专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US08007524B2 Heat treatment and heat loss reduction for treating meibomian gland dysfunction 有权
标题翻译：热处理和热损失减少治疗睑板腺功能障碍
公开(公告)号：US08007524B2
公开(公告)日：2011-08-30
申请号：US12015584
申请日：2008-01-17
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , John Martin Jans
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , John Martin Jans
IPC分类号： A61M35/00 , A61F7/02 , A61F7/08
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： A method of treating meibomian gland dysfunction. Heat is applied to the tissue proximate the patient's meibomian glands to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force may also be applied to the tissue proximate the patient's meibomian glands to improve conductive heat transfer and reduce blood flow in the tissue that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reached desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：治疗睑板腺功能障碍的方法。将热量施加到患者睑板腺附近的组织，以向睑板腺提供导电热传递。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。也可以将力施加到患者睑板腺附近的组织，以改善传导性热传递并减少组织中造成对流热损失的血液流动。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。达到升高的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到所需温度水平的时间量和/或有助于减轻治疗期间患者的不适。

42. 发明授权

US07981147B2 Outer eyelid heat and pressure treatment for treating meibomian gland dysfunction 有权
标题翻译：外眼睑热压治疗睑板腺功能障碍
公开(公告)号：US07981147B2
公开(公告)日：2011-07-19
申请号：US12015576
申请日：2008-01-17
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
IPC分类号： A61M35/00 , A61F7/02 , A61F7/08
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61K31/65 , A61K38/1841 , A61N7/00
摘要： A method of treating meibomian gland dysfunction. Heat is applied to the outside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force may also be applied to the outside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions or occlusions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reach desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：治疗睑板腺功能障碍的方法。将热量施加到眼睑的外侧，以向睑板腺提供导电热传递。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。也可以将力施加到患者眼睑的外侧，以改善导电传热并减少引起对流热损失的眼睑中的血流。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物或闭塞的时间。达到增加的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到期望温度水平的时间量和/或有助于减轻治疗期间对患者的不适。

43. 发明授权

US07981145B2 Treatment of meibomian glands 有权
标题翻译：治疗睑板腺
公开(公告)号：US07981145B2
公开(公告)日：2011-07-19
申请号：US11541418
申请日：2006-09-29
申请人： Donald R. Korb , Timothy R. Willis , Stephen M. Grenon
发明人： Donald R. Korb , Timothy R. Willis , Stephen M. Grenon
IPC分类号： A61M35/00 , A61F7/02 , A61F7/08
CPC分类号： A61B17/22004 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F7/02 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： In one embodiment consistent with the present invention a method of treating mammalian meibomian glands involves clearing the glands by applying a regulated heat to an eyelid containing the meibomian glands to a temperature adequate to melt obstructions in the meibomian glands to put the obstructions in a fluid or suspension (melted) state and maintaining the heat for a time period adequate to melt the obstructions. The glands can then be mechanically treated to express fluid from the glands, wherein the treating is carried out either during the time period or after the time period but while the obstruction remains in a fluid state. Subsequent pharmacological treatment of the glands by use a pharmacological agent (topical or systemic) can then be used to assist in maintaining proper flow of lipids from the glands. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：在与本发明一致的一个实施方案中，治疗哺乳动物睑板腺的方法涉及通过将含有睑板腺的眼睑施加调节的热量至足以融化睑板腺中的阻塞物以将阻塞物置于流体中的方式来清除腺体，或悬浮（熔化）状态并将热量保持足够的时间以融化障碍物。然后可以对腺体进行机械处理以从腺体表达流体，其中治疗在时间段期间或在时间段之后进行，但是当阻塞物保持在流体状态时。然后通过使用药物（局部或全身）对腺体进行的后续药理学治疗可用于帮助保持来自腺体的适当的脂质流动。该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

44. 发明授权

US07758190B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US07758190B2
公开(公告)日：2010-07-20
申请号：US11820664
申请日：2007-06-20
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/10
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和破坏性干扰。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

45. 发明授权

US08585204B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US08585204B2
公开(公告)日：2013-11-19
申请号：US13455628
申请日：2012-04-25
申请人： Benjamin T. Gravely , Donald R. Korb
发明人： Benjamin T. Gravely , Donald R. Korb
IPC分类号： A61B3/10 , A61B3/14
CPC分类号： A61B3/101
摘要： A method for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye. Light is directed to the lipid layer of a patient's eye with an illuminator that is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. The specularly reflected light is collected and focused using a collector such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis.
摘要翻译：用于测量眼表面上的角膜前泪膜的脂质层成分的相对厚度的方法。光被引导到患者眼睛的脂质层，其中照射器是覆盖可见区域的宽光谱光源，并且是透明光发射器，使得光源被镜面反射从脂质层并经历建构性和相消干涉脂质层。使用收集器收集和聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。集电极还产生代表镜面反射光的输出信号，适用于进一步的分析。

46. 发明申请

US20110285961A1 TEAR FILM MEASUREMENT 有权
标题翻译：眼膜测量
公开(公告)号：US20110285961A1
公开(公告)日：2011-11-24
申请号：US13195353
申请日：2011-08-01
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/10
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和相消干涉。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

47. 发明申请

US20080316499A1 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US20080316499A1
公开(公告)日：2008-12-25
申请号：US11820664
申请日：2007-06-20
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： G01B11/06
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和破坏性干扰。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

48. 发明授权

US08591033B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US08591033B2
公开(公告)日：2013-11-26
申请号：US13195353
申请日：2011-08-01
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/10
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和相消干涉。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

49. 发明申请

US20120236260A1 TEAR FILM MEASUREMENT 有权
标题翻译：眼膜测量
公开(公告)号：US20120236260A1
公开(公告)日：2012-09-20
申请号：US13455628
申请日：2012-04-25
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/14
CPC分类号： A61B3/101
摘要： A method for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye. Light is directed to the lipid layer of a patient's eye with an illuminator that is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. The specularly reflected light is collected and focused using a collector such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis.
摘要翻译：用于测量眼表面上的角膜前泪膜的脂质层成分的相对厚度的方法。光被引导到患者眼睛的脂质层，其中照射器是覆盖可见区域的宽光谱光源，并且是透明光发射器，使得光源被镜面反射从脂质层并经历建构性和相消干涉脂质层。使用收集器收集和聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。集电极还产生代表镜面反射光的输出信号，适用于进一步的分析。

50. 发明授权

US08192026B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US08192026B2
公开(公告)日：2012-06-05
申请号：US11900314
申请日：2007-09-11
申请人： Benjamin T. Gravely , Donald R. Korb
发明人： Benjamin T. Gravely , Donald R. Korb
IPC分类号： A61B3/00 , A61B3/10
CPC分类号： A61B3/101
摘要： The disclosure comprises a method for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking. Light is directed to the lipid layer of a patient's eye with an illuminator. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. The specularly reflected light is collected and focused using a collector such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer.
摘要翻译：本公开内容包括一种用于在眨眼之后脂质层分布之后测量眼表面上的眼前表面泪液的脂质层组分的相对厚度的方法。光照射器被引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和相消干涉。使用收集器收集和聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示适于进一步分析的镜面反射光的输出信号，例如投影到高分辨率视频监视器或由计算机分析或存储在计算机中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式