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41. 发明授权

US07211418B2 PUFA polyketide synthase systems and uses thereof 有权
标题翻译： PUFA聚酮化合物系统及其用途
公开(公告)号：US07211418B2
公开(公告)日：2007-05-01
申请号：US10810352
申请日：2004-03-26
申请人： James G. Metz , Craig A. Weaver , William R. Barclay , James H. Flatt
发明人： James G. Metz , Craig A. Weaver , William R. Barclay , James H. Flatt
IPC分类号： C07H21/04 , C12N5/02 , C12P7/46
CPC分类号： C12N15/52 , A23D7/001 , A23L33/115 , A23L33/135 , C07K14/28 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
摘要翻译：本发明一般涉及多不饱和脂肪酸（PUFA）聚酮化合物合酶（PKS）系统，其同源物分离到分离的核酸分子和编码这种PUFA PKS系统的生物活性结构域的重组核酸分子，所述基因修饰的生物体包含PUFA PKS 系统，制备和使用这些系统用于生产感兴趣的生物活性分子的方法，以及用于鉴定具有这种PUFA PKS系统的新的细菌和非细菌微生物的新方法。

42. 发明申请

US20130150599A1 Production of DHA and Other LC-PUFAs in Plants 审中-公开
标题翻译：在植物中生产DHA和其他LC-PUFA
公开(公告)号：US20130150599A1
公开(公告)日：2013-06-13
申请号：US13698412
申请日：2011-05-17
申请人： Terence A. Walsh , Ann Owens Merlo , Daniel Gachotte , Paul Gordon Roessler , Scott Bevan , Jerry M. Kuner , James G. Metz
发明人： Terence A. Walsh , Ann Owens Merlo , Daniel Gachotte , Paul Gordon Roessler , Scott Bevan , Jerry M. Kuner , James G. Metz
IPC分类号： C12N15/82
CPC分类号： C12N15/8247 , C12N9/1029 , C12N9/1288 , C12P7/6427
摘要： The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).
摘要翻译：本发明提供了用多不饱和脂肪酸（PUFA）合酶系统和一种或多种辅助蛋白（例如，PPT酶和/或ACoAS）进行遗传修饰的重组宿主生物（例如，植物），其允许和/或改善PUFA的生产宿主生物体。本发明还涉及制备和使用这些生物体（例如获得PUFA）以及从这些生物（例如油和/或种子）获得的产品的方法。

43. 发明授权

US08426686B2 Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems 有权
标题翻译：使用PUFA聚酮化合物系统在异源生物体中产生多不饱和脂肪酸
公开(公告)号：US08426686B2
公开(公告)日：2013-04-23
申请号：US12796100
申请日：2010-06-08
申请人： James G. Metz , Jerry M. Kuner , James Casey Lippmeier
发明人： James G. Metz , Jerry M. Kuner , James Casey Lippmeier
IPC分类号： A01H5/00 , A01H1/00 , C12N15/82 , C12N1/20 , C07H21/04
CPC分类号： C12N9/1029 , C12N9/93 , C12N15/8247 , C12P7/6427 , C12P7/6472 , Y02P20/52
摘要： Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the organism, and in one aspect, to inhibit KASII or KASIII. Additional modifications, and methods to make and use such organisms, in addition to PUFAs and oils obtained from such organisms, are disclosed, alone with various products including such PUFAs and oils.
摘要翻译：公开了新型酰基辅酶A合成酶和新型酰基转移酶，编码该酰基转移酶的核酸分子，重组核酸分子和包含该核酸分子的重组宿主细胞，包含该核酸分子的转基因生物（微生物和植物），以及制备和使用一样。还公开了经遗传修饰以表达用于生产PUFA（PUFA PKS系统或PUFA合酶）的PKS样系统的遗传修饰生物体（例如，植物，微生物），其中生物体被修饰以表达酰基 -CoA合成酶，以表达酰基转移酶，以删除或失活由生物体表达的脂肪酸合酶（FAS），以减少与PUFA合酶的丙二酰辅酶A竞争或增加生物体中丙二酰辅酶A的水平，以及一方面抑制KASII或KASIII。除了PUFA和从这些生物获得的油之外，还公开了另外的修饰和制造和使用这些生物体的方法，其中包括各种产品，包括这种PUFA和油。

