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41. 发明申请

US20110112280A1 USE OF RGM AND ITS MODULATORS 审中-公开
标题翻译： RGM及其调制器的使用
公开(公告)号：US20110112280A1
公开(公告)日：2011-05-12
申请号：US12939823
申请日：2010-11-04
申请人： Bernhard K. Mueller , Philippe P. Monnier , Paolo Macchi , Friedrich Bonhoeffer , Bernd Stahl , Matthias Mann , Jens S. Andersen
发明人： Bernhard K. Mueller , Philippe P. Monnier , Paolo Macchi , Friedrich Bonhoeffer , Bernd Stahl , Matthias Mann , Jens S. Andersen
IPC分类号： C07K16/00 , C07K14/00 , C07H21/04
CPC分类号： C07K14/47 , A61K38/1709 , A61K2039/505 , C07K14/465 , C07K14/4702 , C07K16/28
摘要： The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with seizures or associated with angiogenic disorders or disorders of the cardiovascular system. Furthermore, the invention provides for the use of a modulator of a polypeptide having or comprising said amino acid sequence of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with angiogenic disorders or disorders of the cardiovascular system. In addition, the invention provides for the use of said polypeptide or said functional fragment or derivative thereof for the preparation of a pharmaceutical compositions for preventing or treating tumor growth or formation of tumor metastases or as a marker of stem cells.
摘要翻译：本发明涉及具有或包含本文公开的氨基酸序列或其功能片段或衍生物或编码所述多肽或片段或衍生物的多核苷酸的调节剂用于制备药物组合物的用途预防，减轻或治疗与癫痫相关的脊髓动物神经组织的退化或损伤相关的疾病或病症，或与心血管系统的血管生成障碍或病症有关。此外，本发明提供了具有或包含其功能片段或其衍生物的所述氨基酸序列或编码所述多肽或片段或衍生物的多核苷酸的多肽的调节剂用于制备用于预防，缓解的药物组合物或治疗与血管生成障碍或心血管系统疾病相关的脊椎动物神经组织的退化或损伤相关的疾病或病症。此外，本发明提供了所述多肽或其功能片段或衍生物用于制备用于预防或治疗肿瘤生长或肿瘤转移形成或作为干细胞标志物的药物组合物的用途。

42. 发明申请

US20110098246A1 METHOD FOR PREVENTING CORTICOSTEROID USAGE 审中-公开
标题翻译：用于预防角质层药物使用的方法
公开(公告)号：US20110098246A1
公开(公告)日：2011-04-28
申请号：US12996344
申请日：2009-06-05
申请人： Bernd Stahl , Jürgen Jelinek , Günther Boehm
发明人： Bernd Stahl , Jürgen Jelinek , Günther Boehm
IPC分类号： A61K31/702 , A61P17/00 , A61P17/06
CPC分类号： A61K31/70 , A61K31/702 , A61K31/733
摘要： The present invention relates to the use of nutritional compositions comprising non-digestible oligosaccharides for preventing corticoid administration, particularly to infants.
摘要翻译：本发明涉及包含不消化的寡糖的营养组合物用于预防皮质激素给药，特别是婴儿的用途。

43. 发明申请

US20100216740A1 Cereal-based Infant Nutrition with Fibre 审中-公开
标题翻译：基于谷物的婴幼儿营养与纤维
公开(公告)号：US20100216740A1
公开(公告)日：2010-08-26
申请号：US12532583
申请日：2008-03-21
申请人： Bernd Stahl , Martine Sandra Alles , Brigitte Antonia Maria Borgmann
发明人： Bernd Stahl , Martine Sandra Alles , Brigitte Antonia Maria Borgmann
IPC分类号： A61K31/715 , A23L1/00 , A61P1/12 , A61P25/20
CPC分类号： A23L33/21 , A23L7/198 , A23L33/40 , A23V2002/00 , A23V2250/5116 , A23V2200/328 , A23V2250/061 , A23V2250/606 , A23V2250/612 , A23V2250/5118 , A23V2250/5072 , A23V2250/5062 , A23V2200/32 , A23V2250/5114
摘要： Cereal-based semi-liquid and/or semi-solid compositions suitable for supporting the transition period wherein the infant changes from a diet consisting of breast milk or liquid infant formula to solid adult foods, comprising uronic acid carbohydrates with a degree of polymerisation (DP) between 10 and 300 and also uses thereof are disclosed.
摘要翻译：适用于支持过渡期的谷物型半液体和/或半固体组合物，其中婴儿由母乳或液体婴儿配方食物组成的饮食改变成固体成年食品，包括具有聚合度的糖醛酸碳水化合物（DP ）在10和300之间，并且还公开了其用途。

