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1. 发明授权

US08877718B2 Antiinfective and antitumoral compounds isolated from tropical lianas 有权
标题翻译：从热带藤本植物中分离的抗感染和抗肿瘤化合物
公开(公告)号：US08877718B2
公开(公告)日：2014-11-04
申请号：US12865333
申请日：2009-02-06
申请人： Gerhard Bringmann , Stefan Rüdenauer , Reto Brun , Andreas Irmer , Ralf Bargou , Manik Chatterjee , Anastasia Voskobojnik
发明人： Gerhard Bringmann , Stefan Rüdenauer , Reto Brun , Andreas Irmer , Ralf Bargou , Manik Chatterjee , Anastasia Voskobojnik
IPC分类号： C07C46/00 , C07C50/32 , C07C49/513 , C07C49/517 , C07D317/70 , C07H15/20 , A61K31/122 , A61K31/704 , A61P35/00 , A61P31/00
CPC分类号： C07C50/32 , C07C46/00 , C07D317/70 , C07H15/20
摘要： The present invention relates to naphthoquinone derivatives isolated from solid callus cultures from two species of the palaeotropical plant families Dioncophyllaceae and Ancistrocladaceae. It further relates to methods of their production as well as to their use as antiinfective and antitumoral pharmaceuticals.
摘要翻译：本发明涉及从两种热带植物家D ae和An科分离自固体愈伤组织培养物的萘醌衍生物。它还涉及其生产方法以及它们作为抗感染药和抗肿瘤药物的用途。

2. 发明申请

US20130072726A1 PROCESS FOR PREPARING 4-CYCLOHEXYL-2-METHYL-2-BUTANOL 有权
公开(公告)号：US20130072726A1
公开(公告)日：2013-03-21
申请号：US13616147
申请日：2012-09-14
申请人： Rudolf Schuch , Stefan Rüdenauer , Klaus Ebel , Ralf Pelzer , Andreas Keller
发明人： Rudolf Schuch , Stefan Rüdenauer , Klaus Ebel , Ralf Pelzer , Andreas Keller
IPC分类号： C07C29/44
CPC分类号： C07C29/44 , B01J21/08 , B01J23/462 , B01J23/56 , B01J33/00 , B01J35/0026 , B01J35/008 , B01J35/023 , B01J35/08 , B01J35/1019 , B01J35/1042 , B01J35/1061 , B01J35/108 , B01J37/0203 , B01J37/18 , C07C29/19 , C07C29/80 , C07C2601/14 , C11B9/0061 , C07C33/20 , C07C31/1355
摘要： A process for preparing 4-cyclohexyl-2-methyl-2-butanol, comprising: a) reaction of styrene with isopropanol at elevated temperature to obtain 2-methyl-4-phenyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 2-methyl-4-phenyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics, where the molar ratio of the styrene used in step a) to the isopropanol used in step a) is in the range from 1:below 5 to 1:0.5.

3. 发明申请

US20130245132A1 PROCESS FOR PREPARING 4-CYCLOHEXYL-2-METHYL-2-BUTANOL 审中-公开
标题翻译：制备4-环丙基-2-甲基-2-丁醇的方法
公开(公告)号：US20130245132A1
公开(公告)日：2013-09-19
申请号：US13873343
申请日：2013-04-30
申请人： Klaus Ebel , Stefan Rüdenauer , Ralf Pelzer , Martin Bock
发明人： Klaus Ebel , Stefan Rüdenauer , Ralf Pelzer , Martin Bock
IPC分类号： C11B9/00
CPC分类号： C07C31/1355 , A61K8/34 , A61K2800/10 , A61Q13/00 , A61Q19/00 , C07C29/19 , C07C29/20 , C07C29/44 , C07C29/80 , C07C33/20 , C07C2601/14 , C11B9/0034 , C11B9/0061 , C11D3/2017 , C11D3/50
摘要： Process for preparing 4-cyclohexyl-2-methyl-2-butanol The present invention relates to a process for preparing 4-cyclohexyl-2-methyl-2-butanol. The process comprises the following steps: a) reaction of styrene with isopropanol at elevated temperature to obtain 4-phenyl-2-methyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 4-phenyl-2-methyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics.
摘要翻译：制备4-环己基-2-甲基-2-丁醇的方法本发明涉及一种制备4-环己基-2-甲基-2-丁醇的方法。该方法包括以下步骤：a）在高温下使苯乙烯与异丙醇反应，得到4-苯基-2-甲基-2-丁醇，b）4-苯基-2-甲基-2-丁醇的非均相催化氢化适用于芳族化合物环加氢的催化剂。

