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1. 发明授权

US09056812B2 Process for preparing 4-cyclohexyl-2-methyl-2-butanol 有权
标题翻译：制备4-环己基-2-甲基-2-丁醇的方法
公开(公告)号：US09056812B2
公开(公告)日：2015-06-16
申请号：US13616147
申请日：2012-09-14
申请人： Rudolf Schuch , Stefan Rüdenauer , Klaus Ebel , Ralf Pelzer , Andreas Keller
发明人： Rudolf Schuch , Stefan Rüdenauer , Klaus Ebel , Ralf Pelzer , Andreas Keller
IPC分类号： C07C31/133 , C07C29/44 , C07C29/19 , C07C29/80 , B01J23/46 , B01J23/56 , B01J35/10 , B01J37/18 , B01J21/08 , B01J33/00 , B01J35/00 , B01J35/02 , B01J35/08 , B01J37/02
CPC分类号： C07C29/44 , B01J21/08 , B01J23/462 , B01J23/56 , B01J33/00 , B01J35/0026 , B01J35/008 , B01J35/023 , B01J35/08 , B01J35/1019 , B01J35/1042 , B01J35/1061 , B01J35/108 , B01J37/0203 , B01J37/18 , C07C29/19 , C07C29/80 , C07C2601/14 , C11B9/0061 , C07C33/20 , C07C31/1355
摘要： A process for preparing 4-cyclohexyl-2-methyl-2-butanol, comprising: a) reaction of styrene with isopropanol at elevated temperature to obtain 2-methyl-4-phenyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 2-methyl-4-phenyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics, where the molar ratio of the styrene used in step a) to the isopropanol used in step a) is in the range from 1:below 5 to 1:0.5.
摘要翻译：一种制备4-环己基-2-甲基-2-丁醇的方法，包括：a）在升高的温度下使苯乙烯与异丙醇反应得到2-甲基-4-苯基-2-丁醇，和b）异构催化氢化2 - 甲基-4-苯基-2-丁醇，其适用于芳族化合物的环加氢，其中步骤a）中使用的苯乙烯的摩尔比与步骤a）中使用的异丙醇的摩尔比在1：低于5至 1：0.5。

2. 发明授权

US08608824B2 Integrated method for producing carbonyl iron powder and hydrocarbons 失效
标题翻译：生产羰基铁粉和碳氢化合物的综合方法
公开(公告)号：US08608824B2
公开(公告)日：2013-12-17
申请号：US13063321
申请日：2009-09-02
申请人： Jochen Steiner , Ekkehard Schwab , Andreas Keller , Otto Watzenberger , Ulrich Gräβle , Manfred Julius
发明人： Jochen Steiner , Ekkehard Schwab , Andreas Keller , Otto Watzenberger , Ulrich Gräβle , Manfred Julius
IPC分类号： B22F9/30 , C07C1/00
CPC分类号： B01J23/745 , B01J23/78 , B01J37/086 , C07C1/044 , C07C2523/745 , C10G2/332 , C10G2400/20 , C10J3/00 , C10J2300/0916 , C10J2300/093 , C10J2300/1659 , C10K1/00 , Y02P20/125 , Y02P20/145 , Y02P20/52 , C07C11/02
摘要： Integrated process, in which pure carbonyl iron powder (CIP) is prepared by decomposition of pure iron pentacarbonyl (IPC) in a plant A, carbon monoxide (CO) liberated in the decomposition of the IPC is used in plant A for the preparation of further CIP from iron or is fed to an associated plant B for the preparation of synthesis gas or is fed to an associated plant C for the preparation of hydrocarbons from synthesis gas, and the CIP prepared in plant A is used as catalyst or catalyst component in an associated plant C for the preparation of hydrocarbons from synthesis gas from plant B.
摘要翻译：通过在植物A中分解纯铁五羰基（IPC）制备纯羰基铁粉（CIP）的综合方法，在植物A中使用在IPC分解中释放出的一氧化碳（CO）用于制备进一步的将CIP从铁中加入到相关联的工厂B中用于制备合成气，或者将其进料到合成工厂C用于从合成气制备烃，并将在工厂A中制备的CIP用作催化剂或催化剂组分联合植物C用于从植物B的合成气制备烃。