44. 发明申请

US20100035828A1 MILK OLIGOSACCHARIDE FOR STIMULATING THE IMMUNE SYSTEM 失效
标题翻译：用于刺激免疫系统的乳清低聚糖
公开(公告)号：US20100035828A1
公开(公告)日：2010-02-11
申请号：US12294768
申请日：2007-03-21
申请人： Laura M'Rabet , Antonie Van Baalen , Bernd Stahl , Arjan Paul Vos , Thomas Hubertus Martinus Snoeren
发明人： Laura M'Rabet , Antonie Van Baalen , Bernd Stahl , Arjan Paul Vos , Thomas Hubertus Martinus Snoeren
IPC分类号： A61K31/70 , A61P37/04
CPC分类号： C07H3/00 , A23L33/10 , A23L33/12 , A23L33/185 , A23L33/19 , A23L33/21 , A23L33/40 , A61K31/702 , A61K35/20
摘要： The present invention relates to methods and nutritional compositions for stimulating the immune system, particularly in subjects with an impaired immune system such as 5 infants, said method comprising administering a composition comprising sheep milk and/or short chain oligosaccharides.
摘要翻译：本发明涉及用于刺激免疫系统的方法和营养组合物，特别是在诸如5名婴儿的免疫系统受损的受试者中，所述方法包括施用包含绵羊乳和/或短链寡糖的组合物。

45. 发明授权

US07445904B2 Cysteine string protein and its role in neurodegenerative diseases 失效
标题翻译：半胱氨酸链蛋白及其在神经退行性疾病中的作用
公开(公告)号：US07445904B2
公开(公告)日：2008-11-04
申请号：US10255989
申请日：2002-09-26
申请人： Thomas C Südhof , Bernd Stahl , Soenke Tobaben
发明人： Thomas C Südhof , Bernd Stahl , Soenke Tobaben
IPC分类号： G01N33/567 , G01N33/53 , A61K49/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , A01K2267/0318
摘要： The present invention relates to in vitro and in vivo assays for the identification of agents that are useful in the treatment of neurodegenerative diseases that are associated with defects in protein folding. The present further relates to in vitro and in vivo assays for the identification of agents that contribute to the neurodegenerative processes which occur in these diseases. The present invention also relates to in vitro and in vivo models of neurodegenerative diseases. These assays and models will be useful in further understanding the pathogenesis of various neurodegenerative diseases in which defects in protein folding have been implicated, in identifying additional endogenous or environmental factors that contribute to the etiologies of these diseases, and in developing effective therapies for the prevention and/or treatment of these diseases.
摘要翻译：本发明涉及用于鉴定可用于治疗与蛋白质折叠缺陷相关的神经变性疾病的药剂的体外和体内测定。本发明还涉及用于鉴定有助于在这些疾病中发生的神经变性过程的试剂的体外和体内测定。本发明还涉及神经变性疾病的体外和体内模型。这些测定和模型将有助于进一步了解各种神经退行性疾病的发病机制，其中涉及蛋白质折叠的缺陷，以及鉴定有助于这些疾病病因的其他内源或环境因素，以及开发有效的预防治疗和/或治疗这些疾病。