4. 发明申请

US20110059911A1 Antiinfective and Antitumoral Compounds Isolated From Tropical Lianas 有权
标题翻译：从热带莲花分离的抗感染和抗肿瘤化合物
公开(公告)号：US20110059911A1
公开(公告)日：2011-03-10
申请号：US12865333
申请日：2009-02-06
申请人： Gerhard Bringmann , Stefan Rüdenauer , Reto Brun , Andreas Irmer , Ralf Bargou , Manik Chatterjee , Anastasia Voskobojnik
发明人： Gerhard Bringmann , Stefan Rüdenauer , Reto Brun , Andreas Irmer , Ralf Bargou , Manik Chatterjee , Anastasia Voskobojnik
IPC分类号： A61K31/704 , C07H15/20 , C07C49/513 , A61K31/122 , C07C49/517 , C07D317/70 , A61K31/357 , A61P35/00 , A61P31/00
CPC分类号： C07C50/32 , C07C46/00 , C07D317/70 , C07H15/20
摘要： The present invention relates to naphthoquinone derivatives isolated from solid callus cultures from two species of the palaeotropical plant families Dioncophyllaceae and Ancistrocladaceae. It further relates to methods of their production as well as to their use as antiinfective and antitumoral pharmaceuticals.
摘要翻译：本发明涉及从两种热带植物家D ae和An科分离自固体愈伤组织培养物的萘醌衍生物。它还涉及其生产方法以及它们作为抗感染药和抗肿瘤药物的用途。

5. 发明申请

US20180208532A1 PROCESS FOR PREPARING AN ARYLPROPENE 审中-公开
公开(公告)号：US20180208532A1
公开(公告)日：2018-07-26
申请号：US15744324
申请日：2016-07-15
申请人： Andrei-Nicolae PARVULESCU , Ulrich MÜLLER , Thomas FENLON , Sumana CHATURVEDULA , Stefan RÜDENAUER , Andreas LANVER , Ralf PELZER , Klaus EBEL
发明人： Andrei-Nicolae PARVULESCU , Ulrich MÜLLER , Thomas FENLON , Sumana CHATURVEDULA , Stefan RÜDENAUER , Andreas LANVER , Ralf PELZER , Klaus EBEL
IPC分类号： C07C41/18 , B01J29/86 , B01J29/70
CPC分类号： C07C41/18 , B01J29/7007 , B01J29/7038 , B01J29/86 , C07C43/215
摘要： A process for preparing an arylpropene from a diarylpropane by gas phase thermolysis in the presence of boron containing zeolitic material comprising a membered ring (MR) pore system greater than 10 MR.

6. 发明授权

US09056812B2 Process for preparing 4-cyclohexyl-2-methyl-2-butanol 有权
标题翻译：制备4-环己基-2-甲基-2-丁醇的方法
公开(公告)号：US09056812B2
公开(公告)日：2015-06-16
申请号：US13616147
申请日：2012-09-14
申请人： Rudolf Schuch , Stefan Rüdenauer , Klaus Ebel , Ralf Pelzer , Andreas Keller
发明人： Rudolf Schuch , Stefan Rüdenauer , Klaus Ebel , Ralf Pelzer , Andreas Keller
IPC分类号： C07C31/133 , C07C29/44 , C07C29/19 , C07C29/80 , B01J23/46 , B01J23/56 , B01J35/10 , B01J37/18 , B01J21/08 , B01J33/00 , B01J35/00 , B01J35/02 , B01J35/08 , B01J37/02
CPC分类号： C07C29/44 , B01J21/08 , B01J23/462 , B01J23/56 , B01J33/00 , B01J35/0026 , B01J35/008 , B01J35/023 , B01J35/08 , B01J35/1019 , B01J35/1042 , B01J35/1061 , B01J35/108 , B01J37/0203 , B01J37/18 , C07C29/19 , C07C29/80 , C07C2601/14 , C11B9/0061 , C07C33/20 , C07C31/1355
摘要： A process for preparing 4-cyclohexyl-2-methyl-2-butanol, comprising: a) reaction of styrene with isopropanol at elevated temperature to obtain 2-methyl-4-phenyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 2-methyl-4-phenyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics, where the molar ratio of the styrene used in step a) to the isopropanol used in step a) is in the range from 1:below 5 to 1:0.5.
摘要翻译：一种制备4-环己基-2-甲基-2-丁醇的方法，包括：a）在升高的温度下使苯乙烯与异丙醇反应得到2-甲基-4-苯基-2-丁醇，和b）异构催化氢化2 - 甲基-4-苯基-2-丁醇，其适用于芳族化合物的环加氢，其中步骤a）中使用的苯乙烯的摩尔比与步骤a）中使用的异丙醇的摩尔比在1：低于5至 1：0.5。

