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41. 发明申请

US20050283229A1 Coatings for controlling erosion of a substrate of an implantable medical device 审中-公开
标题翻译：用于控制植入式医疗装置的基材侵蚀的涂层
公开(公告)号：US20050283229A1
公开(公告)日：2005-12-22
申请号：US11173713
申请日：2005-06-30
申请人： Steve Dugan , David Gale
发明人： Steve Dugan , David Gale
IPC分类号： A61F2/00 , A61F2/90 , A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2230/0013 , A61F2250/0019 , A61F2250/003 , A61L31/10 , A61L31/146 , A61L31/148
摘要： An implantable medical device, such as a stent, with a coating region for controlling erosion of the substrate region is disclosed.
摘要翻译：公开了一种可植入医疗装置，例如支架，其具有用于控制衬底区域侵蚀的涂层区域。

42. 发明授权

US09408526B2 Telescopic support 有权
标题翻译：伸缩支撑
公开(公告)号：US09408526B2
公开(公告)日：2016-08-09
申请号：US12399721
申请日：2009-03-06
申请人： David Gale , Adrian Cooper , Keith Marshall
发明人： David Gale , Adrian Cooper , Keith Marshall
IPC分类号： A61B1/00 , A61B17/00
CPC分类号： A61B1/00149 , A61B1/00147 , A61B34/00 , A61B34/70 , A61B90/50 , A61B2017/00991
摘要： The present invention is a telescopic drive device of a device for holding a surgical instrument. The telescopic drive device includes a support; a first telescopic stage carried by the support; a first telescopic stage carried by the support, the first telescopic stage being able to perform a first motion with respect to the support; a second telescopic stage, which is able to perform a second motion with respect to the first telescopic stage; and a drive system, which is operable to drive the first and second motions. The first telescopic element performs the first motion and the second telescopic element simultaneously performs the second motion. The telescopic drive is operable to support a further device and to move the further device such that the movement is centered around a point or wherein each of the telescopic elements is arcuate.
摘要翻译：本发明是用于保持外科器械的装置的伸缩驱动装置。伸缩驱动装置包括支撑件; 由支架承载的第一伸缩台; 由所述支撑件承载的第一伸缩台，所述第一伸缩台能够执行相对于所述支撑件的第一运动; 第二伸缩台，其能够相对于所述第一伸缩台执行第二运动; 以及可操作以驱动第一和第二运动的驱动系统。第一伸缩元件执行第一运动，第二伸缩元件同时执行第二运动。伸缩驱动器可操作以支撑另一装置并且移动另外的装置，使得该运动围绕一个点居中或其中每个伸缩元件是弓形的。

43. 发明申请

US20110270307A1 SYSTEMS AND METHODS FOR CLOSING A VESSEL WOUND 审中-公开
标题翻译：用于封闭船只的系统和方法
公开(公告)号：US20110270307A1
公开(公告)日：2011-11-03
申请号：US13183603
申请日：2011-07-15
申请人： David Szabo , David Gale , Paul Johnson , Valerie Scott , Ben Morris , Greg Furnish , Trevor Beckett , Michael J. Trezza, II
发明人： David Szabo , David Gale , Paul Johnson , Valerie Scott , Ben Morris , Greg Furnish , Trevor Beckett , Michael J. Trezza, II
IPC分类号： A61B17/04
CPC分类号： A61B17/0057 , A61B17/0401 , A61B17/0467 , A61B17/0487 , A61B2017/00004 , A61B2017/00367 , A61B2017/00637 , A61B2017/00659 , A61B2017/0404 , A61B2017/0414 , A61B2017/0445 , A61B2017/0451 , A61B2017/0464 , A61B2017/06176
摘要： Vessel wound closure systems and method for sealing a puncture wound in a target vessel, such as those puncture wounds that occur from prior interventional procedures. A sealing member is deployed intravascularly into the target vessel, and an anchor member is deployed extravascularly of the target vessel. The sealing member and the anchor member are connected by a suture that may be drawn to tighten the sealing member and the anchor member relative to one another in order to effect the seal of the puncture wound. After tightening, the suture is secured to maintain the sealing member and the anchor member relative to one another in order to maintain the seal. Preferably, the anchor member, the suture and the sealing member are comprised of biocompatible, bioresorbable materials that are absorbed into the body after the sealing of the puncture wound has been achieved. The sealing member, suture and the anchor member are delivered by a delivery rod or other components over a guidewire or through an introducer already in place from the preceding interventional procedure.
摘要翻译：血管伤口闭合系统和密封目标血管中穿刺伤口的方法，例如从先前介入手术发生的那些穿刺伤口。密封构件在血管内部署到靶容器中，并且锚定构件部署在靶血管的血管外。密封构件和锚定构件通过缝合线连接，缝合线可以被拉伸以将密封构件和锚定构件相对于彼此紧固，以便实现穿刺伤口的密封。紧固后，缝合线被固定以保持密封构件和锚固构件相对于彼此以便保持密封。优选地，锚固构件，缝合线和密封构件由生物相容的生物可再吸收材料构成，其在已经实现了穿刺伤口的密封之后被吸收到身体中。密封构件，缝合线和锚固构件通过导线或通过导引器的输送杆或其它部件从前述介入过程传送。

