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1. 发明授权

US08629151B2 Immunomodulatory agent-polymeric compounds 有权
标题翻译：免疫调节剂 - 聚合物
公开(公告)号：US08629151B2
公开(公告)日：2014-01-14
申请号：US12788266
申请日：2010-05-26
申请人： Charles Zepp , Grayson B. Lipford , Yun Gao , Lloyd Johnston , Fen-ni Fu , Mark J. Keegan , Sam Baldwin
发明人： Charles Zepp , Grayson B. Lipford , Yun Gao , Lloyd Johnston , Fen-ni Fu , Mark J. Keegan , Sam Baldwin
IPC分类号： A01N43/90
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译：本发明涉及免疫调节剂和聚合物或其单元的缀合物的组合物及相关化合物和方法。缀合物可以包含在合成纳米载体内，并且免疫调节剂可以以pH敏感的方式从合成纳米载体中释放。

2. 发明授权

US08362070B2 Application of puerarin in the preparation of P2X3 mediated drugs for pain/nervous system diseases 失效
标题翻译：应用葛根素制备P2X3介导的药物用于疼痛/神经系统疾病
公开(公告)号：US08362070B2
公开(公告)日：2013-01-29
申请号：US12922245
申请日：2010-06-29
申请人： Shangdong Liang , Changshui Xu , Yun Gao , Guilin Li , Jiari Lin , Shuangmei Liu , Han Liu , Jun Zhang , Xin Li
发明人： Shangdong Liang , Changshui Xu , Yun Gao , Guilin Li , Jiari Lin , Shuangmei Liu , Han Liu , Jun Zhang , Xin Li
IPC分类号： A61K31/35 , A61K31/70
CPC分类号： A61K31/352
摘要： The invention relates to the new usage of puerarin in the field of pharmaceutical products, in other words, it relates to the application of puerarin in the preparation of drugs for P2X3 mediated pain/nervous system diseases. The experiment shows that puerarin can inhibit pain-related behavioral responses, subsequently immunohistochemical analysis, in situ hybridization, RT-PCR, protein blotting and other techniques were utilized to observe the inhibition of puerarin on mRNA and protein expression of P2X3 receptor in dorsal root ganglion of rats with neuropathic pain and in dorsal root ganglion and sensory nerve ending in the burn model of rats, it was found by using whole-cell patch clamp technique that puerarin can significantly reduce the electric current activated by P2X3 receptor agonist in the neuron of dorsal root ganglion of rats with neuropathic pain. The experiment proves that the mechanism for the inhibitory effects of puerarin on acute and chronic pain is to block the transmission of pain sense information that is mediated by P2X3 receptor in primary sensory neurons. The invention provides a kind of new method for the prevention and treatment on acute and chronic pain, and it also indicates that puerarin can act as a antagonist for P2X3 receptor, which will be helpful for the application of drugs in the prevention and treatment on P2X3 receptor involved nervous system diseases.
摘要翻译：本发明涉及葛根素在药物领域的新用途，换句话说，涉及葛根素在制备P2X3介导的疼痛/神经系统疾病药物中的应用。实验表明，葛根素可以抑制疼痛相关的行为反应，随后免疫组化分析，原位杂交，RT-PCR，蛋白质印迹等技术用于观察葛根素对背根神经节P2X3受体mRNA和蛋白表达的抑制作用的大鼠神经性疼痛和背根神经节和感觉神经结束于大鼠烧伤模型，通过使用全细胞膜片钳技术发现，葛根素可以显着降低P2X3受体激动剂在背侧神经元中活化的电流神经性疼痛大鼠根神经节。实验证明，葛根素对急性和慢性疼痛的抑制作用机制是阻断P2X3受体介导的疼痛感知信息在原发感觉神经元中的传播。本发明提供了一种预防和治疗急性和慢性疼痛的新方法，也表明葛根素可以作为P2X3受体的拮抗剂，有利于药物在P2X3的预防和治疗中的应用受体涉及神经系统疾病。