3. 发明申请

US20130157883A1 Complex miRNA Sets as Novel Biomarkers for an Acute Coronary Syndrome 有权
标题翻译：复杂miRNA作为急性冠脉综合征的新型生物标志物
公开(公告)号：US20130157883A1
公开(公告)日：2013-06-20
申请号：US13642321
申请日：2011-04-19
申请人： Andreas Keller , Peer F. Stähler , Markus Beier , Benjamin Meder , Hugo A. Katus , Wolfgang Rottbauer
发明人： Andreas Keller , Peer F. Stähler , Markus Beier , Benjamin Meder , Hugo A. Katus , Wolfgang Rottbauer
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of an acute coronary syndrome in a blood sample from a human. Further, the present invention relates to means for diagnosing and/or prognosing of an acute coronary syndrome comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of an acute coronary syndrome based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome compared to a reference. In addition, the present invention relates to a kit for diagnosing and/or prognosing of an acute coronary syndrome comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome and at least one reference.
摘要翻译：本发明涉及用于检测来自人的血液样品中用于诊断和/或预测急性冠状动脉综合征的单miRNA或多组miRNA的多核苷酸或多组核苷酸。此外，本发明涉及用于诊断和/或预测包含所述多核苷酸或多组核苷酸的急性冠状动脉综合征的方法。此外，本发明涉及一种用于诊断和/或预测急性冠状动脉综合征的方法，所述方法基于与参考文献相比较来确定代表急性冠状动脉综合征的单个miRNA或miRNA集合的表达谱。此外，本发明涉及一种用于诊断和/或预后的急性冠状动脉综合征的试剂盒，其包括用于确定代表急性冠状动脉综合征的单个miRNA或miRNA集合的表达谱的方法和至少一个参考文献。

4. 发明授权

US08461363B2 Deodorization and stabilization of marine oils 有权
标题翻译：海洋油的除臭和稳定
公开(公告)号：US08461363B2
公开(公告)日：2013-06-11
申请号：US12598968
申请日：2008-05-09
申请人： Andreas Keller , Ingo Koschinski , Albert Lustenberger , Neil MacFarlane , Thomas Meierhans
发明人： Andreas Keller , Ingo Koschinski , Albert Lustenberger , Neil MacFarlane , Thomas Meierhans
IPC分类号： C11B3/00
CPC分类号： C11B5/0092 , A23L5/21 , C11B3/14 , C11B5/0035 , C11B5/0085
摘要： The invention relates to a process for the preparation of deodorized and stabilized food-grade marine oils by submitting marine oils to a counter-current steam distillation (CCSD) in a thin film column containing a structured packing and, if desired, adding antioxidant(s), to the food-grade marine oils thus obtained and to their uses in the food/feed, cosmetic and/or pharmaceutical industry.
摘要翻译：本发明涉及一种通过在含有规整填料的薄膜塔中将海洋油提供给逆流蒸汽蒸馏（CCSD），并且如果需要，加入抗氧化剂（s）的方法来制备除臭和稳定的食品级海洋油），由此获得的食品级海洋油以及其在食品/饲料，化妆品和/或制药工业中的用途。

5. 发明申请

US20120108462A1 MIRNA FINGERPRINT IN THE DIAGNOSIS OF LUNG CANCER 有权
标题翻译： MIRNA指纹在肺癌诊断中的应用
公开(公告)号：US20120108462A1
公开(公告)日：2012-05-03
申请号：US13376281
申请日：2010-06-07
申请人： Andreas Keller , Eckart Meese , Anne Borries , Markus Beier
发明人： Andreas Keller , Eckart Meese , Anne Borries , Markus Beier
IPC分类号： C40B30/04 , C40B40/06 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G06F19/20 , G06F19/24 , C12Q2525/207
摘要： The present invention provides novel methods for diagnosing diseases based on the determination of specific miRNAs that have altered expression levels in disease states compared to healthy controls.
摘要翻译：本发明提供了用于基于与健康对照相比在疾病状态中改变表达水平的特异性miRNA的确定来诊断疾病的新方法。

