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41. 发明申请

US20090069280A1 ANALOGS OF BENZOQUINONE-CONTAINING ANSAMYCINS AND METHODS OF USE THEREOF 有权
标题翻译：含有苯并醌的阿霉素类似物及其使用方法
公开(公告)号：US20090069280A1
公开(公告)日：2009-03-12
申请号：US12199356
申请日：2008-08-27
申请人： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
发明人： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
IPC分类号： A61K31/395 , A61P35/04
CPC分类号： A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
摘要： The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
摘要翻译：本发明提供了含苯醌的安莎霉素类似物及其用于治疗和调节与过度增生相关的疾病如癌症的用途。本发明提供了含有苯醌的安莎霉素的类似物，其中苯醌被还原成氢醌并通过与合适的酸反应而被捕获，优选是增加所得17-氢醌醌霉素类似物的溶解度和空气稳定性的那些。

42. 发明申请

US20060019939A1 Analogs of benzoquinone-containing ansamycins and methods of use thereof 失效
公开(公告)号：US20060019939A1
公开(公告)日：2006-01-26
申请号：US11105203
申请日：2005-04-13
申请人： Julian Adams , Yun Gao , Asimina Evangelinos , Louis Grenier , Roger Pak , James Porter , James Wright
发明人： Julian Adams , Yun Gao , Asimina Evangelinos , Louis Grenier , Roger Pak , James Porter , James Wright
IPC分类号： A61K31/538 , C07D487/02
CPC分类号： A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
摘要： The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

43. 发明申请

US20050288269A1 Analogs of benzoquinone-containing ansamycins and methods of use thereof 有权
公开(公告)号：US20050288269A1
公开(公告)日：2005-12-29
申请号：US11107404
申请日：2005-04-14
申请人： Julian Adams , Yun Gao , Asimina Georges Evangelinos , Louis Grenier , Roger Pak , James Porter , James Wright
发明人： Julian Adams , Yun Gao , Asimina Georges Evangelinos , Louis Grenier , Roger Pak , James Porter , James Wright
IPC分类号： C07D211/60 , C07D225/06 , C07D498/08 , C07F5/02 , C07F9/6561 , A61K31/33 , C07D225/04
CPC分类号： A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
摘要： The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

44. 发明授权

US06429311B2 Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof 失效
标题翻译：含有N-氨基和N-羟基 - 喹唑啉酮的组合物及其制备方法
公开(公告)号：US06429311B2
公开(公告)日：2002-08-06
申请号：US09775339
申请日：2001-02-01
申请人： Yun Gao
发明人： Yun Gao
IPC分类号： C07D23992
CPC分类号： C07D239/92
摘要： The present invention is directed to certain N-amino- and N-hydroxy-quinazolinone compounds and synthetic methods for synthesis thereof, which compounds may find use in combinatorial libraries. More specifically, the invention is directed to the synthesis of 3-hydroxy- and 3-amino-4 (1H)-quinazolinones via the reaction of an appropriate 2-aminobenzamide compound with a carboxylic acid or acyl halide at ambient temperature performed on a solid support or in solution.
摘要翻译：本发明涉及某些N-氨基 - 和N-羟基 - 喹唑啉酮化合物及其合成方法，该化合物可用于组合文库。更具体地，本发明涉及通过适当的2-氨基苯甲酰胺化合物与羧酸或酰基卤在环境温度下对固体进行的反应合成3-羟基 - 和3-氨基-4（1H） - 喹唑啉酮支持或解决方案。

45. 发明授权

US5760251A Taxol process and compounds 失效
标题翻译：紫杉醇工艺和化合物
公开(公告)号：US5760251A
公开(公告)日：1998-06-02
申请号：US589142
申请日：1996-01-19
申请人： Yun Gao , Charles M. Zepp
发明人： Yun Gao , Charles M. Zepp
IPC分类号： C07C271/22 , C07D305/14 , C07F7/18
CPC分类号： C07F7/1856 , C07C271/22 , C07D305/14
摘要： A process for the preparation of taxol and derivatives of taxol ##STR1## is disclosed. The process involves reacting a .beta.-alkoxycarbonylamino-phenylpropionic acid with a 13-hydroxy taxane to produce an ester of the taxane at C-13; and then deprotecting the .beta.-alkoxycarbonylamino-phenylpropionic ester to produce a .beta.-amido-.alpha.-hydroxybenzenepropanoic ester of the taxane. Intermediates useful in the process are also disclosed.
摘要翻译：披露了紫杉醇和紫杉醇衍生物“IMAGE”的制备方法。该方法包括使β-烷氧基羰基氨基 - 苯基丙酸与13-羟基紫杉烷反应以在C-13处产生紫杉烷的酯; 然后脱保护β-烷氧基羰基氨基 - 苯基丙酸酯以产生紫杉烷的β-氨基-α-羟基苯丙酸酯。还公开了在该方法中有用的中间体。

