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41. 发明申请

US20100331717A1 Seizure Sensing and Detection Using an Implantable Device 审中-公开
标题翻译：使用可植入装置进行检测和检测
公开(公告)号：US20100331717A1
公开(公告)日：2010-12-30
申请号：US12880138
申请日：2010-09-12
申请人： Benjamin D. Pless , Stephen T. Archer , Craig M. Baysinger , Barbara Gibb , Suresh Gurunathan , Bruce Kirkpatrick , Thomas K. Tcheng
发明人： Benjamin D. Pless , Stephen T. Archer , Craig M. Baysinger , Barbara Gibb , Suresh Gurunathan , Bruce Kirkpatrick , Thomas K. Tcheng
IPC分类号： A61B5/0476
CPC分类号： A61B5/4094 , A61B5/04012 , A61B5/0476 , A61B5/0478 , A61B5/6868 , A61B5/7203 , A61B5/7242 , A61B5/7246 , A61B5/7264 , A61B5/7275
摘要： A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in an electrographic signal received from a patient's brain. The features and window-based characteristics are combinable in various ways according to the invention to detect and predict neurological events in real time, enabling responsive action by the implantable device.
摘要翻译：使用可植入装置检测和预测神经病学的系统和方法使用与信号处理电路相关联的相对低功率的中央处理单元来识别特征（包括半波）并计算基于窗口的特征（包括线路长度和面积在从患者的大脑接收的电图信号中波形的曲线）。根据本发明的特征和基于窗口的特征可以以各种方式组合以实时检测和预测神经病学事件，从而能够实现可植入装置的响应动作。

42. 发明授权

US07747318B2 Functional ferrule 有权
标题翻译：功能套圈
公开(公告)号：US07747318B2
公开(公告)日：2010-06-29
申请号：US11635885
申请日：2006-12-07
申请人： Michael S. John , Brett Wingeier , Thomas K. Tcheng , Benjamin D. Pless
发明人： Michael S. John , Brett Wingeier , Thomas K. Tcheng , Benjamin D. Pless
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61B8/0808 , A61N1/0531 , A61N1/0534 , A61N1/0539
摘要： Described here are intracranial ferrules, systems, and methods for sensing and stimulating neural tissues. The ferrules are generally designed to include a holding area for retaining an implantable device. In some variations, the ferrule itself may perform the sensing and stimulating functions. In other variations, the ferrule may function to sense data from neural tissues and the implantable device may function to stimulate neural tissues. In yet other variations, the ferrule may function to stimulate, and the implantable device may function to sense data from, the neural tissues. The sensing and stimulating functions may be used to detect and/or treat various neurological conditions.
摘要翻译：这里描述了用于感测和刺激神经组织的颅内套圈，系统和方法。套圈通常设计成包括用于保持可植入装置的保持区域。在一些变型中，套圈本身可以执行感测和刺激功能。在其他变型中，套圈可用于感测来自神经组织的数据，并且可植入装置可用于刺激神经组织。在另外的变型中，套圈可以起刺激的作用，并且可植入装置可用于从神经组织感测数据。感测和刺激功能可用于检测和/或治疗各种神经疾病。

43. 发明授权

US07643147B2 Method and system for device identification 有权
标题翻译：设备识别方法和系统
公开(公告)号：US07643147B2
公开(公告)日：2010-01-05
申请号：US11556357
申请日：2006-11-03
申请人： Benjamin D. Pless
发明人： Benjamin D. Pless
IPC分类号： G01B9/02
CPC分类号： G06K9/2036 , G06K9/00577
摘要： A method and system for performing device identification is disclosed. A source signal may be directed from an energy source towards the surface of a device for reflection therefrom. An interference pattern may be detected from the surface of the device, such as by a sensor. A determination as to whether a match exists between the representation of the interference pattern and a stored representation of an interference pattern may be performed. If a match exists, the device may be identified based on the stored representation of the interference pattern. Otherwise, a representation of the interference pattern may be stored and a unique identifier may be assigned to the stored representation of the interference pattern.
摘要翻译：公开了一种用于执行设备识别的方法和系统。源信号可以从能量源朝向装置的表面引导以从其反射。可以从设备的表面（例如通过传感器）检测干涉图案。可以执行关于在干涉图案的表示和存储的干涉图案的表示之间是否存在匹配的确定。如果存在匹配，则可以基于存储的干涉图案的表示来识别该设备。否则，可以存储干扰图案的表示，并且可以将唯一标识符分配给所存储的干涉图案的表示。

