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41. 发明申请

US20100125314A1 SYSTEM AND METHOD FOR ADJUSTING AUTOMATIC PULSE PARAMETERS TO SELECTIVELY ACTIVATE NERVE FIBERS 有权
标题翻译：用于调整自动脉冲参数以选择性激活神经纤维的系统和方法
公开(公告)号：US20100125314A1
公开(公告)日：2010-05-20
申请号：US12606050
申请日：2009-10-26
申请人： Kerry Bradley , Bradley Hershey , Dongchul Lee
发明人： Kerry Bradley , Bradley Hershey , Dongchul Lee
IPC分类号： A61N1/08
CPC分类号： A61N1/36192 , A61N1/36071 , A61N1/37247
摘要： A method of stimulating nerve tissue, a tissue stimulation system, and an external control device are provided. The method, system, and control device causes an electrical stimulus to be applied to at least one electrode adjacent the nerve tissue of a patient. The applied electrical stimulus comprises a plurality of pulses defined by a pulse width value and an amplitude value. The pulse amplitude value is increased (e.g., manually), and the pulse width value is automatically decreased in response to increasing the pulse amplitude value in a manner that increases the intensity of the applied electrical stimulus. Alternatively, the pulse width value may be decreased (e.g., manually), and the pulse amplitude value automatically increased in response to decreasing the pulse width value in a manner that increases the intensity of the applied electrical stimulus.
摘要翻译：提供刺激神经组织，组织刺激系统和外部控制装置的方法。该方法，系统和控制装置使得电刺激被施加到邻近患者神经组织的至少一个电极。所施加的电刺激包括由脉冲宽度值和振幅值定义的多个脉冲。脉冲幅度值增加（例如，手动），并且响应于以增加所施加的电刺激的强度的方式增加脉冲幅值来自动减小脉冲宽度值。或者，可以减小脉冲宽度值（例如，手动地），并且响应于以增加所施加的电刺激的强度的方式减小脉冲宽度值，脉冲振幅值自动增加。

42. 发明申请

US20090024189A1 USE OF STIMULATION PULSE SHAPE TO CONTROL NEURAL RECRUITMENT ORDER AND CLINICAL EFFECT 有权
标题翻译：刺激脉冲形状的使用来控制神经激励和临床效果
公开(公告)号：US20090024189A1
公开(公告)日：2009-01-22
申请号：US12175758
申请日：2008-07-18
申请人： Dongchul Lee , Michael Moffitt , Christopher Ewan Gillespie , Kerry Bradley
发明人： Dongchul Lee , Michael Moffitt , Christopher Ewan Gillespie , Kerry Bradley
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61N1/36003 , A61N1/36007 , A61N1/36017 , A61N1/36036 , A61N1/36046 , A61N1/3605 , A61N1/3606 , A61N1/36135 , A61N1/37247 , A61N1/378 , A61N1/3787 , A61N1/3906
摘要： A method, electrical tissue stimulation system, and programmer for providing therapy to a patient are provided. Electrodes are placed adjacent tissue (e.g., spinal cord tissue) of the patient, electrical stimulation energy is delivered from the electrodes to the tissue in accordance with a defined waveform, and a pulse shape of the defined waveform is modified, thereby changing the characteristics of the electrical stimulation energy delivered from the electrode(s) to the tissue. The pulse shape may be modified by selecting one of a plurality of different pulse shape types or by adjusting a time constant of the pulse shape.
摘要翻译：提供了一种用于向患者提供治疗的方法，电组织刺激系统和程序员。电极被放置在患者的组织（例如，脊髓组织）的附近，电刺激能量根据定义的波形从电极传送到组织，并且限定波形的脉冲形状被修改，从而改变从电极传递到组织的电刺激能量。可以通过选择多种不同的脉冲形状类型之一或通过调整脉冲形状的时间常数来修改脉冲形状。

43. 发明申请

US20080114416A1 STIMULATION PROGRAMMER WITH CLINICALLY-ADAPTIVE MODALITY 审中-公开
标题翻译：具有临床自适应模式的刺激编程器
公开(公告)号：US20080114416A1
公开(公告)日：2008-05-15
申请号：US11559377
申请日：2006-11-13
申请人： Margaret E. Theriot , Kerry Bradley , Holly A. Segel
发明人： Margaret E. Theriot , Kerry Bradley , Holly A. Segel
IPC分类号： A61N1/08
CPC分类号： A61N1/37264 , A61N1/3605 , A61N1/36071 , A61N1/37247
摘要： Tissue stimulation systems generally include a pulse generating device for generating electrical stimulation pulses, at least one implanted electrode for delivering the electrical stimulation pulses generated by the pulse generating device, and a programmer capable of communicating with the pulse generating device. In tissue stimulation systems, a clinically-adaptive stimulation programmer may be utilized, wherein a user communicates to the programmer a purpose of a programming session and a person who is to control the programming session. The clinically-adaptive stimulation programmer may be capable of determining a series of steps required to implement the programming session based on the selected purpose and the selected person. The clinically-adaptive programmer may implement the determined series of steps and communicate with the selected person during the programming session. Also provided are programming methods employing the clinically-adaptive programmer.
摘要翻译：组织刺激系统通常包括用于产生电刺激脉冲的脉冲产生装置，用于传递由脉冲发生装置产生的电刺激脉冲的至少一个注入电极以及能够与脉冲发生装置通信的编程器。在组织刺激系统中，可以利用临床适应性刺激程序员，其中用户向程序员传达编程会话的目的和要控制编程会话的人。临床适应性刺激程序员可能能够基于所选择的目的和所选择的人来确定实现编程会话所需的一系列步骤。临床适应性程序员可以在编程会话期间实施所确定的一系列步骤并与所选择的人进行通信。还提供了采用临床适应性编程器的编程方法。

