行涉及无序呼吸检测的一个或多个过程。

42. 发明授权

US08442638B2 Adaptive baroreflex stimulation therapy for disordered breathing 有权
标题翻译：适应性压力反射刺激治疗无序呼吸
公开(公告)号：US08442638B2
公开(公告)日：2013-05-14
申请号：US12781447
申请日：2010-05-17
申请人： Imad Libbus , Quan Ni , Kent Lee
发明人： Imad Libbus , Quan Ni , Kent Lee
IPC分类号： A61N1/3601 , A61N1/3611
CPC分类号： A61N1/3611 , A61N1/3601 , A61N1/36135
摘要： An approach to providing disordered breathing therapy includes delivering electrical stimulation therapy modifying a patient's baroreflex response. Disordered breathing therapy may be delivered in response to prediction or detection of disordered breathing events. Various conditions affecting the patient may be evaluated and the baroreflex therapy modified. The therapy may be modified to improve therapy efficacy, to reduce an impact to the patient and/or to mitigate therapy interactions.
摘要翻译：提供无序呼吸治疗的方法包括进行改变患者压力反射反应的电刺激疗法。无序呼吸治疗可以响应于预测或检测到无序呼吸事件而被传送。可以评估影响患者的各种状况，并修改压力反射治疗。可以修改治疗以改善治疗功效，减少对患者的影响和/或减轻治疗相互作用。

43. 发明申请

US20130079842A1 NEURAL CONTROL OF CENTRAL SLEEP APNEA 有权
标题翻译：中央休眠APNEA的神经控制
公开(公告)号：US20130079842A1
公开(公告)日：2013-03-28
申请号：US13626399
申请日：2012-09-25
申请人： Eric A. Mokelke , Yi Zhang , John D. Hatlestad , Kenneth C. Beck , Viktoria A. Averina , Jon Peterson , Kent Lee
发明人： Eric A. Mokelke , Yi Zhang , John D. Hatlestad , Kenneth C. Beck , Viktoria A. Averina , Jon Peterson , Kent Lee
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/36053
摘要： An apparatus comprises a physiologic sensing circuit and a control circuit. The physiologic sensing circuit is configured to sense an electrical respiration signal representative of respiration of a subject. The control circuit includes a respiration monitor circuit and a therapy circuit. The respiration monitor circuit is configured to extract a respiration parameter from the respiration signal and detect that a value of the respiration parameter is outside of a target value range for the respiration parameter. The therapy circuit is configured to deliver neural stimulation to the carotid sinus of the subject to stimulate respiration and to adjust respiration to maintain the value of the respiration parameter within the target value range.
摘要翻译：一种装置包括生理感测电路和控制电路。生理感测电路被配置为感测代表受试者呼吸的电呼吸信号。控制电路包括呼吸监测电路和治疗电路。呼吸监视器电路被配置为从呼吸信号中提取呼吸参数，并且检测呼吸参数的值在呼吸参数的目标值范围之外。治疗电路被配置为将神经刺激递送到受试者的颈动脉窦以刺激呼吸并调节呼吸以将呼吸参数的值保持在目标值范围内。

44. 发明授权

US08401651B2 System for neural control of respiration 有权
公开(公告)号：US08401651B2
公开(公告)日：2013-03-19
申请号：US13229211
申请日：2011-09-09
申请人： Anthony V. Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
发明人： Anthony V. Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/18
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

45. 发明授权

US08380296B2 Automatic activation of medical processes 失效
标题翻译：自动激活医疗过程
公开(公告)号：US08380296B2
公开(公告)日：2013-02-19
申请号：US12649753
申请日：2009-12-30
申请人： Kent Lee , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
发明人： Kent Lee , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
IPC分类号： A61B5/04
CPC分类号： A61N1/3601 , A61B5/04012 , A61B5/1107 , A61B5/4094 , A61B5/4818 , A61B5/6869 , A61B2505/09 , A61M16/024 , A61M16/10 , A61M2016/0039 , A61M2016/0042 , A61M2205/3561 , A61M2205/3584 , A61M2230/04 , A61M2230/10 , A61M2230/63 , A61N1/3611 , A61N1/36114 , A61N1/36135 , A61N1/36514
摘要： Systems and methods involve automatic activation, de-activation or modification of therapies or other medical processes based on brain state. A medical system includes a sensor system having one or more sensors configured to sense signals related to the brain state of the patient. A brain state analyzer detects various brain states, including sleep stage and/or brain seizures. A controller uses the brain state detection information to control a medical system configured to perform at least one respiratory or cardiac process. Methods involve sensing signals related to brain state and determining the brain state of a patient based on the sensed signals. At least one respiratory or cardiac medical process is controlled based on the patient's brain state.
摘要翻译：系统和方法涉及基于脑状态的治疗或其他医疗过程的自动激活，去激活或修饰。医疗系统包括具有一个或多个传感器的传感器系统，该传感器被配置为感测与患者的脑状态相关的信号。脑状态分析仪检测各种脑状态，包括睡眠阶段和/或脑癫痫发作。控制器使用脑状态检测信息来控制被配置为执行至少一个呼吸或心脏过程的医疗系统。方法涉及感测与脑状态相关的信号，并且基于感测到的信号来确定患者的大脑状态。至少一个呼吸或心脏医疗过程是根据患者的大脑状态进行控制的。