44. 发明授权

US07960524B2 PUFA polyketide synthase systems and uses thereof 有权
标题翻译： PUFA聚酮化合物系统及其用途
公开(公告)号：US07960524B2
公开(公告)日：2011-06-14
申请号：US11689596
申请日：2007-03-22
申请人： James G. Metz , James H. Flatt , Jerry M. Kuner , William R. Barclay
发明人： James G. Metz , James H. Flatt , Jerry M. Kuner , William R. Barclay
IPC分类号： C07H21/02 , C12N1/12 , C12N15/87 , C12P7/64 , A01H9/00
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
摘要翻译：本发明通常涉及从分离自非细菌生物体或衍生自非细菌生物体的多不饱和脂肪酸（PUFA）聚酮化合物合酶（PKS）系统，其同源物，分离的核酸分子和编码这种PUFA PKS的生物活性结构域的重组核酸分子系统，涉及包含PUFA PKS系统的转基因生物，制备和使用此类体系用于生产感兴趣的生物活性分子的方法，以及鉴定具有这种PUFA PKS系统的新细菌和非细菌微生物的新方法。

45. 发明授权

US07919320B2 PUFA polyketide synthase systems and uses thereof 有权
公开(公告)号：US07919320B2
公开(公告)日：2011-04-05
申请号：US11777277
申请日：2007-07-12
申请人： James G. Metz , James H. Flatt , Jerry M. Kuner , William R. Barclay
发明人： James G. Metz , James H. Flatt , Jerry M. Kuner , William R. Barclay
IPC分类号： C12N5/02 , C12N1/00 , C12N15/00 , C12N15/82 , C07H21/04 , A01H9/00
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.

46. 发明授权

US5403918A Fatty acyl reductase 失效
标题翻译：脂肪酰基还原酶
公开(公告)号：US5403918A
公开(公告)日：1995-04-04
申请号：US767251
申请日：1991-09-27
申请人： James G. Metz
发明人： James G. Metz
IPC分类号： C12N9/02 , C12N15/82 , C07K15/10 , C07K1/00
CPC分类号： C12N15/8247 , C12N9/0008 , C12Y102/01042
摘要： By this invention, a partially purified seed-plant fatty acyl reductase protein is provided, wherein said protein is active in the formation of a fatty alcohol from a fatty acyl substrate. Of special interest are jojoba embryo reductase proteins having molecular mass of about 54 and 52 kD and sequences obtainable therefrom. Also considered are amino acid and nucleic acid sequences obtainable from such fatty acyl reductases.
摘要翻译：通过本发明，提供了部分纯化的种子脂肪酰基还原酶蛋白质，其中所述蛋白质从脂肪酰基底物形成脂肪醇是有活性的。特别感兴趣的是具有约54和52kD的分子量的霍霍巴胚胎还原酶蛋白和可从其获得的序列。还考虑可从这样的脂肪酰基还原酶获得的氨基酸和核酸序列。

