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41. 发明授权

US06495645B1 Acrylamide derivatives and polymers containing said derivatives 有权
标题翻译：含有所述衍生物的丙烯酰胺衍生物和聚合物
公开(公告)号：US06495645B1
公开(公告)日：2002-12-17
申请号：US09889953
申请日：2001-08-30
申请人： Teruo Okano , Takao Aoyagi
发明人： Teruo Okano , Takao Aoyagi
IPC分类号： C08F12238
CPC分类号： C07C233/49 , C07C233/38 , C08F20/54
摘要： An acrylamide derivative of the following general formula (I) is used to prepare a polymer or copolymer: wherein R1 represents a hydrogen atom, a straight-chain or branched alkyl group containing 1 to 4 carbon atoms or a C3-6 cycloalkyl group, R2 and R3 each independently represent an alkylene group containing 1 to 6 carbon atoms or R2 and R3 may be combined to form a ring, X represents a hydrogen atom, an amino group, a hydroxyl group, a halogen atom, a carboxyl group or a —COOR4 group wherein R4 represents a C1-6 straight-chain or branched alkyl, C3-6 cycloalkyl, phenyl, substituted phenyl, benzyl or substituted benzyl group, and Y represents an amino group, a halogen atom, a carboxyl group or a —COOR4 group wherein R4 represents a C1-6 straight-chain or branched alkyl, C3-6 cycloalkyl, phenyl, substituted phenyl, benzyl or substituted benzyl group. The thus obtained polymer or copolymer is a polymer or hydrogel incorporating many functional groups while maintaining the sensitive temperature response.
摘要翻译：使用以下通式（I）的丙烯酰胺衍生物来制备聚合物或共聚物：其中R 1表示氢原子，含有1至4个碳原子的直链或支链烷基或C 3-6环烷基，R 2 R 3各自独立地表示碳原子数1〜6的亚烷基，R 2和R 3可以结合形成环，X表示氢原子，氨基，羟基，卤素原子，羧基或 - COOR 4基团，其中R 4表示C 1-6直链或支链烷基，C 3-6环烷基，苯基，取代的苯基，苄基或取代的苄基，Y表示氨基，卤素原子，羧基或-COOR 4 基团，其中R 4表示C 1-6直链或支链烷基，C 3-6环烷基，苯基，取代的苯基，苄基或取代的苄基。由此获得的聚合物或共聚物是在保持敏感的温度响应的同时引入许多官能团的聚合物或水凝胶。

42. 发明授权

US5929177A Block polymer having functional groups at both ends 失效
标题翻译：在两端具有官能团的嵌段聚合物
公开(公告)号：US5929177A
公开(公告)日：1999-07-27
申请号：US11329
申请日：1998-02-05
申请人： Kazunori Kataoka , Masao Kato , Yukio Nagasaki , Teruo Okano
发明人： Kazunori Kataoka , Masao Kato , Yukio Nagasaki , Teruo Okano
IPC分类号： C08G63/06 , A61K9/107 , A61K9/51 , A61K47/34 , C08F297/00 , C08G63/664 , C08G63/676 , C08G63/91 , C08G65/26 , C08G65/329 , C08G85/00 , C08L71/02 , A61K31/765 , C08G65/32
CPC分类号： A61K9/1075 , A61K9/5153 , C08G63/664 , C08G63/676 , C08G63/912 , C08G65/2627 , C08G65/329 , C08G85/00 , C08L71/02
摘要： The present invention provides a block polymer which has functional groups on its both ends, and which comprises hydrophilic/hydrophobic segments. As for the functional groups on its both ends, the block polymer has amino group, carboxyl group or mercapto group on .alpha.-terminal, and hydroxyl group, carboxyl group, aldehyde group or vinyl group on .omega.-terminal. Hydrophilic segment comprises polyethylene oxide, while hydrophobic segment is derived from lactide, lactone or (meth)acrylic acid ester. The block polymer of this invention forms a polymeric micelle which is usable as bio-compatible materials.
摘要翻译： PCT No.PCT / JP96 / 02200 Sec。 371日期：1998年2月5日 102（e）日期1998年2月5日PCT提交1996年8月5日PCT公布。出版物WO97 / 06202 日期1997年2月20日本发明提供了在其两端具有官能团并且包含亲水/疏水链段的嵌段聚合物。对于其两端的官能团，嵌段聚合物在α-末端具有氨基，羧基或巯基，在ω-末端具有羟基，羧基，醛基或乙烯基。亲水链段包括聚环氧乙烷，而疏水链段来自丙交酯，内酯或（甲基）丙烯酸酯。本发明的嵌段聚合物形成可用作生物相容性材料的聚合胶束。