46. 发明申请

US20080207559A1 Carbohydrates mixture 有权
标题翻译：碳水化合物混合物
公开(公告)号：US20080207559A1
公开(公告)日：2008-08-28
申请号：US12149300
申请日：2008-04-30
申请人： Gunther Sawatzki , Bernd Stahl
发明人： Gunther Sawatzki , Bernd Stahl
IPC分类号： A61K31/715 , A61K31/7004 , A61K31/7016 , A61P1/00 , A61K31/70 , A61K31/702
CPC分类号： A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/21 , A23L33/40 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/733 , A61K31/7004 , A61K2300/00
摘要： A carbohydrate mixture for dietetic foods and pharmaceuticals containing several carbohydrates is provided according to the present invention. Said carbohydrate mixture is characterized in that they contain or consist of two different, substantially soluble carbohydrate components A and B, which remain undigested in the gastrointestinal tract and enter the large intestine without being resorbed,that said carbohydrate component A is composed of at least one monosaccharide or of at least one oligosaccharide (disaccharide to hexasaccharide) or of a mixture of two or more of these saccharides, that the carbohydrate component B is composed of a polysaccharide (from heptasaccharide onwards) or of a mixture of two or more polysaccharides, that the carbohydrate component A=5 to 95 wt-% and the carbohydrate component B=5 to 95 wt-% of the sum of the carbohydrate components A+B (=100 wt-%), and that at least 80 wt-% of the carbohydrates/saccharides of the carbohydrate components A and B have a prebiotic effect. The inventive carbohydrate mixture have not only a nutritive effect but they also stimulate health-promoting microorganisms present in the natural flora of the large intestine.
摘要翻译：根据本发明提供了含有几种碳水化合物的饮食食品和药物的碳水化合物混合物。所述碳水化合物混合物的特征在于它们含有两种不同的，基本上可溶的碳水化合物组分A和B，其中所述碳水化合物组分A和B在胃肠道中未消化并进入大肠而不被再吸收，所述碳水化合物组分A由至少一种单糖或至少一种寡糖（二糖与六糖）或两种或多种这些糖的混合物，碳水化合物组分B由多糖（来自七糖以上）或两种或多种多糖的混合物组成，该碳水化合物组分A = 5至95重量％，碳水化合物组分B = 5至95重量％的碳水化合物组分A + B（= 100重量％）和至少80重量％的碳水化合物组分碳水化合物组分A和B的碳水化合物/糖具有益生元效应。本发明的碳水化合物混合物不仅具有营养效果，而且还刺激存在于大肠的天然菌群中的健康促进微生物。

47. 发明申请

US20080199446A1 Uronic Acid and Probiotics 有权
标题翻译：尿酸和益生菌
公开(公告)号：US20080199446A1
公开(公告)日：2008-08-21
申请号：US11912084
申请日：2006-04-18
申请人： Adrianus Johannes Maria Vriesema , Jan Knol , Bernd Stahl
发明人： Adrianus Johannes Maria Vriesema , Jan Knol , Bernd Stahl
IPC分类号： A61K35/74 , A61P31/00
CPC分类号： A61K31/702 , A23L33/135 , A61K35/745 , A61K35/747 , A61K2300/00
摘要： The present invention relates to compositions containing probiotic bacteria and uronic acid oligosaccharides. The compositions can suitably be used as infant nutrition and advantageously reduce the incidence of infection.
摘要翻译：本发明涉及含有益生菌和糖醛酸寡糖的组合物。组合物可适当地用作婴儿营养，并有利地降低感染的发生率。

48. 发明申请

US20080193627A1 Process For Drying Uronic Acid Oligosaccharides 失效
标题翻译：干燥酸性低聚糖的方法
公开(公告)号：US20080193627A1
公开(公告)日：2008-08-14
申请号：US11912097
申请日：2006-04-21
申请人： Martin Van Eert , Bernd Stahl , Antonie Van Baalen
发明人： Martin Van Eert , Bernd Stahl , Antonie Van Baalen
IPC分类号： A23D7/005 , A23L1/48 , A23J1/00
CPC分类号： C08L5/06 , A23G3/34 , A23L29/231 , C07H1/00 , C07H3/06 , C08J3/122 , C08J2305/06 , Y10T428/2982
摘要： The present invention relates to a process for spray drying uronic acid oligosaccharides and to a powder compositions thus obtained. Typically the powder composition comprises between 25 and 100 wt. % uronic acid oligosaccharide with a DP between 2 and 50 based on total weight of uronic acid, with and an average particle size between 20 μm and 100 μm.
摘要翻译：本发明涉及一种喷雾干燥糖醛酸寡糖的方法以及由此获得的粉末组合物。通常，粉末组合物包含25至100wt。基于糖醛酸的总重量，DP为2〜50的％糖醛酸寡糖，平均粒径为20〜100μm。