46. 发明申请

US20120283527A1 RESPIRATION MONITORING FOR HEART FAILURE USING IMPLANTABLE DEVICE 失效
标题翻译：使用可移植设备进行心脏衰竭的呼吸监测
公开(公告)号：US20120283527A1
公开(公告)日：2012-11-08
申请号：US13553098
申请日：2012-07-19
申请人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
发明人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
IPC分类号： A61B5/0205 , A61B5/11 , A61B5/08
CPC分类号： A61B5/0816 , A61B5/0031 , A61B5/0452 , A61B5/4818 , A61N1/3627 , A61N1/36521
摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.
摘要翻译：可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。该警报可以通过远程监视来通知病人或看护者。睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。

47. 发明授权

US08251061B2 Methods and systems for control of gas therapy 有权
标题翻译：气体治疗方法和系统
公开(公告)号：US08251061B2
公开(公告)日：2012-08-28
申请号：US10929306
申请日：2004-08-30
申请人： Kent Lee , Jesse W. Hartley , Jeffrey E. Stahmann , Quan Ni
发明人： Kent Lee , Jesse W. Hartley , Jeffrey E. Stahmann , Quan Ni
IPC分类号： A61M15/00 , A61M16/00 , A61M15/08 , A62B7/00 , A62B9/02
CPC分类号： A61M16/024 , A61M2016/0039 , A61M2230/04 , A61M2230/08 , A61M2230/205 , A61M2230/63
摘要： A gas therapy system involves sensing the blood gas concentration of the patient and adapting a gas therapy based on the sensed gas concentration. Disordered breathing may be detected bases on blood gas concentration, and gas or cardiac electrical therapy may be adapted to treat the detected disordered breathing. One or more of sensing the blood gas concentration, detecting disordered breathing, or adapting the therapy may be performed at least in part implantably. The gas therapy is delivered to the patient through an external respiratory device, such as a positive airway pressure device.
摘要翻译：气体治疗系统包括感测患者的血液气体浓度，并根据检测到的气体浓度调整气体治疗。可能会根据血气浓度检测到无效呼吸，气体或心脏电疗可适用于治疗检测到的无序呼吸。感测血气浓度，检测无序呼吸或适应治疗的一种或多种可以至少部分地可植入地进行。气体治疗通过外部呼吸装置（例如气道正压装置）输送给患者。

48. 发明申请

US20120046709A1 METHOD AND APPARATUS FOR CONTROLLING NEURAL STIMULATION DURING DISORDERED BREATHING 有权
标题翻译：用于控制异常呼吸期间神经刺激的方法和装置
公开(公告)号：US20120046709A1
公开(公告)日：2012-02-23
申请号：US13285457
申请日：2011-10-31
申请人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
发明人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36135 , A61B5/0215 , A61B5/08 , A61B5/0816 , A61B5/4035 , A61B5/4818 , A61N1/3601
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统检测呼吸暂停，并且作为响应调整神经刺激脉冲的传递和/或递送治疗所检测的呼吸暂停的呼吸治疗。

49. 发明授权

US07993279B2 Methods and systems for implantably monitoring external breathing therapy 有权
标题翻译：用于植入式监测外部呼吸治疗的方法和系统
公开(公告)号：US07993279B2
公开(公告)日：2011-08-09
申请号：US12218409
申请日：2008-07-15
申请人： Jesse W. Hartley , Quan Ni , Jeffrey E. Stahmann , Kent Lee
发明人： Jesse W. Hartley , Quan Ni , Jeffrey E. Stahmann , Kent Lee
IPC分类号： A61B5/08
CPC分类号： A61B5/0538 , A61B5/0031 , A61B5/0809 , A61B5/4812 , A61B5/4815 , A61B5/4818 , A61M16/0051 , A61M16/026 , A61M2205/3523 , A61M2205/52 , A61M2230/00 , A61M2230/04 , A61M2230/18 , A61M2230/30 , A61M2230/40 , A61M2230/50 , A61M2230/60 , A61M2230/63 , A61M2230/65 , A61N1/368 , A61N1/3684
摘要： An implantable device is used to monitor one or more conditions associated with an external breathing therapy delivered to the patient. The device may monitor therapy parameters including therapy effectiveness, impact of the therapy on the patient, therapy usage, compliance with a prescribed usage, therapy interactions, and/or other parameters.
摘要翻译：可植入装置用于监测与递送给患者的外部呼吸治疗相关联的一个或多个状况。该装置可以监测治疗参数，包括治疗效果，治疗对患者的影响，治疗用途，符合规定用法，治疗相互作用和/或其他参数。

50. 发明授权

US07975115B2 Method and apparatus for separating snapshot preserved and write data 有权
标题翻译：用于分离快照保留和写入数据的方法和装置
公开(公告)号：US07975115B2
公开(公告)日：2011-07-05
申请号：US11779965
申请日：2007-07-19
申请人： James George Wayda , Kent Lee , Ngoclan Thi Vu , Elizabeth G. Rodriguez
发明人： James George Wayda , Kent Lee , Ngoclan Thi Vu , Elizabeth G. Rodriguez
IPC分类号： G06F12/16
CPC分类号： G06F3/065 , G06F3/0608 , G06F3/0644 , G06F3/067 , G06F11/1446 , G06F11/2007 , G06F11/2089 , G06F2201/84
摘要： A method and device for managing snapshot data is provided. Snapshots may be created having a preserved data area and a write data area. The preserved data area is used to maintain snapshot data corresponding to the point-in-time when the snapshot was created while the write data area is used to facilitate host read/write access to the snapshot. By maintaining two separate areas, the snapshot can be written to without altering the point-in-time representation of the snapshot.
摘要翻译：提供了一种用于管理快照数据的方法和设备。可以创建具有保留的数据区域和写入数据区域的快照。保留的数据区域用于在创建快照时保存与时间点对应的快照数据，同时使用写入数据区域来促进对快照的主机读/写访问。通过维护两个单独的区域，可以将快照写入，而无需更改快照的时间点表示。

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