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41. 发明授权

US06508986B1 Devices for use in MALDI mass spectrometry 失效
公开(公告)号：US06508986B1
公开(公告)日：2003-01-21
申请号：US09644780
申请日：2000-08-24
申请人： N. Leigh Anderson , John Joseph Lennon , Jack Goodman
发明人： N. Leigh Anderson , John Joseph Lennon , Jack Goodman
IPC分类号： B01L1100
CPC分类号： G01N35/10 , B01L9/54 , B01L2200/025 , G01N1/22 , G01N35/028 , G01N2035/0494 , G01N2035/1039 , H01J49/00 , H01J49/0031 , H01J49/0418 , Y10T436/2575
摘要： An alignment plate is provided with a plurality of holes for guiding a pipette tip toward a sample plate of a MALDI mass spectrometer. Each of the holes is provided with a conical upper contour in order to guide the pipette tip toward a specific location on the sample plate. Two companion alignment plates are used in order to overlay two separate arrays of samples on the sample plate. For instance, a first of two alignment plates is formed with a 10×10 array of holes so that a 10×10 array of samples is deposited by the pipette tip onto the sample plate. The second of the two alignment plates is formed with a 9×9 array of holes so that a 9×9 array of samples is deposited on the sample plate at locations offset from the 10×10 array of samples already on the sample plate. The number of samples loaded on the sample plate is large and the space on the sample plate is more fully utilized.

42. 发明授权

US06482303B2 Automated system for two-dimensional electrophoresis 失效
公开(公告)号：US06482303B2
公开(公告)日：2002-11-19
申请号：US09813321
申请日：2001-03-21
申请人： N. Leigh Anderson , Norman G. Anderson , Jack Goodman
发明人： N. Leigh Anderson , Norman G. Anderson , Jack Goodman
IPC分类号： G01N2726
CPC分类号： G01N27/44795 , G01N27/44773 , G01N27/44782 , G01N2001/288 , Y10T436/113332 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions and geometries, gel handling systems, sample preparation systems, software and methods. The system is capable of continuous operation at high-throughput to allow construction of large quantitative data sets.

43. 发明授权

US06298874B1 Slab gel processing tank 失效
标题翻译：板状凝胶加工槽
公开(公告)号：US06298874B1
公开(公告)日：2001-10-09
申请号：US09504493
申请日：2000-02-15
申请人： Norman G. Anderson , N. Leigh Anderson
发明人： Norman G. Anderson , N. Leigh Anderson
IPC分类号： C25B700
CPC分类号： G01N27/44704 , Y10T137/8342
摘要： A slab gel processing tank is provided according to the invention. The slab gel processing tank comprises a bottom, two substantially parallel end panels, and two substantially parallel side panels having substantially vertical lower portions and outwardly angled upper portions, with the upper portions being textured to minimize contact with a gel slab, wherein the tank is adapted to be filled with a gel processing working fluid.
摘要翻译：根据本发明提供了一种板坯凝胶加工槽。板坯凝胶处理槽包括底部，两个基本上平行的端板和两个基本上平行的侧板，其具有基本垂直的下部和向外成角度的上部，其中上部是纹理化的，以最小化与凝胶板的接触，其中，适于填充凝胶加工工作液。

44. 发明授权

US06254834B1 Detection and characterization of microorganisms 失效
标题翻译：微生物的检测和表征
公开(公告)号：US06254834B1
公开(公告)日：2001-07-03
申请号：US09265541
申请日：1999-03-09
申请人： Norman G. Anderson , N. Leigh Anderson
发明人： Norman G. Anderson , N. Leigh Anderson
IPC分类号： B01L300
CPC分类号： B01L3/5021 , G01N15/0255 , G01N15/042 , G01N15/14 , G01N2015/0065 , G01N2015/047 , Y10T436/24 , Y10T436/25375 , Y10T436/255
摘要： A method for separating microorganisms, especially infectious agents, from a mixture by two dimensional centrifugation on the basis of sedimentation rate and isopycnic banding density, for sedimenting such microorganisms through zones of immobilized reagents to which they are resistant, for detecting banded particles by light scatter or fluorescence using nucleic acid specific dyes, and for recovering the banded particles in very small volumes for characterization by mass spectrometry of viral protein subunits and intact viral particles, and by fluorescence flow cytometric determination of both nucleic acid mass and the masses of fragments produced by restriction enzymes. The method is based on the discovery that individual microorganisms, such as bacterial and viral species, are each physically relatively homogeneous, and are distinguishable in their biophysical properties from other biological particles, and from non-biological particles found in nature. The method is useful for distinguishing infections, for identifying known microorganisms, and for discovering and characterizing new microorganisms. The method provides very rapid identification of microorganisms, and hence allows a rational choice of therapy for identified infectious agents. A particularly useful application is in clinical trials of new antibiotics and antivirals, where it is essential to identify at the outset individuals infected with the targeted infectious agent.
摘要翻译：基于沉降速率和等压条带密度通过二维离心从混合物中分离微生物特别是感染因子的方法，用于通过其耐受的固定化试剂区沉淀这些微生物，用于通过光散射检测带状颗粒或使用核酸特异性染料的荧光，并且用于以非常小的体积回收带状颗粒，以通过质谱鉴定病毒蛋白质亚基和完整病毒颗粒进行表征，并通过荧光流式细胞术测定核酸质量和由限制酶。该方法基于以下发现：个体微生物，例如细菌和病毒物种各自物理上相对均匀，并且在其生物物理性质与其他生物颗粒以及自然界中发现的非生物颗粒中是可区分的。该方法可用于鉴别感染，识别已知微生物以及发现和表征新的微生物。该方法提供了微生物的非常快速的鉴定，因此可以合理地选择鉴定的感染因子。一个特别有用的应用是在新的抗生素和抗病毒药物的临床试验中，其中必须首先鉴定感染了目标感染因子的个体。

