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41. 发明申请

US20110282226A1 CARDIAC ANALYSIS SYSTEM FOR COMPARING CLINICAL AND INDUCED VENTRICULAR TACHYCARDIA EVENTS 有权
标题翻译：用于比较临床和诱发的心室TACHYCARDIA事件的心脏分析系统
公开(公告)号：US20110282226A1
公开(公告)日：2011-11-17
申请号：US12820879
申请日：2010-06-22
申请人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
发明人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
IPC分类号： A61B5/04
CPC分类号： A61B5/0422 , A61B5/0031 , A61B5/0464 , A61B18/1492 , A61N1/3621
摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.
摘要翻译：提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

42. 发明授权

US07945326B1 Tissue characterization using intracardiac impedances with an implantable lead system 有权
标题翻译：使用可植入引导系统的心内阻抗的组织表征
公开(公告)号：US07945326B1
公开(公告)日：2011-05-17
申请号：US11684677
申请日：2007-03-12
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
IPC分类号： A61N1/18
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.
摘要翻译：可植入系统采用可植入引线系统获得心内阻抗。在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。所施加的脉冲的影响被感测为对应的波形。施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。可以比较这些区域以获得组织的可靠的阻抗值。还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

43. 发明授权

US07546157B1 System and method for emulating a surface EKG using internal cardiac signals sensed by an implantable medical device 有权
标题翻译：使用由可植入医疗装置感测到的内部心脏信号来模拟表面EKG的系统和方法
公开(公告)号：US07546157B1
公开(公告)日：2009-06-09
申请号：US10735948
申请日：2003-12-12
申请人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
发明人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
IPC分类号： A61B5/04
CPC分类号： A61B5/0402 , A61N1/3702
摘要： A surface electrocardiogram (EKG) is emulated using signals detected by the internal leads of an implanted device. In one example, the emulation is performed using a technique that concatenates portions of signals sensed using different electrodes, such as by combining far-field ventricular signals sensed in the atria with far-field atrial signals sensed in the ventricles or by combining near-field signals sensed in the atria with near-field signals sensed in the ventricles. In another example, the emulation is performed using a technique that selectively amplifies or attenuates portions of a single signal sensed using a single pair of electrodes, such as by attenuating near-field portions of an atrial unipolar signal relative to far-field portions of the same signal or by attenuating atrial portions of a cross-chamber signal relative to ventricular portions to the same signal. The surface EKG emulation may be performed by the implanted device itself or by an external programmer based on cardiac signals transmitted thereto.
摘要翻译：使用由植入装置的内部引线检测的信号来模拟表面心电图（EKG）。在一个示例中，使用将使用不同电极感测的信号的部分连接的技术来执行仿真，例如通过将在心房中感测的远场心室信号与在心室中感测到的远场心房信号组合，或者通过组合近场在心房中感测到的信号在心室感测到近场信号。在另一示例中，使用选择性地放大或衰减使用单个电极对感测的单个信号的部分的技术来执行仿真，例如通过衰减相对于该场的远场部分的心房单极信号的近场部分相同的信号或通过将相对于心室部分的交叉室信号的心房部分衰减到相同的信号。表面EKG仿真可以由植入装置本身或外部编程器基于发送到其上的心脏信号执行。

44. 发明授权

US07467012B1 Respiration parameters controlled by heart rate 有权
标题翻译：呼吸参数由心率控制
公开(公告)号：US07467012B1
公开(公告)日：2008-12-16
申请号：US11166617
申请日：2005-06-24
申请人： Euljoon Park , Gene A. Bornzin , Mark W. Kroll
发明人： Euljoon Park , Gene A. Bornzin , Mark W. Kroll
IPC分类号： A61N1/05 , A61B5/08
CPC分类号： A61B5/0809 , A61B5/0205 , A61N1/056 , A61N1/3601 , A61N1/3611 , A61N1/36514 , A61N2001/0585
摘要： Heart rate information is used at least in part to obtain one or more parameters for inducing respiration. In various implementations, respiratory parameters, such as a target breathing rate or a target tidal volume may be delivered by an implantable device to a patient during periods of altered respiration, such as sleep apnea or exercise. A respiratory parameter may also be obtained from a physiological variable, a patient's physical activity level, or metabolic demands.
摘要翻译：心率信息至少部分地用于获得用于诱导呼吸的一个或多个参数。在各种实施方案中，诸如目标呼吸频率或目标潮气量之类的呼吸参数可以在改变呼吸的时段（例如睡眠呼吸暂停或运动）期间由可植入装置递送给患者。也可以从生理变量，患者的身体活动水平或代谢需求获得呼吸参数。