44. 发明申请

US20090069863A1 MODULATION AND ANALYSIS OF CEREBRAL PERFUSION IN EPILEPSY AND OTHER NEUROLOGICAL DISORDERS 有权
标题翻译：脑膜炎和其他神经疾病中的脑膜灌注调节与分析
公开(公告)号：US20090069863A1
公开(公告)日：2009-03-12
申请号：US11925655
申请日：2007-10-26
申请人： Benjamin D. Pless , Brett Wingeier
发明人： Benjamin D. Pless , Brett Wingeier
IPC分类号： A61N1/36 , A61B5/145
CPC分类号： A61B5/14553 , A61B5/0031 , A61B5/0476 , A61B5/1459 , A61B5/4094 , A61B5/7217 , A61N1/36064 , A61N1/36082
摘要： A system including an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required.
摘要翻译：一种包括能够调节脑血流以治疗癫痫和其他神经障碍的可植入神经刺激器装置的系统。在一个实施方案中，系统能够响应于测量和其他观察到的条件而调节脑血流量（也称为脑灌注）。根据临床要求的根据本发明的系统和方法可以增加或减少灌注。

45. 发明申请

US20080195166A1 Devices and methods for monitoring physiological information relating to sleep with an implantable device 有权
标题翻译：用于通过可植入装置监测与睡眠相关的生理信息的装置和方法
公开(公告)号：US20080195166A1
公开(公告)日：2008-08-14
申请号：US11704451
申请日：2007-02-09
申请人： Felice Sun , Benjamin D. Pless , Barbara Gibb
发明人： Felice Sun , Benjamin D. Pless , Barbara Gibb
IPC分类号： A61N1/08
CPC分类号： A61B5/4812 , A61B5/01 , A61B5/0205 , A61B5/02438 , A61B5/026 , A61B5/04012 , A61B5/0452 , A61B5/0476 , A61B5/0478 , A61B5/11 , A61B5/1118 , A61B5/14551 , A61B5/4815 , A61B5/686 , A61N1/36082 , A61N1/36135 , G06F19/00
摘要： Described here are implantable devices and methods for monitoring physiological information relating to sleep. The implantable devices are generally designed to include at least one sensor for sensing physiological information, a processor for processing the physiological information using low computational power to detect a sleep stage, and a battery. The detected sleep stage information may then be used to indicate sleep quality, identify or monitor a medical condition, or guide treatment thereof.
摘要翻译：这里描述的是用于监测与睡眠相关的生理信息的可植入装置和方法。可植入装置通常设计成包括用于感测生理信息的至少一个传感器，用于使用低计算能力处理生理信息以检测睡眠阶段的处理器以及电池。然后可以使用检测到的睡眠阶段信息来指示睡眠质量，识别或监测医疗状况或指导治疗。

46. 发明授权

US07341562B2 Modulation and analysis of cerebral perfusion in epilepsy and other neurological disorders 有权
标题翻译：癫痫和其他神经系统疾病中脑灌注的调节和分析
公开(公告)号：US07341562B2
公开(公告)日：2008-03-11
申请号：US11014628
申请日：2004-12-15
申请人： Benjamin D. Pless , Brett Wingeier
发明人： Benjamin D. Pless , Brett Wingeier
IPC分类号： A61B5/026 , A61B5/0295 , A61N1/36
CPC分类号： A61B5/14553 , A61B5/0031 , A61B5/0476 , A61B5/1459 , A61B5/4094 , A61B5/7217 , A61N1/36064 , A61N1/36082
摘要： A system including an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required.
摘要翻译：一种包括能够调节脑血流以治疗癫痫和其他神经障碍的可植入神经刺激器装置的系统。在一个实施方案中，系统能够响应于测量和其他观察到的条件而调节脑血流量（也称为脑灌注）。根据临床要求的根据本发明的系统和方法可以增加或减少灌注。

47. 发明申请

US20080021514A1 Treatment and warning of recurring therapy and other events using an implantable device 有权
标题翻译：使用植入式装置对复发性治疗和其他事件进行治疗和警告
公开(公告)号：US20080021514A1
公开(公告)日：2008-01-24
申请号：US11490818
申请日：2006-07-21
申请人： Benjamin D. Pless
发明人： Benjamin D. Pless
IPC分类号： A61N1/00
CPC分类号： A61N1/36082 , A61B5/04001 , A61B5/04004 , A61B5/0476 , A61B5/4094 , A61N1/0529 , A61N1/0531 , A61N1/0539
摘要： An implantable neurostimulator system is capable of responsively treating epileptiform activity with electrical stimulation and other therapies and is further configured to detect periods of increased susceptibility to clinical seizures. The event densities of therapy applications (or detections or other events) in time are observed and calculated, and if high enough, measures are taken to warn the patient or provide additional therapy.
摘要翻译：可植入式神经刺激器系统能够通过电刺激和其它治疗来响应性地治疗癫痫样活性，并且还被配置为检测对临床发作敏感性增加的时期。观察和计算治疗应用（或检测或其他事件）的事件密度，如果足够高，采取措施来警告患者或提供额外的治疗。

