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41. 发明授权

US06962918B2 Hexahydropyrazino[1'2';1,6]pyrido[3,4-b]indole-1,4-diones for the treatment of cardiovascular disorders and erectile dysfunction 失效
标题翻译：六氢吡嗪并[1'2'; 1,6]吡啶并[3,4-b]吲哚-1,4-二氢es嗪用于治疗心血管疾病和勃起功能障碍
公开(公告)号：US06962918B2
公开(公告)日：2005-11-08
申请号：US10363569
申请日：2001-09-17
申请人： Mark W. Orme , Lisa M. Schultze , Jason Scott Sawyer , Alain Claude-Marie Daugan , Raymond Brown
发明人： Mark W. Orme , Lisa M. Schultze , Jason Scott Sawyer , Alain Claude-Marie Daugan , Raymond Brown
IPC分类号： C07D487/04 , A61K31/4985 , A61P1/00 , A61P1/04 , A61P7/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P13/08 , A61P13/12 , A61P15/00 , A61P15/10 , A61P19/10 , A61P25/00 , A61P27/06 , A61P27/16 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D471/14 , C07D471/20 , C07D495/04 , C07D519/00 , C07D487/14
CPC分类号： C07D471/14
摘要： Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.
摘要翻译：一般结构式（I）的化合物及其化合物及其盐和溶剂合物的用途作为治疗剂。

42. 发明授权

US06706508B1 Ornithine carbamoyltransferase 失效
标题翻译：鸟氨酸氨基甲酰转移酶
公开(公告)号：US06706508B1
公开(公告)日：2004-03-16
申请号：US09432682
申请日：1999-11-02
申请人： James Raymond Brown , Magdalena Zalacain
发明人： James Raymond Brown , Magdalena Zalacain
IPC分类号： C12N910
CPC分类号： C12N9/1018 , A61K38/00 , A61K39/00 , A61K2039/51
摘要： The invention provides ornithine carbamoyltransferase polypeptides and DNA (RNA) encoding ornithine carbamoyltransferase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ornithine carbamoyltransferase polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了鸟氨酸氨基甲酰基转移酶多肽和编码鸟氨酸氨基甲酰基转移酶多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。还提供了利用鸟氨酸氨基甲酰基转移酶多肽筛选抗菌化合物的方法。

43. 发明授权

US06399343B1 inFB 失效
公开(公告)号：US06399343B1
公开(公告)日：2002-06-04
申请号：US09574912
申请日：2000-05-19
申请人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , Richard Lloyd Warren , Magdalena Zalacain , Chi Young So , Christopher M Traini , David John Holmes , Karen Anne Ingraham , Thomas B Mathie
发明人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , Richard Lloyd Warren , Magdalena Zalacain , Chi Young So , Christopher M Traini , David John Holmes , Karen Anne Ingraham , Thomas B Mathie
IPC分类号： C12N900
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , A61K48/00 , Y10S435/885
摘要： The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供编码infB多肽的infB多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还提供了在多肽中利用筛选抗菌化合物的方法。

44. 发明授权

US06350600B1 trmD 有权
公开(公告)号：US06350600B1
公开(公告)日：2002-02-26
申请号：US09627769
申请日：2000-07-28
申请人： Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N900
CPC分类号： C12N9/1007 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention provides trmA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recominant techniques from strepococcus pneumoniae. Also provided are methods for utilizing polypepides to screen for antibacterial compounds.
摘要翻译：本发明提供trmA甲基转移酶（trmD）多肽和编码trmD多肽的多核苷酸以及通过来自肺炎链球菌的重组技术产生此类多肽的方法。还提供了利用多肽来筛选抗菌化合物的方法。

45. 发明授权

US06261817B1 Guaa 失效
公开(公告)号：US06261817B1
公开(公告)日：2001-07-17
申请号：US09197063
申请日：1998-11-20
申请人： Sanjoy Biswas , James Raymond Brown , Lisa Kathleen Shilling , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Lisa Kathleen Shilling , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12P2106
CPC分类号： C12N9/93 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K14/3156 , G01N33/56944 , G01N33/573 , G01N33/9446 , Y10S435/822
摘要： The invention provides guaA polypeptides and polynucleotides encoding guaA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing guaA polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了guaA多肽和编码guaA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用guaA多肽筛选抗菌化合物的方法。

46. 发明授权

US06245542B1 tRNA methyltransferase from Streptococcus pneumoniae 失效
标题翻译：来自肺炎链球菌的tRNA甲基转移酶
公开(公告)号：US06245542B1
公开(公告)日：2001-06-12
申请号：US09306276
申请日：1999-05-06
申请人： Sanjoy Biswas , Alexander Bryant , James Raymond Brown , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Stephanie Van Horn , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , Alexander Bryant , James Raymond Brown , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Stephanie Van Horn , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N910
CPC分类号： C12N9/1007 , A61K38/00
摘要： The invention provides yfjO polypeptides and polynucleotides encoding yfjO polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yfjO polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了yfjO多肽和编码yfjO多肽的多核苷酸，以及通过重组技术产生此类多肽的方法。还提供了利用yfj多肽筛选抗菌化合物的方法。

