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41. 发明授权

US06254338B1 Water turbine or water pump 失效
标题翻译：水轮机或水泵
公开(公告)号：US06254338B1
公开(公告)日：2001-07-03
申请号：US09319783
申请日：1997-11-13
申请人： Andreas Keller
发明人： Andreas Keller
IPC分类号： F01D1712
CPC分类号： F03B3/126 , F03B3/123 , Y02E10/223
摘要： A water turbine or pump having a rotor (1) and a stator (2). The leading edges (13) and the trailing edges (14) at least of the rotor blades (6) form a bend (15) projecting in opposite relationship to the flow direction (12). That causes a flow force resulting in a self-cleaning effect being applied to impurities which are deposited at the leading edges (13). However the adjustment design providing for adjustability of the rotor blades remains substantially unchanged.
摘要翻译：一种具有转子（1）和定子（2）的水轮机或泵。至少转子叶片（6）的前缘（13）和后缘（14）形成与流动方向（12）成反向突出的弯曲部（15）。这导致流动力导致自清洁效应被施加到沉积在前缘（13）处的杂质。然而，提供转子叶片可调节性的调整设计基本上保持不变。

42. 发明授权

US4960521A Process for performing a dialysis operation using a magnetic weighted clamp 失效
标题翻译：使用磁加权夹具执行透析操作的过程
公开(公告)号：US4960521A
公开(公告)日：1990-10-02
申请号：US367338
申请日：1989-06-16
申请人： Andreas Keller
发明人： Andreas Keller
IPC分类号： B01D61/24 , B01D61/30 , B01D63/16
CPC分类号： B01D61/243 , B01D61/30 , B01D63/16 , Y10T24/15 , Y10T24/44752
摘要： An improved process for performing a dialysis operation and the magnetic weighted clamp used therewith. A dialysis sack is closed at one end with a weighted clamp which includes a magnetic bar. The closed sack is placed in a container filled with a dialysis buffer solution. The container is placed on a magnetic stir plate, and the clamp and dialysis sack are turned within the buffer solution so that the buffer at the surface of the dialysis sack is continuously renewed.
摘要翻译：用于进行透析操作的改进方法和与其一起使用的磁加权夹具。透析袋在一端用包括磁条的加重夹具封闭。将封闭的袋放在装有透析缓冲溶液的容器中。将容器放置在磁力搅拌板上，夹紧和透析袋在缓冲溶液内转动，使透析袋表面的缓冲液不断更新。

43. 发明授权

US10325686B2 System and methods for integrated and predictive analysis of molecular, imaging, and clinical data for patient-specific management of diseases 有权
公开(公告)号：US10325686B2
公开(公告)日：2019-06-18
申请号：US13928430
申请日：2013-06-27
申请人： Tommaso Mansi , Wei Keat Lim , Vanessa King , Andreas Kremer , Bogdan Georgescu , Xudong Zheng , Ali Kamen , Andreas Keller , Cord Friedrich Staehler , Emil Wirsz , Dorin Comaniciu
发明人： Tommaso Mansi , Wei Keat Lim , Vanessa King , Andreas Kremer , Bogdan Georgescu , Xudong Zheng , Ali Kamen , Andreas Keller , Cord Friedrich Staehler , Emil Wirsz , Dorin Comaniciu
IPC分类号： G16H50/50 , G16B5/00
摘要： A system operating in a plurality of modes to provide an integrated analysis of molecular data, imaging data, and clinical data associated with a patient includes a multi-scale model, a molecular model, and a linking component. The multi-scale model is configured to generate one or more estimated multi-scale parameters based on the clinical data and the imaging data when the system operates in a first mode, and generate a model of organ functionality based on one or more inferred multi-scale parameters when the system operates in a second mode. The molecular model is configured to generate one or more first molecular findings based on a molecular network analysis of the molecular data, wherein the molecular model is constrained by the estimated parameters when the system operates in the first mode. The linking component, which is operably coupled to the multi-scale model and the molecular model, is configured to transfer the estimated multi-scale parameters from the multi-scale model to the molecular model when the system operates in the first mode, and generate, using a machine learning process, the inferred multi-scale parameters based on the molecular findings when the system operates in the second mode.

44. 发明申请

US20130072726A1 PROCESS FOR PREPARING 4-CYCLOHEXYL-2-METHYL-2-BUTANOL 有权
公开(公告)号：US20130072726A1
公开(公告)日：2013-03-21
申请号：US13616147
申请日：2012-09-14
申请人： Rudolf Schuch , Stefan Rüdenauer , Klaus Ebel , Ralf Pelzer , Andreas Keller
发明人： Rudolf Schuch , Stefan Rüdenauer , Klaus Ebel , Ralf Pelzer , Andreas Keller
IPC分类号： C07C29/44
CPC分类号： C07C29/44 , B01J21/08 , B01J23/462 , B01J23/56 , B01J33/00 , B01J35/0026 , B01J35/008 , B01J35/023 , B01J35/08 , B01J35/1019 , B01J35/1042 , B01J35/1061 , B01J35/108 , B01J37/0203 , B01J37/18 , C07C29/19 , C07C29/80 , C07C2601/14 , C11B9/0061 , C07C33/20 , C07C31/1355
摘要： A process for preparing 4-cyclohexyl-2-methyl-2-butanol, comprising: a) reaction of styrene with isopropanol at elevated temperature to obtain 2-methyl-4-phenyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 2-methyl-4-phenyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics, where the molar ratio of the styrene used in step a) to the isopropanol used in step a) is in the range from 1:below 5 to 1:0.5.