45. 发明授权

US07383080B1 System and method for emulating a surface EKG using internal cardiac signals sensed by an implantable medical device 有权
标题翻译：使用由可植入医疗装置感测到的内部心脏信号来模拟表面EKG的系统和方法
公开(公告)号：US07383080B1
公开(公告)日：2008-06-03
申请号：US10736111
申请日：2003-12-12
申请人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
发明人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
IPC分类号： A61B5/0402
CPC分类号： A61B5/04021
摘要： A surface electrocardiogram (EKG) is emulated using signals detected by the internal leads of an implanted device. In one example, the emulation is performed using a technique that concatenates portions of signals sensed using different electrodes, such as by combining far-field ventricular signals sensed in the atria with far-field atrial signals sensed in the ventricles or by combining near-field signals sensed in the atria with near-field signals sensed in the ventricles. In another example, the emulation is performed using a technique that selectively amplifies or attenuates portions of a single signal sensed using a single pair of electrodes, such as by attenuating near-field portions of an atrial unipolar signal relative to far-field portions of the same signal or by attenuating atrial portions of a cross-chamber signal relative to ventricular portions to the same signal. The surface EKG emulation may be performed by the implanted device itself or by an external programmer based on cardiac signals transmitted thereto.
摘要翻译：使用由植入装置的内部引线检测的信号来模拟表面心电图（EKG）。在一个示例中，使用将使用不同电极感测的信号的部分连接的技术来执行仿真，例如通过将在心房中感测的远场心室信号与在心室中感测到的远场心房信号组合，或者通过组合近场在心房中感测到的信号在心室感测到近场信号。在另一示例中，使用选择性地放大或衰减使用单个电极对感测的单个信号的部分的技术来执行仿真，例如通过衰减相对于该场的远场部分的心房单极信号的近场部分相同的信号或通过将相对于心室部分的交叉室信号的心房部分衰减到相同的信号。表面EKG仿真可以由植入装置本身或外部编程器基于发送到其上的心脏信号执行。

46. 发明授权

US07225023B1 System and method for modulating the pacing rate based on patient activity and position 有权
标题翻译：基于患者活动和位置调节起搏速率的系统和方法
公开(公告)号：US07225023B1
公开(公告)日：2007-05-29
申请号：US10032793
申请日：2001-10-25
申请人： Euljoon Park , Gene A. Bornzin , Junyu Mai
发明人： Euljoon Park , Gene A. Bornzin , Junyu Mai
IPC分类号： A61N1/365
CPC分类号： A61N1/36542
摘要： A system and method are provided for compensating for the drop in blood pressure upon standing. Upon transition from prolonged sitting, lying down, or standing position, the pacemaker abruptly increasing its pacing rate upon postural transition. This pacing rate is triggered when a patient stands after a prolonged reclined or supine/prone position.
摘要翻译：提供了一种用于补偿静置时血压下降的系统和方法。从长时间的坐姿，躺下或站姿转移时，起搏器在姿势转换时突然增加起搏速度。当患者在长时间倾斜或仰卧/俯卧位后立即触发起搏速率。