6. 发明申请

US20110196170A1 METHOD FOR PRODUCING ASTAXANTHIN DIMETHYLDISUCCINATE 有权
标题翻译：生产酪氨酸二甲酯的方法
公开(公告)号：US20110196170A1
公开(公告)日：2011-08-11
申请号：US13021173
申请日：2011-02-04
申请人： HANSGEORG ERNST , Walter Dobler , Andreas Keller , Klaus Henrich
发明人： HANSGEORG ERNST , Walter Dobler , Andreas Keller , Klaus Henrich
IPC分类号： C07C67/14
CPC分类号： C07C403/24 , C07C2601/16
摘要： The present invention relates to an improved method for producing all-E astaxanthin dimethyldisuccinate of the formula I.
摘要翻译：本发明涉及一种制备式I的全-E虾青素二甲基丁二酸酯的改进方法。

7. 发明授权

US09822416B2 miRNA in the diagnosis of ovarian cancer 有权
公开(公告)号：US09822416B2
公开(公告)日：2017-11-21
申请号：US13577335
申请日：2011-02-07
申请人： Andreas Keller , Matthias Scheffler , Markus Beier
发明人： Andreas Keller , Matthias Scheffler , Markus Beier
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/178
摘要： The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.

8. 发明授权

US09194002B2 miRNA fingerprint in the diagnosis of diseases 有权
标题翻译： miRNA指纹在诊断疾病
公开(公告)号：US09194002B2
公开(公告)日：2015-11-24
申请号：US13376225
申请日：2010-06-07
申请人： Andreas Keller , Eckart Meese , Anne Borries , Peer Friedrich Staehler , Markus Beier
发明人： Andreas Keller , Eckart Meese , Anne Borries , Peer Friedrich Staehler , Markus Beier
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G06F19/20 , G06F19/24 , C12Q2525/207
摘要： The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.
摘要翻译：本发明提供了基于在不同条件下具有改变的表达水平的特异性miRNA的测定来诊断健康状况的新方法，例如，疾病状态与健康对照相比。

9. 发明申请

US20140213476A1 COMPLEX SETS OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR COLON CANCER 有权
标题翻译：复杂的MIRNAS集合作为结肠癌的非侵入性生物标志物
公开(公告)号：US20140213476A1
公开(公告)日：2014-07-31
申请号：US14239264
申请日：2012-08-03
申请人： Andreas Keller , Markus Beier , Eckart Meese , Petra Leidinger , Anke Wendschlag
发明人： Andreas Keller , Markus Beier , Eckart Meese , Petra Leidinger , Anke Wendschlag
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject.
摘要翻译：本发明涉及用于诊断和/或预测来自受试者的体液样品中的结肠癌的非侵入性方法，试剂盒和方法。此外，本发明涉及用于检测来自受试者的体液样品中用于诊断和/或预后结肠癌的miRNA组的多核苷酸或引物对组。此外，本发明涉及用于诊断和/或预测来自受试者的体液样品中的结肠癌的一组miRNA。

10. 发明申请

US20130331278A1 COMPLEX SET OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR PROSTATE DISEASES 审中-公开
标题翻译：复杂的MIRNAS作为非侵入性生物标志物用于前列腺疾病
公开(公告)号：US20130331278A1
公开(公告)日：2013-12-12
申请号：US13995951
申请日：2011-12-28
申请人： Andreas Keller , Markus Beier , Valesca Boisguerin , Eckart Meese , Petra Leidinger
发明人： Andreas Keller , Markus Beier , Valesca Boisguerin , Eckart Meese , Petra Leidinger
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject.
摘要翻译：本发明涉及用于诊断和/或预测来自受试者的体液样品中的前列腺疾病的非侵入性方法，试剂盒和方法。此外，本发明涉及用于检测来自受试者的体液样品中用于诊断和/或预测前列腺疾病的miRNA组的多核苷酸或引物对组。此外，本发明涉及用于诊断和/或预测来自受试者体液样品中前列腺疾病的miRNA组。

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