47. 发明授权

US6165763A Ornithine carbamoyltransferase 失效
标题翻译：鸟氨酸氨基甲酰转移酶
公开(公告)号：US6165763A
公开(公告)日：2000-12-26
申请号：US961536
申请日：1997-10-30
申请人： James Raymond Brown , Magdalena Zalacain
发明人： James Raymond Brown , Magdalena Zalacain
IPC分类号： G01N33/50 , A61K31/00 , A61K38/00 , A61K39/00 , A61K39/07 , A61K39/395 , A61K45/00 , A61K48/00 , A61P11/00 , A61P25/00 , A61P27/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/09 , C12N15/54 , C12Q1/48 , G01N33/15 , G01N33/566 , G01N33/68 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/1018 , A61K38/00 , A61K39/00 , A61K2039/51
摘要： The invention provides ornithine carbamoyltransferase polypeptides and DNA (RNA) encoding ornithine carbamoyltransferase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ornithine carbamoyltransferase polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了鸟氨酸氨基甲酰基转移酶多肽和编码鸟氨酸氨基甲酰基转移酶多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。还提供了利用鸟氨酸氨基甲酰基转移酶多肽筛选抗菌化合物的方法。

48. 发明授权

US6100069A DNA encoding streptococcus pneumoniae trigger factor polypeptides 失效
标题翻译：编码肺炎链球菌触发因子多肽的DNA
公开(公告)号：US6100069A
公开(公告)日：2000-08-08
申请号：US196857
申请日：1998-11-20
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Katz , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Katz , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , C07K14/315 , C12N1/21 , C12N5/02 , C12N9/90 , C12N15/61 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C07K14/3156 , C12N9/90 , C12Y502/01008 , A61K38/00 , A61K39/00
摘要： The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了tig多肽和编码tig多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用tig多肽筛选抗菌化合物的方法。

49. 发明授权

US5883239A aroA 失效
公开(公告)号：US5883239A
公开(公告)日：1999-03-16
申请号：US896345
申请日：1997-07-18
申请人： James Raymond Brown , Alison Frances Chalker , David John Payne , Lisa Kathleen Shilling , Christopher Michael Traini
发明人： James Raymond Brown , Alison Frances Chalker , David John Payne , Lisa Kathleen Shilling , Christopher Michael Traini
IPC分类号： G01N33/53 , A61K31/70 , A61K38/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/16 , A61P29/00 , A61P31/04 , A61P43/00 , C07K16/40 , C12N9/00 , C12N9/10 , C12N15/00 , C12N15/09 , C12N15/54 , C12P21/02 , C12R1/46 , G01N33/566 , G01N33/569 , C07H21/02 , C07H21/04
CPC分类号： C12N9/1092
摘要： The invention provides aroA polypeptides and DNA (RNA) encoding aroA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing aroA polypeptides to screen for antibacterial compounds.

50. 发明授权

US5464652A Green ceramic via metallization technique 失效
标题翻译：绿色陶瓷通过金属化技术
公开(公告)号：US5464652A
公开(公告)日：1995-11-07
申请号：US178352
申请日：1994-01-06
申请人： Richard P. Himmel , Raymond Brown
发明人： Richard P. Himmel , Raymond Brown
IPC分类号： H01L21/48 , H01L23/367 , H01L23/498 , H01L23/538 , H05K1/03 , H05K3/40 , B05D5/12
CPC分类号： H01L23/49827 , H01L21/4853 , H01L21/486 , H01L23/3677 , H01L23/5383 , H05K3/4046 , H01L2224/16 , H01L2924/09701 , H05K1/0306 , H05K2201/0382 , H05K2201/10234 , Y10T29/49117 , Y10T29/49124 , Y10T29/49204 , Y10T29/49218 , Y10T29/49224
摘要： The present invention provides a method for metallizing vias in co-fired ceramic green tape. A vacuum operated pick and place anvil comprising a porous block is used to pick up conductor balls from a bed. Air pressure is used to create a vacuum which pulls the conductor balls to the porous block. A stencil having openings is placed on a contact surface of the anvil, thereby permitting only one conductor ball to attach to each opening in the stencil. With the conductor balls attached to the anvil, the anvil is lowered onto the green tape. Next the anvil pushes the conductor balls into the tape until the conductor balls break through the opposite side of the tape. The anvil is retracted leaving the conductor balls lodged in the tape. It is possible to provide a green tape with pre-formed vias so that forcing the conductor balls into the tape is a simpler task. The locations of the openings in the stencil determines the location of the vias or must correspond to the vias in a tape having pre-formed vias. If the conductor balls protrude from any surface of the tape, the anvil or similar device can be used to flatten the protrusion.
摘要翻译：本发明提供了一种用于在共烧陶瓷生胶带中金属化通孔的方法。使用包括多孔块的真空操作的拾取和放置砧座从床上拾取导体球。空气压力用于产生将导体球拉到多孔块的真空。具有开口的模板被放置在砧座的接触表面上，从而仅允许一个导体球附着在模板中的每个开口上。将导体球连接到砧座上，将砧座下降到生胶带上。接下来，砧将导体球推入带中，直到导体球穿过带的相对侧。砧座被收回，使导体球落在带中。可以提供具有预先形成的通孔的绿色带，使得将导体球强制进入带是更简单的任务。模板中的开口的位置决定了通孔的位置，或者必须与具有预先形成的通孔的带中的通孔相对应。如果导体球从带的任何表面突出，则可以使用砧座或类似装置使突起平坦化。

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