46. 发明授权

US5258517A Method of preparing optically pure precursors of paroxetine 失效
标题翻译：制备帕罗西汀光学纯的前体的方法
公开(公告)号：US5258517A
公开(公告)日：1993-11-02
申请号：US926254
申请日：1992-08-06
申请人： Charles M. Zepp , Yun Gao , Donald L. Heefner
发明人： Charles M. Zepp , Yun Gao , Donald L. Heefner
IPC分类号： C07D211/22 , C07D211/88 , C12P41/00
CPC分类号： C07D211/88 , C07D211/22 , C12P41/005
摘要： A biocatalytic method of preparing optically pure precursors of paroxetine and a method of preparing paroxetine therefrom are disclosed. A racemic trans ester precursor compound of paroxetine is first prepared. The racemic trans ester precursor compound comprises a mixture of (3S,4R) and (3R,4S) enantiomers. The (3R,4S) enantiomer is hydrolyzed biocatalytically to the corresponding (3R,4S)-trans carboxylic acid or alternatively, the (3S,4R) enantiomer is biocatalytically hydrolyzed the to (3S,4R)-trans carboxylic acid in a reaction catalyzed by a isolated enzyme or a microorganism. In the first instance, the unhydrolyzed (3S,4R) enantiomer is separated from the (3R,4S)-trans carboxylic acid, whereas in the second instance the (3S,4R)-trans carboxylic acid is separated from the unhydrolyzed (3R,4S) enantiomer. The (3S,4R) enantiomer obtained following the selective hydrolysis is reduced to form a (-)-trans-(3S,4R) primary alcohol precursor of paroxetine. Paroxetine is then formed from the (-)-trans-(3S,4R) primary alcohol precursor.
摘要翻译：公开了制备帕罗西汀光学纯的前体的生物催化方法及其制备帕罗西汀的方法。首先制备帕罗西汀的外消旋转酯前体化合物。外消旋反式酯前体化合物包含（3S，4R）和（3R，4S）对映异构体的混合物。将（3R，4S）对映异构体生物催化水解生成至相应的（3R，4S） - 羧酸，或者（3S，4R）对映异构体在反应催化下生物催化水解成（3S，4R） - 反式羧酸通过分离的酶或微生物。在第一种情况下，从（3R，4R） - 反式羧酸分离出未水解的（3S，4R）对映异构体，而在第二种情况下，将（3S，4R） - 反式羧酸与未水解的（3R， 4S）对映异构体。在选择性水解后获得的（3S，4R）对映异构体被还原形成帕罗西汀的（ - ） - 反 - （3S，4R）伯醇前体。然后由（ - ） - 反 - （3S，4R）伯醇前体形成帕罗西汀。

47. 发明授权

US5112990A Ruthenium-catalyzed production of cyclic sulfates 失效
标题翻译：硫酸锌的催化生产
公开(公告)号：US5112990A
公开(公告)日：1992-05-12
申请号：US369189
申请日：1989-06-21
申请人： K. Barry Sharpless , Yun Gao
发明人： K. Barry Sharpless , Yun Gao
IPC分类号： B01J27/13 , C07B41/02 , C07B61/00 , C07C67/30 , C07C69/675 , C07C69/732 , C07C69/78 , C07C213/02 , C07C215/20 , C07C227/32 , C07C229/24 , C07C247/12 , C07C331/14 , C07D203/08 , C07D317/28 , C07D327/10 , C07D411/14
CPC分类号： C07D203/08 , C07C213/02 , C07C215/20 , C07C227/32 , C07C247/12 , C07C331/14 , C07D317/28 , C07D327/10 , C07D411/14 , C07C2101/14
摘要： A ruthenium catalyzed method to synthesize cyclic sulfate compounds from the corresponding cyclic sulfites, and the cyclic sulfate reaction products obtained by this method. These cyclic sulfates further react with selected nucleophiles to give various substituted products. The method is an efficient means for the synthesis of chiral building blocks from tartaric acid enantiomers in high yields using an overall two-stage, one-pot reaction procedure. The chiral compounds can be transformed by nucleophilic reactions into chiral building blocks useful for the synthesis of natural biologically active products, such as antibiotics and pheromones.