43. 发明授权

US5449513A Physical trapping type polymeric micelle drug preparation 失效
标题翻译：物理捕获型聚合胶束药物制剂
公开(公告)号：US5449513A
公开(公告)日：1995-09-12
申请号：US105535
申请日：1993-08-11
申请人： Masayuki Yokoyama , Yasuhisa Sakurai , Teruo Okano , Kazunori Kataoka
发明人： Masayuki Yokoyama , Yasuhisa Sakurai , Teruo Okano , Kazunori Kataoka
IPC分类号： A61K9/00 , A61K9/107 , A61K9/51 , A61K47/34 , A61K47/48 , C08G69/10 , A61K9/127 , A61K31/74
CPC分类号： C08G69/10 , A61K9/1075 , Y10T428/2985 , Y10T428/2989
摘要： The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the invention forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug.
摘要翻译：本发明涉及由具有亲水和疏水性片段的嵌段共聚物组成的药物载体，包含通过所述药物载体中的物理治疗而被捕获的疏水性药物的聚合物胶束型药物和用于在药物载体中捕获疏水性药物的方法。由根据本发明的嵌段共聚物组成的药物载体形成稳定的聚合胶束结构，通过物理捕获可以非常有效地引入疏水性药物。发现即使在血清存在下，掺入的药物稳定地保持在胶束中。此外，由于疏水性高的水溶性而难以施用于生物体的药物可以以聚合物胶束药物的形式施用。

44. 发明授权

US5284766A Bed material for cell culture 失效
标题翻译：细胞培养的床料
公开(公告)号：US5284766A
公开(公告)日：1994-02-08
申请号：US817954
申请日：1992-01-07
申请人： Teruo Okano , Kazunori Kataoka , Noriko Yamada , Yasuhisa Sakurai , Takayuki Amiya , Akira Mamada
发明人： Teruo Okano , Kazunori Kataoka , Noriko Yamada , Yasuhisa Sakurai , Takayuki Amiya , Akira Mamada
IPC分类号： C12N5/00 , C12N5/06
CPC分类号： C12N5/0068 , C12N2533/30
摘要： Disclosed is a bed material whereby cultured or grown cells are collected or detached from the material without a proteolysis enzyme or chemical material. The bed material comprises a support and a coating thereon, wherein the coating is formed from a polymer or copolymer which has a critical solution temperature to water within the range of 0.degree. C. to 80.degree. C.
摘要翻译：公开了一种床材料，其中培养的或生长的细胞在没有蛋白水解酶或化学材料的情况下从材料中收集或分离。床料包括载体和其上的涂层，其中涂层由聚合物或共聚物形成，该聚合物或共聚物具有在0摄氏度至80摄氏度范围内的水的临界溶解温度。

45. 发明授权

US5223262A Transdermal delivery system utilizing one way membranes 失效
标题翻译：使用单向膜的透皮递送系统
公开(公告)号：US5223262A
公开(公告)日：1993-06-29
申请号：US565479
申请日：1990-08-10
申请人： Sung W. Kim , Teruo Okano , Soon H. Yuk
发明人： Sung W. Kim , Teruo Okano , Soon H. Yuk
IPC分类号： A61K9/70
CPC分类号： A61K9/7084 , A61K9/7092 , Y10T428/31511 , Y10T428/31663
摘要： A system for transdermally delivering a hydrophobic alkanol soluble active agent to the skin at a constant rate utilizing a lower alkanol penetration enhancer. The system comprises an overlying solvent reservoir containing a lower alkanol solvent and a drug compartment containing an active agent in aqueous alkanol. A one-way membrane is sandwiched between and divides the solvent reservoir from the drum compartment. The one-way membrane is permeable to the alkanol solvent and substantially impermeable to back flux of drug and water into the reservoir. An outer membrane permeable to the alkanol solvent and drug is attached to the outer surface of the drug compartment. Adhesive means is contained on the outer surface of this membrane for attaching the delivery system to the skin of a wearer. Alkanol from the reservoir permeates into the drug compartment and drug and alkanol pass through the outer membrane to the skin of the wearer for transdermal absorption. The rate of alkanol permeation from the reservoir to the drug compartment and from the drug compartment to the skin is substantially constant. The membrane is made up of an epoxidized silicone rubber to which is preferably laminated a layer of a dense hydrophobic copolymer of vinyl-terminated polydimethyl siloxane with methylhydro-dimethyl siloxane. If desired, to prevent any back flux of hydrophobic drugs, and additional layer of cellulose acetate may be sandwiched between the epoxidized silicone rubber and dense hydrophobic membrane.
摘要翻译：一种利用低级烷醇渗透增强剂以一定速率将疏水性链烷醇可溶性活性剂透皮递送至皮肤的系统。该系统包括含有低级链烷醇溶剂的上层溶剂储存器和在链烷醇水溶液中含有活性剂的药物隔室。单向膜夹在溶剂容器和鼓室之间。单向膜对于链烷醇溶剂是可渗透的，并且基本上不可渗透地将药物和水的通量回流到储存器中。可通过链烷醇溶剂和药物的外膜附着到药物隔室的外表面。粘合剂装在该膜的外表面上，用于将输送系统附着到穿着者的皮肤上。来自储存器的烷醇渗透到药物隔室中，药物和链烷醇通过外膜到穿着者的皮肤以经皮吸收。从储存器到药物隔室以及从药物室到皮肤的链烷醇渗透速率基本上是恒定的。膜由环氧化的硅橡胶组成，其优选层压有乙烯基封端的聚二甲基硅氧烷与甲基氢二甲基硅氧烷的致密疏水性共聚物层。如果需要，为了防止疏水性药物的任何回流，并且附加的乙酸纤维素层可夹在环氧化硅橡胶和致密疏水膜之间。