48. 发明授权

US07174213B2 Electrical stimulation strategies to reduce the incidence of seizures 有权
标题翻译：电刺激策略，以减少癫痫发作
公开(公告)号：US07174213B2
公开(公告)日：2007-02-06
申请号：US09952871
申请日：2001-09-11
申请人： Benjamin D. Pless
发明人： Benjamin D. Pless
IPC分类号： A61N1/36
CPC分类号： A61N1/36064
摘要： An implantable multimodal neurostimulator having improved efficacy in treating epilepsy and other neurological disorders and processes of using that neurostimulator are described herein. The neurostimulator itself generally has two modes of electrical stimulation. The first involves delivering a non-responsive electrical stimulation signal that is applied to the central nervous system to reduce the likelihood of a seizure or other undesirable neurological even from occurring. Various waveform morphologies are described for non-responsive stimulation signals. A second mode involves delivering a responsive electrical stimulation signal when epileptiform waveforms are impending or extant. The responsive electrical stimulation signal is intended to terminate epileptiform activity, e.g., to desynchronize abnormally synchronous brain electrical activity.
摘要翻译：本文描述了具有改善的治疗癫痫和其它神经障碍的功效的植入式多模式神经刺激器和使用该神经刺激器的过程。神经刺激器本身通常具有两种电刺激模式。第一个涉及提供应用于中枢神经系统的无反应性电刺激信号，以减少甚至发生癫痫发作或其他不希望的神经系统的可能性。描述了用于无响应刺激信号的各种波形形态。第二模式涉及当癫痫样波形即将到来或现存时递送响应电刺激信号。响应性电刺激信号旨在终止癫痫样活动，例如使异常同步的脑电活动失步。

49. 发明授权

US07158833B2 Ferrule for cranial implant 有权
标题翻译：用于颅骨植入物的套圈
公开(公告)号：US07158833B2
公开(公告)日：2007-01-02
申请号：US10639842
申请日：2003-08-12
申请人： Benjamin D. Pless , Dennis Potts
发明人： Benjamin D. Pless , Dennis Potts
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61B2090/103 , A61M39/0247 , A61N1/0539
摘要： A ferrule for removably retaining a self-contained implantable device within a cranial opening of a patient is set forth. The ferrule includes a shelf portion, a wall portion, and at least one supporting tab connected to the wall portion. The shelf portion has an inner surface and an outer surface. The inner surface of the shelf portion substantially conforms to an implantable device. The wall portion has an inner surface and an outer surface and encompasses the shelf portion. The inner surface of the wall portion substantially conforms to the implantable device and the outer surface of the wall portion substantially conforms to the cranial opening.
摘要翻译：阐述了用于可拆卸地将自包含可植入装置保持在患者的颅内开口内的套圈。套圈包括搁板部分，壁部分和连接到壁部分的至少一个支撑片。搁板部分具有内表面和外表面。搁板部分的内表面基本上符合可植入装置。壁部具有内表面和外表面并且包围搁板部分。壁部分的内表面基本上符合可植入装置，并且壁部分的外表面基本上符合头开口。

50. 发明授权

US07110820B2 Responsive electrical stimulation for movement disorders 有权
公开(公告)号：US07110820B2
公开(公告)日：2006-09-19
申请号：US10072669
申请日：2002-02-05
申请人： Thomas K. Tcheng , Robert E. Fischell , Benjamin D. Pless
发明人： Thomas K. Tcheng , Robert E. Fischell , Benjamin D. Pless
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/36135
摘要： An implantable neurostimulator system for treating movement disorders includes a sensor, a detection subsystem capable of identifying episodes of a movement disorder by analyzing a signal received from the sensor, and a therapy subsystem capable of applying therapeutic electrical stimulation to treat the movement disorder. The system treats movement disorders by detecting physiological conditions characteristic of an episode of symptoms of the movement disorder and selectively initiating therapy when such conditions are detected.

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