44. 发明授权

US07127296B2 Method for increasing the therapeutic ratio/usage range in a neurostimulator 有权
公开(公告)号：US07127296B2
公开(公告)日：2006-10-24
申请号：US10285817
申请日：2002-11-01
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/20
CPC分类号： A61N1/36071
摘要： A system and method for patient control of the stimulation parameters of a Spinal Cord Stimulation (SCS) system, or other neurostimulation system, provides an increased Therapeutic Ratio (TR). Measurements of the just-perceptible stimulation level and the maximum-comfortable stimulation level are made for at least two values of pulse duration and two values of pulse amplitude. A Therapeutic Ratio is determined for stimulation level control strategies based on fixed pulse duration and variable pulse amplitude, and alternatively for fixed pulse amplitude and variable pulse duration. The control strategy providing the greatest therapeutic ratio is then selected for use by the patient. In an alternative embodiment, the pulse durations at the just-perceptible and maximum-comfortable stimulation levels are measured, and the pulse amplitudes at the just-perceptible and maximum-comfortable stimulation levels are determined using a curve-fitting process. Similarly, the pulse amplitudes may first be measured and the pulse widths determined using a curve-fitting process.

45. 发明申请

US20060224187A1 Apparatus and methods for detecting position and migration of neurostimulation leads 有权
公开(公告)号：US20060224187A1
公开(公告)日：2006-10-05
申请号：US11096662
申请日：2005-04-01
申请人： Kerry Bradley , Sunil Kapoor
发明人： Kerry Bradley , Sunil Kapoor
IPC分类号： A61N1/18
CPC分类号： A61N1/37241 , A61N1/0551 , A61N1/08 , A61N1/36071 , A61N1/36135 , A61N1/36185 , A61N2001/083
摘要： Apparatus and methods for detecting lead migration through the use of measured artifactual data about the tissue in the vicinity of the lead.

46. 发明申请

US20060122654A1 Apparatus and method for determining the relative position and orientation of neurostimulation leads 有权
公开(公告)号：US20060122654A1
公开(公告)日：2006-06-08
申请号：US11343007
申请日：2006-01-30
申请人： Kerry Bradley , James Thacker
发明人： Kerry Bradley , James Thacker
IPC分类号： A61N1/37
CPC分类号： A61N1/08 , A61B5/053 , A61N1/0551
摘要： Interelectrode impedance or electric field potential measurements are used to determine the relative orientation of one lead to other leads in the spinal column or other body/tissue location. Interelectrode impedance is determined by measuring impedance vectors. The value of the impedance vector is due primarily to the electrode-electrolyte interface, and the bulk impedance between the electrodes. The bulk impedance between the electrodes is, in turn, made up of (1) the impedance of the tissue adjacent to the electrodes, and (2) the impedance of the tissue between the electrodes. In one embodiment, the present invention makes both monopolar and bipolar impedance measurements, and then corrects the bipolar impedance measurements using the monopolar measurements to eliminate the effect of the impedance of the tissue adjacent the electrodes. The orientation and position of the leads may be inferred from the relative minima of the corrected bipolar impedance values. These corrected impedance values may also be mapped and stored to facilitate a comparison with subsequent corrected impedance measurement values. Such comparison allows a determination to be made as to whether the lead position and/or orientation has changed appreciably over time. In another embodiment, one or more electrodes are stimulated and the resulting electric field potential on the non-stimulated electrodes is measured. Such field potential measurements provide an indication of the relative orientation of the electrodes. Once known, the relative orientation may be used to track lead migration, to setup stimulation configurations and parameters for nominal stimulation and/or navigation. Also, such measurements allow automatic adjustment of stimulation energy to a previously-defined optimal potential field in the case of lead migration or postural changes.

