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41. 发明授权

US11103733B2 Water based concentrated product forms of oil-soluble organic UV absorbers 有权
公开(公告)号：US11103733B2
公开(公告)日：2021-08-31
申请号：US12664666
申请日：2008-06-30
申请人： Stefan Müller , Brigitte Lindemann , Bernd Herzog
发明人： Stefan Müller , Brigitte Lindemann , Bernd Herzog
IPC分类号： A61Q17/04 , A61K8/11 , A61K8/58 , A61K8/37 , A61K8/35 , A61K8/44 , A61K8/81 , A61K8/893 , A61K8/49
摘要： The instant invention refers to the use of a concentrated aqueous polymer dispersion with an average particle size of less than 1000 nm comprising (a) a polymer carrier prepared by heterophase radical polymerization of at least one ethylenically unsaturated monomer in the presence of (b) an oil-soluble organic UV absorber selected from the class of p-aminobenzoic acid derivatives; salicylic acid derivatives; benzophenone derivatives; diphenyl acrylate derivatives; benzofuran derivatives; polymeric UV absorbers, comprising one or more organosilicon radicals; cinnamic acid derivatives; camphor derivatives; s-triazine derivatives; trianilino-s-triazine derivatives; menthyl anthranilates; and benzotriazole derivatives; wherein the weight ratio of the oil-soluble organic UV absorber (b) to polymer carrier (a) is greater than 50 parts UV absorber per 100 parts of carrier; for the protection of human and animal hair and skin against the damaging effect of UV radiation. The concentrated aqueous polymer dispersions show unexpectedly high sunscreen effects and a positive skin feeling.

42. 发明授权

US09328386B2 Markers for susceptibility to an inhibitor of an Src-family kinase 有权
标题翻译：对Src家族激酶抑制剂敏感的标记物
公开(公告)号：US09328386B2
公开(公告)日：2016-05-03
申请号：US14239067
申请日：2012-08-16
申请人： Christoph Schaab , Klaus Godl , Martin Klammer , Andreas Tebbe , Stefan Müller
发明人： Christoph Schaab , Klaus Godl , Martin Klammer , Andreas Tebbe , Stefan Müller
IPC分类号： G01N33/53 , C12Q1/68 , G01N33/574 , G01N33/569
CPC分类号： C12Q1/6881 , G01N33/56966 , G01N33/574 , G01N2333/70546
摘要： The present invention relates to a method for predicting the responsiveness of a mammalian tumor cell or cancer cell to an inhibitor of a kinase of the Src family, such as dasatinib, bosutinib, saracatinib or ponatinib. The present invention also provides for a method for predicting the responsiveness of an individual to an inhibitor of a kinase of the Src family, whereby the individual is suspected to suffer from cancer. These methods involve the evaluation of the status of integrin β4, wherein said status is indicative for the responsiveness to the inhibitor. Furthermore, a kit useful for carrying out the methods described herein as well as an oligo—or polynucleotide and/or antibodies capable of detecting the expression level of integrin β4 for predicting the responsiveness to the inhibitor are provided.
摘要翻译：本发明涉及一种用于预测哺乳动物肿瘤细胞或癌细胞对Src家族的激酶抑制剂（如达沙替尼，波斯库替尼，沙拉单抗或番茄碱）的反应性的方法。本发明还提供了一种用于预测个体对Src家族的激酶抑制剂的反应性的方法，由此该个体怀疑患有癌症。这些方法包括评价整联蛋白的状态; 4，其中所述状态指示对抑制剂的反应性。此外，提供了可用于实施本文所述方法的试剂盒以及能够检测整联蛋白4的表达水平以预测对抑制剂的反应性的寡核苷酸和/或多核苷酸和/或抗体。

43. 发明授权

US08793018B2 Data processing system for an industrial robot and method for managing available resources thereof 有权
标题翻译：用于工业机器人的数据处理系统和用于管理其可用资源的方法
公开(公告)号：US08793018B2
公开(公告)日：2014-07-29
申请号：US12741234
申请日：2008-10-29
申请人： Stefan Müller
发明人： Stefan Müller
IPC分类号： G05B19/04
CPC分类号： H04L12/40163 , H04L2012/4026
摘要： In a method and a computer system for controlling an industrial robot, multiple data packets are received by the computer system, each of the data packets having a destination address with different priority classes being associated therewith in advance by the computer system. A chronological association of tasks with the resources of the computer system is made for processing the individual received data packets, based on the relevant priority class of the destination address of a received data packet.
摘要翻译：在用于控制工业机器人的方法和计算机系统中，计算机系统接收多个数据分组，每个数据分组具有不同优先级的目的地地址，由计算机系统预先与其相关联。根据接收到的数据分组的目的地址的相关优先级，对任务与计算机系统的资源进行时间顺序的关联，用于处理各个接收的数据分组。