3. 发明申请

US20120058153A1 SYNTHETIC NANOCARRIER VACCINES COMPRISING PROTEINS OBTAINED OR DERIVED FROM HUMAN INFLUENZA A VIRUS HEMAGGLUTININ 审中-公开
标题翻译：包含从人类流感病毒获得或衍生的蛋白质的合成纳米抗体疫苗
公开(公告)号：US20120058153A1
公开(公告)日：2012-03-08
申请号：US13213529
申请日：2011-08-19
申请人： Petr Ilyinskii , Yun Gao , Grayson B. Lipford
发明人： Petr Ilyinskii , Yun Gao , Grayson B. Lipford
IPC分类号： A61K39/385 , A61K9/14 , A61P31/16 , A61P37/04 , C07K14/11 , C08G65/333 , B82Y40/00 , B82Y5/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/55511 , A61K2039/55555 , A61K2039/6093 , C12N2760/16134 , Y10T428/2982
摘要： This invention relates to compositions and methods that can be used immunize a subject against influenza. Generally, the compositions and methods include polypeptides obtained or derived from human influenza A virus hemagglutinin.
摘要翻译：本发明涉及可用于免疫受试者免受流感的组合物和方法。通常，组合物和方法包括获自或源自人流感病毒血凝素的多肽。

4. 发明申请

US20110256351A1 ANTI-COUNTERFEIT FILM WITH AN AMPHICHROIC PATTERN AND A PREPARATION METHOD THEREOF 有权
标题翻译：具有AMPHICHROIC图案的防伪膜及其制备方法
公开(公告)号：US20110256351A1
公开(公告)日：2011-10-20
申请号：US13125749
申请日：2009-06-09
申请人： Liangheng Xu , Lanxin Dong , Yun Gao , Zhixi Zhang
发明人： Liangheng Xu , Lanxin Dong , Yun Gao , Zhixi Zhang
IPC分类号： B32B3/30 , G03F7/20
CPC分类号： C09K19/0403 , C09K19/406 , C09K2019/0448 , C09K2219/03
摘要： An anti-counterfeit film comprising an amphichroic pattern is prepared by (1) mixing a polymerizable liquid crystal material of chiral structure and a photoinitiator, blade-coating the mixture on a base film and then drying; (2) partially exposing the resulting material produced in step (1) using a positioned UV lamp, then drying and exposing in an UV radiation to obtain a desired film. The film prepared by the method has an amphichroic pattern which typically presents a red and green picture when being vertically observed, the original red and green respectively changes into green and blue when being observed at a certain incline angel. The anti-counterfeit film is characterized by obvious color change, easy identification, practicability and convenience, thus facilitating promotion and application.
摘要翻译：通过（1）将手性结构的可聚合液晶材料和光引发剂混合，将该混合物刮涂在基膜上，然后干燥，制备包含两性图案的防伪膜。（2）使用定位的UV灯将步骤（1）中产生的所得材料部分曝光，然后在UV辐射下干燥和曝光以获得所需的膜。通过该方法制备的薄膜具有两性图案，其在垂直观察时通常呈现红色和绿色图像，当以某种倾斜角度观察时，原始红色和绿色分别变为绿色和蓝色。防伪膜的特点是颜色变化明显，易于识别，实用性和便利性，促进推广应用。

5. 发明申请

US20110086110A1 Analogs of Benzoquinone-Containing Ansamycins and Methods of Use Thereof 有权
标题翻译：含有苯并醌的Ansamycins的类似物及其使用方法
公开(公告)号：US20110086110A1
公开(公告)日：2011-04-14
申请号：US12899187
申请日：2010-10-06
申请人： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
发明人： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
IPC分类号： A61K33/24 , A61K31/395 , A61K31/69 , A61K31/538 , A61K31/423 , A61K33/04 , A61K31/305 , A61K31/685 , A61K31/496 , A61K31/7068 , A61K31/282 , A61K31/513 , A61P35/00
CPC分类号： A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
摘要： The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
摘要翻译：本发明提供了含苯醌的安莎霉素类似物及其用于治疗和调节与过度增生相关的疾病如癌症的用途。本发明提供了含有苯醌的安莎霉素的类似物，其中苯醌被还原成氢醌并通过与合适的酸反应而被捕获，优选是增加所得17-氢醌醌霉素类似物的溶解度和空气稳定性的那些。