44. 发明授权

US07887572B2 Implantable devices for accelerated healing 有权
标题翻译：用于加速愈合的植入式装置
公开(公告)号：US07887572B2
公开(公告)日：2011-02-15
申请号：US12509222
申请日：2009-07-24
申请人： Syed F. A. Hossainy , Florian Niklas Ludwig , David Gale
发明人： Syed F. A. Hossainy , Florian Niklas Ludwig , David Gale
IPC分类号： A61F2/06 , A61K38/17
CPC分类号： A61L31/043 , A61L27/22 , A61L27/54 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/416
摘要： Implantable devices (e.g., stent) having a protein patterning or bioactive patterning for accelerated healing and method of forming and using the same are provided.
摘要翻译：提供了具有用于加速愈合的蛋白质图案化或生物活性图案化的可植入装置（例如，支架）及其形成和使用方法。

45. 发明申请

US20090285874A1 Implantable Devices For Accelerated Healing 有权
标题翻译：用于加速治疗的植入式装置
公开(公告)号：US20090285874A1
公开(公告)日：2009-11-19
申请号：US12509222
申请日：2009-07-24
申请人： Syed Faiyaz Ahmed Hossainy , Florian Niklas Ludwig , David Gale
发明人： Syed Faiyaz Ahmed Hossainy , Florian Niklas Ludwig , David Gale
IPC分类号： A61F2/00 , A61K38/00 , A61K38/39 , A61K38/18
CPC分类号： A61L31/043 , A61L27/22 , A61L27/54 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/416
摘要： Implantable devices (e.g., stent) having a protein patterning or bioactive patterning for accelerated healing and method of forming and using the same are provided.
摘要翻译：提供了具有用于加速愈合的蛋白质图案化或生物活性图案化的可植入装置（例如，支架）及其形成和使用方法。

46. 发明申请

US20080160061A1 Implantable devices for accelerated healing 有权
标题翻译：用于加速愈合的植入式装置
公开(公告)号：US20080160061A1
公开(公告)日：2008-07-03
申请号：US11303724
申请日：2005-12-16
申请人： Syed Faiyaz Ahmed Hossainy , Florian Niklas Ludwig , David Gale
发明人： Syed Faiyaz Ahmed Hossainy , Florian Niklas Ludwig , David Gale
IPC分类号： A61K38/44 , A61K38/18 , A61K31/56 , A61K31/4745 , A61K31/337 , A61F2/02
CPC分类号： A61L31/043 , A61L27/22 , A61L27/54 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/416
摘要： Implantable devices (e.g., stent) having a protein patterning or bioactive patterning for accelerated healing and method of forming and using the same are provided.
摘要翻译：提供了具有用于加速愈合的蛋白质图案化或生物活性图案化的可植入装置（例如，支架）及其形成和使用方法。

47. 发明申请

US20080058919A1 Composite polymeric and metallic stent with radiopacity 有权
标题翻译：复合聚合物和金属支架具有放射不透性
公开(公告)号：US20080058919A1
公开(公告)日：2008-03-06
申请号：US11888500
申请日：2007-07-31
申请人： Pamela Kramer-Brown , David Gale , Vincent Gueriguian , Yunbing Wang
发明人： Pamela Kramer-Brown , David Gale , Vincent Gueriguian , Yunbing Wang
IPC分类号： A61F2/06
CPC分类号： A61L31/18 , A61F2/82 , A61F2/915 , A61F2002/91558 , A61F2002/91566 , A61F2210/0004 , A61F2250/0067 , A61F2250/0096 , A61F2250/0097 , A61L31/08 , A61L31/128 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/606 , C08L67/04
摘要： Various embodiments of stents with a polymeric body with radiopaque metallic particles incorporated in the stent body.
摘要翻译：具有聚合体的支架的各种实施例，其具有结合在支架主体中的不透射线金属颗粒。