45. 发明申请

US20110237840A1 PROCESS FOR PREPARING POTASSIUM AND POTASSIUM COMPOUNDS 审中-公开
标题翻译：制备钾和钾化合物的方法
公开(公告)号：US20110237840A1
公开(公告)日：2011-09-29
申请号：US13071989
申请日：2011-03-25
申请人： Hagen Wilmer , Andreas Keller
发明人： Hagen Wilmer , Andreas Keller
IPC分类号： C07C29/70 , C22B26/10
CPC分类号： C22B5/04 , C07C29/70 , C22B26/10 , C07C31/30
摘要： The invention relates to a process for preparing potassium and potassium compounds
摘要翻译：本发明涉及一种制备钾和钾化合物的方法

46. 发明申请

US20100143337A1 COMPOSITIONS AND METHODS FOR CHARACTERIZING AND REGULATING OLFACTORY SENSATION 有权
标题翻译：用于表征和调节OLFACTORY SENSATION的组合物和方法
公开(公告)号：US20100143337A1
公开(公告)日：2010-06-10
申请号：US12598901
申请日：2008-05-08
申请人： Hiroaki Matsunami , Andreas Keller , Hanyi Zhuang , Qiuyi Chi , Leslie B. Vosshall
发明人： Hiroaki Matsunami , Andreas Keller , Hanyi Zhuang , Qiuyi Chi , Leslie B. Vosshall
IPC分类号： A61K39/395 , G01N33/53 , C12Q1/68
CPC分类号： C12Q1/6897 , C12Q1/6876 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/566 , G01N2333/726 , G01N2500/04
摘要： The present invention relates to the characterization of odorant receptors. In particular, the present invention relates to the OR7D4 proteins and nucleic acids encoding OR7D4 proteins and cell systems for screening for modulators of OR7D4 receptors. The present invention further provides assays for the detection of OR7D4 polymorphisms and mutations associated with altered olfactory sensation states, as well as methods of screening for therapeutic agents, ligands, and modulators of OR7D4 receptors.
摘要翻译：本发明涉及加臭剂受体的表征。特别地，本发明涉及编码OR7D4蛋白质的OR7D4蛋白质和核酸以及用于筛选OR7D4受体调节剂的细胞系统。本发明还提供了用于检测OR7D4多态性和与改变的嗅觉状态相关的突变的检测方法，以及筛选OR7D4受体的治疗剂，配体和调节剂的方法。

47. 发明授权

US07339085B2 Method for producing 2,7-dimethyl-octa-2,4,6-trienedial 有权
标题翻译： 2,7-二甲基 - 八氢-2,4,6-三烯的方法
公开(公告)号：US07339085B2
公开(公告)日：2008-03-04
申请号：US10588683
申请日：2005-02-04
申请人： Hansgeorg Ernst , Klaus Henrich , Andreas Keller
发明人： Hansgeorg Ernst , Klaus Henrich , Andreas Keller
IPC分类号： C07C45/45
CPC分类号： C07C45/515 , C07C41/54 , C07C45/65 , C07C47/277 , C07C47/21 , C07C43/315
摘要： The present invention relates to an improved process for preparing 2,7-dimethylocta-2,4,6-trienedial of the formula I, by a) double enol ether condensation of a butenedial bisacetal of the formula II with an enol ether of the formula III, in the presence of a Lewis acid catalyst to give a condensation product of the formula IV, where the radicals R1 and R2 in formulae II to IV are independently of one another C1-C6-alkyl;b) hydrolysis of the acetal groups of IV by adding an aqueous acid to form the dialdehyde of the formula V; d) crystallization of I from the reaction mixture,Wherein process steps a) to d) are carried out in the presence of an inert, water-immiscible organic solvent.
摘要翻译：本发明涉及通过以下方式制备式I的2,7-二甲基辛-2,4,6-三烯酸的改进方法：a）式Ⅱ的丁二醛双缩醛与式II的烯醇醚的双烯醇醚缩合 III，在路易斯酸催化剂的存在下，得到式IV的缩合产物，其中式II至IV中的基团R 1和R 2与式另一个C 1 -C 6 - 烷基; b）通过加入酸水溶液来水解IV的缩醛基以形成式V的二醛; d）从反应混合物中结晶I，其中方法步骤a）至d）在惰性的与水不混溶的有机溶剂的存在下进行。