47. 发明授权

US07212862B2 Cardiac stimulation device including sleep apnea prevention and treatment 有权
标题翻译：心脏刺激装置包括睡眠呼吸暂停预防和治疗
公开(公告)号：US07212862B2
公开(公告)日：2007-05-01
申请号：US10247137
申请日：2002-09-18
申请人： Euljoon Park , Steve Koh , Gene A. Bornzin
发明人： Euljoon Park , Steve Koh , Gene A. Bornzin
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/3601 , A61N1/36542 , A61N1/36557
摘要： An implantable cardiac stimulation device comprises a physiologic sensor and one or more pulse generators. The physiologic sensor is capable of sensing a physiologic parameter. The pulse generators can generate cardiac pacing pulses with a timing based on the physiologic parameter. The timed cardiac pacing pulses can prevent a sleep apnea condition. In one example, a cardiac stimulation device has a physiologic sensor and can be configured to pace a patient's heart according to a rest mode of operation. The cardiac stimulation device uses measurements from the physiologic sensor to prevent and treat sleep apnea using a revised rest mode of operation. The revised rest mode operates under a presumption that sleep apnea is primary to a reduced heart rate, rather than secondary, so that pacing at a rate higher than the natural cardiac rate during sleep will prevent sleep apnea.
摘要翻译：植入式心脏刺激装置包括生理传感器和一个或多个脉冲发生器。生理传感器能感测生理参数。脉冲发生器可以产生基于生理参数的定时的心脏起搏脉冲。定时的心脏起搏脉冲可以防止睡眠呼吸暂停状态。在一个示例中，心脏刺激装置具有生理传感器，并且可以被配置为根据休息的操作模式来对患者的心脏进行加速。心脏刺激装置使用来自生理传感器的测量来使用修改的休息模式来预防和治疗睡眠呼吸暂停。修改后的休息模式的作用是假设睡眠呼吸暂停是降低心率而不是继发性睡眠呼吸暂停的原因，因此在睡眠期间以高于自然心率的速率起搏将防止睡眠呼吸暂停。

48. 发明授权

US07149584B1 System and method for determining patient posture based on 3-D trajectory using an implantable medical device 失效
公开(公告)号：US07149584B1
公开(公告)日：2006-12-12
申请号：US10328642
申请日：2002-12-23
申请人： Steve Koh , Mark W. Kroll , Euljoon Park , Gene A. Bornzin
发明人： Steve Koh , Mark W. Kroll , Euljoon Park , Gene A. Bornzin
IPC分类号： A61N1/00
CPC分类号： A61N1/37252 , A61N1/36535 , A61N1/36542 , A61N1/37235
摘要： Time-varying spatial signals are detected by accelerometers mounted within the patient. The signals, representative of the actual 3-D trajectory of the patient, are compared with information representative of expected trajectories retrieved from memory to identify a current patient posture, which may be either a dynamic posture such as walking or running or a change in posture such as rising from a seated position to a standing position. In this manner, a change in posture of the patient is identified based upon a full 3-D trajectory, rather than merely the orientation of the patient at the beginning and the end of the change in posture. In an example described herein, the implantable device stores information representative of expected 3-D trajectories in the form of pre-calculated comparison matrices derived from orthonormal kernels employing Laguerre functions or Lagrange functions. A technique is also described for use by an external programmer for pre-calculating comparison matrices so as to reduce the processing burden within the implanted device during posture detection.

49. 发明授权

US06999817B2 Cardiac stimulation device including sleep apnea prevention and treatment 有权
公开(公告)号：US06999817B2
公开(公告)日：2006-02-14
申请号：US10077660
申请日：2002-02-14
申请人： Euljoon Park , Steve Koh , Gene A. Bornzin
发明人： Euljoon Park , Steve Koh , Gene A. Bornzin
IPC分类号： A61N1/36
CPC分类号： A61N1/365 , A61N1/36557
摘要： An implantable cardiac stimulation device comprises a physiologic sensor and one or more pulse generators. The physiologic sensor is capable of sensing a physiologic parameter. The pulse generators can generate cardiac pacing pulses with a timing based on the physiologic parameter. The timed cardiac pacing pulses can prevent a sleep apnea condition. In one example, a cardiac stimulation device has a physiologic sensor and can be configured to pace a patient's heart according to a rest mode of operation. The cardiac stimulation device uses measurements from the physiologic sensor to prevent and treat sleep apnea using a revised rest mode of operation. The revised rest mode operates under a presumption that sleep apnea is primary to a reduced heart rate, rather than secondary, so that pacing at a rate higher than the natural cardiac rate during sleep will prevent sleep apnea.

50. 发明授权

US09107585B1 Tissue characterization using intracardiac impedances with an implantable lead system 有权
标题翻译：使用可植入引导系统的心内阻抗的组织表征
公开(公告)号：US09107585B1
公开(公告)日：2015-08-18
申请号：US11684664
申请日：2007-03-12
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
IPC分类号： A61N1/18 , A61B5/02 , A61B5/053 , A61N1/37 , A61B5/029 , A61B5/08 , A61B5/00
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.
摘要翻译：可植入系统采用可植入引线系统获得心内阻抗。在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。所施加的脉冲的影响被感测为对应的波形。施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。可以比较这些区域以获得组织的可靠的阻抗值。还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

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