49. 发明授权

US08754064B2 Milk oligosaccharide for stimulating the immune system 失效
标题翻译：乳寡糖用于刺激免疫系统
公开(公告)号：US08754064B2
公开(公告)日：2014-06-17
申请号：US12294768
申请日：2007-03-21
申请人： Laura M'Rabet , Antonie Van Baalen , Bernd Stahl , Arjan Paul Vos , Thomas Hubertus Martinus Snoeren
发明人： Laura M'Rabet , Antonie Van Baalen , Bernd Stahl , Arjan Paul Vos , Thomas Hubertus Martinus Snoeren
IPC分类号： C07H3/00 , A61K31/702
CPC分类号： C07H3/00 , A23L33/10 , A23L33/12 , A23L33/185 , A23L33/19 , A23L33/21 , A23L33/40 , A61K31/702 , A61K35/20
摘要： The present invention relates to methods and nutritional compositions for stimulating the immune system, particularly in subjects with an impaired immune system such as 5 infants, said method comprising administering a composition comprising sheep milk and/or short chain oligosaccharides.
摘要翻译：本发明涉及用于刺激免疫系统的方法和营养组合物，特别是在诸如5名婴儿的免疫系统受损的受试者中，所述方法包括施用包含绵羊乳和/或短链寡糖的组合物。

50. 发明授权

US08580295B2 Carbohydrates mixture 有权
标题翻译：碳水化合物混合物
公开(公告)号：US08580295B2
公开(公告)日：2013-11-12
申请号：US12149300
申请日：2008-04-30
申请人： Gunther Sawatzki , Bernd Stahl
发明人： Gunther Sawatzki , Bernd Stahl
IPC分类号： A61K47/00
CPC分类号： A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/21 , A23L33/40 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/733 , A61K31/7004 , A61K2300/00
摘要： A carbohydrate mixture for dietetic foods and pharmaceuticals is provided. The carbohydrate mixture comprises two different, substantially soluble carbohydrate components A and B, which remain undigested in the gastrointestinal tract and enter the large intestine without being resorbed. Carbohydrate component A may comprise at least one monosaccharide or of at least one oligosaccharide (disaccharide to hexasaccharide) or a mixture of two or more of these saccharides. Carbohydrate component B may comprise a polysaccharide (from heptasaccharide onwards) or a mixture of two or more polysaccharides. Carbohydrate component A=5 to 95 wt-% and carbohydrate component B=5 to 95 wt-% of the sum of the carbohydrate components A+B (=100 wt-%), and at least 80 wt-% of the carbohydrates/saccharides of both carbohydrate components have a prebiotic effect. The carbohydrate mixtures have not only a nutritive effect but they also stimulate health-promoting microorganisms present in the natural flora of the large intestine.
摘要翻译：提供饮食食品和药物的碳水化合物混合物。碳水化合物混合物包含两种不同的，基本上可溶的碳水化合物组分A和B，其在胃肠道中未消化并进入大肠而不被再吸收。碳水化合物成分A可以包含至少一种单糖或至少一种寡糖（二糖与六糖）或两种或更多种这些糖的混合物。碳水化合物组分B可以包含多糖（来自七糖以上）或两种或更多种多糖的混合物。碳水化合物组分A = 5至95重量％，碳水化合物组分B =碳水化合物组分A + B（= 100重量％）和至少80重量％的碳水化合物/ 两种碳水化合物组分的糖都具有益生元效应。碳水化合物混合物不仅具有营养作用，而且还刺激存在于大肠的天然菌群中的健康促进微生物。

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