44. 发明申请

US20140013749A1 WASTE-HEAT RECOVERY SYSTEM 审中-公开
标题翻译：废热回收系统
公开(公告)号：US20140013749A1
公开(公告)日：2014-01-16
申请号：US13996220
申请日：2011-12-23
申请人： Anayet Temelci-Andon , Konrad Herrmann , Stefan Müller , Harald Köhler
发明人： Anayet Temelci-Andon , Konrad Herrmann , Stefan Müller , Harald Köhler
IPC分类号： F01K25/08
CPC分类号： F01K25/08 , F01K25/10
摘要： A waste-heat recovery system for a waste-heat source includes an ORC (Organic-Rankine Cycle) postconnected thereto, the waste-heat source being in connection with the heating device of the ORC, as well as with an expansion machine, coupled to a generator, for steam expansion in the ORC, which has magnetic bearings with an associated control device and a power supply via a direct current intermediate circuit of a generator frequency converter. The unit made up of the expansion machine, the generator and the frequency converter is cooled by the coolant from the ORC circuit.
摘要翻译：用于废热源的废热回收系统包括与其后连接的ORC（有机 - 兰金循环），废热源与ORC的加热装置连接，以及与膨胀机联接用于在ORC中进行蒸汽膨胀的发电机，该发电机具有通过发电机变频器的直流中间电路与相关联的控制装置的电磁轴承和电源。由膨胀机，发电机和变频器组成的单元由来自ORC电路的冷却液冷却。

45. 发明申请

US20140001762A1 WASTE-HEAT RECOVERY SYSTEM 有权
标题翻译：废热回收系统
公开(公告)号：US20140001762A1
公开(公告)日：2014-01-02
申请号：US13997606
申请日：2011-12-21
申请人： Anayet Temelci-Andon , Konrad Herrmann , Stefan Müller , Harald Köhiller
发明人： Anayet Temelci-Andon , Konrad Herrmann , Stefan Müller , Harald Köhiller
IPC分类号： H02K7/18 , F01K13/02
CPC分类号： H02K7/1823 , F01K13/02 , F01K23/06 , F01K23/065 , F01K25/10
摘要： A waste-heat recovery system for a waste-heat source, made up of an ORC (Organic-Rankine Cycle) postconnected thereto. The waste-heat source is connected with the heating device of the ORC as well as an expansion machine, coupled to a generator, for steam expansion in the ORC, which has magnetic bearings with an associated control device and a power supply via a direct current intermediate circuit of a generator frequency converter. The design and safe operating behavior of a waste-heat recovery system made up of an ORC post-connected to a waste-heat source are optimized. In a power supply failure, the electric energy that a down-running generator continues to generate is used to supply the magnetic bearings with the associated control device in order to ensure a safe operation in the event of a power supply failure.
摘要翻译：用于废热源的废热回收系统，其由与之相连的ORC（有机 - 兰金循环）组成。废热源与ORC的加热装置连接，以及一个连接到发电机的膨胀机，用于在ORC中进行蒸汽膨胀，其具有带相关控制装置的磁性轴承和通过直流电的电源发电机变频器的中间电路。优化了与废热源后连接的ORC组成的废热回收系统的设计和安全操作行为。在电源故障中，下行发电机继续产生的电能用于向相关的控制装置供应磁性轴承，以确保电源故障时的安全运行。

46. 发明申请

US20130327628A1 METHOD AND APPARATUS FOR PRODUCING PYROLYSIS OIL HAVING IMPROVED STABILITY 有权
标题翻译：用于生产具有改进稳定性的热解油的方法和装置
公开(公告)号：US20130327628A1
公开(公告)日：2013-12-12
申请号：US13492551
申请日：2012-06-08
申请人： Lance A. Baird , Timothy A. Brandvold , Stefan Müller
发明人： Lance A. Baird , Timothy A. Brandvold , Stefan Müller
IPC分类号： C10B57/00
CPC分类号： B01D46/00 , B01D2273/00 , B07B7/00 , C10B53/02 , C10J3/84 , C10K1/024 , C10K1/04 , C10L1/02 , Y02E50/14 , Y02P30/20
摘要： Methods and apparatus to improve hot gas filtration to reduce the liquid fuel loss caused by prolonged residence time at high temperatures are described. The improvement can be obtained by reducing the residence time at elevated temperature by reducing the temperature of the pyrolysis vapor, by reducing the volume of the pyrolysis vapor at the elevated temperature, by increasing the volumetric flow rate at constant volume of the pyrolysis vapor, or by doing a combination of these.
摘要翻译：描述了改善热气过滤以减少由于在高温下延长的停留时间引起的液体燃料损失的方法和装置。通过降低热分解蒸气的温度，通过在升高的温度下降低热分解蒸气的体积，通过增加在热解蒸气的恒定体积下的体积流量来降低高温下的停留时间，可以获得改进，或者通过组合这些。