48. 发明申请

US20140033278A1 SYSTEM AND METHOD OF SECURING SHARING OF RESOURCES WHICH REQUIRE CONSENT OF MULTIPLE RESOURCE OWNERS USING GROUP URI'S 有权
标题翻译：使用GROUP URI的多个资源所有者同意的资源共享的系统和方法
公开(公告)号：US20140033278A1
公开(公告)日：2014-01-30
申请号：US13557474
申请日：2012-07-25
申请人： KIRANKUMAR NIMASHAKAVI , XU PENG WANG , YUN GAO , MIN FENG XU
发明人： KIRANKUMAR NIMASHAKAVI , XU PENG WANG , YUN GAO , MIN FENG XU
IPC分类号： G06F21/00
CPC分类号： H04L63/08 , G06F21/335 , G06F21/40 , G06F21/6218 , H04L63/10
摘要： In accordance with various embodiments, services gatekeeper systems and methods allow mapping and protecting communication services APIs with OAuth and group access to user information. Such a system can include a plurality of applications, executing on one or more application servers. The services gatekeeper is operable to define a group of members using a group URI, intercept requests for access to communication services APIs, obtain authorization from a group owner for access to a specified communication services API for each member of the group, and enable access to the specified communication services API of each member of the group in accordance with the scope authorized by the group owner.
摘要翻译：根据各种实施例，服务网守系统和方法允许使用OAuth映射和保护通信服务API并且对用户信息进行组访问。这样的系统可以包括在一个或多个应用服务器上执行的多个应用。业务关守可操作地使用组URI来定义一组成员，拦截对通信服务API的访问请求，从组所有者获取对该组的每个成员访问指定的通信服务API的授权，并且允许访问根据组所有者授权的范围，组中每个成员的指定通信服务API。

49. 发明申请

US20130068269A1 Folding Canopy 审中-公开
标题翻译：折叠天篷
公开(公告)号：US20130068269A1
公开(公告)日：2013-03-21
申请号：US13237127
申请日：2011-09-20
申请人： Jian Yun Gao
发明人： Jian Yun Gao
IPC分类号： E04H15/50
CPC分类号： E04H15/50 , E04H15/58
摘要： A folding canopy has a canopy top made of flexible sheet material; and a canopy frame. The canopy top is adapted to attach onto the canopy frame, and the canopy frame includes a number of members. A pair of left cross support bars have a first left cross support bar, and a second left cross support bar. The first left cross support bar is pivotally connected to the second left cross support bar. A pair of right cross support bars includes a first right cross support bar, and a second right cross support bar. The first right cross support bar is pivotally connected to the second right cross support bar.
摘要翻译：折叠篷具有由柔性片材制成的顶盖; 和一个遮篷架。顶篷适用于遮盖架，遮篷架包括多个构件。一对左交叉支撑杆具有第一左交叉支撑杆和第二左交叉支撑杆。第一左交叉支撑杆枢转地连接到第二左交叉支撑杆。一对右交叉支撑杆包括第一右交叉支撑杆和第二右交叉支撑杆。第一右交叉支撑杆枢转地连接到第二右交叉支撑杆。

50. 发明申请

US20130028857A1 SYNTHETIC NANOCARRIERS COMPRISING POLYMERS COMPRISING MULTIPLE IMMUNOMODULATORY AGENTS 审中-公开
标题翻译：包含多重免疫调节剂的聚合物合成纳米颗粒
公开(公告)号：US20130028857A1
公开(公告)日：2013-01-31
申请号：US13560943
申请日：2012-07-27
申请人： Yun Gao , David H. Altreuter
发明人： Yun Gao , David H. Altreuter
IPC分类号： C08G63/91 , A61P37/02 , B32B5/16 , A61K39/00 , A61P37/04 , B82Y5/00 , B82B1/00
CPC分类号： A61K39/385 , A61K39/39 , A61K47/59 , A61K47/593 , A61K47/645 , A61K2039/55555 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y10T428/2982
摘要： This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise polymers that comprise at least two immunomodulatory agent moieties.
摘要翻译：本发明涉及包含至少两种免疫调节剂部分的聚合物的合成纳米载体的组合物和相关方法。

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