48. 发明申请

US20070253996A1 Method of fabricating an implantable medical device by controlling crystalline structure 有权
标题翻译：通过控制晶体结构制造可植入医疗器械的方法
公开(公告)号：US20070253996A1
公开(公告)日：2007-11-01
申请号：US11413220
申请日：2006-04-28
申请人： Huang Bin , David Gale
发明人： Huang Bin , David Gale
IPC分类号： A61F2/06
CPC分类号： B29C71/0063 , A61L31/042 , A61L31/043 , A61L31/06 , B29B13/02 , B29L2031/7532 , C08L67/04
摘要： A method of fabricating an implantable medical device that includes deforming and heating setting a polymer construct, for use in fabricating the device, in a temperature range in which the crystal nucleation rate is greater than the crystal growth rate is disclosed.
摘要翻译：公开了一种制造可植入医疗装置的方法，该方法包括在晶体成核速率大于晶体生长速率的温度范围内使用于制造该器件的聚合物构件变形和加热。

49. 发明授权

US09427216B2 Systems and methods for closing a vessel wound 有权
标题翻译：关闭容器伤口的系统和方法
公开(公告)号：US09427216B2
公开(公告)日：2016-08-30
申请号：US11317479
申请日：2005-12-23
申请人： David Szabo , Jonathan Gabel , Roddi Simpson , Benjamin Wicks , David Gale
发明人： David Szabo , Jonathan Gabel , Roddi Simpson , Benjamin Wicks , David Gale
IPC分类号： A61B17/08 , A61B17/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00637 , A61B2017/00654
摘要： Vessel wound closure systems and method for sealing a puncture wound in a target vessel, such as those puncture wounds that occur from interventional procedures. The vessel wound closure system comprises at least a biocompatible, viscoelastic, self-sealing septum material injected onto the adventitia of the target vessel prior to performance of an interventional procedure. The prior injected septum material remains and seals the puncture wound of the target vessel even after various components associated with accessing the target vessel and the performance of the interventional procedure are removed from the target vessel and the puncture wound.
摘要翻译：容器伤口闭合系统和密封目标血管中穿刺伤口的方法，例如从介入手术发生的穿刺伤口。血管伤口闭合系统在执行介入手术之前至少包括注射到靶血管的外膜上的生物相容性，粘弹性的自密封隔膜材料。即使在与进入靶容器相关联的各种部件之后，先前注射的隔膜材料保留并密封靶容器的穿刺伤口，并且从靶容器和穿刺伤口移除介入手术的执行。

50. 发明申请

US20090270880A1 CLUTCH MECHANISM 有权
标题翻译：离合器机构
公开(公告)号：US20090270880A1
公开(公告)日：2009-10-29
申请号：US12415993
申请日：2009-03-31
申请人： David Gale , Adrian Cooper , Keith Marshall
发明人： David Gale , Adrian Cooper , Keith Marshall
IPC分类号： A61B19/00 , F16D43/20
CPC分类号： F16H25/2021 , F16H2025/2046
摘要： A clutch mechanism for use with a carrier of a linear drive device includes a housing, a first gear, and a first clutch arrangement. The first gear coupled to the housing and has gear teeth to engage a threaded shaft of a linear drive device. Rotation of the shaft causes the housing to move along the shaft in a first mode of operation. The first clutch arrangement prevents substantial rotation of the first gear. The first gear permits rotation of the first gear with respect to the housing. The housing can be manually moved along a length of the shaft, in a second mode of operation, by exerting a force on the housing. The rotational force applied to the first gear through the interaction of the threaded shaft and the gear teeth exceeds the first threshold.
摘要翻译：用于线性驱动装置的载体的离合器机构包括壳体，第一齿轮和第一离合器装置。第一齿轮联接到壳体并具有啮合线性驱动装置的螺纹轴的齿轮齿。轴的旋转使得壳体在第一操作模式下沿着轴移动。第一离合器装置防止第一档位的大量旋转。第一档允许第一档位相对于外壳旋转。通过在壳体上施加力，壳体可以在第二操作模式中沿轴的长度手动移动。通过螺纹轴和齿轮齿的相互作用施加到第一齿轮的旋转力超过第一阈值。

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