7. 发明授权

US08609903B2 Process for preparing hydroxy-substituted aromatic aldehydes 有权
标题翻译：制备羟基取代的芳族醛的方法
公开(公告)号：US08609903B2
公开(公告)日：2013-12-17
申请号：US13078195
申请日：2011-04-01
申请人： Ebel Klaus , Stefan Rüdenauer
发明人： Ebel Klaus , Stefan Rüdenauer
IPC分类号： C07C45/90
CPC分类号： C07C45/65 , C07C47/575
摘要： The present invention therefore relates to a process for preparing an aldehyde of the formula (I) where one, two or all three radicals from the group of R1, R3 and R5 are hydroxyl, and that radical or those radicals from the group of R1, R3 and R5 which are not hydroxyl are each independently hydrogen, C1-C8-alkyl or C6-C14-aryl, and R2 and R4 are each independently hydrogen, C1-C8-alkyl, C1-C8-alkoxy or C6-C14-aryl, which comprises converting an aldehyde of the formula (II) in which one, two or all three radicals from the group of R′1, R′3 and R′5 are C1-C8-alkoxy, and that radical or those radicals from the group of R′1, R′3 and R′5 which are not C1-C8-alkoxy are each independently hydrogen, C1-C8-alkyl or C6-C14-aryl, and R2 and R4 are each as defined for formula (I), at elevated temperature and elevated pressure in the presence of (C1-C4-alkyl)2-amine, and then isolating the reaction product of the formula (I).
摘要翻译：因此，本发明涉及一种制备式（I）的醛的方法，其中R 1，R 3和R 5基团中的一个，两个或全部三个基团是羟基，并且该基团或那些来自R1，不是羟基的R 3和R 5各自独立地为氢，C 1 -C 8 - 烷基或C 6 -C 14 - 芳基，R 2和R 4各自独立地为氢，C 1 -C 8 - 烷基，C 1 -C 8 - 烷氧基或C 6 -C 14 - 芳基其包括将式（II）的醛转化为其中R 1，R'3和R'5基团中的一个，两个或全部三个基团是C 1 -C 8 - 烷氧基，并且该基团或那些基团不是C1-C8-烷氧基的R'1，R'3和R'5各自独立地为氢，C1-C8-烷基或C6-C14 - 芳基，R2和R4各自如式 I）在升高的温度和升高的压力下，在（C 1 -C 4 - 烷基）-2-胺的存在下，然后分离式（I）的反应产物。

8. 发明授权

US08450534B2 Process for preparing 4-cyclohexyl-2-methyl-2-butanol 有权
公开(公告)号：US08450534B2
公开(公告)日：2013-05-28
申请号：US13071002
申请日：2011-03-24
申请人： Klaus Ebel , Stefan Rüdenauer , Ralf Pelzer , Martin Bock
发明人： Klaus Ebel , Stefan Rüdenauer , Ralf Pelzer , Martin Bock
IPC分类号： C07C29/32
CPC分类号： C07C31/1355 , A61K8/34 , A61K2800/10 , A61Q13/00 , A61Q19/00 , C07C29/19 , C07C29/20 , C07C29/44 , C07C29/80 , C07C33/20 , C07C2601/14 , C11B9/0034 , C11B9/0061 , C11D3/2017 , C11D3/50
摘要： The present invention relates to a process for preparing 4-cyclohexyl-2-methyl-2-butanol. The process comprises the following steps: a) reaction of styrene with isopropanol at elevated temperature to obtain 4-phenyl-2-methyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 4-phenyl-2-methyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics.