47. 发明申请

US20100024050A1 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 有权
标题翻译：多不饱和脂多糖合成酶系统及其用途
公开(公告)号：US20100024050A1
公开(公告)日：2010-01-28
申请号：US11777277
申请日：2007-07-12
申请人： James G. Metz , James H. Flatt , Jerry M. Kuner , William R. Barclay
发明人： James G. Metz , James H. Flatt , Jerry M. Kuner , William R. Barclay
IPC分类号： A01K67/027 , C12N15/11 , C12N15/00 , C12N1/21 , A01H5/00 , C12Q1/02 , C12P7/64 , C12N15/82 , C12N15/87
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
摘要翻译：本发明通常涉及从分离自非细菌生物体或衍生自非细菌生物体的多不饱和脂肪酸（PUFA）聚酮化合物合酶（PKS）系统，其同源物，分离的核酸分子和编码这种PUFA PKS的生物活性结构域的重组核酸分子系统，涉及包含PUFA PKS系统的转基因生物，制备和使用此类体系用于生产感兴趣的生物活性分子的方法，以及鉴定具有这种PUFA PKS系统的新细菌和非细菌微生物的新方法。

48. 发明申请

US20090192304A1 Product and Process for Transformation of Thraustochytriales Microorganisms 有权
标题翻译：破囊壶菌转化的产物和方法微生物
公开(公告)号：US20090192304A1
公开(公告)日：2009-07-30
申请号：US11925885
申请日：2007-10-27
申请人： Paul S. Roessler , T. Dave Matthews , Tom M. Ramseier , James G. Metz
发明人： Paul S. Roessler , T. Dave Matthews , Tom M. Ramseier , James G. Metz
IPC分类号： C12N15/11
CPC分类号： C12N15/82 , C12N9/88 , C12N15/79 , C12P21/02 , C12Y202/01006
摘要： Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, α-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.
摘要翻译：公开了乙酰乳酸合酶，乙酰乳酸合成酶调节区，α-微管蛋白启动子，破囊壶菌聚酮合成酶（PKS）系统的启动子和来自破囊壶菌菌体的脂肪酸去饱和酶启动子的核酸和氨基酸序列。还公开了可用于转录破囊索杆菌微生物的重组载体，以及转变破囊壶菌微生物的方法。本发明的重组核酸分子可用于在破囊壶菌属微生物中表达外源核酸，以及用于在裂囊酵素微生物中的基因的缺失，突变或失活。

49. 发明申请

US20070220634A1 PLANT SEED OILS CONTAINING POLYUNSATURATED FATTY ACIDS 审中-公开
公开(公告)号：US20070220634A1
公开(公告)日：2007-09-20
申请号：US11686872
申请日：2007-03-15
申请人： James G. Metz
发明人： James G. Metz
IPC分类号： A01H5/00 , C12N15/82 , C12N5/04
CPC分类号： C12N9/1029 , C12N9/93 , C12N15/8247 , C12P7/6427 , C12P7/6472 , Y02P20/52
摘要： Disclosed are plants that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system), wherein oils produced by the plant contain at least one PUFA produced by the PUFA PKS system and are free of the mixed shorter-chain and less unsaturated PUFAs that are fatty acid products produced by the modification of products of the FAS system in standard fatty acid pathways. Also disclosed are the oil seeds, oils, and products comprising such oils produced by this system, as well as methods for producing such plants.

50. 发明授权

US07259295B2 PUFA polyketide synthase systems and uses thereof 有权
标题翻译： PUFA聚酮化合物系统及其用途
公开(公告)号：US07259295B2
公开(公告)日：2007-08-21
申请号：US11087100
申请日：2005-03-21
申请人： James G. Metz , James H. Flatt , Jerry M. Kuner , William R. Barclay
发明人： James G. Metz , James H. Flatt , Jerry M. Kuner , William R. Barclay
IPC分类号： A01H1/00 , A01H5/00 , C12P7/64
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
摘要翻译：本发明通常涉及从分离自非细菌生物体或衍生自非细菌生物体的多不饱和脂肪酸（PUFA）聚酮化合物合酶（PKS）系统，其同源物，分离的核酸分子和编码这种PUFA PKS的生物活性结构域的重组核酸分子系统，涉及包含PUFA PKS系统的转基因生物，制备和使用此类体系用于生产感兴趣的生物活性分子的方法，以及鉴定具有这种PUFA PKS系统的新细菌和非细菌微生物的新方法。

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