46. 发明授权

US4931287A Heterogeneous interpenetrating polymer networks for the controlled release of drugs 失效
标题翻译：用于控释药物的非均相互穿聚合物网络
公开(公告)号：US4931287A
公开(公告)日：1990-06-05
申请号：US206593
申请日：1988-06-14
申请人： You H. Bae , Teruo Okano , Sung W. Kim
发明人： You H. Bae , Teruo Okano , Sung W. Kim
IPC分类号： A61K9/20
CPC分类号： A61K9/2031 , A61K9/2027
摘要： A heterogeneous interpenetrating polymer network is provided for use in the controlled release of drugs. The network is a heterogeneous matrix that is formed from a hydrophilic component such as polyethylene oxide or poly(N,N'-dimethyl acrylamide-co-styrene) and a hydrophobic component such as styrene, an alkyl methacrylate, or polytetramethylene ether glycol. The relative amounts of the two components, or "domains", can be varied, as can the diffusivities and solubilities of the drug combinations to be loaded therein, to control and change as desired the timed release profile of incorporated drug. Prolonged pseudo-zero order release can be obtained where one domain acts as a diffusion barrier layer to the release of drug from the other domain.
摘要翻译：提供异构互穿聚合物网络用于药物的控制释放。该网络是由亲水组分如聚环氧乙烷或聚（N，N'-二甲基丙烯酰胺 - 共 - 苯乙烯）和疏水组分如苯乙烯，甲基丙烯酸烷基酯或聚四亚甲基醚二醇形成的非均相基体。可以改变两种组分或“结构域”的相对量，以及待加载的药物组合的扩散性和溶解度，以控制并根据需要改变并入药物的定时释放曲线。可以获得延长的伪零次释放，其中一个结构域充当从另一个域释放药物的扩散阻挡层。

47. 发明申请

US20120232255A1 PRETREATMENT CARTRIDGE FOR SEPARATING SUBSTANCE AND METHOD OF PRETREATMENT USING THE SAME 审中-公开
标题翻译：用于分离物质的预处理盒和使用其的预处理方法
公开(公告)号：US20120232255A1
公开(公告)日：2012-09-13
申请号：US13393391
申请日：2010-09-01
申请人： Hideko Kanazawa , Teruo Okano
发明人： Hideko Kanazawa , Teruo Okano
IPC分类号： B01D15/38 , C07K1/16
CPC分类号： G01N30/08 , B01D15/3876 , B01J20/261 , B01J20/264 , B01J20/28033 , B01J20/28042 , B01J20/285 , B01J20/286 , B01J20/3204 , B01J20/3208 , B01J20/327 , B01J20/3276 , B01J2220/54 , B01J2220/62 , B01J2220/82 , G01N1/405 , G01N30/30 , G01N30/6091
摘要： Pretreatment is performed using a pretreatment cartridge for separating substances that is packed with a stationary phase that is coated on its surface with a polymer whose tendency to hydration will change within a temperature range of 0-80° C. and which is capable of changing the affinity between the substance to be separated and the surface of the stationary phase in response to the shrinkage or swelling of the polymer chain due to temperature change. By using this pretreatment cartridge for separating substances, a convenient operation will suffice for a sample solution to be reduced to a solution containing the substance that need be separated from the specimen. If this method of pretreatment is used, useful substances can be separated intact by merely changing the temperature and it becomes possible to perform the subsequent analyzing or fraction collecting operation efficiently.
摘要翻译：使用预处理盒进行预处理，用于分离在其表面上涂覆有固定相的物质，聚合物的倾向在0-80℃的温度范围内变化，并且能够改变响应于由于温度变化引起的聚合物链的收缩或膨胀，要分离的物质与固定相的表面之间的亲和力。通过使用这种预处理盒来分离物质，方便的操作就足以将样品溶液还原成含有需要与样品分离的物质的溶液。如果使用这种预处理方法，只要改变温度即可将有用的物质完全分离，并且可以有效地进行后续的分析或分馏收集操作。