9. 发明申请

US20110245544A1 PROCESS FOR PREPARING HYDROXY-SUBSTITUTED AROMATIC ALDEHYDES 有权
标题翻译：制备羟基取代的芳族醛的方法
公开(公告)号：US20110245544A1
公开(公告)日：2011-10-06
申请号：US13078195
申请日：2011-04-01
申请人： Klaus Ebel , Stefan Rüdenauer
发明人： Klaus Ebel , Stefan Rüdenauer
IPC分类号： C07C45/61
CPC分类号： C07C45/65 , C07C47/575
摘要： The present invention therefore relates to a process for preparing an aldehyde of the formula (I) where one, two or all three radicals from the group of R1, R3 and R5 are hydroxyl, and that radical or those radicals from the group of R1, R3 and R5 which are not hydroxyl are each independently hydrogen, C1-C8-alkyl or C6-C14-aryl, and R2 and R4 are each independently hydrogen, C1-C8-alkyl, C1-C8-alkoxy or C6-C14-aryl, which comprises converting an aldehyde of the formula (II) in which one, two or all three radicals from the group of R′1, R′3 and R′5 are C1-C8-alkoxy, and that radical or those radicals from the group of R′1, R′3 and R′5 which are not C1-C8-alkoxy are each independently hydrogen, C1-C8-alkyl or C6-C14-aryl, and R2 and R4 are each as defined for formula (I), at elevated temperature and elevated pressure in the presence of (C1-C4-alkyl)2-amine, and then isolating the reaction product of the formula (I).
摘要翻译：因此，本发明涉及一种制备式（I）的醛的方法，其中R 1，R 3和R 5基团中的一个，两个或全部三个基团是羟基，并且该基团或那些来自R1，不是羟基的R 3和R 5各自独立地为氢，C 1 -C 8 - 烷基或C 6 -C 14 - 芳基，R 2和R 4各自独立地为氢，C 1 -C 8 - 烷基，C 1 -C 8 - 烷氧基或C 6 -C 14 - 芳基其包括将式（II）的醛转化为其中R 1，R'3和R'5基团中的一个，两个或全部三个基团是C 1 -C 8 - 烷氧基，并且该基团或那些基团不是C1-C8-烷氧基的R'1，R'3和R'5各自独立地为氢，C1-C8-烷基或C6-C14 - 芳基，R2和R4各自如式 I）在升高的温度和升高的压力下，在（C 1 -C 4 - 烷基）-2-胺的存在下，然后分离式（I）的反应产物。

10. 发明申请

US20110237684A1 Process for preparing 4-cyclohexyl-2-methyl-2-butanol 有权
标题翻译：制备4-环己基-2-甲基-2-丁醇的方法
公开(公告)号：US20110237684A1
公开(公告)日：2011-09-29
申请号：US13071002
申请日：2011-03-24
申请人： Klaus Ebel , Stefan Rüdenauer , Ralf Pelzer , Martin Bock
发明人： Klaus Ebel , Stefan Rüdenauer , Ralf Pelzer , Martin Bock
IPC分类号： A61K8/34 , A61Q13/00 , C07C29/32 , C07C31/135 , C07C33/20 , C11D3/50
CPC分类号： C07C31/1355 , A61K8/34 , A61K2800/10 , A61Q13/00 , A61Q19/00 , C07C29/19 , C07C29/20 , C07C29/44 , C07C29/80 , C07C33/20 , C07C2601/14 , C11B9/0034 , C11B9/0061 , C11D3/2017 , C11D3/50
摘要： The present invention relates to a process for preparing 4-cyclohexyl-2-methyl-2-butanol. The process comprises the following steps: a) reaction of styrene with isopropanol at elevated temperature to obtain 4-phenyl-2-methyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 4-phenyl-2-methyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics.
摘要翻译：本发明涉及一种制备4-环己基-2-甲基-2-丁醇的方法。该方法包括以下步骤：a）在高温下使苯乙烯与异丙醇反应，得到4-苯基-2-甲基-2-丁醇，b）4-苯基-2-甲基-2-丁醇的非均相催化氢化适用于芳族化合物环加氢的催化剂。

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