6. 发明申请

US20110027217A1 IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS 有权
标题翻译：免疫组化试剂 - 聚合物
公开(公告)号：US20110027217A1
公开(公告)日：2011-02-03
申请号：US12788266
申请日：2010-05-26
申请人： CHARLES ZEPP , GRAYSON B. LIPFORD , YUN GAO , LLOYD JOHNSTON , FEN-NI FU FU , MARK J. KEEGAN , SAM BALDWIN
发明人： CHARLES ZEPP , GRAYSON B. LIPFORD , YUN GAO , LLOYD JOHNSTON , FEN-NI FU FU , MARK J. KEEGAN , SAM BALDWIN
IPC分类号： A61K47/48 , A61P37/02
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译：本发明涉及免疫调节剂和聚合物或其单元的缀合物的组合物及相关化合物和方法。缀合物可以包含在合成纳米载体内，并且免疫调节剂可以以pH敏感的方式从合成纳米载体中释放。

7. 发明申请

US20110020388A1 TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS 审中-公开
标题翻译：具有敏感性释放免疫调节剂的靶向合成纳米颗粒
公开(公告)号：US20110020388A1
公开(公告)日：2011-01-27
申请号：US12788260
申请日：2010-05-26
申请人： CHARLES ZEPP , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Lloyd Johnston , Grayson B. Lipford
发明人： CHARLES ZEPP , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Lloyd Johnston , Grayson B. Lipford
IPC分类号： A61K39/385 , C07D471/04 , C07D473/34 , C07H21/00 , A61P37/02
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译：本发明涉及靶细胞中诸如抗原呈递细胞（APC）的作用位点的合成纳米载体的组合物和相关方法，并且包含以pH敏感方式从合成纳米载体解离的免疫调节剂。还公开了与合成纳米载体相关的组合物和方法，其包封以pH敏感方式从合成纳米载体解离的不稳定免疫调节剂。

8. 发明授权

US07833997B2 Analogs of benzoquinone-containing ansamycins and methods of use thereof 有权
公开(公告)号：US07833997B2
公开(公告)日：2010-11-16
申请号：US12199578
申请日：2008-08-27
申请人： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
发明人： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
IPC分类号： C07D225/06 , C07D211/60 , C07D498/08 , A61K31/395 , A61P35/00
CPC分类号： A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
摘要： The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

9. 发明授权

US07282493B2 Analogs of benzoquinone-containing ansamycins and methods of use thereof 有权
标题翻译：含有苯醌的安莎霉素的类似物及其使用方法
公开(公告)号：US07282493B2
公开(公告)日：2007-10-16
申请号：US11022057
申请日：2004-12-23
申请人： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
发明人： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
IPC分类号： C07D225/06 , C07D211/60 , C07D498/08 , A61K31/395 , A61K35/00
CPC分类号： A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
摘要： The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
摘要翻译：本发明提供了含苯醌的安莎霉素类似物及其用于治疗和调节与过度增生相关的疾病如癌症的用途。本发明提供了含有苯醌的安莎霉素的类似物，其中苯醌被还原成氢醌并通过与合适的酸反应而被捕获，优选是增加所得17-氢醌醌霉素类似物的溶解度和空气稳定性的那些。

10. 发明申请

US20060014731A1 Analogs of benzoquinone-containing ansamycins and methods of use thereof 有权
公开(公告)号：US20060014731A1
公开(公告)日：2006-01-19
申请号：US11108165
申请日：2005-04-14
申请人： Julian Adams , Yun Gao , Asimina Georges Evangelinos , Louis Grenier , Roger Pak , James Porter , James Wright
发明人： Julian Adams , Yun Gao , Asimina Georges Evangelinos , Louis Grenier , Roger Pak , James Porter , James Wright
IPC分类号： C07D225/04 , C07D491/02 , A61K31/33
CPC分类号： A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
摘要： The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

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