47. 发明申请

US20120261231A1 SORTING APPARATUS 失效
标题翻译：分拣装置
公开(公告)号：US20120261231A1
公开(公告)日：2012-10-18
申请号：US13491185
申请日：2012-06-07
申请人： Katrin Eiserloh , Stefan Müller
发明人： Katrin Eiserloh , Stefan Müller
IPC分类号： B65G47/34
CPC分类号： B65G47/647 , B65H29/58 , B65H2404/6112
摘要： A sorter device and sorting apparatus for use in a conveyor line, and a conveyor line including such a sorter device and sorting apparatus. A sorting apparatus may be used in a conveyor line with an inspection device, and may include an infeed device and an outfeed device to move the products to and from a sorter device with a sorting element that can be swiveled downward. The sorter device may be equipped with at least one guide element that is arranged at a vertical distance from the sorting element and acts from above to guide the transport direction of a product that is moved on the sorting element. The guide element may be connected to the sorting element and may be designed to swivel therewith. An optional take-along device may also be present.
摘要翻译：用于输送线的分拣机装置和分拣装置，以及包括这种分拣装置和分拣装置的输送线。分拣装置可以用于具有检查装置的输送线中，并且可以包括进给装置和出料装置，用于将产品移动到分拣机装置和从分拣装置移动，该分拣装置可以向下旋转。分拣机装置可以配备有至少一个引导元件，该引导元件布置成与分拣元件垂直的距离并且从上方起作用以引导在分拣元件上移动的产品的输送方向。引导元件可以连接到分选元件，并且可以设计成与其一起旋转。也可以存在可选的取出装置。

48. 发明授权

US07893292B2 Merocyanine derivatives for cosmetic use 有权
标题翻译：用于化妆品使用的花青衍生物
公开(公告)号：US07893292B2
公开(公告)日：2011-02-22
申请号：US12378566
申请日：2009-02-17
申请人： Barbara Wagner , Thomas Ehlis , Stefan Müller
发明人： Barbara Wagner , Thomas Ehlis , Stefan Müller
IPC分类号： C07C255/00 , A61K8/00 , A61K8/18 , A61K8/49 , A61K31/13 , A61K31/16 , A61Q17/04 , A01N33/00 , A01N33/02
CPC分类号： C07D295/116 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/494 , A61K8/81 , A61Q17/00 , A61Q17/02 , C07C225/20 , C07C229/46 , C07C255/31 , C07C317/48 , C07C2601/14 , C07C2601/16 , C07D295/155
摘要： Described are merocyanine derivatives of formula wherein R2 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; a cyano group; or R1 and R2 together with the nitrogen atom linking them form a —(CH2)m— ring which is optionally interrupted by —O— or by —NR7—; R4 is a cyano group; or -Q1-R5; Q1 is —COO—; —CONH—; —CO—; —SO2—; or —CONR6—; R5 is C1-C22alkyl; cyclo-C3-C8alkyl; or unsubstituted or C1-C6alkyl-substituted C6-C20aryl; R6 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; R7 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; the cyclohexene radical C is not substituted or substituted by one or more C1-C5alkyl; m is from 3 to 7; n is from 2 to 4; and o is from 2 to 4. Said merocyanine derivatives are useful in protecting human and animal hair and skin from UV radiation and to cosmetic compositions comprising said derivatives.
摘要翻译：描述的是下式的部花青衍生物其中R2是氢; C 1 -C 22烷基; 环-C 3 -C 8烷基; 未取代的或C 1 -C 6烷基 - 或C 1 -C 6烷氧基取代的C 6 -C 20芳基; 氰基; 或R 1和R 2与连接它们的氮原子一起形成 - （CH 2）m - 环，其任选被-O-或-NR 7 - 间隔; R4是氰基; 或-Q1-R5; Q1是-COO-; -CONH-; -CO-; -SO2-; 或-CONR6-; R5是C1-C22烷基; 环C 3 -C 8烷基; 或未取代的或C 1 -C 6烷基取代的C 6 -C 20芳基; R6是氢; C 1 -C 22烷基; 环-C 3 -C 8烷基; 未取代的或C 1 -C 6烷基 - 或C 1 -C 6烷氧基取代的C 6 -C 20芳基; R7是氢; C 1 -C 22烷基; 环-C 3 -C 8烷基; 未取代的或C 1 -C 6烷基 - 或C 1 -C 6烷氧基取代的C 6 -C 20芳基; 环己烯基C不被一个或多个C 1 -C 5烷基取代或取代; m为3〜7; n为2〜4; 和o为2至4.所述的部花青衍生物可用于保护人和动物毛发和皮肤免受紫外线辐射和包含所述衍生物的化妆品组合物。