45. 发明授权

US06245206B1 Automated system for two-dimensional electrophoresis 失效
公开(公告)号：US06245206B1
公开(公告)日：2001-06-12
申请号：US09339164
申请日：1999-06-24
申请人： N. Leigh Anderson , Norman G. Anderson , Jack Goodman
发明人： N. Leigh Anderson , Norman G. Anderson , Jack Goodman
IPC分类号： G01N2726
CPC分类号： G01N27/44795 , G01N27/44773 , G01N27/44782 , G01N2001/288 , Y10T436/113332 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions and geometries, gel handling systems, sample preparation systems, software and methods. The system is capable of continuous operation at high-throughput to allow construction of large quantitative data sets.

46. 发明授权

US6136173A Automated system for two-dimensional electrophoresis 失效
公开(公告)号：US6136173A
公开(公告)日：2000-10-24
申请号：US339165
申请日：1999-06-24
申请人： N. Leigh Anderson , Norman G. Anderson , Jack Goodman
发明人： N. Leigh Anderson , Norman G. Anderson , Jack Goodman
IPC分类号： C25B7/00 , G01N1/28 , G01N27/447 , G01N27/26
CPC分类号： G01N27/44795 , G01N27/44773 , G01N27/44782 , G01N2001/288 , Y10T436/113332 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions and geometries, gel handling systems, sample preparation systems, software and methods. The system is capable of continuous operation at high-throughput to allow construction of large quantitative data sets.

47. 发明授权

US5273656A System for solid phase reactions 失效
标题翻译：固相反应体系
公开(公告)号：US5273656A
公开(公告)日：1993-12-28
申请号：US943286
申请日：1992-10-07
申请人： Norman G. Anderson , N. Leigh Anderson
发明人： Norman G. Anderson , N. Leigh Anderson
IPC分类号： B01D15/02 , B01D15/08 , B01J19/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14
CPC分类号： C07K1/045 , B01D15/02 , B01D15/08 , B01J19/0046 , B01D2215/029 , B01J2219/00279 , B01J2219/00281 , B01J2219/00421 , B01J2219/0049 , B01J2219/005 , B01J2219/0059 , B01J2219/00596 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14
摘要： A rotating processor is disclosed. The apparatus includes a hollow enclosed rotor, a rotor drive, internal space to hold particulate porous reaction or separations media which may be porous, lines connecting the center and periphera of the internal space with the exterior through fluid line seals, valving to control fluid flow, gradient makers, and a microprocessor to control and monitor the entire system. Optionally the rotor may be spun with the axis vertical or horizontal, and may be used as a conventional column at rest. The rotating processor permits any synthetic or separative process utilizing particulate or solid phase supports or separations involving phases of different density to be accomplished under conditions which facilitate precise control of fluid flow and minimization of both micro- and macro-anomalous flow. A computer-controlled flat multiport valve system is also described to facilitate programmed scheduling of reagents through the rotor.
摘要翻译：公开了一种旋转处理器。该设备包括中空封闭转子，转子驱动器，用于保持微粒多孔反应的内部空间或可以是多孔的分离介质，将内部空间的中心和外围与外部连接通过流体管线密封件的管线，阀门以控制流体流动，梯度制造商和微处理器来控制和监控整个系统。可选地，转子可以轴线垂直或水平旋转，并且可以用作静止的常规柱。旋转处理器允许在促进精确控制流体流动和使微量和宏观异常流动最小化的条件下，使用包括不同密度相的微粒或固相支持物或分离物的任何合成或分离方法来实现。还描述了计算机控制的扁平多端口阀系统，以促进通过转子的试剂的编程调度。

48. 发明授权

US5272075A System for solid phase reactions 失效
公开(公告)号：US5272075A
公开(公告)日：1993-12-21
申请号：US942836
申请日：1992-10-06
申请人： Norman G. Anderson , N. Leigh Anderson
发明人： Norman G. Anderson , N. Leigh Anderson
IPC分类号： B01D15/02 , B01D15/08 , B01J19/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C12N9/00 , C07H19/00 , C07H21/00
CPC分类号： B01D15/02 , B01J19/0046 , C07K1/045 , B01D2215/029 , B01J2219/00279 , B01J2219/00281 , B01J2219/00421 , B01J2219/0049 , B01J2219/005 , B01J2219/0059 , B01J2219/00596 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14
摘要： A rotating processor is disclosed. The apparatus includes a hollow enclosed rotor, a rotor drive, internal space to hold particulate porous reaction or separations media which may be porous, lines connecting the center and periphera of the internal space with the exterior through fluid line seals, valving to control fluid flow, gradient makers, and a microprocessor to control and monitor the entire system. Optionally the rotor may be spun with the axis vertical or horizontal, and may be used as a conventional column at rest. The rotating processor permits any synthetic or separative process utilizing particulate or solid phase supports, or separations involving phases of different density to be accomplished under conditions which facilitate precise control of fluid flow and minimization of both micro- and macro-anomalous flow. A computer-controlled flat multiport valve system is also described to facilitate programmed scheduling of reagents through the rotor.

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