48. 发明授权

US06881854B2 Conjugated unsaturated glyceride mixtures and a method for producing the same 失效
标题翻译：共轭不饱和甘油酯混合物及其制备方法
公开(公告)号：US06881854B2
公开(公告)日：2005-04-19
申请号：US10473217
申请日：2002-03-26
申请人： Arne Ptock , Kai-Uwe Baldenius , Andreas Keller
发明人： Arne Ptock , Kai-Uwe Baldenius , Andreas Keller
IPC分类号： A23D9/007 , A23D9/013 , A23K20/158 , A23L33/12 , A61K8/31 , A61K8/37 , A61K8/92 , A61K31/201 , A61K31/231 , A61P3/04 , A61P3/10 , A61P9/00 , A61P35/00 , A61P37/08 , A61Q19/00 , C07B37/08 , C07B61/00 , C07C51/353 , C07C67/333 , C07C69/587 , C11C3/14 , C07C57/00
CPC分类号： C11C3/14 , A23D9/007 , A23D9/013 , A23K20/158 , A23L33/12 , A23V2002/00 , A61K8/31 , A61K8/375 , A61K8/922 , A61Q19/00 , C07B37/08 , C07C51/353 , C07C67/333 , C07C57/12 , C07C69/587 , A23V2250/1866
摘要： The invention relates to a process for conjugating two double bonds separated by a methylene bridge in a long-chain alkene, in which the long-chain alkene is isomerized with an a) imino base, or b) iminophosphorane base, as catalyst.
摘要翻译：本发明涉及一种将长链烯烃中亚甲基桥隔开的两个双键结合的方法，其中长链烯烃与a）亚氨基或b）亚氨基磷酰基作为催化剂异构化。

49. 发明授权

US06271320B1 Method for the production of a polymer dispersion by radical aqueous emulsion polymerization with a continuously produced aqueous monomer emulsion 有权
标题翻译：用连续制备的含水单体乳液通过自由基水乳液聚合制备聚合物分散体的方法
公开(公告)号：US06271320B1
公开(公告)日：2001-08-07
申请号：US09308231
申请日：1999-05-20
申请人： Andreas Keller , Sven Lawrenz , Gerhard Bauer , Jürgen Schmidt-Thümmes , Reinhard Bächer , Jürgen Hartmann , Chung-Ji Tschang
发明人： Andreas Keller , Sven Lawrenz , Gerhard Bauer , Jürgen Schmidt-Thümmes , Reinhard Bächer , Jürgen Hartmann , Chung-Ji Tschang
IPC分类号： C08F208
CPC分类号： C08F2/22
摘要： A polymer dispersion is prepared by free radical polymerization of an aqueous monomer emulsion by a process in which the monomer emulsion is prepared continuously at the rate of consumption.
摘要翻译：通过单体乳液以消耗速率连续制备的方法通过水性单体乳液的自由基聚合来制备聚合物分散体。

50. 发明授权

US4206999A Method and apparatus for ascertaining the magnitude and direction of the flow speed in a flowing medium 失效
标题翻译：用于确定流动介质中的流速的大小和方向的方法和装置
公开(公告)号：US4206999A
公开(公告)日：1980-06-10
申请号：US886350
申请日：1978-03-14
申请人： Andreas Keller
发明人： Andreas Keller
IPC分类号： G01P5/26 , G01P3/36
CPC分类号： G01P5/26
摘要： The invention relates to a method for determining the magnitude and direction of the flow speed in a flowing medium comprising the following steps:(a) Irradiating the flowing medium in a first direction with a laser beam of a defined cross-section having a maximum principal dimension;(b) Observing a defined position (measured volume) in the longitudinal extent of the laser beam in a second direction at a defined angle to the first direction;(c) Measuring the pulse duration of diffuse light pulses given off in the second direction by particles of a defined size contained in the flowing medium and passing through the measured volume; and(d) Turning the laser beam cross-section about the rotary axis defined by the first direction until diffuse light pulses of maximum pulse duration can be observed.By means of this method one obtains in a single measuring operation an indication of the magnitude and direction of flow in the plane formed by the laser beam and the flow direction.
摘要翻译：本发明涉及一种用于确定流动介质中的流速的大小和方向的方法，包括以下步骤：（a）用具有最大主体的限定横截面的激光束沿第一方向辐射流动介质尺寸; （b）以与第一方向限定的角度在第二方向观察激光束的纵向范围内的限定位置（测量体积）; （c）通过包含在流动介质中并通过测量体积的具有规定尺寸的颗粒在第二方向上测出漫射光脉冲的脉冲持续时间; 和（d）旋转围绕由第一方向限定的旋转轴的激光束横截面，直到观察到最大脉冲持续时间的漫射光脉冲。通过该方法，在单个测量操作中获得由激光束和流动方向形成的平面中的流动的大小和方向的指示。

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