49. 发明申请

US20100120593A1 Device for processing a flat material web, and method for processing a flat material web 审中-公开
标题翻译：用于处理扁平材料幅材的装置以及用于处理扁平材料幅材的方法
公开(公告)号：US20100120593A1
公开(公告)日：2010-05-13
申请号：US12523764
申请日：2008-01-25
申请人： Horst-Elmar Böhm , Stefan Müller
发明人： Horst-Elmar Böhm , Stefan Müller
IPC分类号： B26D5/34 , B26D1/36
CPC分类号： B26D5/34 , B26D1/626 , B26D5/32 , Y10T83/4795 , Y10T83/4804 , Y10T83/896
摘要： A device for processing a flat material web including a sensor for detecting processing marks of the material web is provided. A control unit assigns a first location information to each detected processing mark. Furthermore, the control unit and a processing unit assign a second location information to the time of processing of the processing mark. Both pieces of location information are calculated together by the control unit to determine a correcting value. A processing position of the material web is corrected by the correcting value.
摘要翻译：提供了一种用于处理包括用于检测材料网的加工标记的传感器的扁平材料网的装置。控制单元向每个检测到的处理标记分配第一位置信息。此外，控制单元和处理单元将第二位置信息分配给处理标记的处理时间。两个位置信息由控制单元一起计算以确定校正值。通过校正值来校正材料幅的加工位置。

50. 发明申请

US20100008873A1 Use of benzotriazole derivatives for photostabilisation 有权
标题翻译：苯并三唑衍生物用于光稳定化
公开(公告)号：US20100008873A1
公开(公告)日：2010-01-14
申请号：US11919104
申请日：2006-04-20
申请人： Stefan Müller , Jochen Giesinger , Thomas Ehlis , Bernd Herzog , Peter König , Gilbert Kreyer , Katja Quass
发明人： Stefan Müller , Jochen Giesinger , Thomas Ehlis , Bernd Herzog , Peter König , Gilbert Kreyer , Katja Quass
IPC分类号： A61K8/49 , A61P17/04
CPC分类号： A61Q17/04 , A61K8/496 , A61K2800/52
摘要： Use of benzotriazole derivatives of formula (1), wherein R1 is C1-C30alkyl; C1C5alkoxy; C1-C5alkoxycarbonyl; C5-C7cycloalkyl; C6-C10aryl; aralkyl; —SO3M; a radical of formula (1a) R3 is hydrogen; C1C5alkyl; C1C5alkoxy; halogen, preferably Cl; or hydroxy; R4 and R5 are each independently of the other hydrogen; or d-C5alkyl; m is 1 or 2; n is O or 1; if m=1, R2 is hydrogen; unsubstituted or phenyl-substituted d-C1-C12alkyl; or C6-C10aryl; if m=2, R2 is the direct bond; or —(CH2)p—; and p is 1 to 3; for enhancing the photostability of cosmetic or dermatologic compositions comprising at least one further organic UV absorber.
摘要翻译：式（1）的苯并三唑衍生物的用途，其中R 1是C 1 -C 30烷基; C1C5烷氧基 C1-C5烷氧基羰基; C5-C7环烷基; C6-C10芳基; 芳烷基 -SO3M; 式（1a）的基团R 3是氢; C 1 -C 5烷基; C1C5烷氧基卤素，优选Cl; 或羟基; R4和R5各自独立地为氢; 或d-C 5烷基; m为1或2; n为0或1; 如果m = 1，则R2为氢; 未取代或苯基取代的d-C 1 -C 12烷基; 或C 6 -C 10芳基; 如果m = 2，则R2是直接键; 或 - （CH 2）p - ; p为1〜3; 用于增强包含至少一种另外的有机UV吸收剂的化妆品或皮肤病学组合物的光稳定性。

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