48. 发明申请

US20120210451A1 ISLET CELL SHEET, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF 审中-公开
标题翻译：印刷电路板，其生产工艺及其使用
公开(公告)号：US20120210451A1
公开(公告)日：2012-08-16
申请号：US13388535
申请日：2010-08-02
申请人： Hirofumi Shimizu , Kazuo Ohashi , Rie Utoh , Kazuya Ise , Masayuki Yamato , Teruo Okano , Mitsukazu Gotoh
发明人： Hirofumi Shimizu , Kazuo Ohashi , Rie Utoh , Kazuya Ise , Masayuki Yamato , Teruo Okano , Mitsukazu Gotoh
IPC分类号： A61K35/39 , C12N5/071 , A61P1/18 , G01N21/64 , A61P3/10 , A61K9/00 , A01K67/027
CPC分类号： A61L27/3804 , A61L27/3604 , A61L27/38 , C12N5/0676 , C12N2533/30 , C12N2533/52 , C12N2539/10
摘要： A polymer that changes hydration at a temperature between 0 to 80° C. is coated on the surface of a cell culture support, and islet cells are cultured on the support at a temperature range that causes polymer to have weak hydration, then the temperature of a culture solution is changed to a temperature that causes the polymer to have strong hydration to obtain islet cells in a sheet form. Such islet cells in a sheet form have an insulin producing function even if there is no blood flow.
摘要翻译：将在0至80℃温度下变化水合的聚合物涂覆在细胞培养载体的表面上，并且在使得聚合物具有弱水合的温度范围内将胰岛细胞在载体上培养，然后将温度将培养溶液变为导致聚合物具有强水合作用以获得片状的胰岛细胞的温度。即使没有血液流动，片状的这种胰岛细胞也具有产生胰岛素的功能。

49. 发明申请

US20090011504A1 Cultured cell construct which contains spheroids of cultured animal cells and the use thereof 有权
标题翻译：含有培养的动物细胞的球体的培养细胞构建体及其用途
公开(公告)号：US20090011504A1
公开(公告)日：2009-01-08
申请号：US12230916
申请日：2008-09-08
申请人： Kazunori Kataoka , Hidenori Otsuka , Teruo Okano , Yukio Nagasaki , Yasuhiro Horiike
发明人： Kazunori Kataoka , Hidenori Otsuka , Teruo Okano , Yukio Nagasaki , Yasuhiro Horiike
IPC分类号： C12N5/06
CPC分类号： C12N5/0671 , C12N5/0697 , C12N2502/14 , C12N2502/28 , C12N2533/30 , C12N2533/40 , C12N2535/10
摘要： Parenchymal cells are cultivated on cultivated endothelial cells or cultivated fibroblasts which have been separated by a surface of a specific hydrophilic polymer, and which have been patterned. A culture which contains thus formed patterned spheroids of cultivated parenchymal cells is thereby provided by this invention. This culture maintains a function which is specific to the parenchymal cells over a long period of time.
摘要翻译：将实质细胞培养在培养的内皮细胞或培养的成纤维细胞上，这些成纤维细胞已经被特定的亲水性聚合物的表面分离并且已被图案化。因此本发明提供了含有如此形成的培养实质细胞的图案化球体的培养物。该培养物保持长时间对实质细胞特异的功能。

50. 发明申请

US20050224415A1 Temperature-responsive polymer compound and process for producing the same 审中-公开
标题翻译：温度敏感性高分子化合物及其制造方法
公开(公告)号：US20050224415A1
公开(公告)日：2005-10-13
申请号：US11132675
申请日：2005-05-19
申请人： Yoshikatsu Akiyama , Kimihiro Yoshizako , Yukio Hasegawa , Teruo Okano
发明人： Yoshikatsu Akiyama , Kimihiro Yoshizako , Yukio Hasegawa , Teruo Okano
IPC分类号： B01J20/26 , C08F20/28 , C08F20/36 , C08F20/58 , C08F20/60 , G01N30/54 , B01D15/08
CPC分类号： B01J20/265 , B01D15/20 , B01D15/3876 , B01J20/261 , B01J20/285 , B01J2220/54 , C08F20/28 , C08F20/36 , C08F20/58 , C08F20/60 , C08F220/60 , G01N30/54
摘要： A temperature-responsive polymer and polymer material which has ester bond(s) and/or acid amide bond(s) respectively at one or more sites in the side chain and can be arbitrarily controlled by varying the side chain is provided. The process for production thereof and the use thereof are also provided.
摘要翻译：提供了在侧链的一个或多个位置处分别具有酯键和/或酰胺键的温度敏感性聚合物和聚合物材料，并且可以通过改变侧链任意控制。还提供了其生产方法及其用途。

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