47. 发明授权

US06931281B2 Method and apparatus for monitoring myocardial conduction velocity for diagnostics of therapy optimization 有权
标题翻译：监测心肌传导速度的方法和装置，用于诊断治疗优化
公开(公告)号：US06931281B2
公开(公告)日：2005-08-16
申请号：US10121523
申请日：2002-04-12
申请人： Kerry Bradley , Jeffery D. Snell
发明人： Kerry Bradley , Jeffery D. Snell
IPC分类号： A61N1/37 , A61N1/362
CPC分类号： A61N1/371
摘要： A cardiac stimulation device and method to measure a myocardial conduction time and to store its long-term running average. A multipolar lead is used to deliver a stimulation pulse from a tip electrode and detect the evoked response after it has propagated to a ring electrode. The time between the stimulation pulse and a detected feature of the evoked response is determined as the myocardial conduction time. A long-term average myocardial conduction time is calculated by averaging on the order of five hundred stimulated cardiac cycles, and a running average is stored in memory. Shifts in the myocardial conduction time may be used for monitoring disease progression or the long-term response to a treatment.
摘要翻译：心脏刺激装置和测量心肌传导时间并存储其长期运行平均值的方法。多极引线用于从尖端电极传递刺激脉冲，并在其传播到环形电极之后检测诱发反应。刺激脉冲与诱发反应的检测特征之间的时间被确定为心肌传导时间。长期平均心肌传导时间是通过对五百个刺激心脏周期的量级进行平均来计算的，运行平均值存储在记忆中。心肌传导时间的变化可用于监测疾病进展或对治疗的长期反应。

48. 发明授权

US06738666B1 Detection of orthostatic hypotension using positional data and cross-check data 失效
标题翻译：使用位置数据和交叉检查数据检测直立性低血压
公开(公告)号：US06738666B1
公开(公告)日：2004-05-18
申请号：US10002615
申请日：2001-11-01
申请人： Euljoon Park , Kerry Bradley
发明人： Euljoon Park , Kerry Bradley
IPC分类号： A61N1365
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device is programmed to administer pacing therapy in response to a postural change in a patient's position and a confirmation of that postural change using a cross-check parameter. The stimulation device is equipped with a position sensor to sense a position parameter indicative of when a patient changes from a horizontal position to an upright position. The stimulation device further monitors a cross-check parameter that is affected or modulated by position changes. When the position sensor indicates a postural change and the cross-check parameter confirms this change as being sufficient to induce orthostatic hypotension, the device administers cardiac pacing therapy to the patient.
摘要翻译：可植入心脏刺激装置被编程为响应于患者位置的姿势变化来管理起搏治疗，并且使用交叉检查参数来确认该姿势改变。刺激装置配备有位置传感器，用于感测指示患者什么时候从水平位置变化到直立位置的位置参数。刺激装置还监视受位置变化影响或调制的交叉检查参数。当位置传感器指示姿势变化并且交叉检查参数证实该变化足以引起直立性低血压时，该装置对患者进行心脏起搏治疗。

49. 发明授权

US06490486B1 Implantable cardiac stimulation device and method that monitors displacement of an implanted lead 有权
标题翻译：可植入的心脏刺激装置和监测植入引线位移的方法
公开(公告)号：US06490486B1
公开(公告)日：2002-12-03
申请号：US09709698
申请日：2000-11-09
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N104
CPC分类号： A61N1/37 , A61N1/37241 , A61N2001/083
摘要： An implantable cardiac stimulation device and method that monitors displacement of a cardiac lead implanted in a heart. The device includes an impedance measurement circuit that generates a template representing the impedance measured using the lead over a cardiac cycle of the patient's heart. The impedance measurement circuit generates subsequent impedance measurement signals, which are then compared to the template to derive a comparison factor. The comparison factors are stored in a memory and are indicative of lead displacement. A telemetry circuit transmits the comparison factors to a non-implanted receiver for analysis of lead displacement.
摘要翻译：一种可植入心脏刺激装置和方法，其监测植入心脏的心脏线的位移。该装置包括阻抗测量电路，其生成表示在患者心脏的心动周期上使用引线测量的阻抗的模板。阻抗测量电路产生随后的阻抗测量信号，然后与模板进行比较以得出比较因子。比较因子存储在存储器中并且指示引线位移。遥测电路将比较因子传送到非植入接收器，以分析铅位移。

50. 发明授权

US10537741B2 System and method for choosing electrodes in an implanted stimulator device 有权
公开(公告)号：US10537741B2
公开(公告)日：2020-01-21
申请号：US11295168
申请日：2005-12-05
申请人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
发明人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
IPC分类号： A61N1/36
摘要： A method of selecting a subset of electrodes in a stimulator device implanted in a patient for further clinical evaluation is disclosed. The method comprises measuring at least first and second measurement for each of the plurality of electrodes that are indicative of the ability of the electrode if activated to provide useful therapy to the patient in which the stimulator device is implanted A weight is then determined for each of the measurements. The weight is then applied to each electrode measurement, which measurement may be normalized, and the weighted measurements for each electrode are preferably summed to arrive at a value which itself is indicative of a particular electrode's ability to provide useful therapy to the patient. These values can then be used to determine a subset of the electrodes useful for further clinical evaluation in the patient, which improved the accuracy and speeding determining appropriate patient therapy.

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